118 completed, 48 recruiting, 43 unknown, 20 terminated. 175 Not applicable, 25 Phase 2, 22 Phase 1, 22 Phase 3, 4 Phase 4.
Follow Hyperthermia: new trials by email Literature Review of Hyperthermia trials Research Report on Hyperthermia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Work Design Interventions for Older Workers During Consecutive Days in the Heat Standard work pace, Additional rest breaks - Hyperthermia, Fatigue; Heat | Not applicable | Not yet recruiting | State University of New York at Buffalo | 32 | 2028-09-01 | 2026-06-30 |
| Work Design Interventions for Heat Resilience Standard work pace, Reduced-pace work, Increased-pace work - Hyperthermia, Fatigue; Heat | Not applicable | Not yet recruiting | State University of New York at Buffalo | 32 | 2027-09-01 | 2026-06-30 |
| A Prospective Study of Concurrent Hyperthermia, Chemotherapy and Radiotherapy in Borderline and Locally Advanced Pancreatic Cancer (PANHEAT) Hyperthermia plus neoadjuvant chemotherapy/radiotherapy Arm Description: Hyperthermia plus neoadjuvant chemotherapy (mFOLFIRINOX/nab Paclitaxel) followed by a) surgically resectable: Hyp - Borderline and Locally Advanced Pancreatic Cancer | Not applicable | Not yet recruiting | Fernando Pessoa Canarias University | 60 | 2027-03-31 | 2026-09-24 |
| Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain serial whole body hyperthermia - Hyperthermia, Chronic Primary Pain | Not applicable | Not yet recruiting | Bern University of Applied Sciences | 60 | 2026-12-01 | 2026-09-30 |
| Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder Tocilizumab, Placebo, Whole-Body Hyperthermia - Major Depressive Disorder | Phase 2 | Suspended | Massachusetts General Hospital | 35 | 2026-12-01 | 2025-11-13 |
| Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study Cognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia - Major Depressive Disorder | Not applicable | Not yet recruiting | University of California, San Francisco | 60 | 2026-12-01 | 2026-10-13 |
| TECAR Therapy in Chronic Back Pain TECAR Therapy plus Hi-EMS, Tecar therapy alone - Chronic Low-back Pain (cLBP), Non Specific Chronic Low Back Pain | Not applicable | Not yet recruiting | University of Hartford | 37 | 2026-10-19 | 2026-09-15 |
| Electrosurgical Patterns and Learning Curve in Elective Laparoscopic Cholecystectomy Elective laparoscopic cholecystectomy - Cholelithiasis | Recruiting | University Hospital of Split | 165 | 2026-10-15 | 2026-10-22 | |
| Progressive Heat Exposure and Physiological Strain Constant Heat Exposure, Progressively Increasing Heat Exposure - Body Temperature Changes, Heat Stress | Not applicable | Not yet recruiting | University of Ottawa | 14 | 2026-10-01 | 2026-09-29 |
| Intratumoral Targeted Hyperthermia Therapy (THT) for Cutaneous Metastatic Melanoma Targeted Hyperthermia Therapy - Cutaneous Metastatic Melanoma | Not applicable | Not yet recruiting | Sona Nanotech Inc | 10 | 2026-10-01 | 2026-04-24 |
| A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic Cancer Whole-body hyperthermia, Standard-of-Care Systemic therapy - Pancreatic Ductal Adenocarcinoma (mPDAC), Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 2 / Phase 3 | Not yet recruiting | ElmediX | 95 | 2026-10-01 | 2026-07-17 |
| Rapid Cool: Heat Stroke Treatment Recirculated water, Phoenix protocol - Hyperthermia | Not applicable | Not yet recruiting | State University of New York at Buffalo | 20 | 2026-09-21 | 2026-08-04 |
| Thermotherapy for Head and Neck Cancer Patients Thermotherapy, Radiotherapy, Concurrent chemoradiation - Head and Neck Cancer, Oropharyngeal Carcinoma | Phase 1 | Recruiting | Erasmus Medical Center | 30 | 2026-09-01 | 2026-09-02 |
| Hyperthermia Safety Study Uses Temperature Management System to Gently Raise Participant's Body Temperature to a Fever-range Level in a Controlled Setting. Hyperthermia - Safety Study | Not applicable | Enrolling by invitation | Marc Abreu | 20 | 2026-09-01 | 2026-09-21 |
| Temperature Optimization in Afebrile Septic PatienTs External Warming - Sepsis, Temperature | Not applicable | Recruiting | Matt Harmon | 50 | 2026-07-17 | 2026-09-21 |
| Consecutive Occupational Heat Exposure With and Without Overnight Cooling Simulated occupational heat exposure with recovery at recommended indoor temperature limit, Simulated occupational heat exposure with recovery in an overheated indoor environment - Body Temperature Changes, Heat Stress | Not applicable | Recruiting | University of Ottawa | 10 | 2026-06-24 | 2026-10-05 |
| Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain Simulated Occupational heat exposure under normoxic conditions, Simulated Occupational heat exposure under hypoxic conditions - Body Temperature Changes, Heat Stress | Not applicable | Recruiting | University of Ottawa | 20 | 2026-06-17 | 2026-07-14 |
| Laboratory Heat Biomarker and Cooling Interventions Hand cooling table, Cooling bandana - Hyperthermia | Not applicable | Not yet recruiting | Stanford University | 30 | 2026-06-01 | 2026-06-01 |
| Home-Based Heat Therapy in Spinal Cord Injury to Improve Cardiovascular Health HEAT - Passive Heat Therapy, Sham (No Treatment) - SCI - Spinal Cord Injury | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 48 | 2026-03-24 | 2026-05-05 |
| The Effect of Heat Pads and Foam Rolling on Strength in Athletes. Heating Pad, Foam Roller - Healthy Participants | Not applicable | Active not recruiting | University of Redlands | 38 | 2026-02-01 | 2026-05-06 |
Showing 20 of 266. Sign in to see all of them.
Heat Stress Disorders (25) · Motor Activity (14) · Hypothermia (13) · Malignant Hyperthermia (12) · Neoplasms (11) · Breast Neoplasms (8) · Depression (7) · Fever (7) · Body Temperature Changes (6) · Pancreatic Neoplasms (6) · Rectal Neoplasms (6) · Head and Neck Neoplasms (5) · Leishmaniasis, Cutaneous (5) · Neoplasm Metastasis (5)
Pathological Conditions, Signs and Symptoms (266) · Signs and Symptoms (266) · Body Temperature Changes (260) · Wounds and Injuries (256) · Heat Stress Disorders (230) · Neoplasms (56) · Pathologic Processes (52) · Neoplasms by Site (46) · Digestive System Diseases (27) · Skin and Connective Tissue Diseases (23) · Digestive System Neoplasms (22) · Neurologic Manifestations (22) · Skin Diseases (22) · Behavior (21) · Female Urogenital Diseases and Pregnancy Complications (21)
Diathermy (40) · Radiotherapy (13) · Hyperthermia, Induced (11) · Exercise (7) · Electrosurgery (6) · Cisplatin (5) · Drug Therapy (5) · Electrocoagulation (4) · Fluorouracil (4) · Acetaminophen (3) · Brachytherapy (3) · Cryotherapy (3) · Cytoreduction Surgical Procedures (3) · Hot Temperature (3) · Immune Checkpoint Inhibitors (3)
University of Ottawa (16) · University of Texas Southwestern Medical Center (11) · State University of New York at Buffalo (10) · Medtronic Surgical Technologies (7) · University of Connecticut (7) · National Cancer Institute (NCI) (6) · Clinical Laserthermia Systems AB (5) · First Hospital of China Medical University (5) · University of Erlangen-Nürnberg Medical School (5) · Universität Duisburg-Essen (5) · Indiana University (3) · Purdue University (3) · University of California, San Francisco (3) · University of Malaga (3) · Al-Azhar University (2)
United States (89) · Canada (23) · Germany (21) · China (14) · Netherlands (9) · Brazil (7) · Spain (7) · Switzerland (7) · Italy (5) · South Korea (5) · United Kingdom (5) · Egypt (4) · Pakistan (4) · France (3) · Israel (3)
Glen P Kenny, PhD (9) · Douglas Casa, PhD (3) · Ronald J Sigal, MD, MPH (3) · Xinghua Gao (3) · Abhay Gupta, MD (2) · Ashley E Mason, PhD (2) · Beverly Winikoff, MD, MPH (2) · Gustav Dobos, Prof. MD (2) · Jill Durocher (2) · Julie Parsonnet, MD (2) · Manimaran Ramani, MD (2) · Michiel Kroesen, MD, Dr. (2) · Oliver Ott, MD (2) · Peter Naruns, MD (2) · Riana R Pryor, PhD (2)
PMID 11234459, PMID 12937509, PMID 14666667, PMID 14964587, PMID 15970955, PMID 16091763, PMID 16558145, PMID 16558418, PMID 16558608, PMID 17296783, PMID 17714574, PMID 20374659, PMID 20649524, PMID 20689450, PMID 21400025, PMID 21701326, PMID 21735398, PMID 22319684, PMID 22373120, PMID 22388047, PMID 22459699, PMID 22594858, PMID 22769055, PMID 22814453, PMID 22885279, PMID 23076403, PMID 23234265, PMID 23290179, PMID 23606872, PMID 23715806, PMID 23739984, PMID 23740007, PMID 23953605, PMID 24399113, PMID 24648633, PMID 24758395, PMID 24856792, PMID 24904204, PMID 25516462, PMID 25603738, PMID 25783647, PMID 25786484, PMID 25795108, PMID 26206681, PMID 26291952, PMID 26340453, PMID 26504041, PMID 26506402, PMID 26803476, PMID 27270841
R00AT004711 (2), R01AG069005 (2), 2008 (1), 2015 (1), 2016 (1), K23GM129630 (1), P20GM103418 (1), P30DK097512 (1), R01AG073634 (1), R01AG089307 (1), R01AT013214 (1), R01DK146310 (1), R01HG011794 (1), R01NS102176 (1), R34AT011221 (1)