341 completed, 58 unknown, 22 terminated, 18 withdrawn. 159 Phase 4, 127 Phase 3, 91 Phase 1, 45 Phase 2, 36 Not applicable.
Follow Amlodipine: new trials by email Literature Review of Amlodipine trials Research Report on Amlodipine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy Spironolactone (drug), Candesartan 8mg, Hydrochlorothiazide (HCTZ) 25 milligrams. - Hypertension | Phase 4 | Not yet recruiting | Ottawa Hospital Research Institute | 30 | 2027-01-01 | 2026-10-14 |
| Calcium Channel Blocker in Myotonic Dystrophy Type 1 Amlodipine - Myotonic Dystrophy 1 | Phase 1 | Not yet recruiting | University of Rochester | 20 | 2026-12-07 | 2025-12-09 |
| A Clinical Study Comparing Ankle Swelling Caused by Two Different Blood Pressure Medications, Levamlodipine and Amlodipine, in Post-menopausal Women With Mild High Blood Pressure. Amlodipine - Hypertension, Oedema | Phase 3 | Not yet recruiting | Zentiva, k.s. | 344 | 2026-11-30 | 2026-06-01 |
| Ramipril vs. Amlodipine in Pediatric Hemodialysis Patients Ramipril tablet, Amlodipine tablet - Endothelial Dysfunction, End-Stage Renal Disease | Phase 3 | Not yet recruiting | Ain Shams University | 50 | 2026-11-01 | 2026-10-21 |
| Comparing Inclisiran Versus Statin for Primary Aldosteronism inclisiran, Lipophilic statins (such as Simvastatin, Atorvastatin, Fluvastatin, Lovastatin,Pitavastatin), Spironolactone (drug) - Primary Aldosteronism | Not applicable | Recruiting | Third Military Medical University | 50 | 2026-10-01 | 2026-10-21 |
| Sitogilun Malate Plus Amlodipine in Patients With Hypertension and Risk of Early Kidney Damage Sitogilun Malate, Allisartan Isoproxil, Amlodipine besylate - Hypertension | Phase 4 | Recruiting | Shanghai Jiao Tong University School of Medicine | 456 | 2026-09-22 | 2026-10-15 |
| Comparative Effectiveness of Dual Antihypertensive Regimens in Patients After Percutaneous Coronary Intervention Losartan + Hydrochlorothiazide, Amlodipine + Azilsartan - Hypertension, Coronary Arterial Disease | Not applicable | Recruiting | National Medical Research Center for Therapy and Preventive Medicine | 207 | 2026-04-01 | 2026-07-06 |
| Role of Amlodipine in Reduction of CIN Calcium channel blocker, Hydration - Contrast-induced Nephropathy | Early Phase 1 | Not yet recruiting | Minia University | 40 | 2025-12-20 | 2025-12-18 |
| Sacubitril/Allisartan for Hypertensive Patients With Overweight or Obesity sacubitril/allisartan, Amlodipine - Hypertension | Phase 4 | Not yet recruiting | Jing Liu | 104 | 2025-11-01 | 2025-11-21 |
| Calcium Channel Blocker Amlodipine for Endometrial Cancer Therapy Amlodipine - Endometrial Cancer | Phase 2 | Not yet recruiting | Peking University People's Hospital | 140 | 2025-07-15 | 2025-07-08 |
| To Evaluate the Efficacy and Safety of Co-administrated HODO-2224-1 and HODO-2224-2 in Patients With Essential Hypertension and Primary Hypercholesterolemia Ezetimibe/Rosuvastatin/Candesartan/Amlodipine, Candesartan/Amlodipine, Candesartan/Rosuvastatin/Ezetimibe - Hypertension, Primary Hypercholesterolaemia | Phase 3 | Enrolling by invitation | Hyundai Pharm | 125 | 2025-04-22 | 2025-05-22 |
| Protecting Renal Function in Chronic Kidney Disease Patients with Isolated Nighttime Hypertension Antihypertensive treatment with Arotinolol or Amlodipine or Clonidine, Placebo-controlled group - Chronic Kidney Disease(CKD), Nocturnal Hypertension | Not applicable | Not yet recruiting | Shanghai Institute of Hypertension | 200 | 2025-01-30 | 2025-01-17 |
| Monitoring the Effectiveness and Safety of Antihypertensive Therapy With a Fixed-Dose Combination of Perindopril and Amlodipine in Patients With Uncontrolled Essential Hypertension fixed combination of perindopril + amlodipine - Essential Hypertension | Active not recruiting | Bosnalijek D.D | 600 | 2025-01-16 | 2026-10-15 | |
| Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries Amlodipine, Nebivolol, Placebo - Angina Pectoris, Microvascular Angina | Phase 2 / Phase 3 | Recruiting | Stanford University | 150 | 2024-10-10 | 2024-11-27 |
| Statin Combined with Amlodipine Treats Primary Aldosteronism Simvastatin combined with Amlodipine besylate, Simvastatin combined with Spironolactone and Amlodipine besylate., Amlodipine besylate combined Spironolactone - Primary Aldosteronism, Statin | Phase 4 | Recruiting | Third Military Medical University | 180 | 2024-09-10 | 2024-11-22 |
| China Stroke Primary Prevention Trial 2 for Participants With H-type Hypertension and MTHFR 677 CC/CT Genotype (CSPPT2-CC/CT) Amlodipine besylate, Amlodipine besylate and folic acid, Amlodipine placebos - Hypertension, MTHFR 677 CC or CT Genotype | Phase 4 | Recruiting | Shenzhen Ausa Pharmed Co.,Ltd | 32000 | 2024-08-22 | 2025-02-26 |
| China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype Amlodipine besylate, Amlodipine besylate And Folic Acid, 5-methyltetrahydrofolate (5-MTHF) - Hypertension, MTHFR 677 TT Genotype | Phase 4 | Recruiting | Shenzhen Ausa Pharmed Co.,Ltd | 24000 | 2024-08-22 | 2025-02-26 |
| Bioequivalence Study of Amlodipine/Valsartan 10/160 mg Film Coated Tablets Amlodipine/Valsartan, Amlodipine 10 mg &valsartan 160 mg (Exforge) - Healthy Volunteer | Phase 1 | Unknown | International Bio service | 48 | 2024-05-07 | 2024-01-09 |
| Evaluation of the Antihypertensive effectIveness, Tolerability, and Adherence With Amlodipine/ Indapamide/ Perindopril Triple Single-pill Combination in Hypertensive Patients Without Concomitant Antihypertensive Therapy (TRIPTYCH) Amlodipine 5 mg + indapamide 1.25 mg + perindopril 5 mg, Amlodipine 5 mg + indapamide 2.5 mg + perindopril 10 mg, Amlodipine 10 mg + indapamide 2.5 mg + perindopril 10 mg - Arterial Hypertension, HTN | Completed | Servier Russia | 396 | 2024-05-01 | 2025-06-11 | |
| Study of Efficacy and Safety of LCZ696/Amlodipine in Grade 1 and 2 Hypertension Patients Uncontrolled by LCZ696 Monotherapy LCZ, LCZ/AML 200 mg/2.5 mg, LCZ/AML 200 mg/5 mg - Hypertension | Phase 3 | Completed | Novartis Pharmaceuticals | 718 | 2024-04-08 | 2026-01-13 |
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Hypertension (312) · Essential Hypertension (54) · Diabetes Mellitus (18) · Cardiovascular Diseases (13) · Hyperlipidemias (12) · Diabetes Mellitus, Type 2 (11) · Obesity (11) · Dyslipidemias (10) · Hypercholesterolemia (9) · Coronary Artery Disease (6) · Hyperaldosteronism (6) · Metabolic Syndrome (6) · Stroke (6) · Heart Diseases (5) · Hypertrophy, Left Ventricular (5)
Novartis (36) · Novartis Pharmaceuticals (25) · Boehringer Ingelheim (23) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (13) · Hanmi Pharmaceutical Company Limited (12) · Daiichi Sankyo (10) · Boryung Pharmaceutical Co., Ltd (9) · Chong Kun Dang Pharmaceutical (9) · HK inno.N Corporation (9) · Yuhan Corporation (9) · Daewoong Pharmaceutical Co. LTD. (6) · Dr. Reddy's Laboratories Limited (6) · Shanghai Jiao Tong University School of Medicine (6) · Jeil Pharmaceutical Co., Ltd. (5) · Takeda (5)
South Korea (92) · United States (84) · China (48) · Germany (37) · Japan (29) · Italy (23) · Spain (19) · United Kingdom (19) · Brazil (18) · Canada (18) · France (18) · Russia (18) · Netherlands (15) · Australia (14) · Switzerland (14)
Jang Hee Hong (3) · Seung-Yun Cho, M.D., Ph.D. (3) · Alexandra Konradi (2) · Anthony Rodgers, Professor (2) · Carlo Gaudio, MD (2) · Chong-Jin Kim (2) · Dorian Williams, M.D. (2) · Francesco Pelliccia, MD (2)
PMID 37975597, PMID 32905623, PMID 36398903, PMID 21869730, PMID 22230384, PMID 22470539, PMID 22880024, PMID 22897803, PMID 24653513, PMID 25771069, PMID 27834686, PMID 29030456, PMID 33000470, PMID 41903707, PMID 11386927, PMID 12435255, PMID 15207952, PMID 16084849, PMID 16651474, PMID 16988754, PMID 17324745, PMID 17389264, PMID 17846352, PMID 17922981, PMID 18000186, PMID 18227370, PMID 18326958, PMID 18475165, PMID 18511605, PMID 18539917, PMID 18676075, PMID 18716365, PMID 19001024, PMID 19052124, PMID 19196360, PMID 19257800, PMID 19371934, PMID 19407658, PMID 19444280, PMID 19499960, PMID 19683638, PMID 19751459, PMID 19782922, PMID 19898642, PMID 19898644, PMID 19926008, PMID 19996069, PMID 20061358, PMID 20061360, PMID 20170948
2009 (6), 2008 (3), 2005 (1), 2016 (1), 2023 (1), 5KL2TR000370 (1), N01HC95178 (1), N01HC95179 (1), N01HC95180 (1), N01HC95181 (1), N01HC95182 (1), N01HC95183 (1), N01HC95184 (1), P20RR011104 (1), R01AG076660 (1)