25 completed, 3 terminated, 3 withdrawn, 2 not yet recruiting. 35 Phase 1, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 35 | Completed 25, Terminated 3, Withdrawn 3, Not yet recruiting 2, Recruiting 1, Unknown 1 |
| Phase 2 | 7 | Completed 4, Recruiting 1, Unknown 1, Withdrawn 1 |
Follow Anesthesia: new trials by email Literature Review of Anesthesia trials Research Report on Anesthesia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Dexmedetomidine in Pediatric MRI Dexmedetomidine, General Anesthesia (control group) - Anesthesia | Phase 1 | Not yet recruiting | Soroush Merchant | 18 | 2026-11-01 | 2026-08-04 |
| Prospective IR-led Sedation Feasibility ketamine, Fentanyl (IV), Midazolam - Anesthesia, Sedation and Analgesia | Phase 1 / Phase 2 | Recruiting | CAMC Health System | 40 | 2026-03-02 | 2026-03-09 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| Comparison of Procedural Sedation in TEE Remimazolam, Propofol - Anesthesia | Phase 1 | Completed | University of Alabama at Birmingham | 105 | 2025-02-25 | 2025-12-22 |
| Neural Correlates of Lidocaine Analgesia Peripheral Nerve Stimulation, Lidocaine IV - Anesthesia, Pain | Phase 1 | Completed | Keith M Vogt | 30 | 2022-11-22 | 2024-12-24 |
| Cardioprotective Effect of Ketamine-dexmeditomidine Versus Fentanyl-midazolam in Open Heart Surgery in Pediatrics Ketamine- dexmedetomidine, Fentanyl- midazolam, Isoflurane - Anesthesia | Phase 1 | Completed | Cairo University | 81 | 2022-04-15 | 2024-02-07 |
| Assessment of the Pharmacodynamic and Pharmacokinetic Interaction of Remimazolam and Remifentanil Remimazolam, Remifentanil - Anesthesia | Phase 1 | Completed | Paion UK Ltd. | 28 | 2021-04-13 | 2023-09-11 |
| Memory & Conditioning Under Anesthesia Dexmedetomidine, Propofol, Fentanyl - Anesthesia, Pain | Phase 1 | Completed | Keith M Vogt | 92 | 2020-07-30 | 2025-04-18 |
| A Study to Evaluate the Differences in Pharmadynamics, Pharmacokinetics, and Safety Between Ciprofol and Propofol Ciprofol, Propofol - Anesthesia | Phase 1 | Completed | Haisco Pharmaceutical Group Co., Ltd. | 18 | 2020-05-26 | 2020-11-20 |
| A Study Evaluating the Mass Balance of Micro-dose[14C]HSK3486 Emulsion Injection in Healthy Adults HSK3486 - Anesthesia, Sedation | Phase 1 | Withdrawn | Sichuan Haisco Pharmaceutical Group Co., Ltd | 2020-03-30 | 2022-06-02 | |
| A Study Evaluating Drug-Drug Interaction (DDI) Between HSK3486 Injectable Emulsion and Voriconazole Tablets HSK3486, voriconazole +HSK3486 - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 16 | 2019-12-14 | 2020-12-19 |
| EEG Study of IV Methylphenidate-Induced Emergence From Propofol Sedation IV Methylphenidate, Propofol - Anesthesia | Phase 1 / Phase 2 | Withdrawn | Massachusetts General Hospital | 2019-11-01 | 2020-02-21 | |
| A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486 HSK3486, Propofol - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 16 | 2019-01-09 | 2020-01-09 |
| A Study Evaluating the Mass Balance of [14C]HSK3486 Emulsion Injection in Healthy Adults. HSK3486 - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 6 | 2019-01-06 | 2019-10-28 |
| A Study Evaluating Drug-Drug Interaction (DDI) Between HSK3486 Injectable Emulsion and Rifampin Capsules HSK3486, rifampin , HSK3486 - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 16 | 2018-12-14 | 2019-08-20 |
| The Effect of Low Dose Intra-operative Ketamine on Closed-loop Controlled General Anesthesia Ketamine Injectable Solution, Placebo - Anesthesia | Phase 1 | Completed | NeuroWave Systems Inc. | 60 | 2018-03-13 | 2019-05-06 |
| A Study in Healthy Male Volunteers to Investigate the Safety and Tolerability of a Single Dose of Neosaxitoxin Alone and in Combination With Bupivacaine (With and Without Epinephrine) for Brachial Plexus Blockade Neosaxitoxin combined with bupivacaine low and epinephrine (T1), Bupivacaine low combined with epinephrine (C1), Bupivacaine high combined with epinephrine (C2) - Anesthesia, Anesthesia, Local | Phase 1 | Terminated | Grünenthal GmbH | 242 | 2018-01-30 | 2018-10-11 |
| Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery Midazolam Hydrochloride, Fentanyl, Ketamine - Anesthesia, Tooth Extraction | Phase 1 | Completed | Albert Einstein College of Medicine | 73 | 2016-10-04 | 2026-03-27 |
| Adductor Canal Block Versus Patient Controlled Analgesia, in the Surgical Stress Response for Anterior Cruciate Ligament Repair Adductor Canal Block, Morphine Patient Controlled Analgesia - Anesthesia, Stress, Physiological | Phase 1 | Withdrawn | Pontificia Universidad Catolica de Chile | 2016-09-01 | 2021-03-15 | |
| A Study Evaluating Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Single IV Dose of HSK3486 Injectable Emulsion in Healthy Subjects. HSK3486 - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 24 | 2016-05-01 | 2020-03-03 |
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Pain (4) · Agnosia (2) · Alzheimer Disease (1) · Amnesia (1) · Anxiety Disorders (1) · Cancer Pain (1) · Chronobiology Disorders (1) · Combat Disorders (1) · Depression (1) · Idiopathic Hypersomnia (1) · Psychological Well-Being (1) · REM Sleep Behavior Disorder (1) · Renal Insufficiency (1) · Sleep Deprivation (1) · Sleep Disorders, Circadian Rhythm (1)
Neurologic Manifestations (6) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (6) · Nervous System Diseases (4) · Neurobehavioral Manifestations (3) · Mental Disorders (2) · Neurocognitive Disorders (2) · Perceptual Disorders (2) · Behavior (1) · Behavioral Symptoms (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Dementia (1) · Disorders of Excessive Somnolence (1) · Dyssomnias (1)
Propofol (12) · HSK3486 (9) · Dexmedetomidine (4) · Fentanyl (3) · Ketamine (3) · Lidocaine (3) · Midazolam (3) · Transcutaneous Electric Nerve Stimulation (3) · Anesthesia (2) · Epinephrine (2) · Nitrous Oxide (2) · Remifentanil (2) · Sevoflurane (2) · remimazolam (2) · (2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenol (1)
Sichuan Haisco Pharmaceutical Group Co., Ltd (9) · Keith M Vogt (2) · Albert Einstein College of Medicine (1) · Arbor Pharmaceuticals, Inc. (1) · CAMC Health System (1) · Cairo University (1) · Children's Hospital Medical Center, Cincinnati (1) · Grünenthal GmbH (1) · Haisco Pharmaceutical Group Co., Ltd. (1) · Jiangsu HengRui Medicine Co., Ltd. (1) · Klein, Jeffrey A., M.D. (1) · Massachusetts General Hospital (1) · NeuroWave Systems Inc. (1) · Nyree Penn (1) · Paion UK Ltd. (1)
United States (13) · China (6) · Brazil (2) · Canada (2) · Netherlands (2) · Chile (1) · Egypt (1) · France (1) · North Macedonia (1) · Sweden (1)
Keith M Vogt, MD, PhD (3) · Aleksandra Gavrilovska-Brzanov, MD. Msc (1) · Amany H Saleh, MD (1) · Amy R Deipolyi, M.D., Ph.D. (1) · David MacLeod, MD (1) · Fernando Altermatt, MD (1) · Jeffrey A Klein, MD (1) · Ken Solt, MD (1) · Liyan Miao, PhD (1) · Micael Taavo, MD (1) · Nyree Penn, MHSc., CAA, Master of Health Science (1) · Patrick R Brain, DDS (1) · Pei Hu (1) · Remco Vellinga, MD (1) · Richard Merchant, MD FRCPC (1)
PMID 21106282, PMID 32178858, PMID 32415708, PMID 37713021, PMID 39438214, PMID 40067039, PMID 41836529
R35GM146822 (2), 2016 (1)