91 completed, 22 unknown, 12 terminated, 10 withdrawn. 60 Not applicable, 33 Phase 2, 24 Phase 3, 24 Phase 4, 13 Phase 1.
Follow Saline Solution, Hypertonic: new trials by email Literature Review of Saline Solution, Hypertonic trials Research Report on Saline Solution, Hypertonic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Hyperosmolar Agent in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Ultrasonography Mannitol (20%), Hypertonic Saline ( 3% Sodium Chloride Saline) - TBI (Traumatic Brain Injury), ICP (Intracranial Pressure) Increase | Not applicable | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-08-25 |
| The Rhinovirus Hospitalization and Investigation of Nasal-airway Omics (RHINO) Study Nasal Swab Healthy Surveillance, Nasal Swab Sick Samples, Nasal Swab Hospitalized Cohort - Rhinovirus | Recruiting | University of Wisconsin, Madison | 670 | 2026-08-04 | 2026-08-10 | |
| Efficacy of Early Continuous Infusion of HSS on the Neurological Outcome at 6 Months in TBI Patients. Hypertonic saline solution - TBI Traumatic Brain Injury | Phase 3 | Recruiting | Nantes University Hospital | 760 | 2026-04-21 | 2026-07-29 |
| Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection Mechanical insufflation-exsufflation, Standard of Care, Hypertonic saline with hyaluronic acid - Nosocomial Infection, Nosocomial Pneumonia | Not applicable | Not yet recruiting | Hospital San Carlos, Madrid | 100 | 2026-01-01 | 2025-03-26 |
| Hypertonic Saline in Posterior Spinal Fusion Normosol-R, buffered 2% hypertonic saline - Scoliosis Idiopathic, Scoliosis;Congenital | Phase 2 / Phase 3 | Withdrawn | Joseph D. Tobias | 2025-12-01 | 2025-11-10 | |
| Hypertonic Saline Inhalation for Nontuberculous Mycobacterial Lung Disease Nebulized 3% Hypertonic Saline, Nebulized Normal Saline - Nontuberculous Mycobacterial Lung Disease, Bronchiectasis | Not applicable | Recruiting | Taipei Veterans General Hospital, Taiwan | 262 | 2025-10-03 | 2026-06-15 |
| Therapeutic Effect of Using Injectable Hypertonic Saline 5% Versus Injectable Dextrose 20% on Pain in Painful Cases of Disc Displacement With Reduction hypertonic saline 5% sodium chloride, hypertonic dextrose 20% - TMJ Disc Displacement With Reduction | Not applicable | Not yet recruiting | Cairo University | 20 | 2025-08-20 | 2025-03-07 |
| A Phase II/III of Hepenofovir Fumarate Tablets (HTS) for Chronic Hepatitis B HTS 20mg, HTS 30mg, HTS 40mg - Chronic Hepatitis B | Phase 2 / Phase 3 | Active not recruiting | Xi'an Xintong Pharmaceutical Research Co.,Ltd. | 1444 | 2025-07-01 | 2025-10-02 |
| Comparison of 5% Hypertonic Saline Versus 3% Hypertonic Saline in Resolution of Post-operative Corneal Edema. 5% Hypertonic Saline, 3% Hypertonic Saline - Corneal Edema | Not applicable | Completed | Muhammad Aamir Latif | 70 | 2025-06-01 | 2026-05-22 |
| Comparison of 3% Hypertonic Saline and Salbutamol in Children With Bronchiolitis 3% Hypertonic Saline, Intervention: Salbutamol (Ventolin) - BRONCHIOLITIS | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 100 | 2024-12-03 | 2024-10-30 |
| Implications of Post-Operative Irrigation Fluid's Osmolarity on the Recurrence of Non-Muscle Invasive Bladder Cancer Following Transurethral Resection Continuous Bladder Irrigation with distilled water, Continuous Bladder Irrigation with normal saline, Continuous Bladder Irrigation with hypertonic saline - Bladder (Urothelial, Transitional Cell) Cancer, Nonmuscle Invasive Bladder Cancer | Phase 2 / Phase 3 | Completed | Ain Shams University | 150 | 2024-10-01 | 2025-12-29 |
| The Effects of Performing a Motor Imagery Task on Cortical Excitability During Acute Experimental Muscle Pain and Acute Itch Hypertonic Saline, Histamine, Cowhage - Itch, Pain | Not applicable | Recruiting | Aalborg University | 30 | 2024-10-01 | 2024-11-22 |
| Effect of Fluid Resuscitation on Lactate in Traumatic Injury Patients 3% hypertonic Saline, Ringer's lactated solution, 0.9% Normal saline - Fluid Resuscitation | Phase 1 / Phase 2 | Unknown | Assiut University | 150 | 2024-08-01 | 2024-04-17 |
| Investigation of Corticospinal Excitability Aspects of Itch and Pain Hypertonic Saline, Histamine, Cowhage - Itch, Pain | Not applicable | Completed | Aalborg University | 30 | 2024-07-01 | 2024-11-22 |
| SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF Dapagliflozin tablet, Hypertonic Saline Solution, 1 Ml, Furosemide Injection - Heart Failure Acute, Diabetes Type 2 | Phase 4 | Unknown | University of Palermo | 544 | 2024-06-01 | 2024-06-06 |
| Benefits of Inhalation of Hypertonic Saline Solution Prior to Physiotherapy ELTGOL Technique in Bronchiectasis Hypertonic saline, Isotonic saline, ELTGOL - Bronchiectasis Adult | Phase 3 | Recruiting | Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta | 57 | 2024-06-01 | 2024-07-03 |
| Sodium Lactate Versus Hypertonic Saline Solution in the Treatment of Intracranial Hypertensive Episodes in Severe Brain Injured Patients Lactate, Sodium, Hypertonic saline - Intra Cerebral Hypertension, Lactate Sodium Solution | Phase 3 | Unknown | University Hospital, Geneva | 52 | 2024-01-01 | 2023-10-31 |
| Exploration of Gait Biomechanics and Muscle Pain of the Lower Extremity Hypertonic saline injection, Isotonic saline injection - Pain, Acute | Not applicable | Recruiting | Kristian Kjær Petersen | 36 | 2023-11-08 | 2025-10-02 |
| Nebulised 3% Hypertonic Saline Versus 0.9% Saline for Treating Patients Hospitalized With Acute Bronchiolitis Hypertonic saline, Normal saline - Bronchiolitis | Not applicable | Completed | Szpital im. Św. Jadwigi Śląskiej | 180 | 2023-11-01 | 2025-05-18 |
| Influence of Osmotic Stimulation of Vasopressin on Autonomic Function Hypertonic Saline, Normal Saline - Water Stress, Body Water Dehydration | Not applicable | Withdrawn | University of North Carolina, Greensboro | 2023-11-01 | 2023-11-13 |
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Bronchiolitis (22) · Cystic Fibrosis (20) · Brain Injuries, Traumatic (11) · Intracranial Hypertension (8) · Pain (7) · Brain Edema (6) · Bronchiectasis (5) · Bronchiolitis, Viral (4) · Heart Failure (4) · Renal Insufficiency (4) · Brain Injuries (3) · Dehydration (3) · Hyponatremia (3) · Kidney Diseases (3) · Pulmonary Disease, Chronic Obstructive (3)
Aalborg University (7) · Assiut University (4) · The Hospital for Sick Children (4) · Parion Sciences (3) · Regional Hospital Holstebro (3) · University Hospital, Grenoble (3) · University of North Carolina, Chapel Hill (3) · University of Washington (3) · Belfast Health and Social Care Trust (2) · Beth Israel Deaconess Medical Center (2) · CF Therapeutics Development Network Coordinating Center (2) · Cairo University (2) · Hospital San Carlos, Madrid (2) · Joseph Zabner (2) · Kristian Kjær Petersen (2)
United States (47) · Canada (17) · Denmark (15) · Egypt (9) · France (9) · Spain (8) · Italy (6) · Pakistan (4) · Poland (4) · United Kingdom (4) · Brazil (3) · Belgium (2) · Germany (2) · India (2) · Netherlands (2)
Margaret Rosenfeld, MD, MPH (4) · Stephanie Davis, MD (4) · Felix Ratjen, MD (2) · Felix Ratjen, MD, PhD (2) · Felix Ratjen, MD, PhD, FRCPC (2) · Karl Donn (2) · Myron L Weisfeldt, MD (2) · Aayush Khanal, MD (1) · Achikam Oren-Grinberg, MD (1) · Adelaida Lamas, MD (1) · Ahmed ELbadawy, MD (1) · Ali Alshanqeeti, MD (1) · Alicja Rydzewska-Rosolowska, MD (1) · Alison Church, MD (1)
PMID 37319354, PMID 25072443, PMID 11232182, PMID 11511368, PMID 12403874, PMID 12660656, PMID 12675760, PMID 12794404, PMID 1285737, PMID 12927665, PMID 15196097, PMID 15644669, PMID 15654403, PMID 15672845, PMID 15963399, PMID 16421364, PMID 16474108, PMID 16860701, PMID 17053496, PMID 17172977, PMID 17992382, PMID 18006882, PMID 18828160, PMID 19245725, PMID 19602136, PMID 19884591, PMID 19953579, PMID 20100768, PMID 20346637, PMID 20435858, PMID 20585638, PMID 20607462, PMID 20630539, PMID 20646715, PMID 20864608, PMID 20924011, PMID 21073773, PMID 21178763, PMID 21330456, PMID 21440872, PMID 21458735, PMID 21749847, PMID 21830316, PMID 21841534, PMID 21885727, PMID 21885793, PMID 21896198, PMID 22018993, PMID 22243938, PMID 22349069
2015 (2), P50HL084934 (2), U01HL077863 (2), R01AI182200 (1), R01AT001415 (1), R01CA120228 (1), U01AI126610 (1), U01HL092931 (1), U01HL092932 (1), U01HL131046 (1), U10EY011751 (1)