125 completed, 38 unknown, 23 not yet recruiting, 17 recruiting. 121 Not applicable, 29 Phase 4, 13 Phase 1, 11 Phase 2, 9 Phase 3.
Follow Altitude Sickness: new trials by email Literature Review of Altitude Sickness trials Research Report on Altitude Sickness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution, Placebo - Acute Mountain Sickness | Phase 4 | Not yet recruiting | Insel Gruppe AG, University Hospital Bern | 30 | 2027-06-01 | 2026-07-01 |
| High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in Children High-altitude Pulmonary Edema High-flow Nasal Cannula Oxygen Therapy (HFNC) - High-altitude Pulmonary Edema | Not applicable | Not yet recruiting | Ye Fan | 116 | 2027-01-01 | 2026-11-02 |
| Optimization of Two-Indicator Screening Protocol for Neonatal Congenital Heart Disease at High Altitude Neonatal Congenital Heart Disease | Not yet recruiting | Children's Hospital of Fudan University | 6300 | 2026-10-01 | 2026-10-28 | |
| Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Patients With Pulmonary Arterial Hypertension PAH Re-ascent from sea level to 2850m - Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 20 | 2026-09-25 | 2026-09-04 |
| Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Healthy Individuals H Descent from 2850m to sea level and re-ascent back to 2850m - Healthy, Healthy Adult | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 14 | 2026-09-25 | 2026-09-03 |
| Assessment of Total Pulmonary Resistance sPAP/CO Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH Descent from 2850m to sea level - Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 20 | 2026-09-25 | 2026-09-04 |
| Assessment of Heart Rate Variability HRV During Descent DE From 2850m to Sea Level and During Re-ascent A From Sea Level to 2850m in Healthy Individuals H Descent and re-ascent (2850m, sea level) - Healthy, Healthy Adult | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 14 | 2026-09-25 | 2026-09-03 |
| Assessment of Six-minute Walking Distance Between Sea Level LA vs. High Altitude HA After Re-ascent in Patients With Pulmonary Arterial Hypertension PAH Re-Ascent sea level to 2850m - Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 20 | 2026-09-25 | 2026-09-01 |
| Assessment of Six-minute Walking Distance Between Sea Level LA vs. High Altitude HA After Re-ascent in Healthy Individuals Re-Ascent sea level to 2850m - High Altitude, Healthy | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 14 | 2026-09-25 | 2026-09-01 |
| Assessment of Heart Rate Variability HRV During Descent DE From 2850m to Sea Level and During Re-ascent A From Sea Level to 2850m in Patients With Pulmonary Arterial Hypertension PAH Descent and re-ascent (2850m, sea level) - High Altitude Effects, High Altitude | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 20 | 2026-09-25 | 2026-09-03 |
| Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH Descent to sea level - Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 20 | 2026-09-25 | 2026-09-03 |
| Assessment of Six-minute Walking Distance 6MWD Between High Altitude HA vs. Sea Level LA in Healthy Individuals H Descent from 2850m to sea level - High Altitude, Six-minute Walk Test | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 14 | 2026-09-25 | 2026-09-03 |
| Assessment of Total Pulmonary Resistance sPAP/CO Between Sea Level LA vs. High Altitude HA After Re-ascent in Healthy Individuals Re-Ascent from sea level to 2850m - High Altitude, Healthy | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 14 | 2026-09-25 | 2026-09-04 |
| Assessment of Six-minute Walking Distance 6MWD Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH Descent from 2850m to sea level - Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 20 | 2026-09-25 | 2026-09-04 |
| Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Healthy Individuals Re-ascent from sea level to 2850m - Healthy, Healthy Adult | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 14 | 2026-09-25 | 2026-09-04 |
| Assessment of Total Pulmonary Resistance sPAP/CO Between Sea Level LA vs. High Altitude HA After Re-ascent in Patients With Pulmonary Arterial Hypertension PAH Re-Ascent from sea level to 2850m - Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 20 | 2026-09-25 | 2026-09-04 |
| Assessment of Total Pulmonary Resistance sPAP/CO Between High Altitude HA vs. Sea Level LA in Healthy Individuals H Descent from 2850m to sea level - High Altitude, Healthy Adult | Not applicable | Not yet recruiting | Silvia Ulrich Somaini | 14 | 2026-09-25 | 2026-09-04 |
| The Cardiovascular Effects of Patent Foramen Ovale in Hypoxia Patent Foramen Ovale (PFO), High Altitude Pulmonary Edema | Not yet recruiting | University of Texas Southwestern Medical Center | 50 | 2026-09-15 | 2026-08-03 | |
| Key Diagnostic & Therapeutic Technologies for Severe Acute High Altitude Disease (SAHAD): Integration and Application Multicenter study of HAPE：CPAP or BiPAP Group, Multicenter study of HAPE group：NO Group, Protocol for Proteomics and Peptidomics Study of HAPE：Case Group - Severe High Altitude Pulmonary Edema, Severe High Altitude Cerebral Edema | Not applicable | Not yet recruiting | Tibet Autonomous Region People's Hospital | 3035 | 2026-07-01 | 2026-06-10 |
| Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain Simulated Occupational heat exposure under normoxic conditions, Simulated Occupational heat exposure under hypoxic conditions - Body Temperature Changes, Heat Stress | Not applicable | Recruiting | University of Ottawa | 20 | 2026-06-17 | 2026-07-14 |
Showing 20 of 214. Sign in to see all of them.
Hypoxia (63) · Hypertension, Pulmonary (30) · Motor Activity (13) · Pulmonary Arterial Hypertension (10) · Respiratory Aspiration (9) · Pulmonary edema of mountaineers (6) · Pulmonary Disease, Chronic Obstructive (5) · Sleep Apnea Syndromes (5) · Dyspnea (3) · Familial Primary Pulmonary Hypertension (3) · Polycythemia (3) · Anemia, Iron-Deficiency (2) · Breast Neoplasms (2) · COVID-19 (2)
Respiration Disorders (214) · Respiratory Tract Diseases (214) · Pathological Conditions, Signs and Symptoms (83) · Signs and Symptoms (69) · Signs and Symptoms, Respiratory (65) · Lung Diseases (41) · Cardiovascular Diseases (37) · Vascular Diseases (32) · Hypertension (30) · Pathologic Processes (20) · Behavior (16) · Nervous System Diseases (14) · Sleep Wake Disorders (8) · Apnea (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6)
Acetazolamide (29) · Ibuprofen (5) · Methazolamide (4) · Exercise (3) · Ferric Oxide, Saccharated (3) · Nifedipine (3) · RE1-silencing transcription factor (3) · Saline Solution (3) · Aminophylline (2) · Blood Specimen Collection (2) · Budesonide (2) · Continuous Positive Airway Pressure (2) · Dexamethasone (2) · Erythropoietin (2) · Melatonin (2)
University of Zurich (38) · Silvia Ulrich Somaini (14) · University of Colorado, Denver (9) · Stanford University (5) · United States Army Research Institute of Environmental Medicine (5) · Heidelberg University (4) · Insel Gruppe AG, University Hospital Bern (4) · Affiliated Hospital of Qinghai University (3) · Centre d'Expertise sur l'Altitude EXALT (3) · Children's Hospital of Fudan University (3) · Macao Polytechnic University (3) · Massachusetts General Hospital (3) · Mona Lichtblau (3) · Tasly Pharmaceuticals, Inc. (3) · Altitude Physiology Expeditions (2)
Switzerland (41) · United States (38) · China (30) · Kyrgyzstan (22) · Germany (10) · Nepal (8) · Peru (8) · France (6) · Canada (5) · Poland (4) · United Kingdom (4) · Italy (3) · Austria (2) · Belgium (2) · Bolivia (2)
Rodrigo Hoyos (14) · Silvia Ulrich (14) · Konrad E Bloch, MD (12) · Silvia Ulrich, Prof. (9) · Silvia Ulrich, Prof. Dr. (9) · Talant M Sooronbaev, MD (9) · Michael Furian, MSc (7) · Talant M Sooronbaev, Prof. Dr. (4) · Christoph Dehnert, MD (3) · Michael Furian, Prof. Dr. (3) · Mona Lichtblau (3) · Rodrigo Hoyos, Dr. (3) · Silvia Ulrich, MD (3) · Talant Sooronbaev, Prof. Dr. (3) · Grant S Lipman, MD (2)
PMID 23270443, PMID 41921908, PMID 10732898, PMID 12527602, PMID 14617262, PMID 15220175, PMID 16310554, PMID 17015867, PMID 17339571, PMID 1758616, PMID 17611205, PMID 17951621, PMID 18388356, PMID 18625667, PMID 18641094, PMID 18719057, PMID 19124989, PMID 19273551, PMID 19326598, PMID 19793859, PMID 19809026, PMID 19921365, PMID 20525717, PMID 20843247, PMID 21654697, PMID 21700688, PMID 21856702, PMID 21885723, PMID 21941649, PMID 21962063, PMID 22440488, PMID 22829927, PMID 22922469, PMID 22943271, PMID 23085214, PMID 23098412, PMID 23795742, PMID 239384, PMID 24067184, PMID 24176010, PMID 24269266, PMID 24465370, PMID 24616593, PMID 25375664, PMID 25647235, PMID 25803140, PMID 25895588, PMID 25918120, PMID 25945551, PMID 25950723
2018 (9), 2019 (1), 2023 (1)