1715 completed, 530 unknown, 327 recruiting, 188 terminated. 1610 Not applicable, 183 Phase 2, 159 Phase 4, 145 Phase 3, 78 Phase 1.
Follow Apnea: new trials by email Literature Review of Apnea trials Research Report on Apnea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PAP Systems External Clinical Studies (ECS) PAP System A (with Amalfi) then PAP System B (with CLA11), PAP System B (with CLA11) then PAP System A (with Amalfi) - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | ResMed | 30 | 2028-08-01 | 2026-04-24 |
| Testing Settings of NovaResp's cMAP® Software During Home PAP Therapy Dynamic cMAP, Direct cMAP - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | NovaResp Technologies Inc | 50 | 2027-11-30 | 2026-10-27 |
| Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs Intranasal Oxytocin 40 i.u., Intranasal Placebo Spray - Obesity & Overweight, Respiratory Depression | Phase 2 | Not yet recruiting | George Washington University | 100 | 2027-05-15 | 2026-10-29 |
| KPAP vs EPR for Efficacy APAP + KPAP, APAP + EPR - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | SleepRes Inc. | 24 | 2027-03-01 | 2026-08-04 |
| Study to Examine the Effect of Silicone Mouth Tape on Snoring and Mild Sleep Apnea. Mouth Tape - Mild Obstructive Sleep Apnea, Snoring | Phase 2 | Recruiting | Johns Hopkins University | 100 | 2027-03-01 | 2026-06-23 |
| Registry of Central Sleep Apnea Patients Undergoing remedē System Implant Phrenic nerve stimulation - Central Sleep Apnea (Diagnosis), Central Sleep Apnea Syndrome | Not yet recruiting | Zoll Medical Corporation | 300 | 2027-03-01 | 2026-11-12 | |
| Automated vs Manual Polysomnography Scoring in Adults With Obstructive Sleep Apnea Polysomnographic Scoring (Automated vs. Manual) - Obstructive Sleep Apnea | Not yet recruiting | Ain Shams University | 50 | 2027-02-01 | 2026-09-23 | |
| HFNC vs Conventional Oxygen During Gastrocolonoscopy in Elderly Patients HİGH FLOW NASAL CANNULA OXYGEN, NASAL CANNULA OXYGEN - Hypoxemia, Eldery People | Not applicable | Not yet recruiting | Turkish Society of Anesthesiology and Reanimation | 154 | 2027-02-01 | 2026-11-04 |
| Strap To Reduce Apnea in Preterm Infants: A Randomized Crossover Trial Chinstrap - Apnea of Prematurity, Intermittent Hypoxemia | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 20 | 2027-01-15 | 2026-10-27 |
| Behavioral Optimization to Overcome Obstructive Sleep Apnea Treatment Barriers Behavioral strategy program X plus Y, Behavioral strategy program X - Sleep Apnea | Not applicable | Not yet recruiting | VA Office of Research and Development | 128 | 2027-01-04 | 2026-11-10 |
| C-LIFT Efficacy in Patients With Obstructive Sleep Apnea C-Lift - Obstructive Sleep Apnea (OSA) | Not applicable | Not yet recruiting | Ata Murat Kaynar | 10 | 2027-01-01 | 2026-09-08 |
| PAP-NAP Device Clinical Study APL Device - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | ResMed | 10 | 2027-01-01 | 2026-08-27 |
| Pediatric/Adolescent WatchPAT 400 Reliability Pilot Study WatchPAT 400 - Pediatric Sleep Disordered Breathing, Obstructive Sleep Apnea | Not applicable | Not yet recruiting | Milton S. Hershey Medical Center | 35 | 2026-12-01 | 2026-10-05 |
| Natural History of Central and Mixed Sleep Apneas Followed by Maxillomandibular Advancement for Obstructive Sleep Apnea Sleep Apnea Syndrome (OSAS), Central Sleep Apnea | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 60 | 2026-12-01 | 2026-05-19 | |
| Splintless Versus Conventional Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea Splintless MMA surgery, Splint MMA surgery - Sleep Apnea Syndrome (OSAS), Orthognathic Surgical Procedures | Not applicable | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 66 | 2026-12-01 | 2026-05-20 |
| UBT251 Injection Phase Ⅲ Study (OSA-NPAP) UBT251, Placebo - Obstructive Sleep Apnea, Obesity | Phase 3 | Not yet recruiting | The United Bio-Technology (Hengqin) Co., Ltd. | 150 | 2026-12-01 | 2026-11-03 |
| Comprehensive Opioid Management and Breathing During Sleep Comprehensive Opioid Management, Usual Care - Sleep-Disordered Breathing, Chronic Opioid Use | Not applicable | Not yet recruiting | University of California, San Diego | 68 | 2026-12-01 | 2026-11-06 |
| Supplemental Oxygen for Sleep-Disordered Breathing in Adults With Chronic Opioid Use. Sham Air, Supplemental Oxygen - Sleep-disordered Breathing, Chronic Opioid Use | Phase 2 | Not yet recruiting | University of California, San Diego | 62 | 2026-12-01 | 2026-11-06 |
| Association Between Metabolic Associated Fatty Liver Disease and Obstructive Sleep Apnea Obstructive Sleep Apnea, Metabolic Dysfunction-Associated Steatotic Liver Disease | Not yet recruiting | Assiut University | 127 | 2026-12-01 | 2026-11-02 | |
| Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea With Complete Concentric Collapse Inspire Hypoglossal Nerve Stimulation System - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 20 | 2026-12-01 | 2026-10-27 |
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Sleep Apnea, Obstructive (2172) · Sleep Apnea Syndromes (1084) · Obesity (165) · Hypertension (121) · Sleep Wake Disorders (98) · Sleep Apnea, Central (96) · Heart Failure (89) · Snoring (88) · Obesity Hypoventilation Syndrome (73) · Sleep Initiation and Maintenance Disorders (71) · Pulmonary Disease, Chronic Obstructive (70) · Hypoxia (69) · Cardiovascular Diseases (52) · Stroke (52)
Respiratory Tract Diseases (3134) · Respiration Disorders (3118) · Nervous System Diseases (2967) · Dyssomnias (2955) · Sleep Disorders, Intrinsic (2953) · Sleep Wake Disorders (2864) · Sleep Apnea Syndromes (1874) · Pathological Conditions, Signs and Symptoms (977) · Signs and Symptoms (784) · Signs and Symptoms, Respiratory (422) · Cardiovascular Diseases (408) · Nutritional and Metabolic Diseases (374) · Pathologic Processes (298) · Mental Disorders (295)
Continuous Positive Airway Pressure (252) · Polysomnography (62) · Occlusal Splints (41) · Acetazolamide (26) · Therapeutics (24) · Exercise (23) · caffeine citrate (20) · Standard of Care (18) · Surveys and Questionnaires (18) · Oxygen (16) · Atomoxetine Hydrochloride (14) · Diet (14) · Eszopiclone (14) · Modafinil (14) · Control Groups (13)
ResMed (69) · Fisher and Paykel Healthcare (68) · University Hospital, Grenoble (63) · Brigham and Women's Hospital (59) · VA Office of Research and Development (44) · University of California, San Diego (34) · Sociedad Española de Neumología y Cirugía Torácica (31) · Chinese University of Hong Kong (28) · University of Michigan (28) · University of Zurich (27) · Assistance Publique - Hôpitaux de Paris (26) · University of Pennsylvania (25) · National Taiwan University Hospital (24) · Mayo Clinic (23) · University Hospital, Antwerp (23)
United States (1013) · France (308) · Canada (194) · Spain (138) · China (126) · Germany (123) · Brazil (120) · Belgium (99) · Taiwan (96) · United Kingdom (90) · Switzerland (89) · Australia (78) · Turkey (Türkiye) (71) · Egypt (51) · Italy (51)
Atul Malhotra, MD (10) · Klaus Schindhelm, PhD (8) · Olivier Vanderveken, MD, PhD (8) · Dennis Hwang, MD (7) · Louise M O'Brien, PhD (7) · Peilin Lee, M.D. (7) · Ching-Hsia Hung, PhD (6) · Konrad E Bloch, MD (6) · Sairam Parthasarathy, MD (6) · Scott A Sands, PhD (6) · Winfried J Randerath, Prof. Dr. (6) · Eric Deflandre, MD, PhD (5) · Ferran Barbe, MD (5) · Francisco Garcia-Rio, MD (5)
PMID 34739082, PMID 15781100, PMID 21454399, PMID 23661689, PMID 25348130, PMID 26094920, PMID 26567858, PMID 27206567, PMID 27571048, PMID 27659698, PMID 27888609, PMID 39688178, PMID 40123555, PMID 40183988, PMID 8464434, PMID 16473983, PMID 16696743, PMID 17083302, PMID 17765762, PMID 1798888, PMID 19234106, PMID 19536571, PMID 19688045, PMID 19960649, PMID 20522795, PMID 20625114, PMID 20847081, PMID 21123449, PMID 21372306, PMID 21539679, PMID 21886365, PMID 22131599, PMID 22334808, PMID 22618923, PMID 22837377, PMID 22926176, PMID 23016888, PMID 23066376, PMID 23589584, PMID 23675433, PMID 24810282, PMID 25601979, PMID 25915102, PMID 25950418, PMID 26402736, PMID 26856225, PMID 26923627, PMID 27091542, PMID 27116910, PMID 27242272
2023 (7), 2019 (6), 2018 (5), R01HL102321 (5), 2015 (3), 2025 (3), R44HL158286 (3), 2009 (2), K23HL151880 (2), P01HL094307 (2), P01HL095491 (2), P50HD057796 (2), R01HL065176 (2), R01HL085188 (2), R01HL128658 (2)