5 completed, 4 unknown, 2 recruiting, 2 terminated. 15 Phase 2, 6 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Completed 5, Unknown 4, Recruiting 2, Terminated 2, Not yet recruiting 1, Withdrawn 1 |
| Phase 3 | 6 | Recruiting 2, Terminated 2, Unknown 2 |
| Phase 1 | 2 | Completed 1, Withdrawn 1 |
Follow Hematoma, Subdural: new trials by email Literature Review of Hematoma, Subdural trials Research Report on Hematoma, Subdural
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH) Tranexamic Acid (Cyklokapron) - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Recruiting | St. Olavs Hospital | 274 | 2025-12-10 | 2026-07-17 |
| Tranexamic Acid Therapy For The Treatment of Subdural Hematomas Tranexamic Acid 650 MG, Placebo - Chronic Subdural Hematoma | Phase 2 | Not yet recruiting | Baylor College of Medicine | 240 | 2025-10-01 | 2025-05-14 |
| Prospective Clinical Investigation on Infection as a Cause of Chronic Subdural Hematoma. Amoxicillin + clavulanic acid, Placebo ( FE) - Chronic Subdural Hematomas | Phase 2 / Phase 3 | Recruiting | University of Rostock | 164 | 2024-09-01 | 2026-04-29 |
| Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma -2 Tranexamic Acid 500 MG, Placebo - Chronic Subdural Hematoma | Phase 2 | Unknown | Unity Health Toronto | 90 | 2021-07-01 | 2021-05-24 |
| Magnesium Sulphate Versus Fentanyl Sedation During Burr-hole Surgery Magnesium Sulphate, Fentanyl, Propofol - Monitored Anesthesia Care | Phase 2 | Completed | Kasr El Aini Hospital | 32 | 2019-03-01 | 2021-04-13 |
| Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury Bromocriptine 5 MG, Acetaminophen 650 MG - Subarachnoid Hemorrhage, Subdural Hematoma | Phase 1 / Phase 2 | Completed | University of California, San Francisco | 47 | 2018-11-30 | 2021-06-24 |
| Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST) Temozolomide - Gastrointestinal Stromal Tumors, Sdh | Phase 2 | Completed | Adam Burgoyne, MD, PhD | 23 | 2018-09-12 | 2026-07-28 |
| Magnesium Sulphate Versus Fentanyl for Conscious Sedation in CSDH Magnesium sulphate, Fentanyl, Propofol - Conscious Sedation | Phase 2 | Completed | Kasr El Aini Hospital | 34 | 2018-04-10 | 2018-12-04 |
| Tocilizumab (RoActemra) and Tranexamic Acid (Cyklokapron) Used as Adjuncts to Chronic Subdural Hematoma Surgery Tranexamic acid and Tocilizumab - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Terminated | Oslo University Hospital | 382 | 2017-11-28 | 2021-10-13 |
| Mgt of Chronic Subdural Hematoma Using Dexamethasone Dexamethasone, Any surgical intervention aim at treating chronic subdural hematoma - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Unknown | University of Calgary | 326 | 2016-09-17 | 2020-07-01 |
| Tranexamic Acid in Chronic Subdural Hematomas Tranexamic Acid, Placebo - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Unknown | Centre de recherche du Centre hospitalier universitaire de Sherbrooke | 130 | 2015-11-01 | 2023-09-05 |
| The Clinical Study of Atorvastatin and Dexamethasone on Treatment for Chronic Subdural Hematoma in the Patients With Coagulation Disorders Atorvastatin, Atorvastatin and Dexamethasone - Chronic Subdural Hematoma | Phase 2 | Unknown | Oriental Neurosurgery Evidence-Based-Study Team | 60 | 2014-07-01 | 2015-03-26 |
| Dexamethasone Versus Burr Hole Craniostomy for Symptomatic Chronic Subdural Hematoma Dexamethasone, Burr Hole Craniostomy - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Terminated | University of Virginia | 10 | 2014-03-01 | 2018-12-11 |
| Effect and Safety Study of Atorvastatin to Treat Chronic Subdural Hematoma Atorvastatin, placebo - Chronic Subdural Hematoma | Phase 2 | Completed | Oriental Neurosurgery Evidence-Based-Study Team | 200 | 2013-12-01 | 2016-10-25 |
| Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury Induced, sustained hypernatremia using hypertonic saline, Standard of care (hypertonic saline and mannitol; serum sodium) - Traumatic Brain Injury, Subdural Hematoma | Phase 1 / Phase 2 | Withdrawn | Massachusetts General Hospital | 2012-07-01 | 2016-12-12 |
Hematoma, Subdural, Chronic (12) · Brain Injuries, Traumatic (2) · Brain Contusion (1) · Brain Diseases (1) · Brain Edema (1) · Brain Injuries (1) · Central Nervous System Diseases (1) · Cerebral Hemorrhage (1) · Craniocerebral Trauma (1) · Fever (1) · Gastrointestinal Stromal Tumors (1) · Head Injuries, Closed (1) · Hypernatremia (1) · Hyperthermia (1)
Cardiovascular Diseases (15) · Cerebrovascular Disorders (15) · Hematoma (15) · Hemorrhage (15) · Intracranial Hemorrhage, Traumatic (15) · Pathologic Processes (15) · Pathological Conditions, Signs and Symptoms (15) · Trauma, Nervous System (15) · Vascular Diseases (15) · Brain Diseases (14) · Central Nervous System Diseases (14) · Craniocerebral Trauma (14) · Intracranial Hemorrhages (14) · Nervous System Diseases (14) · Wounds and Injuries (14)
Tranexamic Acid (5) · Dexamethasone (3) · Atorvastatin (2) · Fentanyl (2) · Magnesium Sulfate (2) · Propofol (2) · Acetaminophen (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Bromocriptine (1) · Calcium Dobesilate (1) · Mannitol (1) · Saline Solution, Hypertonic (1) · Standard of Care (1) · Temozolomide (1) · tocilizumab (1)
Kasr El Aini Hospital (2) · Oriental Neurosurgery Evidence-Based-Study Team (2) · Adam Burgoyne, MD, PhD (1) · Baylor College of Medicine (1) · Centre de recherche du Centre hospitalier universitaire de Sherbrooke (1) · Massachusetts General Hospital (1) · Oslo University Hospital (1) · St. Olavs Hospital (1) · Unity Health Toronto (1) · University of Calgary (1) · University of California, San Francisco (1) · University of Rostock (1) · University of Virginia (1)
Canada (3) · United States (3) · China (2) · Egypt (2) · Germany (1) · India (1) · Norway (1)
Adam Burgoyne, MD, PhD (1) · Brian P Walcott, MD (1) · Brian V Nahed, MD (1) · Chandrashekhar Gendle, MD PhD (1) · David Mathieu, M.D. (1) · Jason Sicklick, MD (1) · Jennifer De Jong (1) · Judy H Ch'ang, MD (1) · Mattis A Madsbu, MD PhD (1) · Michael D Cusimano, MD, PhD (1) · Milo Stanisic (1) · Omar Tanweer, MD (1) · Sameer A Sheth, MD PhD (1)
PMID 26581842, PMID 27150916, PMID 30073290, PMID 35133631, PMID 42423601
2017 (1)