114 completed, 62 recruiting, 55 unknown, 13 not yet recruiting. 193 Not applicable, 16 Phase 1, 13 Phase 2, 11 Early Phase 1, 10 Phase 3.
Follow Deep Brain Stimulation: new trials by email Literature Review of Deep Brain Stimulation trials Research Report on Deep Brain Stimulation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cognitive Network Restoration Therapy for Moderate to Severe Traumatic Brain Injury: A Feasibility Study Deep brain stimulation - Chronic Traumatic Brain Injury, TBI (Traumatic Brain Injury) | Not applicable | Not yet recruiting | ReEmerge, Inc. | 40 | 2027-02-01 | 2026-07-28 |
| Deep Brain Stimulation + Therapy for Stroke Boston Scientific Vercise Deep Brain Stimulation (DBS) System, Rehabilitation Training Protocol - Stroke, Dysarthria | Not applicable | Not yet recruiting | Pirondini, Elvira, PhD | 15 | 2027-01-01 | 2026-09-30 |
| Novel Brain Stimulation Treatment for Neuropsychiatric Symptoms in Alzheimer's Disease Brain Stimulation - Alzheimer&Amp;#39;s Disease-related Dementia, Alzheimer Disease | Not applicable | Not yet recruiting | Baylor College of Medicine | 20 | 2026-12-01 | 2026-10-05 |
| Bayesian Optimization of DBS for Gait Deep Brain Stimulation - Parkinson Disease (PD) | Early Phase 1 | Recruiting | University of Minnesota | 15 | 2026-12-01 | 2026-09-28 |
| Combined CM and STN Stimulation for Motor Epilepsy Deep brain stimulation - Motor Epilepsy | Not applicable | Not yet recruiting | Boston Scientific Corporation | 10 | 2026-10-31 | 2026-09-25 |
| Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury Deep Brain Stimulation (DBS), Deep Brain Stimulation (DBS) Device Implant Procedure, Training Sessions - Spinal Cord Injuries | Not applicable | Recruiting | University of Miami | 6 | 2026-10-30 | 2026-06-12 |
| Investigating Adaptive Deep Brain Stimulation in Parkinson's Disease Management Deep Brain Stimulation - Parkinson Disease, Idiopathic | Not applicable | Recruiting | Newronika | 104 | 2026-08-26 | 2026-09-24 |
| In-depth Investigation of Brain Network Interactions Brain stimulation - Episodic Memory | Not applicable | Withdrawn | Northwestern University | 2026-08-01 | 2025-07-25 | |
| Characterization of the Involvement of the Subthalamic Nucleus During Wakefulness and Sleep in Parkinson's Disease: Contribution of Deep Brain Stimulation Deep Brain Stimulation - Parkinson Disease | Not applicable | Not yet recruiting | University Hospital, Grenoble | 15 | 2026-07-01 | 2026-06-10 |
| Automated Daytime Adaptive Deep Brain Stimulation Parameter Optimization in Patients Implanted With Percept Neurostimulator Medtronic Percept Deep Brain Stimulation (adaptive DBS), Medtronic Percept Deep Brain Stimulation (cDBS) - PD - Parkinson's Disease | Not applicable | Recruiting | University of California, San Francisco | 40 | 2026-06-04 | 2026-09-14 |
| Interposed Nucleus aDBS for Ataxia Deep Brain Stimulation - Spinocerebellar Ataxia (SCA), Spinocerebellar Ataxia Type 6 | Not applicable | Recruiting | University of Florida | 5 | 2026-06-02 | 2026-07-20 |
| Deep Brain Stimulation in Parkinson's Disease: Motor and Functional Outcomes Deep Brain Stimulation - Parkinson Disease | Not applicable | Enrolling by invitation | Federal University of Minas Gerais | 40 | 2026-06-02 | 2026-07-29 |
| Deep Brain Stimulation for Spinocerebellar Ataxia Deep Brain Stimulation (DBS) - Spinocerebellar Ataxia (SCA), Spinocerebellar Ataxia Type 6 | Not applicable | Recruiting | University of California, San Francisco | 5 | 2026-04-27 | 2026-07-13 |
| Simplified, Scalable, 24-hour Adaptive DBS in Parkinson's Disease Medtronic Percept Deep Brain Stimulation (cDBS), Medtronic Percept Deep Brain Stimulation (daytime aDBS), Medtronic Percept Deep Brain Stimulation (nighttime aDBS) - PD - Parkinson's Disease | Not applicable | Recruiting | University of California, San Francisco | 24 | 2026-04-09 | 2026-09-14 |
| The Children's Adaptive Deep Brain Stimulation for Epilepsy Trial Deep Brain Stimulation - Lennox Gastaut Syndrome (LGS) | Not applicable | Recruiting | University College, London | 22 | 2026-03-24 | 2026-04-07 |
| Deep Brain Stimulation of the Nucleus Accumbens and Anterior Limb of the Internal Capsule in the Treatment of Refractory Schizophrenia Deep Brain Stimulation - Refractory Schizophrenia | Not applicable | Not yet recruiting | First Affiliated Hospital of Fujian Medical University | 10 | 2026-01-20 | 2026-01-27 |
| Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor Deep Brain Stimulation - Tremor, Essential Tremor | Phase 1 | Recruiting | The Cleveland Clinic | 12 | 2026-01-15 | 2026-07-10 |
| REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study Deep brain stimulation (DBS) electrode implantation - Disorders of Consciousness | Early Phase 1 | Recruiting | Samuel Snider, MD | 2 | 2025-11-01 | 2026-06-23 |
| Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder Deep Brain Stimulation - Substance Use Disorder (SUD), Opioid Use Disorder (OUD) | Not applicable | Recruiting | University of California, San Francisco | 6 | 2025-10-24 | 2025-10-28 |
| Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease Deep Brain Stimulation (DBS) - Parkinson Disease | Not applicable | Recruiting | University of Florida | 60 | 2025-10-01 | 2026-07-15 |
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Parkinson Disease (81) · Obsessive-Compulsive Disorder (25) · Dystonia (20) · Essential Tremor (17) · Depressive Disorder, Major (12) · Depressive Disorder, Treatment-Resistant (10) · Epilepsy (10) · Movement Disorders (10) · Stroke (10) · Alzheimer Disease (9) · Behavior, Addictive (9) · Depression (9) · Tremor (7) · Tourette Syndrome (6) · Anorexia Nervosa (5)
Beijing Pins Medical Co., Ltd (9) · University of Florida (9) · Ruijin Hospital (7) · University of Minnesota (7) · Boston Scientific Corporation (6) · Charite University, Berlin, Germany (6) · University Health Network, Toronto (6) · University of California, San Francisco (6) · University College, London (5) · Second Affiliated Hospital, Zhejiang University, School of Medicine (4) · Sunnybrook Health Sciences Centre (4) · Tang-Du Hospital (4) · University Hospital, Grenoble (4) · Xuanwu Hospital, Beijing (4) · Abbott Medical Devices (3)
United States (98) · China (35) · Canada (28) · France (24) · Germany (23) · United Kingdom (17) · Italy (9) · Spain (9) · Brazil (7) · Belgium (6) · Switzerland (6) · Israel (5) · Netherlands (5) · South Korea (5) · Austria (3)
Li Luming, PhD (8) · Dianyou Li, MD, PhD (3) · Guo-dong Gao, M.D. (3) · Hongxing Wang, MD & PhD (3) · Natalie Bloom Lyons (3) · Ali Rezai, MD (2) · Andreas R Kupsch, MD (2) · Jens Kuhn, MD (2) · Jorge Gonzalez-Martinez, MD, PhD (2) · Luc Mallet, MD, PhD (2) · Marie Vidailhet, MD, PhD (2) · Nanthia Suthana, PhD (2) · Nicole Bentley, MD (2) · Scott Cooper, MD, PhD (2)
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R01MH124761 (2), 1DP2OD006469-01 (1), 1UG3NS140730-01 (1), 1UH3NS113769 (1), 2014 (1), 2016 (1), 5UH3NS095553-04 (1), K08MH138741 (1), K23NS052557 (1), K23NS117735 (1), R01MH122431 (1), R01MH124763 (1), R01MH139889 (1), R01NS045049 (1), R01NS075321 (1)