103 completed, 7 recruiting, 7 terminated, 7 withdrawn. 52 Phase 2, 37 Phase 1, 26 Phase 3, 22 Phase 4, 7 Not applicable.
Follow carbidopa, levodopa drug combination: new trials by email Literature Review of carbidopa, levodopa drug combination trials Research Report on carbidopa, levodopa drug combination
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Brain Dopamine Biomarker Levadopa/Carbidopa eyedrops, Sham, Levodopa/Carbidopa (Sinemet) - Parkinson Disease, Healthy Adult Participants | Not yet recruiting | University of South Florida | 50 | 2026-10-01 | 2026-08-12 | |
| Celecoxib in Parkinson Disease as Adjuvant Therapy Levodopa Carbidopa, Celecoxib 200mg - Parkinson Disease | Phase 1 / Phase 2 | Recruiting | Tanta University | 80 | 2025-11-20 | 2025-12-05 |
| Metformin in Parkinson Disease Levodopa Carbidopa, Metformin - Parkinson Disease | Phase 2 / Phase 3 | Recruiting | Tanta University | 60 | 2025-11-10 | 2025-11-21 |
| Vinpocetine in Patients With Parkinsonian Disease Levodopa Carbidopa, Vinpocetine - Parkinson Disease | Phase 2 / Phase 3 | Recruiting | Tanta University | 60 | 2025-11-10 | 2025-12-10 |
| Role of Silymarin in Neuroprotection and Symptom Management in Parkinson's Disease levodopa-carbidopa, Silymarin - Parkinson Disease | Phase 2 | Recruiting | Tanta University | 50 | 2025-05-10 | 2025-09-10 |
| Fexofenadine as Adjuvant Therapy in Parkinson Disease Levodopa/carbidopa, Fexofenadine - Parkinson Disease | Phase 2 / Phase 3 | Recruiting | Tanta University | 46 | 2024-12-10 | 2026-01-21 |
| Neurobiological Drivers of Mobility Resilience: The Dopaminergic System - Supplemental Open-Label Arm Carbidopa 25 mg, Carbidopa-Levodopa 25/100 mg - Parkinsonian Signs in Older Persons | Phase 1 / Phase 2 | Completed | University of Michigan | 5 | 2024-10-29 | 2026-04-14 |
| Neurobiological Drivers of Mobility Resilience: The Dopaminergic System - Placebo-Controlled Arm Carbidopa 25 mg, Carbidopa-Levodopa 25/100 mg, Placebo 1 - Parkinsonian Signs in Older Persons | Phase 1 / Phase 2 | Completed | University of Michigan | 13 | 2024-03-15 | 2025-06-17 |
| Observational Small Intestine and Blood Fingerprint (SmIle) Study in Parkinson's Disease Fluid biopsy capsule, Levodopa-Carbidopa Immediate Release - Parkinson Disease | Terminated | Nimble Science Ltd. | 51 | 2024-02-19 | 2026-10-20 | |
| The Role of Brain Dopamine in Chronic Pain Methylphenidate, carbidopa-levodopa, Placebo - Chronic Pain | Phase 2 | Recruiting | University of Rochester | 10 | 2024-01-31 | 2026-05-15 |
| Dopaminergic Therapy for Anhedonia - 2 Carbidopa Levodopa, Placebo - Anhedonia, Depression | Phase 4 | Recruiting | Emory University | 70 | 2023-11-21 | 2026-01-28 |
| Montelukast in Parkinson Disease levodopa-carbidopa, Montelukast - Parkinson Disease | Phase 2 / Phase 3 | Completed | Mostafa Bahaa | 60 | 2023-11-05 | 2026-10-02 |
| Role of Pentoxifylline and Celecoxib in Parkinsonism carbidopa-levodopa, Pentoxifylline 400 MG, Celecoxib 200mg - Parkinson Disease | Phase 2 | Completed | Mostafa Bahaa | 80 | 2023-08-07 | 2025-08-12 |
| Research on Translational Outcomes of Alcohol (Project RETRO) Carbidopa Levodopa, Placebo - Alcohol Drinking | Phase 4 | Withdrawn | University of Washington | 2023-02-01 | 2023-02-13 | |
| Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease levodopa-carbidopa, Metformin - Parkinson Disease | Phase 2 | Completed | Tanta University | 60 | 2023-01-06 | 2026-03-13 |
| Dopaminergic Enhancement of Rehabilitation Therapy Early After Stroke Telerehabilitation, Sinemet Pill, Placebo - Stroke | Phase 1 / Phase 2 | Completed | University of California, Los Angeles | 25 | 2022-08-01 | 2025-03-24 |
| Treating Early Stage Diabetic Retinopathy Sinemet CR, placebo - Diabetic Retinopathy | Early Phase 1 | Enrolling by invitation | VA Office of Research and Development | 244 | 2022-07-01 | 2026-04-07 |
| Opicapone as Adjunctive Therapy to Levodopa-Carbidopa Intestinal Gel in Parkinson's Disease Opicapone 50 mg, Duodopa - Parkinson Disease, Effect of Drug | Not applicable | Completed | University Hospital of Ferrara | 22 | 2022-07-01 | 2025-03-03 |
| Novel Non-opioid Post-surgical Pain Treatment in Females Carbidopa-Levodopa (100mg/25mg):, Naproxen - Acute Pain, Bunionectomy | Phase 2 | Withdrawn | Northwestern University | 2021-11-01 | 2024-03-18 | |
| Levodopa and Exercise for Older Adults With Depression and Psychomotor Slowing Carbidopa/levodopa, Placebo, Exercise training - Depressive Disorder | Phase 4 | Terminated | New York State Psychiatric Institute | 1 | 2021-10-07 | 2023-02-02 |
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Parkinson Disease (74) · Cocaine-Related Disorders (6) · Depression (6) · Dyskinesias (6) · Stroke (5) · Macular Degeneration (4) · Angelman Syndrome (3) · Anhedonia (3) · Pain (3) · Spinal Cord Injuries (3) · Acute Pain (2) · Amblyopia (2) · Chronic Pain (2) · Cognitive Dysfunction (2) · Depressive Disorder, Major (2)
Orion Corporation, Orion Pharma (10) · Bial - Portela C S.A. (9) · Impax Laboratories, LLC (9) · Tanta University (6) · AbbVie (5) · AbbVie (prior sponsor, Abbott) (5) · Emory University (5) · Northwestern University (5) · Snyder, Robert W., M.D., Ph.D., P.C. (5) · New York State Psychiatric Institute (4) · The University of Texas Health Science Center, Houston (4) · University of Michigan (4) · Acorda Therapeutics (3) · Intec Pharma Ltd. (3) · Jaeb Center for Health Research (2)
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Robert W Snyder, MD, PhD (5) · Timothy C Fagan, MD (4) · Janet Benesh (3) · Jennifer Felger, PhD (3) · Apkar V Apkarian, PhD (2) · Bret R Rutherford, MD (2) · Charles Oh, MD (2) · Chatkaew Pongmala, PhD (2) · Eric Sicard, MD (2) · Joy M Schmitz, PhD (2) · Mika Scheinin, MD (2) · Rainard Fuhr, MD (2)
PMID 24361112, PMID 25962554, PMID 30425824, PMID 31779508, PMID 10662747, PMID 11391738, PMID 11904109, PMID 11927799, PMID 12119802, PMID 12498954, PMID 12832331, PMID 15066944, PMID 15710782, PMID 15738343, PMID 15956161, PMID 16874752, PMID 17138744, PMID 17515447, PMID 17515448, PMID 19127579, PMID 19146929, PMID 19190638, PMID 19846332, PMID 19877202, PMID 20582993, PMID 20837811, PMID 20837887, PMID 22311903, PMID 23229334, PMID 23485610, PMID 24424425, PMID 25676904, PMID 25758422, PMID 27271310, PMID 28131167, PMID 29570853, PMID 31127735, PMID 32051147, PMID 32482490, PMID 32597817, PMID 32986682, PMID 34032202, PMID 34236101, PMID 34374961, PMID 34600245, PMID 35705502, PMID 35927580, PMID 36402160, PMID 37578800, PMID 38345741
2014 (3), U01AG061393 (3), 2008 (2), 2009 (2), 2018 (2), 2019 (2), P50DA009262 (2), R01DE022746 (2), U10EY011751 (2), 2005 (1), 2016 (1), 2017 (1), K24MH122514 (1), R01DA023608 (1), R01DA034131 (1)