41 completed, 14 unknown, 6 terminated, 4 recruiting. 27 Not applicable, 16 Phase 3, 14 Phase 2, 8 Phase 4, 4 Early Phase 1.
Follow Eicosapentaenoic Acid: new trials by email Literature Review of Eicosapentaenoic Acid trials Research Report on Eicosapentaenoic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacokinetic Study of Eicosapentaenoic Acid (EPA) and Calcium L-5-Methyltetrahydrofolate (L-5-MTHF) After Administration of CreNeuroS® CNS Fish Oil Plus Softgels in Healthy Subjects Under Fasting Conditions Eicosapentaenoic Acid (EPA) and Calcium L-5-Methyltetrahydrofolate (L-5-MTHF) - Bioavailability and Pharmacokinetics | Not applicable | Not yet recruiting | Sichuan Credit Pharmaceutical Co., Ltd. | 32 | 2026-03-15 | 2026-03-16 |
| Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRactice Soybean oil (Standard treatment), Eicosapentaenoic acid (omega-3 fatty acid) - Major Depressive Disorder (MDD) | Not applicable | Recruiting | National Science and Technology Council, Taiwan | 120 | 2025-10-01 | 2026-06-17 |
| Differential Thrombogenesis by EPA and DHA Mediated by HDL EPA, DHA - Lipid Metabolism Disorders, Hypertriglyceridemia | Early Phase 1 | Recruiting | The Miriam Hospital | 80 | 2025-07-10 | 2025-10-01 |
| NUTRIMOOD-Inflammation and Depressive Comorbidity in Obesity: Modulation by Omega-3 Polyunsaturated Fatty Acids Status Eicosapentaenoic acid (omega-3 fatty acid), Placebo - Obese Adults, MDD | Not applicable | Recruiting | National Science and Technology Council, Taiwan | 50 | 2025-03-01 | 2026-02-27 |
| Impact of "Targeted" Nutritional Apport and Exercise on the Modulation of Metabolic and Immune-related Gene Expression Signatures in Early Breast Cancer (eBC) Patients Candidate to Neoadjuvant Therapy (NAT) omega-3 (n-3 Lc-PUFA), EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) plus a source of palmitoleic acid (hexadecenoic acid) - Early Breast Cancer, Neoadjuvant Treatment | Not applicable | Recruiting | University of Eastern Piedmont | 160 | 2024-09-01 | 2025-04-15 |
| The Efficacy of Long-Chain Fatty Acids, Eicosapentaenoic Acid (EPA) and Specialized Pro-Resolving Mediators (SPMs), in Treating Long COVID Neuropsychiatric Symptoms Eicosapentaenoic acid (omega-3 fatty acid), Specialized Pro-Resolving Lipid Mediator, Placebo - COVID - 19, Depression - Major Depressive Disorder | Not applicable | Completed | National Science and Technology Council, Taiwan | 54 | 2024-06-01 | 2026-07-21 |
| Omega-3 Treatment for Concussion in Adolescents Omega-3, Placebo - Concussion, Mild | Not applicable | Unknown | University of Manitoba | 140 | 2023-06-01 | 2023-06-23 |
| Eicosapentaenoic Acid Serum Levels in Patients With Gestational Diabetes eicosapentaenoic acid - Gestational Diabetes | Unknown | Recep Tayyip Erdogan University Training and Research Hospital | 118 | 2022-10-17 | 2022-10-24 | |
| Efficacy of Diet on Quality of Life in Multiple Sclerosis BodyBio Balance Oil, Kirunal Fish Oil, BodyBio PC - Multiple Sclerosis, Relapsing-Remitting | Not applicable | Active not recruiting | Terry L. Wahls | 162 | 2022-02-10 | 2026-09-18 |
| Effect of Fish Oil on Athlete's Executive Function Fish Oil, Safflower Oil - Brain Health, Brain Function | Not applicable | Terminated | Wake Forest University Health Sciences | 22 | 2020-11-05 | 2023-03-22 |
| Omega -3 Fatty Acid in Combination With Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia Eicosapentaenoic Acid, Tyrosine kinase inhibitor - Chronic Myeloid Leukemia, Chronic Phase | Phase 1 / Phase 2 | Terminated | Milton S. Hershey Medical Center | 1 | 2020-09-14 | 2022-07-01 |
| Effects of Omega-3 Fatty Acids on Muscle Wasting omega 3 fatty acid - Muscle Wasting | Unknown | Karadeniz Technical University | 80 | 2020-07-20 | 2020-10-14 | |
| Long-term Safety and Efficacy Study of MND-2119 in Patients With Hypertriglyceridemia Icosapent - Hypertriglyceridemia | Phase 3 | Completed | Mochida Pharmaceutical Company, Ltd. | 120 | 2020-02-14 | 2021-08-23 |
| Impact of Fish Oil Monoglycerides on the Modulation of Mitochondrial Functions and Lactate Threshold Eicosapentaenoic acid + Docosahexaenoic acid, Eicosapentaenoic acid - Healthy Athletes | Phase 4 | Terminated | Samuel Fortin | 9 | 2019-09-19 | 2022-04-15 |
| Omega-3 Supplementation for LIver VolumE Reduction Study (OLIVER) Study 2 capsules of Concentrated omega-3 triglycerides- fish 1000mg (600mg Eicosapentaenoic acid (EPA), 1400mg Docosahexaenoic acid (DHA)) per day - Fatty Liver, Bariatric Surgery Candidate | Early Phase 1 | Unknown | Khoo Teck Puat Hospital | 50 | 2019-09-17 | 2021-09-14 |
| Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older Adults EPA+DHA, placebo - Chronic Venous Leg Ulcers | Not applicable | Completed | Ohio State University | 96 | 2019-04-15 | 2026-06-17 |
| Effects of Omega-3 Fatty Acids Supplement in Cognition of Young Healthy Adults and in Their Reaction Time of Computerized Test After 3 Months of Taking High-concentrated DHA and EPA Fish Softgels Docosahexaenoic acid, Eicosapentaenoic acid, Olive oil - Cognition, Brain | Phase 4 | Unknown | Sulaiman AlRajhi Colleges | 60 | 2019-01-01 | 2018-12-20 |
| Efficacy of MND-2119 in Participants With Hypertriglyceridemia Icosapent (MND-2119), Icosapent (EPADEL CAPSULES 300) - Hypertriglyceridemia | Phase 3 | Completed | Mochida Pharmaceutical Company, Ltd. | 580 | 2018-10-27 | 2019-08-01 |
| Omega 3 Fatty Acids and ERPR(-)HER2(+/-) Breast Cancer Prevention omega 3 fatty acids - Breast Cancer | Not applicable | Active not recruiting | City of Hope Medical Center | 80 | 2017-08-09 | 2026-04-03 |
| Effect of Fish Oil Enriched In Omega-11 Fatty Acid On Lipoprotein Metabolism In Adults control fish oil, LCMUFA-rich saury oil - Lipoprotein Metabolism, PCSK9 | Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 37 | 2017-06-15 | 2020-08-12 |
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Depressive Disorder, Major (7) · Depression (4) · Inflammation (4) · Breast Neoplasms (3) · Colorectal Neoplasms (3) · Coronary Artery Disease (3) · Diabetes Mellitus, Type 2 (3) · Hypertriglyceridemia (3) · Schizophrenia (3) · Cardiovascular Diseases (2) · Colitis, Ulcerative (2) · Critical Illness (2) · Hyperplasia (2) · Muscular Atrophy (2) · Obesity (2)
Brigham and Women's Hospital (6) · National Science and Technology Council, Taiwan (3) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (2) · Massachusetts General Hospital (2) · Mochida Pharmaceutical Company, Ltd. (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (2) · S.L.A. Pharma AG (2) · University of Manitoba (2) · William Coryell (2) · Alliance for Clinical Trials in Oncology (1) · Andrea Bonny (1) · Carol Fabian, MD (1) · Charite University, Berlin, Germany (1) · City of Hope Medical Center (1)
United States (33) · Canada (5) · Italy (4) · Germany (3) · Taiwan (3) · Israel (2) · Japan (2) · Switzerland (2) · United Kingdom (2) · Austria (1) · Brazil (1) · China (1) · France (1) · India (1) · Iran (1)
Marcelo J Amar, M.D. (2) · Nicholas J West, MB BS FRCS (2) · Ahmet Oguzhan Kucuk, MD (1) · Alessandra Gennari, MD (1) · Alessandro Pontes-Arruda, MD, PhD (1) · Aminah Jatoi, MD (1) · Andrea Bonny, MD (1) · Anton Cheng, MBBS FRCS (1) · Aruna Pradhan, MD, MPH (1) · Babu Suresh Balasubramaniam, MBBS FRCR (1) · Carol J. Fabian, M.D. (1) · Christopher E Ramsden, M.D. (1) · David Luria, MD (1) · David Mischoulon, MD, PhD (1)
PMID 34817851, PMID 15197210, PMID 18421079, PMID 20348368, PMID 22751375, PMID 22879423, PMID 23620429, PMID 23644932, PMID 23645227, PMID 23830564, PMID 23887802, PMID 24252845, PMID 24310343, PMID 24476345, PMID 24638908, PMID 25272149, PMID 25790022, PMID 25802980, PMID 26305649, PMID 26784651, PMID 28394724, PMID 29391271, PMID 29866196, PMID 30050374, PMID 30736445, PMID 30746344, PMID 30832289, PMID 30871265, PMID 31699704, PMID 31827448, PMID 31948466, PMID 32213121, PMID 32285590, PMID 32575774, PMID 32583982, PMID 33170239, PMID 34244155, PMID 34291724, PMID 34793832, PMID 35082139, PMID 35236290, PMID 35487733, PMID 35821820, PMID 36005883, PMID 37058600, PMID 37425294, PMID 37543639, PMID 37702300, PMID 38199870, PMID 38272846
2016 (1), R01AG059981 (1), R01AR059086 (1), R01AT011729 (1), R01CA138962 (1), R01CA160938 (1), R01CA164019 (1), R01CA178263 (1), R01DK088078 (1), R01HL101932 (1), R01HL159204 (1), R01MH074085 (1), U01CA138962 (1)