178 completed, 44 recruiting, 40 unknown, 31 terminated. 134 Phase 2, 63 Phase 1, 38 Phase 3, 32 Not applicable, 10 Phase 4.
Follow Gastrointestinal Stromal Tumors: new trials by email Literature Review of Gastrointestinal Stromal Tumors trials Research Report on Gastrointestinal Stromal Tumors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autologous Tumor Infiltrating Lymphocytes With Interleukin-2 for the Treatment of Locally Advanced, Recurrent or Metastatic Gastrointestinal Stromal Tumors Aldesleukin, Biospecimen Collection, Chest Radiography - Locally Advanced Gastrointestinal Stromal Tumor, Metastatic Gastrointestinal Stromal Tumor | Phase 2 | Not yet recruiting | Joal Beane | 59 | 2027-02-15 | 2026-10-13 |
| Hyperpolarized MRI for GIST on Imatinib Hyperpolarized 13C-MRI - Imatinib Therapy Response, Gastrointestinal Stromal Tumor (GIST) | Not yet recruiting | Chang Gung Memorial Hospital | 30 | 2027-01-01 | 2026-07-24 | |
| A Legacy Study in Participants With Gastrointestinal Stromal Tumors (GIST) Velzatinib - Gastrointestinal Neoplasms | Phase 2 | Not yet recruiting | GlaxoSmithKline | 72 | 2026-10-13 | 2026-09-28 |
| A Study of Velzatinib in Participants With Metastatic and/or Unresectable GIST After Imatinib, Sunitinib, Regorafenib, and Pimitespib Velzatinib - Gastrointestinal Neoplasms | Phase 2 | Recruiting | GlaxoSmithKline | 24 | 2026-08-17 | 2026-10-01 |
| A Study to Investigate Velzatinib Compared With Imatinib in Adult Participants With Previously Untreated Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (StrateGIST Frontline) Velzatinib, Imatinib - Gastrointestinal Stromal Neoplasms | Phase 3 | Recruiting | GlaxoSmithKline | 800 | 2026-07-27 | 2026-10-23 |
| Study of DCC-2618 in Patients With GIST After at Least 3 Prior Treatments DCC-2618 - Gastrointestinal Stromal Tumors | Phase 1 | Recruiting | Ono Pharmaceutical Co., Ltd. | 10 | 2026-07-07 | 2026-07-20 |
| KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line) KQB198, Imatinib (Gleevec) - GIST - Gastrointestinal Stromal Tumor, GIST | Phase 2 | Recruiting | Kumquat Biosciences Inc. | 46 | 2026-06-23 | 2026-08-10 |
| PH 2 Pemigatinib in SDH-deficient GIST Pemigatinib - SDH Gene Mutation, Gastrointestinal Stromal Tumor | Phase 2 | Recruiting | Dana-Farber Cancer Institute | 24 | 2026-05-19 | 2026-05-22 |
| Preoperative Imatinib and Fampridine in KIT Mutant Gastrointestinal Stromal Tumor Imatinib, Fampridine - Gastrointestinal Stromal Tumors | Phase 1 | Recruiting | University of California, San Diego | 18 | 2026-05-13 | 2026-05-27 |
| Efficacy and Safety of NB003 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST) NB003, regorafenib - GIST - Gastrointestinal Stromal Tumor, Advanced | Phase 2 / Phase 3 | Recruiting | Ningbo Newbay Technology Development Co., Ltd | 255 | 2026-05-11 | 2026-06-10 |
| A Novel Two-Tooth Clip for ESD and EFTR of GIST A Novel Two-Tooth Endoscopic Clip, Clip - GIST - Gastrointestinal Stromal Tumor | Not applicable | Recruiting | Affiliated Hospital to Academy of Military Medical Sciences | 60 | 2026-04-24 | 2026-05-22 |
| Mesenteric Vascular Preconditioning Combined With Laparoscopic and Endoscopic Cooperative Surgery for Submucosal Tumor at the Gastroesophageal Junction laparoscopic and endoscopic cooperative surgery - Submucosal Tumor of Gastrointestinal Tract, Gastrointestinal Stromal Tumor (GIST) | Phase 2 | Enrolling by invitation | Peking University People's Hospital | 40 | 2026-04-01 | 2026-04-30 |
| Development of a Multimodal AI System for GIST Management Multimodal AI Analysis System - Gastrointestinal Stromal Tumors, Gastric Subepithelial Tumors | Completed | Qun Zhao | 300 | 2026-03-01 | 2026-10-06 | |
| A Comprehensive, Multinational GIST Registry Gastrointenstinal Stromal Tumor (GIST), GIST - Gastrointestinal Stromal Tumor | Not yet recruiting | Universität Duisburg-Essen | 1000 | 2026-01-01 | 2025-12-09 | |
| Development and External Validation of a Prognostic Model for DFS After Curative Resection of Duodenal GIST Duodenal, Gastrointestinal Stromal Tumors | Active not recruiting | First Affiliated Hospital of Fujian Medical University | 288 | 2026-01-01 | 2026-09-23 | |
| A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy IDRX-42, Sunitinib - Gastrointestinal Neoplasms | Phase 3 | Recruiting | GlaxoSmithKline | 450 | 2025-12-03 | 2026-10-05 |
| DESTINY-PANTUMOUR04 Trastuzumab deruxtecan - Adenocarcinoma (NOS), Anal Cancer | Recruiting | AstraZeneca | 100 | 2025-09-18 | 2026-09-25 | |
| Resistance Profiling Using Functional Imaging and Next Generation Sequencing in Refractory Gastrointestinal Stomal Tumors (GIST) Generation of a comprehensive and single-lesion resistance profile - Gastrointestinal Stromal Tumor (GIST) | Not yet recruiting | Universität Duisburg-Essen | 40 | 2025-09-01 | 2025-08-19 | |
| CEH-EUS for Differentiating GISTs and Leiomyomas: A Multicenter Prospective Self-Controlled Study Endoscopic Ultrasound, Contrast-Enhanced Harmonic Endoscopic Ultrasound (CEH-EUS) - Submucosal Tumor, Gastrointestinal Stromal Tumor (GIST) | Not yet recruiting | Huazhong University of Science and Technology | 288 | 2025-08-01 | 2025-08-06 | |
| A Study of Regorafenib Combined With Envafolimab for Metastatic Gastrointestinal Stromal Tumors With Kit Gene Exon 17 Mutation That Failed Standard Treatment regorafenib combined with envafolimab, Control Group - Metastatic Gastrointestinal Stromal Tumors (GIST) | Phase 2 | Not yet recruiting | Peking University | 100 | 2025-07-30 | 2025-07-31 |
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Neoplasms by Histologic Type (334) · Neoplasms, Connective Tissue (334) · Neoplasms, Connective and Soft Tissue (334) · Digestive System Diseases (332) · Gastrointestinal Diseases (331) · Digestive System Neoplasms (330) · Neoplasms (314) · Gastrointestinal Neoplasms (313) · Neoplasms by Site (92) · Pathological Conditions, Signs and Symptoms (53) · Neoplasms, Glandular and Epithelial (51) · Pathologic Processes (47) · Neoplasms, Nerve Tissue (43) · Endocrine System Diseases (42) · Endocrine Gland Neoplasms (41)
Imatinib Mesylate (71) · Sunitinib (31) · regorafenib (17) · nilotinib (15) · ripretinib (13) · avapritinib (7) · Dasatinib (5) · Ipilimumab (5) · Laparoscopy (5) · 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one (4) · Blood Specimen Collection (4) · CTLA-4 Antigen (4) · Surgical Procedures, Operative (4) · spartalizumab (4) · Bevacizumab (3)
Novartis Pharmaceuticals (25) · National Cancer Institute (NCI) (23) · Asan Medical Center (18) · Deciphera Pharmaceuticals, LLC (9) · Pfizer (9) · European Organisation for Research and Treatment of Cancer - EORTC (7) · M.D. Anderson Cancer Center (7) · Bayer (6) · Blueprint Medicines Corporation (5) · First Affiliated Hospital, Sun Yat-Sen University (5) · GlaxoSmithKline (5) · Stanford University (5) · Centre Leon Berard (4) · Chang Gung Memorial Hospital (4) · Memorial Sloan Kettering Cancer Center (4)
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Yoon-Koo Kang, MD, PhD (6) · Suzanne George, MD (4) · Jonathan Trent, MD, PhD (3) · Axel Le Cesne, MD (2) · Chun-Nan Yeh, MD (2) · Franco M. Muggia, MD (2) · Heikki Joensuu, M.D. (2) · Hui Cao, Professor (2) · Jacob Verweij, MD, PhD (2) · Johanna Bendell, MD (2) · Lin Shen, MD (2)
PMID 30274985, PMID 17046465, PMID 32615108, PMID 33465704, PMID 12094370, PMID 14645423, PMID 16624552, PMID 18076015, PMID 18774375, PMID 21387287, PMID 21826194, PMID 23177515, PMID 24444087, PMID 25655899, PMID 28385194, PMID 28947860, PMID 29093181, PMID 30617491, PMID 32511981, PMID 33301227, PMID 33453089, PMID 34272196, PMID 34343033, PMID 36470211, PMID 10197236, PMID 10636102, PMID 11215292, PMID 11705489, PMID 12032772, PMID 12038814, PMID 12297746, PMID 12522257, PMID 12528778, PMID 12949711, PMID 12957454, PMID 14515284, PMID 15010069, PMID 15177491, PMID 15592836, PMID 15613856, PMID 15654796, PMID 15659504, PMID 15928335, PMID 16046979, PMID 16110036, PMID 16551858, PMID 16876399, PMID 16996566, PMID 17095209, PMID 17336514
2008 (4), U01CA069856 (3), U10CA032102 (3), U10CA180888 (3), 2014 (2), 2025 (2), N01CM62206 (2), P30CA008748 (2), P30CA016087 (2), P30CA068485 (2), U10CA076001 (2), 2004 (1), 2005 (1), 2009 (1), 2015 (1)