24 completed, 14 unknown, 5 withdrawn, 2 not yet recruiting. 24 Not applicable, 5 Phase 4, 4 Phase 2, 2 Phase 3, 1 Early Phase 1.
Follow Hypernatremia: new trials by email Literature Review of Hypernatremia trials Research Report on Hypernatremia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Can Changes in Dialysate Sodium Concentration Improve Blood Pressure and Endothelial Function in Chronic HD Patients? Low-Sodium Dialysate (133 mmol/L), Standard-Sodium Dialysate (139 mmol/L) - Dialysis Dependent Chronic Kidney Disease, Dialysis Patients | Not applicable | Not yet recruiting | Gødstrup Hospital | 25 | 2026-11-01 | 2026-09-15 |
| Rapid Rehydration for Severe Hypernatremia Intravenous Dextrose 5% solution - Hypernatremia | Phase 2 | Not yet recruiting | Columbia University | 80 | 2026-10-01 | 2026-08-24 |
| Effects of a Six-Day Whole-Diet Intervention on Taste Perception and Dietary Behaviour in Young Adults Experimental: Increased Salty Food Intake, Experimental: Decrease Salty Food Intake, Active Comparator: Maintain Usual Diet - Sodium Excess, Hypertension | Not applicable | Completed | Sunway University | 115 | 2026-04-01 | 2026-08-27 |
| Hypernatremia Fluid Therapy in Childhood Diarrhoea Oral rehydration solution (ORS) - Hypernatremia, Acute Watery Diarrhea | Not applicable | Enrolling by invitation | International Centre for Diarrhoeal Disease Research, Bangladesh | 268 | 2026-01-13 | 2026-10-21 |
| Comparing Natriuretic Effects of ER Torsemide to IR Torsemide in Patients With Heart Failure Extended Release Torsemide Tablets, Immedate Release Torsemide Tablets - Heart Failure, Edema | Phase 4 | Withdrawn | Sarfez Pharmaceuticals, Inc. | 2025-05-01 | 2026-09-28 | |
| Correction of Hypernatremia by Intravenous Hypotonic Solution Compared to Enteral Water Hypotonic Solution, Water Purified - Hypernatremia | Not applicable | Unknown | Hospital Civil de Guadalajara | 178 | 2023-11-30 | 2023-09-29 |
| Plasma Sodium and Sodium Administration in the ICU Hypernatremia, Hyponatremia | Unknown | University Hospital, Linkoeping | 200 | 2023-09-04 | 2023-09-26 | |
| Early Versus Conventional Cessation of Hydrocortisone in Septic Shock normal saline solution, Hydrocortisone and normal saline solution - Septic Shock, Adverse Event | Phase 2 | Unknown | Mahidol University | 160 | 2023-07-05 | 2024-04-05 |
| A Short, Animated Storytelling Video to Increase Knowledge About Sodium Intake as a Cardiovascular Risk Factor A short, animated storytelling video on dietary sodium, A short, animated storytelling attention placebo video - Sodium Excess, Cardiovascular Risk Factor | Not applicable | Unknown | University Hospital Freiburg | 10000 | 2023-06-01 | 2023-05-10 |
| Increasing Vegetable Intake Using Monosodium Glutamate: A Reduced-Effort Intervention Salt replacement seasoning (50% salt and 50% MSG) mix, Salt replacement seasoning (70% salt and 30% MSG) mix, NaCl (sodium chloride/table salt) - Healthy Nutrition, Culinary Medicine | Not applicable | Completed | Texas Tech University | 148 | 2023-02-10 | 2024-08-01 |
| Comparison of Isotonic Versus Hypotonic Fluids in Neonates for Maintenance Fluid Therapy After Surgery Isotonic Saline with Dextrose - Hyponatremia, Hypernatremia | Not applicable | Completed | Rawalpindi Medical College | 84 | 2023-01-01 | 2024-07-03 |
| Cardiac Tissue Sodium Assessment in CKD Patients Using Sodium MRI Cardiac Sodium and Proton MRI - Chronic Kidney Diseases, Dialysis; Complications | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 150 | 2022-07-10 | 2024-07-24 | |
| Prospective Analysis Into Development of Hypernatremia in Critically Ill Patients Daily urine collection for biochemical analysis, Subanalysis for comparison of 24hour urine collection versus spot-check measurements - Hypernatremia, Critical Illness | Unknown | Catharina Ziekenhuis Eindhoven | 1500 | 2021-10-01 | 2021-10-27 | |
| The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress PR Lotion - AMP Human Performance, Placebo Lotion, AminoVital - Rapid Recovery - Fluid Retention, Sodium Retention | Not applicable | Completed | University of Connecticut | 18 | 2021-09-03 | 2022-10-24 |
| Vascular Effects of Acute Sodium (VEAS) Study Low Sodium Meal (140 mg sodium chloride), High Sodium Meal (2500 mg sodium chloride) - Sodium Excess, Racial Disparities | Not applicable | Completed | Indiana University | 71 | 2021-05-03 | 2025-12-19 |
| Efficacy and Safety of Rapid Intermittent Correction Compared With Slow Continuous Correction in Patients With Severe Hypernatremia Dextrose 5% in water - Hypernatremia | Phase 4 | Completed | Seoul National University Hospital | 178 | 2021-05-01 | 2025-08-29 |
| Hypernatremia in Hydatid Cyst Treatment Treatment - Echinococcosis, Hepatic | Unknown | Trabzon Kanuni Education and Research Hospital | 30 | 2021-02-01 | 2021-10-22 | |
| The Effect of AMP Human Sodium Bicarbonate Lotion on Hydration PR Lotion - AMP Human Performance, Placebo Lotion - Fluid Retention, Fluid Loss | Not applicable | Completed | University of Connecticut | 20 | 2020-12-09 | 2021-10-14 |
| Amiloride in Nephrotic Syndrome Amiloride, Furosemide - Nephrotic Syndrome, Edema | Phase 3 | Terminated | University Hospital Tuebingen | 20 | 2020-06-08 | 2025-01-14 |
| Low Sodium Neapolitan Pizza Prepared With Seawater: Nutritional Properties, Sensory Characteristics, Metabolic Effects Seawater Pizza, Standard pizza - Satiety Response, Carbohydrate Metabolism | Not applicable | Completed | Federico II University | 12 | 2020-03-10 | 2020-11-16 |
Showing 20 of 47. Sign in to see all of them.
Hyponatremia (9) · Edema (6) · Critical Illness (4) · Dehydration (3) · Hypertension (3) · Brain Edema (2) · Craniocerebral Trauma (2) · Heart Failure (2) · Renal Insufficiency, Chronic (2) · Water-Electrolyte Imbalance (2) · Ascites (1) · Brain Contusion (1) · Brain Diseases (1) · Brain Injuries (1)
Nutritional and Metabolic Diseases (47) · Metabolic Diseases (46) · Water-Electrolyte Imbalance (45) · Pathological Conditions, Signs and Symptoms (22) · Pathologic Processes (16) · Signs and Symptoms (9) · Disease Attributes (8) · Cardiovascular Diseases (6) · Female Urogenital Diseases (6) · Female Urogenital Diseases and Pregnancy Complications (6) · Kidney Diseases (6) · Male Urogenital Diseases (6) · Urogenital Diseases (6) · Urologic Diseases (6) · Renal Insufficiency (4)
Sodium Chloride (5) · Glucose (4) · Water (3) · Blood Specimen Collection (2) · Furosemide (2) · Hematologic Tests (2) · Saline Solution (2) · Amiloride (1) · Continuous Renal Replacement Therapy (1) · Control Groups (1) · Diet, Sodium-Restricted (1) · Echocardiography (1) · Fractional Exhaled Nitric Oxide Testing (1) · Hydrochlorothiazide (1) · Hydrocortisone (1)
Catharina Ziekenhuis Eindhoven (2) · Frisius Medisch Centrum (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · University of Connecticut (2) · Air Force Military Medical University, China (1) · Case Western Reserve University (1) · Centre Hospitalier Arras (1) · Centre Hospitalier Universitaire de Besancon (1) · Centre Hospitalier Universitaire de la Réunion (1) · Columbia University (1) · Copenhagen University Hospital, Rigshospitalet (1) · Federico II University (1) · Gødstrup Hospital (1) · Hamilton Health Sciences Corporation (1) · Hospital Civil de Guadalajara (1)
United States (11) · Netherlands (4) · Canada (3) · Denmark (3) · France (3) · Turkey (Türkiye) (3) · China (2) · Sweden (2) · Bangladesh (1) · Belgium (1) · Brazil (1) · Finland (1) · Georgia (1) · Germany (1) · Italy (1)
Douglas J Casa, PhD (2) · Annette Dam, MD (1) · Aydin Aktas (1) · Berdine R Martin, PhD (1) · Brian P Walcott, MD (1) · Brian V Nahed, MD (1) · Christiaan Boerma, MD (1) · Christiaan Boerma, MD PhD (1) · Christopher W McIntyre, MD PhD (1) · Christopher W McIntyre, MD/PhD (1) · Connie M Weaver, PhD (1) · Dan Hagg, MS MD (1) · Daniel Shepshelovich, MD (1)
PMID 15070956, PMID 15817862, PMID 17556706, PMID 18414066, PMID 20007307, PMID 20405264, PMID 20658124, PMID 22002075, PMID 22007013, PMID 23369520, PMID 23553157, PMID 23653182, PMID 24888281, PMID 24944242, PMID 28347943, PMID 29422070, PMID 30462243, PMID 33104176, PMID 37296468, PMID 38556717, PMID 39873709, PMID 40535918, PMID 41514069
2019 (1), K01HL147998 (1), R01DK149765 (1)