31 terminated. 31 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 31 | Terminated 31 |
Follow Depressive Disorder: new trials by email Literature Review of Depressive Disorder trials Research Report on Depressive Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Levodopa and Exercise for Older Adults With Depression and Psychomotor Slowing Carbidopa/levodopa, Placebo, Exercise training - Depressive Disorder | Phase 4 | Terminated | New York State Psychiatric Institute | 1 | 2021-10-07 | 2023-02-02 |
| Antidepressant Response in Older Adults With Comorbid PTSD and MDD Escitalopram, Duloxetine - Post Traumatic Stress Disorder, Major Depressive Disorder | Phase 4 | Terminated | New York State Psychiatric Institute | 1 | 2021-03-03 | 2022-05-11 |
| Tianeptine for Treatment Resistant Depression Tianeptine Sodium - Treatment Resistant Depression | Phase 4 | Terminated | Jonathan A. Javitch, MD, PhD | 38 | 2020-10-14 | 2026-01-23 |
| Predicting SSRI Efficacy in Veterans With PTSD LDAEP, Placebo, sertraline - Posttraumatic Stress Disorder, Major Depressive Disorder | Phase 4 | Terminated | VA Office of Research and Development | 19 | 2019-09-11 | 2026-06-17 |
| Promoting Enhanced Pharmacotherapy Choice Through Immunomarkers Evaluation in Depression Escitalopram, Bupropion - Depression | Phase 4 | Terminated | University of Texas Southwestern Medical Center | 18 | 2019-07-23 | 2023-04-18 |
| L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older Adults L-DOPA, Placebo Oral Tablet - Major Depressive Disorder, Dysthymia | Phase 4 | Terminated | New York State Psychiatric Institute | 51 | 2019-01-09 | 2023-05-22 |
| A Trial to Measure the Difference in All-cause Hospitalizations for Participants Who Are Using Abilify MyCite Versus Virtual Matched Controls in Adults With Schizophrenia, Bipolar 1 Disorder, and Major Depressive Disorder Abilify MyCite - Digital Medicine System, Aripiprazole or other oral antipsychotics - Schizophrenia, Bipolar 1 Disorder | Phase 4 | Terminated | Otsuka Pharmaceutical Development & Commercialization, Inc. | 2 | 2018-06-28 | 2019-11-08 |
| Combinatorial Pharmacogenomics Testing in Treatment-Naïve Major Depressive Disorder GeneSight Psychotropic test, FDA-approved antidepressant or antipsychotic treatment - Major Depressive Disorder, Depression | Phase 4 | Terminated | Washington University School of Medicine | 6 | 2018-05-04 | 2020-06-05 |
| Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of Vortioxetine Vortioxetine - Depressive Disorder, Major Depression | Phase 4 | Terminated | Massachusetts General Hospital | 2 | 2017-08-24 | 2019-10-14 |
| Escitalopram Plus PS128 vs. Escitalopram Lactobacillus plantarum PS128 - Major Depression | Phase 4 | Terminated | Kaohsiung Kai-Suan Psychiatric Hospital | 41 | 2016-11-18 | 2019-09-18 |
| Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females 5-hydroxytryptophan and Creatine, Placebo control - Major Depressive Disorder | Phase 4 | Terminated | Brent Michael Kious, MD, PhD | 32 | 2016-11-01 | 2022-05-31 |
| Bupropion for Depression in ESRD Patients on Hemodialysis Fluoxetine, Bupropion - Major Depression, End Stage Renal Disease | Phase 4 | Terminated | University of Arkansas | 1 | 2016-03-31 | 2018-07-17 |
| Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life Depression Sertraline, Candesartan - Depression, Hypertension | Phase 4 | Terminated | Vanderbilt University | 1 | 2013-05-01 | 2016-10-20 |
| Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction? Vilazodone, Sertraline - Sexual Dysfunction, Major Depressive Disorder | Phase 4 | Terminated | Thomas Jefferson University | 4 | 2013-01-01 | 2016-08-25 |
| Neurobiological Bases of Placebo Response in Major Depressive Disorder Escitalopram 10mg, Placebo - Major Depressive Disorder | Phase 4 | Terminated | Massachusetts General Hospital | 20 | 2012-11-01 | 2017-05-16 |
| Study of Probiotic GanedenBC30 for Irritable Bowel Syndrome and Major Depressive Disorder Ganeden BC30, Placebo (sugar pill), Ganeden BC30, Placebo (sugar pill) - Major Depressive Disorder, Irritable Bowel Syndrome | Phase 4 | Terminated | Massachusetts General Hospital | 5 | 2011-06-01 | 2013-08-09 |
| N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major Depression ketamine, IV Saline, ECT - Major Depressive Disorder | Phase 4 | Terminated | Massachusetts General Hospital | 17 | 2010-11-01 | 2017-05-22 |
| PET Biomarkers in Treatment Resistant Depression tranylcypromine - Major Depressive Disorder | Phase 4 | Terminated | New York State Psychiatric Institute | 13 | 2009-11-01 | 2014-09-18 |
| Relapse Prevention With Escitalopram or Nortriptyline Following Electro-Convulsive Treatment (DUAG-7) escitalopram, nortriptyline - Major Depression | Phase 4 | Terminated | Hillerod Hospital, Denmark | 47 | 2009-08-01 | 2014-12-09 |
| Effect of Antidepressants on the Treatment for Korean Major Depressive Disorder Patients paroxetine, Escitalopram, Venlafaxine XR - Major Depressive Disorder | Phase 4 | Terminated | Ministry of Health & Welfare, Korea | 692 | 2009-05-01 | 2015-09-02 |
Showing 20 of 31. Sign in to see all of them.
Depressive Disorder, Major (26) · Depression (13) · Depressive Disorder, Treatment-Resistant (3) · Dysthymic Disorder (2) · Mood Disorders (2) · Stress Disorders, Post-Traumatic (2) · Agoraphobia (1) · Alcoholism (1) · Anxiety Disorders (1) · Cerebrovascular Disorders (1) · Depression, Postpartum (1) · Epilepsy (1) · Generalized Anxiety Disorder (1) · Hypertension (1)
Mental Disorders (31) · Mood Disorders (29) · Behavior (13) · Behavioral Symptoms (13) · Urogenital Diseases (3) · Brain Diseases (2) · Cardiovascular Diseases (2) · Central Nervous System Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Nervous System Diseases (2) · Stress Disorders, Traumatic (2) · Trauma and Stressor Related Disorders (2) · Vascular Diseases (2) · Alcohol-Related Disorders (1)
Escitalopram (6) · Bupropion (5) · Sertraline (5) · Paroxetine (3) · Aripiprazole (2) · Creatine (2) · Fluoxetine (2) · Tranylcypromine (2) · carbidopa, levodopa drug combination (2) · 5-Hydroxytryptophan (1) · Anesthetics (1) · Carbidopa (1) · Dextroamphetamine (1) · Duloxetine Hydrochloride (1) · Estradiol (1)
New York State Psychiatric Institute (7) · Massachusetts General Hospital (4) · Weill Medical College of Cornell University (2) · Brent Michael Kious, MD, PhD (1) · GlaxoSmithKline (1) · Hamilton Health Sciences Corporation (1) · Herzog Hospital (1) · Hillerod Hospital, Denmark (1) · Jonathan A. Javitch, MD, PhD (1) · Kaohsiung Kai-Suan Psychiatric Hospital (1) · Ministry of Health & Welfare, Korea (1) · Northwestern University (1) · Otsuka Pharmaceutical Development & Commercialization, Inc. (1) · Thomas Jefferson University (1) · University of Arkansas (1)
United States (25) · Canada (1) · Denmark (1) · Israel (1) · Japan (1) · South Korea (1) · Taiwan (1)
Bret R Rutherford, MD (2) · Alla Landa, PhD (1) · Andrew Nierenberg, M.D. (1) · Anita Clayton, MD (1) · Boris Nemets, Dr. (1) · Bret Rutherford, MD (1) · Charles Conway, MD (1) · Cristina Cusin, M.D. (1) · Ellen M. Whyte, MD (1) · James H Kocsis, MD (1) · Jonathan W. Stewart, MD (1) · Joseph Levine, Prof. (1) · Katherine L Wisner, MD, MS (1) · Klaus Martiny, MD,PhD (1)
PMID 21993207, PMID 22283499, PMID 24107760, PMID 24972362, PMID 26529118, PMID 39626074
K23MH067710 (1), K23MH076049 (1), K24MH122514 (1), P20AA015630 (1), R21DK097470 (1), R33MH110029 (1), RC1MH088405-01 (1)