99 completed, 43 unknown, 18 recruiting, 14 terminated. 70 Phase 4, 36 Not applicable, 31 Phase 3, 30 Phase 2, 28 Phase 1.
Follow Carvedilol: new trials by email Literature Review of Carvedilol trials Research Report on Carvedilol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DICE Study- Diastolic Improvement With Carvedilol & Empagliflozin in Patients With Cirrhosis Empagliflozin + Carvedilol, Carvedilol - Cirrhotic Cardiomyopathy, Empagliflozin | Phase 4 | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 400 | 2026-04-01 | 2026-05-14 |
| Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis Apixaban, Carvedilol, Placebo - Cirrhosis, Esophageal and Gastric Varices | Phase 4 | Recruiting | Asian Institute Of Medical Sciences | 220 | 2026-04-01 | 2026-04-09 |
| Carvedilol and Midodrine Versus Carvedilol Alone in Preventing Early Rebleed in Patients With Cirrhosis. Carvedilol, Midodrine Oral Product - Liver Cirrhosis | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 210 | 2026-03-01 | 2026-03-12 |
| The Therapeutic Value of Mavacamten in Hypertrophic Cardiomyopathy With Mid-to-Apical Left Ventricular Obstruction mavacamten, Beta Blocker (BB) - metoprolol, bisoprolol, carvedilol, diltiazem - Hypertrophic Cardiomyopathy (HCM) | Phase 4 | Enrolling by invitation | Second Affiliated Hospital, Zhejiang University, School of Medicine | 132 | 2026-03-01 | 2026-09-15 |
| Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF) Placebo (matching), Beta-blockers - Heart Failure, HFpEF | Phase 4 | Enrolling by invitation | Weill Medical College of Cornell University | 240 | 2026-02-02 | 2026-10-16 |
| Carvedilol vs. Propranolol for Preventing Rebleeding After Endoscopic Treatment of Cirrhotic Varices Propranolol, Carvedilol - Rebleeding of Portal Hypertension in Liver Cirrhosis, Propranolol | Phase 4 | Enrolling by invitation | Xijing Hospital | 350 | 2026-01-01 | 2026-01-20 |
| TACE Combined With Tislelizumab, Lenvatinib, and Carvedilol for Unresectable HCC With Cirrhotic Portal Hypertension TACE Combined With Tislelizumab, Lenvatinib, and Carvedilol - HCC, Liver Cirrhosis | Phase 2 | Not yet recruiting | Tongji Hospital | 78 | 2025-12-31 | 2026-01-20 |
| Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator Metoprolol Succinate, Carvedilol - Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death | Phase 4 | Recruiting | University of Rochester | 2000 | 2025-08-17 | 2025-09-18 |
| Effect of Long-term Carvedilol to Prevent Decompensation or Death in Patients With Asymptomatic Child-Pugh A5 to B8 Cirrhosis and Clinically Significant Portal Hypertension: a Multicenter Double-blind Randomized Control Trial Experimental group: Patients will be treated with carvedilol., Control group: Patients will receive a placebo. - Asymptomatic Cirrhosis, Clinically Significant Portal Hypertension | Phase 3 | Not yet recruiting | University Hospital, Tours | 290 | 2025-06-17 | 2025-06-04 |
| Acute Portal Pressure Reduction by Metformin and Carvedilol Compared to Carvedilol Alone in Cirrhosis. Carvedilol, Metformin - Liver Cirrhosis | Not applicable | Recruiting | Institute of Liver and Biliary Sciences, India | 72 | 2025-06-14 | 2025-08-06 |
| Carvedilol + Simvastatin vs. Carvedilol Alone for Cirrhosis and Cirrhotic Cardiomyopathy and Impact on Hepatic Decompensation and Survival Simvastatin 20mg, Carvedilol 3.125 mg - Decompensated Cirrhosis, Cirrhotic Cardiomyopathy | Not applicable | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 260 | 2025-06-10 | 2025-06-08 |
| HER2HEART-US: Prevention of Cardiotoxicity in Breast Cancer Patients Receiving HER2-directed Therapy Carvedilol, Empagliflozin - HER2-positive Breast Cancer, HER2+ Breast Cancer | Phase 2 | Terminated | Washington University School of Medicine | 7 | 2025-04-16 | 2026-05-13 |
| CARPEUS : Effect of Carvedilol on the Portosystemic Gradient as Measured by Endoscopic Ultrasound Carvedilol - Cirrhosis, Portal Hypertension Related to Cirrhosis | Not applicable | Recruiting | University Hospital, Clermont-Ferrand | 30 | 2025-04-16 | 2025-09-22 |
| Comparative Study of Carvedilol Monotherapy Versus Combination Therapy With Endoscopic Variceal Ligation (EVL) for Primary Prophylaxis of Variceal Bleeding in Patients With Hepatocellular Carcinoma With High-Risk Esophageal Varices Carvedilol Tablets, Endoscopic Variceal Ligation - Hepatocellular Carcinoma | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 100 | 2025-02-20 | 2025-02-20 |
| Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury control, propranolol, Carvedilol - TBI Traumatic Brain Injury | Phase 1 / Phase 2 | Recruiting | Mansoura University | 100 | 2025-01-20 | 2025-04-02 |
| Carvedilol Plus EVL or Not for the Primary Prevention of Esophageal Variceal Bleeding in Carvedilol Non-responders Carvedilol plus endoscopic variceal ligation, Carvedilol alone - Cirrhosis, Esophageal Varices | Phase 4 | Recruiting | Taipei Veterans General Hospital, Taiwan | 80 | 2025-01-06 | 2025-02-11 |
| Carvedilol and Alverine in Portal Hypertension Carvedilol and alverine - Hypertension, Portal | Phase 2 / Phase 3 | Not yet recruiting | Shanghai Changzheng Hospital | 30 | 2024-11-15 | 2024-11-20 |
| Endoscopic Variceal Ligation vs Carvedilol for the Prevention of First Esophageal Variceal Bleeding in Patients With HCC Endoscopic variceal ligation, Carvedilol - Hepatocellular Carcinoma (HCC), Esophageal Varices | Phase 4 | Recruiting | Taipei Veterans General Hospital, Taiwan | 120 | 2024-10-01 | 2025-02-13 |
| KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism Caffeine Tablet, Bupropion Hydrochloride Capsels, Repaglinide Capsels - Drug Interaction | Not applicable | Completed | Helsinki University Central Hospital | 12 | 2024-08-22 | 2026-03-06 |
| Non-selective Beta-blocker in Compensated Advanced Chronic Liver Disease Carvedilol - Portal Hypertension, Hepatic Decompensation | Phase 4 | Recruiting | Chinese University of Hong Kong | 474 | 2024-07-17 | 2026-10-22 |
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Heart Failure (32) · Hypertension (30) · Hypertension, Portal (23) · Fibrosis (16) · Esophageal and Gastric Varices (15) · Liver Cirrhosis (14) · Breast Neoplasms (8) · Diabetes Mellitus, Type 2 (8) · Atrial Fibrillation (7) · Cardiotoxicity (7) · Diabetes Mellitus (6) · Cardiovascular Diseases (5) · Heart Diseases (5) · Cardiomyopathies (4) · Essential Hypertension (4)
Institute of Liver and Biliary Sciences, India (14) · GlaxoSmithKline (9) · Mayo Clinic (4) · Chong Kun Dang Pharmaceutical (3) · Shanghai Changzheng Hospital (3) · Shanghai Zhongshan Hospital (3) · University of Minnesota (3) · Weill Medical College of Cornell University (3) · Actavis Inc. (2) · Aga Khan University (2) · Beijing Friendship Hospital (2) · Bispebjerg Hospital (2) · Changqing Yang (2) · Dr. Reddy's Laboratories Limited (2) · E-DA Hospital (2)
United States (78) · India (17) · China (12) · South Korea (12) · United Kingdom (8) · Canada (7) · Italy (7) · Denmark (6) · Spain (6) · Egypt (5) · Taiwan (5) · Brazil (4) · Japan (4) · France (3) · Pakistan (3)
Shiyao Chen, Professor (3) · Eric Bircell, MD (2) · James Carlson, Pharm. D. (2) · Joanna Kolodney, MD (2) · M David Ayra, M.D. (2) · Parag Goyal, MD (2) · Ramon C Hermida, PhD (2) · Thenappan Thenappan, MD (2) · Wei-Fen Xie, M.D. (2) · Xiaojuan Ou (2) · Aaron S Kelly, PhD (1) · Adam P Bress, PharmD, MS (1) · Ahmed A Ali, PhD (1)
PMID 27298379, PMID 11211893, PMID 11303974, PMID 14571769, PMID 15349904, PMID 15753544, PMID 17383291, PMID 17586413, PMID 17848651, PMID 18474343, PMID 18539917, PMID 19407805, PMID 19477398, PMID 19610055, PMID 19898642, PMID 20061358, PMID 20061360, PMID 20215456, PMID 20228401, PMID 20228404, PMID 20427682, PMID 20500877, PMID 20558165, PMID 20571135, PMID 20587587, PMID 20594588, PMID 21051458, PMID 21306286, PMID 21366473, PMID 21450573, PMID 21617110, PMID 21663644, PMID 21734087, PMID 21757643, PMID 21884956, PMID 21958949, PMID 21999413, PMID 22019270, PMID 22049171, PMID 22179956, PMID 22374637, PMID 22401315, PMID 22432114, PMID 22450889, PMID 22515638, PMID 22619083, PMID 22646230, PMID 22666844, PMID 22700038, PMID 22700888
2005 (1), 2018 (1), 2023 (1), K76AG064428 (1), M01RR000036 (1), N01HC95178 (1), N01HC95179 (1), N01HC95180 (1), N01HC95181 (1), N01HC95182 (1), N01HC95183 (1), N01HC95184 (1), P50DA018165 (1), P50DA018197 (1), R01AG091005 (1)