102 completed, 49 recruiting, 35 unknown, 19 not yet recruiting. 78 Not applicable, 37 Phase 2, 34 Phase 1, 14 Phase 3, 7 Early Phase 1.
Follow Hypoxia-Ischemia, Brain: new trials by email Literature Review of Hypoxia-Ischemia, Brain trials Research Report on Hypoxia-Ischemia, Brain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal Stem Cells to Treat Perinatal Brain Injury to Combat Cerebral Palsy MSC, marrow, Placebo - Perinatal Arterial Ischemic Stroke, Perinatal Asphyxia | Phase 2 / Phase 3 | Not yet recruiting | UMC Utrecht | 162 | 2027-04-01 | 2026-09-21 |
| Cell-Based Therapy for White Matter Repair in Periventricular Leukomalacia Investigational Combination Product - Periventricular Leukomalacia, White Matter Disease | Early Phase 1 | Withdrawn | MGAM LLC | 2027-01-01 | 2025-07-22 | |
| Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury Acute Brain Injury, Traumatic Brain Injury | Not yet recruiting | Virginia Commonwealth University | 220 | 2026-11-30 | 2026-08-19 | |
| The PROTECT-HIE Pilot Trial Dobutamine, TnECHO - Hypoxic-ischemic Encephalopathy (HIE) | Phase 2 | Recruiting | University of Alberta | 40 | 2026-10-13 | 2026-10-20 |
| Sildenafil Plus Hypothermia to Treat Neonatal Encephalopathy Sildenafil Citrate (IV) - Hypoxic-Ischemic Encephalopathy | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 24 | 2026-10-01 | 2026-03-31 |
| Neuro-MoD: Neuroplasticity With Motor Development Constraint-Induced Movement Therapy (CIMT), Transcutaneous auricular vagus nerve stimulation (taVNS) - Perinatal Brain Injury | Not applicable | Recruiting | University of Wisconsin, Madison | 8 | 2026-10-01 | 2026-10-19 |
| EEG-Based Decision-Support Algorithm for Hypoxic-Ischemic Encephalopathy in Term Newborns Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 310 | 2026-09-16 | 2026-08-13 | |
| Mesenchymal Stem Cells With Cooling Therapy for Infants With Hypoxic-Ischemic Encephalopathy Wharton's jelly-derived mesenchymal stem cells, 0.9 % Normal Saline - Hypoxic-Ischemic Encephalopathy, Neonatal, Brain Injuries, Hypoxic-Ischemic | Phase 1 / Phase 2 | Not yet recruiting | Mahidol University | 40 | 2026-09-15 | 2026-09-02 |
| Group-based Emotional Awareness and Expression Therapy to Support Recovery After Acquired Brain Injury: A Clinical Development and Evaluation Study TAU + Group Therapy (EAET), Treatment as Usual (TAU) - Aquired Brain Injury, Stroke | Not applicable | Recruiting | Uppsala University | 110 | 2026-09-15 | 2026-10-01 |
| Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography Premature Baby, Pulmonary Hypertension of Newborn | Not yet recruiting | Birmingham Women's NHS Foundation Trust | 190 | 2026-09-01 | 2026-07-07 | |
| Effect of Citicoline on Neurological Severity Score and Cerebral Doppler Resistive Index in Neonatal Hypoxic Ischemic Encephalopathy Citicoline, Standard medical treatment - Hypoxic Ischaemic Encephalopathy (HIE) | Not applicable | Not yet recruiting | Khyber Girls Medical College | 86 | 2026-09-01 | 2026-08-24 |
| Neonatal Neurological Observation With Video AI Continuous bedside video monitoring with AI anatomic landmark tracking for neurologic monitoring - Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy | Recruiting | Artemis AI Labs | 200 | 2026-07-13 | 2026-07-15 | |
| Effects of Neurofeedback Training and tRNS on Attentional Deficits in Patients With Acquired Brain Injury verum tRNS + Neurofeedback, sham tRNS + Neurofeedback - Acquired Brain Injury Including Stroke, TBI | Not applicable | Recruiting | Hospitales Nisa | 30 | 2026-06-26 | 2026-09-14 |
| Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy Traumatic Brain Injury, Cerebral Palsy | Enrolling by invitation | Healing Hope International | 36 | 2026-06-01 | 2026-04-09 | |
| Caffeine for Hypoxic Ischemic Encephalopathy Caffeine citrate oral solution, Oral placebo solution - Hypoxic Ischemic Encephalopathy (HIE) | Phase 3 | Recruiting | NICHD Global Network for Women's and Children's Health | 830 | 2026-04-08 | 2026-06-24 |
| Hydrogen In Neonatal Encephalopathy (HIE) Trial Hydrogen Gas (H2) - HIE, Hypoxic-Ischemic Encephalopathy | Phase 1 | Not yet recruiting | Boston Children's Hospital | 54 | 2026-03-01 | 2026-02-17 |
| Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD) | Recruiting | Healing Hope International | 100 | 2026-03-01 | 2026-03-25 | |
| Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE) Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE) | Enrolling by invitation | Healing Hope International | 25 | 2026-03-01 | 2026-03-23 | |
| Regional Ventilation Evaluation During Neuro-injury Weaning Study Internal Thoracic Impedance - Acute Brain Injury, Mechanical Ventilation | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 60 | 2026-03-01 | 2026-02-19 | |
| Genetics of Neonatal Encephalopathy and Related Disorders Neonatal Encephalopathy, Hypoxic Ischaemic Encephalopathy (HIE) | Recruiting | Boston Children's Hospital | 300 | 2026-02-04 | 2026-03-11 |
Showing 20 of 243. Sign in to see all of them.
Brain Injuries (27) · Heart Arrest (23) · Asphyxia Neonatorum (20) · Stroke (19) · Brain Injuries, Traumatic (17) · Hypothermia (16) · Cerebral Palsy (15) · Hypoxia, Brain (10) · Premature Birth (10) · Asphyxia (9) · Intracranial Hemorrhages (9) · Coma (8) · Seizures (7) · Consciousness Disorders (6)
Cardiovascular Diseases (243) · Pathological Conditions, Signs and Symptoms (243) · Signs and Symptoms, Respiratory (243) · Vascular Diseases (243) · Central Nervous System Diseases (242) · Cerebrovascular Disorders (242) · Signs and Symptoms (242) · Hypoxia (241) · Brain Ischemia (239) · Nervous System Diseases (239) · Brain Diseases (238) · Hypoxia, Brain (233) · Pathologic Processes (46) · Wounds and Injuries (45) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (44)
Hypothermia, Induced (9) · Saline Solution (6) · Umbilical Cord Clamping (6) · Magnetic Resonance Imaging (5) · Melatonin (4) · caffeine citrate (4) · Dexmedetomidine (3) · Electroencephalography (3) · Epoetin Alfa (3) · Erythropoietin (3) · Lasers, Gas (3) · Sildenafil Citrate (3) · Spectroscopy, Near-Infrared (3) · Allopurinol (2) · Blood Specimen Collection (2)
Assistance Publique - Hôpitaux de Paris (5) · Boston Children's Hospital (5) · Semmelweis University (5) · University of California, San Francisco (5) · University of Florida (5) · McGill University Health Centre/Research Institute of the McGill University Health Centre (4) · NICHD Neonatal Research Network (4) · University College Cork (4) · University of Wisconsin, Madison (4) · Assiut University (3) · Children's Hospital of Fudan University (3) · Healing Hope International (3) · Imperial College London (3) · Nemours Children's Clinic (3) · The Hospital for Sick Children (3)
United States (81) · Canada (19) · China (18) · United Kingdom (15) · Turkey (Türkiye) (14) · France (13) · India (9) · Denmark (8) · Italy (6) · Sweden (6) · Egypt (5) · Finland (5) · Hungary (5) · Ireland (5) · Netherlands (5)
Seetha Shankaran, MD (5) · Abhik Das, PhD (4) · Anup Katheria, MD (3) · Barbara J. Stoll, MD (3) · Brenda B. Poindexter, MD MS (3) · Brian Kalish, MD (3) · Kathleen A. Kennedy, MD MPH (3) · Krisa P. Van Meurs, MD (3) · Kurt Schibler, MD (3) · Michael D Weiss, MD (3) · Ronald N. Goldberg, MD (3) · Waldemar A. Carlo, MD (3) · Abbot R Laptook, MD (2) · Abbot R. Laptook, MD (2)
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U10HD021364 (4), U10HD021373 (4), U10HD021385 (4), U10HD027851 (4), U10HD027853 (4), U10HD027856 (4), U10HD027880 (4), U10HD027904 (4), U10HD034216 (4), U10HD040492 (4), U10HD040689 (4), U10HD027871 (3), U10HD036790 (3), U10HD053109 (3), U10HD068244 (3)