144 completed, 59 recruiting, 46 unknown, 20 not yet recruiting. 118 Not applicable, 42 Phase 2, 36 Phase 1, 18 Phase 3, 7 Early Phase 1.
Follow Hypoxia, Brain: new trials by email Literature Review of Hypoxia, Brain trials Research Report on Hypoxia, Brain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal Stem Cells to Treat Perinatal Brain Injury to Combat Cerebral Palsy MSC, marrow, Placebo - Perinatal Arterial Ischemic Stroke, Perinatal Asphyxia | Phase 2 / Phase 3 | Not yet recruiting | UMC Utrecht | 162 | 2027-04-01 | 2026-09-21 |
| Cell-Based Therapy for White Matter Repair in Periventricular Leukomalacia Investigational Combination Product - Periventricular Leukomalacia, White Matter Disease | Early Phase 1 | Withdrawn | MGAM LLC | 2027-01-01 | 2025-07-22 | |
| Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury Acute Brain Injury, Traumatic Brain Injury | Not yet recruiting | Virginia Commonwealth University | 220 | 2026-11-30 | 2026-08-19 | |
| The PROTECT-HIE Pilot Trial Dobutamine, TnECHO - Hypoxic-ischemic Encephalopathy (HIE) | Phase 2 | Recruiting | University of Alberta | 40 | 2026-10-13 | 2026-11-05 |
| Neuro-MoD: Neuroplasticity With Motor Development Constraint-Induced Movement Therapy (CIMT), Transcutaneous auricular vagus nerve stimulation (taVNS) - Perinatal Brain Injury | Not applicable | Recruiting | University of Wisconsin, Madison | 8 | 2026-10-01 | 2026-10-19 |
| Sildenafil Plus Hypothermia to Treat Neonatal Encephalopathy Sildenafil Citrate (IV) - Hypoxic-Ischemic Encephalopathy | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 24 | 2026-10-01 | 2026-03-31 |
| Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest Minimal sedation, Standard continuous sedation - Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury | Not applicable | Recruiting | University Medical Centre Ljubljana | 100 | 2026-09-22 | 2026-10-26 |
| EEG-Based Decision-Support Algorithm for Hypoxic-Ischemic Encephalopathy in Term Newborns Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 310 | 2026-09-16 | 2026-08-13 | |
| Mesenchymal Stem Cells With Cooling Therapy for Infants With Hypoxic-Ischemic Encephalopathy Wharton's jelly-derived mesenchymal stem cells, 0.9 % Normal Saline - Hypoxic-Ischemic Encephalopathy, Neonatal, Brain Injuries, Hypoxic-Ischemic | Phase 1 / Phase 2 | Not yet recruiting | Mahidol University | 40 | 2026-09-15 | 2026-09-02 |
| Group-based Emotional Awareness and Expression Therapy to Support Recovery After Acquired Brain Injury: A Clinical Development and Evaluation Study TAU + Group Therapy (EAET), Treatment as Usual (TAU) - Aquired Brain Injury, Stroke | Not applicable | Recruiting | Uppsala University | 110 | 2026-09-15 | 2026-10-01 |
| Brain Radiotherapy Imaging for High-grade Glioma Using Hypoxia Targeting Through Oxygen-Enhanced Response Oxygen-Enhanced MRI (OE-MRI) - High Grade Gliomas, Hypoxia Brain | Not applicable | Not yet recruiting | The Leeds Teaching Hospitals NHS Trust | 25 | 2026-09-01 | 2026-06-30 |
| Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography Premature Baby, Pulmonary Hypertension of Newborn | Not yet recruiting | Birmingham Women's NHS Foundation Trust | 190 | 2026-09-01 | 2026-07-07 | |
| Effect of Citicoline on Neurological Severity Score and Cerebral Doppler Resistive Index in Neonatal Hypoxic Ischemic Encephalopathy Citicoline, Standard medical treatment - Hypoxic Ischaemic Encephalopathy (HIE) | Not applicable | Not yet recruiting | Khyber Girls Medical College | 86 | 2026-09-01 | 2026-08-24 |
| Neonatal Neurological Observation With Video AI Continuous bedside video monitoring with AI anatomic landmark tracking for neurologic monitoring - Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy | Recruiting | Artemis AI Labs | 200 | 2026-07-13 | 2026-07-15 | |
| Portable MRI for Pediatric Hypoxic Ischemic Brain Injury Portable MRI, Scavenged Sample Collection - Acute Brain Injury, Hypoxia, Brain | Not applicable | Recruiting | Children's Mercy Hospital Kansas City | 200 | 2026-07-06 | 2026-09-24 |
| Effects of Neurofeedback Training and tRNS on Attentional Deficits in Patients With Acquired Brain Injury verum tRNS + Neurofeedback, sham tRNS + Neurofeedback - Acquired Brain Injury Including Stroke, TBI | Not applicable | Recruiting | Hospitales Nisa | 30 | 2026-06-26 | 2026-09-14 |
| Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy Traumatic Brain Injury, Cerebral Palsy | Enrolling by invitation | Healing Hope International | 36 | 2026-06-01 | 2026-04-09 | |
| Promoting Recovery After Brain Injury Using Focused Ultrasound Low-intensity focused ultrasound - Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury | Not applicable | Recruiting | Massachusetts General Hospital | 36 | 2026-05-26 | 2026-06-15 |
| Study of the Effects of Acute Exposure to Moderate Altitude Hypoxia on Prospective Memory. Hypoxia exposure, Oxygen administration, Air administration - Hypoxia, Hypoxia Brain | Not applicable | Not yet recruiting | Direction Centrale du Service de Santé des Armées | 50 | 2026-05-06 | 2026-05-13 |
| Caffeine for Hypoxic Ischemic Encephalopathy Caffeine citrate oral solution, Oral placebo solution - Hypoxic Ischemic Encephalopathy (HIE) | Phase 3 | Recruiting | NICHD Global Network for Women's and Children's Health | 830 | 2026-04-08 | 2026-06-24 |
Showing 20 of 315. Sign in to see all of them.
Hypoxia-Ischemia, Brain (244) · Brain Injuries (32) · Heart Arrest (29) · Stroke (29) · Brain Injuries, Traumatic (26) · Asphyxia Neonatorum (22) · Cerebral Palsy (18) · Hypothermia (18) · Coma (16) · Premature Birth (13) · Consciousness Disorders (11) · Hypoxia (10) · Intracranial Hemorrhages (10) · Asphyxia (9)
Pathological Conditions, Signs and Symptoms (315) · Signs and Symptoms, Respiratory (315) · Signs and Symptoms (314) · Central Nervous System Diseases (313) · Nervous System Diseases (311) · Brain Diseases (308) · Hypoxia (305) · Cardiovascular Diseases (272) · Vascular Diseases (264) · Cerebrovascular Disorders (257) · Brain Ischemia (240) · Pathologic Processes (62) · Wounds and Injuries (59) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (49)
Hypothermia, Induced (9) · Umbilical Cord Clamping (7) · Saline Solution (6) · Blood Specimen Collection (5) · Magnetic Resonance Imaging (5) · Melatonin (4) · caffeine citrate (4) · Dexmedetomidine (3) · Electroencephalography (3) · Epoetin Alfa (3) · Erythropoietin (3) · Lasers, Gas (3) · Levetiracetam (3) · Magnetic Resonance Spectroscopy (3) · Oxygen (3)
Assistance Publique - Hôpitaux de Paris (8) · Boston Children's Hospital (6) · Semmelweis University (5) · University of California, San Francisco (5) · University of Florida (5) · McGill University Health Centre/Research Institute of the McGill University Health Centre (4) · NICHD Neonatal Research Network (4) · University College Cork (4) · University Hospital, Grenoble (4) · University of Michigan (4) · University of Wisconsin, Madison (4) · Alexandria University (3) · Assiut University (3) · Children's Hospital of Fudan University (3) · Healing Hope International (3)
United States (98) · France (27) · Canada (23) · China (20) · Turkey (Türkiye) (18) · United Kingdom (17) · Italy (10) · India (9) · Denmark (8) · Germany (8) · Sweden (8) · Belgium (7) · Egypt (7) · Finland (7) · Ireland (7)
Seetha Shankaran, MD (5) · Abhik Das, PhD (4) · Anup Katheria, MD (3) · Barbara J. Stoll, MD (3) · Brenda B. Poindexter, MD MS (3) · Brian Kalish, MD (3) · Kathleen A. Kennedy, MD MPH (3) · Krisa P. Van Meurs, MD (3) · Kurt Schibler, MD (3) · Michael D Weiss, MD (3) · Ronald N. Goldberg, MD (3) · Waldemar A. Carlo, MD (3) · Abbot R Laptook, MD (2) · Abbot R. Laptook, MD (2)
PMID 24524452, PMID 35835616, PMID 21876461, PMID 22224835, PMID 27567470, PMID 28901969, PMID 32813884, PMID 41250198, PMID 10211806, PMID 10763759, PMID 10869046, PMID 11015501, PMID 11465176, PMID 11703564, PMID 11891439, PMID 12165594, PMID 13326155, PMID 14977901, PMID 15199405, PMID 15607598, PMID 15607599, PMID 16186047, PMID 16221780, PMID 1622910, PMID 16350986, PMID 16631096, PMID 17079582, PMID 17671503, PMID 17695343, PMID 18534246, PMID 18720323, PMID 18762517, PMID 18784420, PMID 18829776, PMID 19020525, PMID 19172693, PMID 19252411, PMID 19451846, PMID 19455024, PMID 19883750, PMID 19948631, PMID 19954851, PMID 19955500, PMID 20207600, PMID 20381069, PMID 20385632, PMID 20631189, PMID 20679291, PMID 20695757, PMID 20847327
2017 (4), U10HD021364 (4), U10HD021373 (4), U10HD021385 (4), U10HD027851 (4), U10HD027853 (4), U10HD027856 (4), U10HD027880 (4), U10HD027904 (4), U10HD034216 (4), U10HD040492 (4), U10HD040689 (4), U10HD027871 (3), U10HD036790 (3), U10HD053109 (3)