73 completed, 16 unknown, 7 terminated, 6 recruiting. 57 Not applicable, 12 Phase 4, 5 Phase 2, 4 Phase 1, 4 Phase 3.
Follow Hyperoxia: new trials by email Literature Review of Hyperoxia trials Research Report on Hyperoxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treating Spinal Cord Injury With Early Normobaric Hyperoxia Normobaric Hyperoxia - Traumatic Spinal Cord Injuries | Phase 2 | Recruiting | University of Florida | 12 | 2026-10-31 | 2026-11-09 |
| Hyperoxemia and Oxygen Reserve Index During Neurointerventional Anesthesia Oxygen Reserve Index Monitoring (Observational) - Hyperoxia, Hyperoxemia | Not yet recruiting | Fatih Sultan Mehmet Training and Research Hospital | 100 | 2026-10-01 | 2026-10-06 | |
| ORI-Guided Oxygen Therapy During One-Lung Ventilation ORI-Guided FiO2 Titration, Conventional SpO₂-Guided FiO₂ Titration - Thoracic Surgery With One-lung Ventilation | Not applicable | Not yet recruiting | Konkuk University Medical Center | 58 | 2026-08-01 | 2026-07-22 |
| Oxygen Reserve Index-Guided Oxygen Titration During Surgery in the Beach Chair Position ORi-Guided FiO₂ Titration, SpO₂-Guided FiO₂ Titration - Hyperoxemia, Intraoperative Oxygen Therapy | Not applicable | Not yet recruiting | Fatih Sultan Mehmet Training and Research Hospital | 80 | 2026-02-15 | 2026-02-11 |
| Association Between Early FiO₂ Exposure and Changes in the Uric Acid/Albumin Ratio in Septic ICU Patients Oxygen Exposure (Fraction of Inspired Oxygen, FiO₂) - Standard of Care (Observational, No Experimental Intervention) - Hyperoxia / High FiO₂ Exposure, Uric Acid/Albumin Ratio (UAR) | Not yet recruiting | Istinye University | 110 | 2026-01-15 | 2026-01-13 | |
| Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity Inhaled Hydrogen-Enriched Oxygen Gas, Inhaled Nitrogen-Enriched Oxygen Gas - Oxygen Toxicity, Oxidative Stress | Not applicable | Not yet recruiting | Blekinge Institute of Technology | 32 | 2026-01-01 | 2025-12-04 |
| Cerebral Hemodynamic Effects of Oxygen and Antioxidants (CHEOXANT) Oxygen, Vitamin C (Ascorbic Acid) - Oxygen, Hyperoxemia | Not applicable | Completed | Erasme University Hospital | 13 | 2025-09-01 | 2026-05-19 |
| Can Atelectasis Be Prevented With Oxygen Reserve Index (ORI) Monitoring? Peripheral Oxygen Saturation (SpO₂) Group, Peripheral Oxygen Saturation and Oxygen Reserve Index (SpO₂-ORI) Group - Atelectasis, Lung Ultrasonography Score | Not applicable | Completed | Antalya Training and Research Hospital | 58 | 2025-07-15 | 2025-12-10 |
| Hyperoxia vs Normoxia During Cardiopulmonary Bypass Hyperoxia group, Normoxia group (control) - AKI, Renal Replacement Therapy | Not applicable | Completed | University of Padova | 104 | 2025-07-01 | 2026-04-03 |
| Hyperoxia During Outpatient Pulmonary Rehabilitation in Chronic Lung Disease - Does it Matter? Oxygen, Room Air (placebo) - Chronic Obstructive Pulmonary Disease (COPD) | Not applicable | Recruiting | Eastern Switzerland University of Applied Sciences | 32 | 2025-01-06 | 2026-09-10 |
| Automated Versus Manual Oxygen Control in Preterm Babies on Respiratory Support automated oxygen vs manual oxygen - Preterm | Not applicable | Completed | Aga Khan University Hospital, Pakistan | 26 | 2024-10-03 | 2025-09-30 |
| The Association Between Sensory Block Level, Oxygen Therapy, and ORi in Varicose Vein Patients Undergoing Spinal Anesthesia (ORi: Oxygen Reserve Index) Addition of ORi monitoring to SpO2 monitoring - Hyperoxia, Hypoxia | Completed | Kocaeli University | 56 | 2024-08-29 | 2026-03-09 | |
| Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult Volunteers Cross Over Assignment Supplemental Oxygen and Supplemental Air - Cognition | Not applicable | Completed | Inogen Inc. | 40 | 2024-05-28 | 2025-01-31 |
| Impact of Perioperative Hyperoxia on Cancer Recurrence and Mortality After Elective Colorectal Cancer Surgery Recurrence, Survival Rate | Completed | Parc de Salut Mar | 403 | 2024-05-17 | 2025-05-25 | |
| Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention Automated Titration (O2matic) - Critical Illness, Wounds and Injury | Not applicable | Completed | University of Colorado, Denver | 300 | 2024-04-29 | 2026-10-14 |
| Electronic Optimization of Inspired Oxygen During Mechanical Ventilation, a Pragmatic Randomized Trial (OPTI-Oxygen) FiO2 titration using electronic alert system - Hyperoxia | Not applicable | Suspended | Ohio State University | 936 | 2024-01-15 | 2025-04-11 |
| HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics Normobaric Hyperoxic Stimulus (NBHO) - Hyperoxemia, Cerebrovascular Circulation | Not applicable | Recruiting | Erasme University Hospital | 80 | 2024-01-01 | 2026-01-29 |
| Effect of Hyperoxia or Hypoxemia on the Incidence of Delirium in Patients After Cardiac Surgery Cardiac Surgery, Delirium - Postoperative | Completed | Southeast University, China | 1000 | 2024-01-01 | 2026-04-23 | |
| Oxygen Reserve Index in Different Fresh Gas Flow Oxygen reserve index - Oxygen Reserve Index | Completed | Sakarya University | 64 | 2024-01-01 | 2024-10-18 | |
| The Effect of Intraoperative Hyperoxemia on Postoperative Delirium in Geriatric Patients control, ORi+SpO2 - Hyperoxia, Delirium in Old Age | Completed | Tepecik Training and Research Hospital | 114 | 2023-10-01 | 2024-07-09 |
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Hypoxia (37) · Critical Illness (9) · Premature Birth (8) · Respiratory Insufficiency (6) · Hypercapnia (5) · Wounds and Injuries (5) · Coronary Artery Disease (4) · Pulmonary Atelectasis (4) · Burns (3) · Delirium (3) · Disease Attributes (3) · Heart Failure (3) · Obstetric Labor, Premature (3) · Pathologic Processes (3)
Pathological Conditions, Signs and Symptoms (114) · Signs and Symptoms (114) · Signs and Symptoms, Respiratory (114) · Pathologic Processes (31) · Respiratory Tract Diseases (23) · Cardiovascular Diseases (18) · Heart Diseases (16) · Respiration Disorders (14) · Lung Diseases (12) · Disease Attributes (11) · Vascular Diseases (11) · Nervous System Diseases (10) · Female Urogenital Diseases and Pregnancy Complications (9) · Urogenital Diseases (9) · Obstetric Labor Complications (8)
Oxygen (25) · Oxygen Saturation (4) · Hyperbaric Oxygenation (3) · Ascorbic Acid (2) · nitrox (2) · Acetazolamide (1) · Acetylcysteine (1) · Air (1) · Antioxidants (1) · Carbon Dioxide (1) · Clinical Protocols (1) · Control Groups (1) · Finasteride (1) · Lactoperoxidase (1) · Lipopolysaccharides (1)
University of Colorado, Denver (4) · University of Edinburgh (4) · Amsterdam UMC, location VUmc (3) · Insel Gruppe AG, University Hospital Bern (3) · Laval University (3) · Tepecik Training and Research Hospital (3) · Zonguldak Bulent Ecevit University (3) · Australian and New Zealand Intensive Care Research Centre (2) · Beth Israel Deaconess Medical Center (2) · Erasme University Hospital (2) · Fatih Sultan Mehmet Training and Research Hospital (2) · Hvidovre University Hospital (2) · Medical University of Vienna (2) · Norwegian University of Science and Technology (2) · Ohio State University (2)
United States (27) · Turkey (Türkiye) (18) · Canada (7) · France (7) · Netherlands (7) · United Kingdom (7) · Switzerland (6) · Belgium (5) · Denmark (5) · Italy (4) · China (3) · Norway (3) · Australia (2) · Austria (2) · South Korea (2)
Adit Ginde, MD, MPH (3) · Dominik P Guensch, MD (2) · Stephen Trzeciak, MD, MPH (2) · Abele Donati, MD (1) · Ali Shabbir Hussain (1) · Amir Hadanny, MD (1) · Andrew Cumpstey, BM BCh (1) · Anita Simonds, FRCP (1) · Anup Katheria, MD (1)
PMID 17486089, PMID 17579950, PMID 18609057, PMID 19821224, PMID 21168853, PMID 23322670, PMID 23475767, PMID 23510092, PMID 25015353, PMID 27007078, PMID 27706466, PMID 28219612, PMID 28335733, PMID 28506763, PMID 28651648, PMID 28760461, PMID 28760799, PMID 28787294, PMID 28791567, PMID 29254495, PMID 29730991, PMID 30916028, PMID 30966908, PMID 31154522, PMID 31409407, PMID 31410497, PMID 31440853, PMID 31527093, PMID 31650500, PMID 31767144, PMID 32089047, PMID 32969781, PMID 33398714, PMID 34039929, PMID 34051711, PMID 34112721, PMID 34460936, PMID 34463696, PMID 34709067, PMID 34749762, PMID 34914658, PMID 36525683, PMID 37142388, PMID 37256885, PMID 37364027, PMID 37535937, PMID 37588173, PMID 37700687, PMID 37863418, PMID 37876374
R01HL112815 (2), 2009 (1), 2014 (1), 2015 (1), 2018 (1), R00GM159353 (1), R01GM112871 (1), R03HD105224 (1)