16 completed, 11 unknown, 6 recruiting, 2 active not recruiting. 42 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 42 | Completed 16, Unknown 11, Recruiting 6, Active not recruiting 2, Not yet recruiting 2, Terminated 2, Withdrawn 2, Enrolling by invitation 1 |
Follow Depressive Disorder: new trials by email Literature Review of Depressive Disorder trials Research Report on Depressive Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Web-based Intervention Program for Postpartum Depression Web-based program for postpartum depression - Postpartum Depression (PPD), Web-based Intervention | Early Phase 1 | Recruiting | Babes-Bolyai University | 30 | 2026-10-27 | 2026-10-28 |
| Individualized fMRI-guided TMS for Depression Active Repetitive Transcranial Magnetic Stimulation (rTMS), Sham Transcranial Magnetic Stimulation (TMS) - Depression, Major Depressive Disorder (MDD) | Early Phase 1 | Not yet recruiting | University of Pennsylvania | 60 | 2026-09-15 | 2026-09-09 |
| Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101 TMS, NRX-101 - Major Depression | Early Phase 1 | Not yet recruiting | Mclean Hospital | 30 | 2026-09-01 | 2026-09-22 |
| Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine Ketamine only - Major Depressive Disorder (MDD) | Early Phase 1 | Recruiting | University of Pennsylvania | 10 | 2026-04-01 | 2026-10-07 |
| Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression D-Cycloserine (DCS), Continuous theta-burst stimulation (cTBS), Transcranial Magnetic Stimulation Sham - Major Depression | Early Phase 1 | Recruiting | Mclean Hospital | 80 | 2026-03-11 | 2026-05-13 |
| Mood Effects of Serotonin Agonists: Depression LSD, Placebo - LSD, Major Depressive Disorder | Early Phase 1 | Completed | University of Chicago | 41 | 2025-06-09 | 2026-07-10 |
| Feasibility Pilot of Accelerated Stimulation With TMS for Treatment of Major Depressive Disorder (FAST-MDD) aTMS utilizing the MagVenture TMS device - Major Depressive Disorder | Early Phase 1 | Completed | University of Minnesota | 11 | 2025-06-09 | 2026-02-09 |
| Probiotic Administration for Adolescent Depression Visbiome, Placebo - Depression | Early Phase 1 | Recruiting | University of California, San Francisco | 77 | 2025-05-15 | 2026-07-14 |
| Long-term Potentiation Disruption Underlying Cognitive Impairment in ECT Electroconvulsive Therapy - Major Depressive Disorder, Bipolar Disorder II | Early Phase 1 | Withdrawn | University of New Mexico | 2025-01-21 | 2026-01-21 | |
| Personalized DBS Targeting for Treating Depression Deep Brain Stimulation(DBS), Esketamine - Treatment-resistant Depression (TRD) | Early Phase 1 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 5 | 2025-01-05 | 2026-04-27 |
| Testing a Transdiagnostic TMS Treatment Target transcranial magnetic stimulation - Major Depressive Disorder, Depression | Early Phase 1 | Completed | Brigham and Women's Hospital | 10 | 2024-09-09 | 2026-07-13 |
| Quetiapine Versus Trazadone in Women With Postpartum Depression Trazodone, Quetiapine - Postpartum Depression | Early Phase 1 | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 50 | 2024-09-01 | 2024-08-09 |
| Electroconvulsive Therapy and Concomitant Lithium in Depressive Disorder: A Pilot Study Lithium - Depressive Disorder | Early Phase 1 | Unknown | Melbourne Health | 20 | 2023-06-01 | 2023-08-01 |
| Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine Ketamine, Placebo - Major Depressive Disorder | Early Phase 1 | Recruiting | Emory University | 140 | 2022-11-08 | 2026-05-26 |
| A Clinical Study on the Effects of Inhalation of Volatile Oil of Cang-Ai Via the Nose on Patients With Depression Volatile Oil of Cang-Ai, Bergamot essential oils - Depressive Disorder, Mental Disorder in Adolescence | Early Phase 1 | Unknown | Jieqiong Cui | 60 | 2022-11-01 | 2022-10-20 |
| Effects of Ciprofol Anesthesia on Learning and Memory Function and Antidepressant Effects of ECT in Depressive Patients ciprofol, Propofol - Depressive Disorder | Early Phase 1 | Unknown | First Affiliated Hospital of Chongqing Medical University | 390 | 2022-03-01 | 2022-03-04 |
| Pulse Width 0.15ms vs 0.30ms in Electroconvulsive Therapy Electroconvulsive therapy - Major Depressive Disorder, Bipolar Depression | Early Phase 1 | Unknown | Charles University, Czech Republic | 40 | 2022-01-18 | 2022-07-20 |
| Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine Naltrexone, Placebo, Ketamine - Depressive Disorder, Treatment-Resistant | Early Phase 1 | Completed | King's College London | 27 | 2021-09-27 | 2023-03-02 |
| Psychostimulant Augmentation of Repetitive TMS for the Treatment of Major Depressive Disorder Adderall-XR, Placebo - Major Depressive Disorder | Early Phase 1 | Enrolling by invitation | University of California, Los Angeles | 30 | 2021-09-27 | 2026-02-03 |
| The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women ketamine in lactation - Ketamine, Lactation | Early Phase 1 | Completed | The Ketamine Research Foundation | 4 | 2019-12-20 | 2021-12-13 |
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Depressive Disorder, Major (28) · Depression (11) · Bipolar Disorder (5) · Depression, Postpartum (5) · Depressive Disorder, Treatment-Resistant (5) · Anxiety Disorders (2) · Mood Disorders (2) · Suicidal Ideation (2) · Breast Feeding (1) · Cognitive Dysfunction (1) · Coronary Artery Disease (1) · Disease (1) · Fractures, Stress (1) · Heart Diseases (1)
Mental Disorders (41) · Mood Disorders (40) · Behavior (13) · Behavioral Symptoms (12) · Bipolar and Related Disorders (5) · Female Urogenital Diseases and Pregnancy Complications (5) · Pregnancy Complications (5) · Puerperal Disorders (5) · Urogenital Diseases (5) · Self-Injurious Behavior (2) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Cardiovascular Diseases (1) · Cognition Disorders (1)
Ketamine (7) · Transcranial Magnetic Stimulation (4) · Citalopram (3) · Cycloserine (2) · Deep Brain Stimulation (2) · Docosahexaenoic Acids (2) · Eicosapentaenoic Acid (2) · Escitalopram (2) · (2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenol (1) · Acetylcysteine (1) · Aripiprazole (1) · Baclofen (1) · Bupropion (1) · Celecoxib (1) · Creatine (1)
Centre for Addiction and Mental Health (2) · Mclean Hospital (2) · University of California, Los Angeles (2) · University of Pennsylvania (2) · William Coryell (2) · Babes-Bolyai University (1) · Beijing Pins Medical Co., Ltd (1) · Brigham and Women's Hospital (1) · Charles University, Czech Republic (1) · China Academy of Chinese Medical Sciences (1) · Emory University (1) · First Affiliated Hospital of Chongqing Medical University (1) · Janssen Pharmaceutica N.V., Belgium (1) · Jieqiong Cui (1) · Karolinska Institutet (1)
United States (20) · Canada (5) · China (5) · Australia (1) · Belgium (1) · Czechia (1) · Romania (1) · Sweden (1) · United Kingdom (1)
Jeffrey H Meyer, MD, PhD (2) · A Elias (1) · Andrew Nierenberg, MD (1) · Balwinder Singh, MD, MS (1) · Cherry Leung, PhD, RN (1) · Chunshui Yu, MD (1) · Douglas Kondo, MD (1) · Eliza Park, MD (1) · Francesca Beaudoin, MD PhD (1) · Gary Hasey, MD (1) · Hanna Molla (1) · Jennifer R Goldschmied, PhD (1)
PMID 16677714, PMID 26364274, PMID 26619358, PMID 27869829, PMID 27918562, PMID 28521048, PMID 29632383, PMID 30423462, PMID 30819549, PMID 33309459, PMID 33933839, PMID 34608328, PMID 34711062, PMID 34973601, PMID 35086123, PMID 35738038, PMID 36999619, PMID 37730990, PMID 37815563, PMID 38265467, PMID 38701878, PMID 40224600, PMID 40707608
P20GM109089 (1), R01DA002812 (1), R01MH059668 (1), R01MH126083 (1), R01MH139697 (1), R33MH135428 (1), R61AT012028 (1)