207 completed, 59 unknown, 31 terminated, 25 recruiting. 86 Phase 4, 83 Not applicable, 71 Phase 3, 67 Phase 2, 34 Phase 1.
Follow Estradiol: new trials by email Literature Review of Estradiol trials Research Report on Estradiol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hormone thERapy Effects on BRAin-HEART Health During the Menopausal Transition Transdermal estradiol, Standard of care - non hormonal - Menopause, Perimenopause | Phase 4 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 100 | 2026-11-01 | 2026-07-29 |
| Estrogen to Improve Quality of Life for Men With Newly Diagnosed or Recurrent Metastatic Hormone Sensitive Prostate Cancer, EQUIP Trial Androgen Receptor Pathway Inhibitor, Transdermal Estrogen, Bone Scan - Castration-Sensitive Prostate Adenocarcinoma, Metastatic Castration-Sensitive Prostate Adenocarcinoma | Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 60 | 2026-11-01 | 2026-10-16 |
| Cycle-to-cycle Variability of Progesterone in the Endometrium in Patients Undergoing an Euploid Blastocyst Transfer in a Hormone Replacement Therapy (HRT) Cycle (PROMICOFET) Oestrogel® 0.75 mg (estradiol transdermal gel), Progesterone 200 mg vaginal capsules, Endometrial biopsy - Fertility, Implantation, Embryo | Phase 4 | Not yet recruiting | University Hospital, Ghent | 70 | 2026-10-01 | 2026-09-14 |
| Post-traumatic Estradiol Administration and Care Evaluation (PEACE) 17β-estradiol, Placebo - Chronic Musculoskeletal Pain, Sexual Assault | Phase 2 | Not yet recruiting | University of North Carolina, Chapel Hill | 30 | 2026-09-28 | 2026-10-09 |
| Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women Living With HIV Vaginal estradiol tablets, Vaginal moisturizer - Menopausal Complaints, Vaginal Atrophy | Phase 4 | Not yet recruiting | Albert Einstein College of Medicine | 62 | 2026-09-01 | 2026-07-28 |
| Estrogen Deficiency on Cardiovascular Risk Placebo, Estradiol - Postmenopausal Symptoms, Cardiovascular Diseases | Early Phase 1 | Not yet recruiting | Milton S. Hershey Medical Center | 20 | 2026-09-01 | 2025-11-17 |
| A Study to Assess the Skin Irritation and Sensitization of Estradiol/Levonorgestrel TDS in Healthy Postmenopausal Subjects Estradiol/Levonorgestrel Transdermal System - Menopause, Healthy Female Participants | Phase 1 | Recruiting | Corium Innovations, Inc. | 250 | 2026-08-10 | 2026-09-10 |
| VEDA Study (DHEA vs Estradiol) DHEA ovals, Estradiol 0.01% Vag Cream - Post-menopause, Pre-menopause | Not applicable | Recruiting | University of Arizona | 324 | 2026-08-04 | 2026-09-21 |
| Acute Effects of Estradiol Administration on Brain Function During Fear Learning estradiol - PTSD and Trauma-related Symptoms, Cognitive Decline in Older Adults | Early Phase 1 | Not yet recruiting | University of Arizona | 30 | 2026-08-01 | 2026-07-30 |
| A Study to Assess the Bioavailability and Adhesion of Estradiol/Levonorgestrel TDS in Healthy Post-Menopausal Female Participants Test Estradiol/Levonorgestrel Transdermal Delivery System, Climara Pro® (Estradiol/Levonorgestrel Transdermal System) - Healthy Female Participants, Postmenopause | Phase 1 | Active not recruiting | Corium Innovations, Inc. | 68 | 2026-07-01 | 2026-10-01 |
| The Role of Estradiol and Progesterone on Appetite Regulation and Energy Balance Placebo Comparator, Estradiol Only, Progesterone Only - Energy Balance, Physiology - Regulation of Appetite and Food Intake | Not applicable | Recruiting | Wilfrid Laurier University | 60 | 2026-06-01 | 2026-06-02 |
| The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans GnRH antagonist, Estradiol (E2), Testosterone - Cerebral Blood Flow, Cerebral Blood Flow Regulation | Not applicable | Not yet recruiting | University of British Columbia | 50 | 2026-04-01 | 2026-02-10 |
| Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletes Testosterone Enanthate, Testosterone Cypionate, Testosterone Propionate - Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes | Not applicable | Enrolling by invitation | Enhanced Emirates Limited | 60 | 2026-03-12 | 2026-05-06 |
| Endometrial Response in Polyendocrine Metabolic Ovarian Syndrome (PMOS) Treated With Letrozole Alone or With Added Estradiol Valerate Letrozole (Aromatase Inhibitors), Letrozole (Aromatase Inhibitors) + Estradiol valerate - Polyendocrine Metabolic Ovarian Syndrome (PMOS) | Not applicable | Completed | CMH Kharian Medical College | 60 | 2026-03-05 | 2026-09-10 |
| A Study Comparing Different Treatment Approaches for the Initiation of Puberty in Girls With Turner Syndrome Using a TRIFECTA-DARED Approach for Rare Diseases Oral estradiol valerate, Transdermal 17β estradiol - Turner Syndrome | Phase 2 | Not yet recruiting | Universiti Kebangsaan Malaysia Medical Centre | 24 | 2026-02-15 | 2026-02-02 |
| Effects of Estrogen on Muscle Gain During 12-weeks of Exercise in Post-menopausal Women Estrogel, Physical exercise - Menopause Related Conditions, Exercise Training | Not applicable | Recruiting | Mette Hansen | 30 | 2026-02-01 | 2026-06-01 |
| Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency estradiol valerate, esthinylestradiol - AVP Deficiency, Diabetes Insipidus | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 28 | 2026-01-09 | 2026-08-11 |
| Effects of Estrogen Therapy on Lipid Metabolism and Insulin Sensitivity in Hypogonadal Women Estrogen - Female Hypogonadism | Not applicable | Active not recruiting | Khyber Medical University Peshawar | 30 | 2025-12-04 | 2026-09-15 |
| Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled Trial Estradiol 0.01% Vag Cream, testosterone 0.1% and estradiol 0.01% vaginal cream - Vulvodynia, Dyspareunia | Phase 2 / Phase 3 | Not yet recruiting | TriHealth Inc. | 44 | 2025-12-01 | 2025-12-03 |
| COMPASS - COpenhagen MenoPAuSe Study Triptorelin 11.25 mg, Sodium Chloride 0.9%, Estradiol (E2) - Menopausal Osteoporosis, Bone Markers | Phase 2 | Recruiting | Martin Blomberg Jensen | 192 | 2025-10-02 | 2026-03-02 |
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Infertility (34) · Breast Neoplasms (14) · Hot Flashes (13) · Polycystic Ovary Syndrome (12) · Cardiovascular Diseases (10) · Depression (9) · Dyspareunia (9) · Infertility, Female (9) · Menorrhagia (9) · Gender Dysphoria (8) · Hypogonadism (8) · Leiomyoma (8) · Osteoporosis (8) · Turner Syndrome (8) · Primary Ovarian Insufficiency (7)
Novo Nordisk A/S (15) · Bayer (12) · University of Colorado, Denver (10) · University of North Carolina, Chapel Hill (9) · Cairo University (6) · Organon and Co (6) · University of Virginia (6) · AbbVie (5) · Massachusetts General Hospital (5) · National Institute of Mental Health (NIMH) (5) · Ain Shams University (4) · Mayo Clinic (4) · Myovant Sciences GmbH (4) · Universitair Ziekenhuis Brussel (4) · University of Arizona (4)
United States (158) · Egypt (20) · Canada (16) · Germany (15) · Denmark (14) · China (12) · France (12) · Belgium (11) · Brazil (10) · Spain (10) · Sweden (10) · United Kingdom (10) · Finland (8) · Poland (8) · Italy (7)
Peter J Schmidt, M.D. (5) · Mohamed S Abdelhafez, Dr (3) · Ahmed Maged, MD (2) · Birgit Derntl, Prof. (2) · Claus H Gravholt, Professor (2) · Crystal E Schiller, PhD (2) · Jayashri Kulkarni, MBBS, MPM, FRANZCP, PhD (2) · John C. Marshall, MD, PhD (2) · Kerry J Murphy, MD (2) · Kerry L Hildreth, MD (2)
PMID 18165394, PMID 18978105, PMID 19996872, PMID 20859151, PMID 21774563, PMID 22240178, PMID 27648659, PMID 31971678, PMID 33596357, PMID 33650259, PMID 34553161, PMID 34582715, PMID 34878624, PMID 35415708, PMID 35675604, PMID 35717987, PMID 36357960, PMID 37183454, PMID 37283994, PMID 37477173, PMID 37863160, PMID 37982388, PMID 39381651, PMID 39466126, PMID 10221715, PMID 10518082, PMID 10622350, PMID 11318766, PMID 11458304, PMID 12413988, PMID 12763518, PMID 14671159, PMID 14714588, PMID 14962527, PMID 1503131, PMID 15036255, PMID 15285956, PMID 17329508, PMID 17453860, PMID 17487652, PMID 17906008, PMID 1791769, PMID 17995496, PMID 18077316, PMID 18191855, PMID 18202966, PMID 18364505, PMID 18678800, PMID 18794456, PMID 19246470
U54HD028934 (4), 2004 (3), 2009 (3), 2005 (2), 2016 (2), 2017 (2), 2025 (2), R01AG013241 (2), R56HL114073 (2), UL1TR001082 (2), 2008 (1), 2014 (1), 2015 (1), 2018 (1), 2019 (1)