29 completed, 6 unknown, 5 recruiting, 3 not yet recruiting. 48 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 48 | Completed 29, Unknown 6, Recruiting 5, Not yet recruiting 3, Terminated 3, Enrolling by invitation 1, Withdrawn 1 |
Follow Hypoxia: new trials by email Literature Review of Hypoxia trials Research Report on Hypoxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Hypoxia or Caffeine on 4km Time-trial Morning Cycling. Caffeine (300mg), Placebo (caffeine, paracetamol, cephalexin, or ibuprofen), Control - Caffeine, Hypoxia | Phase 4 | Recruiting | Liverpool John Moores University | 20 | 2026-11-15 | 2026-11-13 |
| Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy Fentanyl and Propofol, Esketamine and remimazolam - Adverse Respiratory Events, Hypoxemia | Phase 4 | Not yet recruiting | Second Affiliated Hospital of Wenzhou Medical University | 120 | 2026-08-01 | 2026-08-06 |
| Effect of Supplemental Oxygen Therapy on Neurocognitive Performance in Healthy Highlanders Supplemental oxygen therapy, Sham intervention - Neurocognition | Phase 4 | Not yet recruiting | University of Zurich | 50 | 2026-06-18 | 2026-06-16 |
| Steroid Treatment for Severe Acute Respiratory Infection (STAR) Trial Corticosteroid - Hypoxemia, Severe Acute Respiratory Syndrome | Phase 4 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 3000 | 2026-03-01 | 2026-02-19 |
| Usefulness of High-flow Oxygen Therapy of Patients at Risk of Hypoxemia Undergoing Digestive Endoscopy Under Deep Sedation High-flow medical oxygen insufflation, Low-flow medical oxygen insufflation - Hypoxemia During Surgery | Phase 4 | Enrolling by invitation | Outcomes'10 | 326 | 2026-03-01 | 2026-02-27 |
| Remimazolam for Bronchoscopy in High-Risk Patients propofol and alfentanil, remimazolam combined with propofol and alfentanil - Pulmonary Infection, Pulmonary Nodule | Phase 4 | Recruiting | First Affiliated Hospital of Zhejiang University | 360 | 2026-02-09 | 2026-02-24 |
| HighCycle Study: Acetazolamide, High Altitude and Plasma Volume Acetazolamide, Placebo - High Altitude Effects, High Altitude Hypoxia | Phase 4 | Recruiting | Centre d'Expertise sur l'Altitude EXALT | 270 | 2024-07-15 | 2025-08-12 |
| HighCycle Study: Effect of Acetazolamide on Sleep Disordered Breathing in Women Compared to Men Acetazolamide, Placebo - Sleep-Disordered Breathing | Phase 4 | Completed | University of Zurich | 303 | 2024-07-15 | 2026-06-05 |
| HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men Acetazolamide, Placebo - Acute Mountain Sickness | Phase 4 | Completed | University of Zurich | 303 | 2024-07-15 | 2026-01-23 |
| HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men Acetazolamide, Placebo - High Altitude | Phase 4 | Completed | University of Zurich | 303 | 2024-07-15 | 2026-06-05 |
| Antiseizure Medication in Seizure Networks at Early Acute Brain Injury Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product - Brain Injuries, Acute, Brain Injuries, Traumatic | Phase 4 | Terminated | University of North Carolina, Chapel Hill | 5 | 2023-11-20 | 2025-11-14 |
| Efficacy of 20% Human Albumin in Reducing Pleural Effusion After Cardiopulmonary Bypass Adding 100ml of 20% human albumin to cardiopulmonary bypass priming solution - Pleural Effusions Post Coronary Artery Bypass Graft, Hypoxia | Phase 4 | Completed | Pauls Stradins Clinical University Hospital | 70 | 2022-09-01 | 2024-11-08 |
| Intravenous Iron Effects on Performance at High Altitude Injectafer, Placebo - Hypoxia | Phase 4 | Recruiting | United States Army Research Institute of Environmental Medicine | 24 | 2022-04-15 | 2025-03-30 |
| Intrapartum Sildenafil Citrate to Prevent Non Reassuring Foetal Status Among Parturients Delivering at Term Sildenafil citrate - Foetal Hypoxia | Phase 4 | Unknown | Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso | 176 | 2022-04-08 | 2022-09-28 |
| Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates Hydrocortisone - Hypoxic-Ischemic Encephalopathy, Asphyxia | Phase 4 | Recruiting | Semmelweis University | 50 | 2021-09-21 | 2026-04-28 |
| Sargramostim in Patients With Acute Hypoxic Respiratory Failure Due to COVID-19 (SARPAC) Sargramostim, Control - COVID-19 | Phase 4 | Completed | University Hospital, Ghent | 87 | 2020-03-24 | 2022-11-16 |
| Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome Dexmedetomidine, Normal saline - Brain Tumor, Metabolic Disturbance | Phase 4 | Completed | Georgia Tsaousi | 56 | 2020-03-12 | 2026-03-25 |
| Acute Effects of SGLT2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes Forxiga - Nephropathy, Hypoxia | Phase 4 | Completed | Steno Diabetes Center Copenhagen | 30 | 2020-02-01 | 2021-02-03 |
| TC02 Obese Women Using It Morphine vs PCA IV Hydromorphone for Post-Cesarean Analgesia Intrathecal Morphine, Intravenous hydromorphone - Pain, Postoperative, Obesity | Phase 4 | Withdrawn | Northwestern University | 2019-08-01 | 2022-05-06 | |
| AT1R Blockade and Periodic Breathing During Sleep in Hypoxia Hyperoxic Hypercapnic Ventilatory Response Test, Hypoxic Hypercapnic Ventilatory Response Test, Repeated Hypoxic Apneas - Sleep Disordered Breathing, Hypoxia | Phase 4 | Completed | University of British Columbia | 14 | 2018-01-01 | 2020-09-04 |
Showing 20 of 48. Sign in to see all of them.
Altitude Sickness (5) · Sleep Apnea, Obstructive (4) · Apnea (3) · Hypercapnia (3) · Hyperoxia (3) · Hypoxia, Brain (3) · Sleep Apnea Syndromes (3) · Acute Lung Injury (2) · Heart Failure (2) · Hypoxia-Ischemia, Brain (2) · Motor Activity (2) · Obesity (2) · Respiratory Aspiration (2) · Respiratory Insufficiency (2)
Pathological Conditions, Signs and Symptoms (48) · Signs and Symptoms (48) · Signs and Symptoms, Respiratory (48) · Respiratory Tract Diseases (18) · Respiration Disorders (15) · Nervous System Diseases (12) · Pathologic Processes (12) · Cardiovascular Diseases (8) · Neurologic Manifestations (7) · Dyssomnias (6) · Heart Diseases (6) · Sleep Disorders, Intrinsic (6) · Brain Diseases (5) · Central Nervous System Diseases (5)
Acetazolamide (8) · Oxygen (5) · Propofol (4) · Noninvasive Ventilation (3) · Sodium Chloride (3) · Alfentanil (2) · Carvedilol (2) · Nebivolol (2) · Saline Solution (2) · Standard of Care (2) · 2-(3',4'-dihydroxyphenyl)ethylene sulfate (1) · 5'-palmitoyl cytarabine (1) · Acetaminophen (1) · Adrenal Cortex Hormones (1) · Amlodipine (1)
University of Zurich (6) · Northwestern University (2) · United States Army Research Institute of Environmental Medicine (2) · University of British Columbia (2) · Amsterdam UMC, location VUmc (1) · Assistance Publique - Hôpitaux de Paris (1) · Association pour la Recherche en Physiologie de l'Environnement (1) · Case Western Reserve University (1) · Centre d'Expertise sur l'Altitude EXALT (1) · Centro Cardiologico Monzino (1) · Chang Gung Memorial Hospital (1) · First Affiliated Hospital of Zhejiang University (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Georgia Tsaousi (1) · Helsinki University Central Hospital (1)
United States (8) · Italy (5) · France (4) · Kyrgyzstan (4) · Canada (3) · China (3) · Greece (2) · Switzerland (2) · Austria (1) · Belgium (1) · Denmark (1) · Finland (1) · Hungary (1) · Kazakhstan (1) · Latvia (1)
Michael Furian, Prof. Dr. (3) · Talant Sooronbaev, Prof. Dr. (3) · Konrad E Bloch, MD (2) · Alexander V. Mironenko, MD, PhD (1) · Alexandra Biedrzycka, M.D., Ph.D. (1) · Bart Lambrecht (1) · Benoit Champigneulle, MD, PhD (1) · Charles S Fulco, ScD (1) · Chung Hsing Hsieh, M.D. (1) · Dmitriy B. Selivanov, MD, PhD (1) · Edith M Schneider, Dr. (1) · Emilio G. Cediel, MD (1) · Eva Strike, MD, PhD (1)
PMID 16627862, PMID 17433956, PMID 18388356, PMID 18595959, PMID 18699897, PMID 18719057, PMID 20426859, PMID 21450573, PMID 24570244, PMID 25015353, PMID 25536092, PMID 26655725, PMID 27401083, PMID 29406184, PMID 29792554, PMID 30739002, PMID 31993819, PMID 32410951, PMID 32503663, PMID 32559419, PMID 34386735, PMID 34463696, PMID 36459994, PMID 37700687, PMID 39753402, PMID 40645282
2014 (1), 2019 (1)