82 completed, 21 unknown, 14 recruiting, 8 terminated. 67 Not applicable, 14 Phase 3, 10 Phase 4, 9 Phase 2, 6 Phase 1.
Follow Sleep Disorders, Circadian Rhythm: new trials by email Literature Review of Sleep Disorders, Circadian Rhythm trials Research Report on Sleep Disorders, Circadian Rhythm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption Standard Periodontal Treatment - Gingivitis, Circadian Rhythm Disruption | Not yet recruiting | Inonu University | 116 | 2026-11-01 | 2026-10-27 | |
| Recovery and Early Sleep Tracking Using the SuperPatch REM Patch SuperPatch REM Patch, Sham REM Patch - Shift Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder | Not applicable | Enrolling by invitation | SuperPatch Limited LLC | 20 | 2026-05-15 | 2026-08-25 |
| Improvement of Sleep Disorders in Patients With Alzheimer's Disease After Sunlight Exposure Therapy. sunlight therapy - Alzheimer's Disease (AD), Sleep Disorders, Circadian Rhythm | Not applicable | Active not recruiting | National Taiwan University Hospital | 60 | 2026-05-13 | 2026-07-17 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| A Study on the Effectiveness of a Dietary Supplement FitoAvia for Jet Lag Fitoavia, Placebo, Questionnaire and Physical Exam - Jet Lag Disorder, Jet Lag | Not applicable | Completed | MiraxBioPharma | 120 | 2025-10-01 | 2026-07-10 |
| Pupillometry in Delayed Sleep Wake Phase Disorder Light and Citalopram - Delayed Sleep-Wake Phase Disorder | Not applicable | Recruiting | Northwestern University | 220 | 2025-09-01 | 2026-06-08 |
| A Prospective Study: the Impact of Sleep Disturbances on Immunotherapy in Patients With Lung Cancer PSQI, PQSI - Lung Cancer (NSCLC), Sleep Disorders, Circadian Rhythm | Not yet recruiting | Shanghai Zhongshan Hospital | 350 | 2025-06-01 | 2025-05-01 | |
| Effects of VR-based Respiratory Training on Motor Reaction Time and Correctness, Stress Levels, Attention, Motor Skills, Postural Stability and Sleep Quality in Shift Healthcare Workers Experimental group (B) - breathing training using VR, Experimental group (C) - breathing training using relaxation music - Healthcare Workers, Stress Level | Not applicable | Not yet recruiting | Poznan University of Physical Education | 60 | 2025-04-07 | 2025-04-13 |
| Tailored Treatment of Insomnia in Social and Health Care Sector Shift Workers in Occupational Health Care Cognitive behavioral therapy for insomnia, Sleep hygiene counselling - Insomnia Chronic, Shift Work Sleep Disorder | Not applicable | Active not recruiting | Finnish Institute of Occupational Health | 84 | 2025-02-17 | 2026-04-13 |
| Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Patients with Chronic Obstructive Bronchopneumopathy. COPD, COPD Exacerbation | Not yet recruiting | University Hospital, Grenoble | 42 | 2025-01-01 | 2024-10-23 | |
| The Sleep Clinic Outcome and Practice Study Chronotherapy, Cognitive Behavioral Therapy for Insomnia - Insomnia Disorder, Circadian Rhythm Sleep Disorder | Not applicable | Recruiting | St. Olavs Hospital | 3400 | 2025-01-01 | 2026-07-20 |
| Evaluating the Effectiveness of Intervention Based on the Model of Occupational Harmony in Patients With Sleep Disorders Occupational Therapy, Conventional Treatment - Circadian Rhythm Sleep-Wake Disorder | Not applicable | Active not recruiting | Peking University First Hospital | 40 | 2024-11-01 | 2025-09-10 |
| Effect of a Grape Seed Proanthocyanidin Extract (GSPE) on LDL Cholesterol Levels in Rotating Night Shift Workers grape seed proanthocyanidin extract, Placebo - Cardiovascular Diseases, Circadian Rhythm Sleep Disorder, Shift Work Type | Not applicable | Recruiting | Fundació Eurecat | 22 | 2024-10-28 | 2025-08-27 |
| Evaluating the Effects of Tasimelteon Vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD) and the CRY1Δ11 Variant Tasimelteon, Placebo - Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm | Phase 3 | Recruiting | Vanda Pharmaceuticals | 60 | 2024-10-08 | 2024-11-22 |
| Relieving Pain and Improving Sleep: Evaluating Topical Pain Relief and Sleep Patches Drug- free, non-invasive patch (FREEDOM or REM Patch) with haptic vibrotactile trigger technology (VTT) Other Names:, Sham Patch without haptic vibrotactile trigger technology (VTT) - Pain, Back, Pain, Acute | Not applicable | Completed | SuperPatch Limited LLC | 150 | 2024-09-20 | 2026-08-20 |
| Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder Melatonin, Placebo, Behavioral sleep intervention - Bipolar Disorder, Delayed Sleep-Wake Phase Disorder | Phase 2 | Recruiting | Leslie Swanson | 50 | 2024-08-13 | 2026-05-11 |
| Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN) Solriamfetol 150 mg, Solriamfetol 300 mg, Placebo - Excessive Sleepiness, Shift-work Disorder | Phase 3 | Recruiting | Axsome Therapeutics, Inc. | 520 | 2024-08-01 | 2026-07-24 |
| Effect of an Eye Mask-Based Blackout Protocol on Sleep Quality and Melatonin Eye Mask-Based Blackout Protocol - Sleep Disturbance, Circadian Rhythm Sleep Disorders | Not applicable | Completed | Ataturk University | 60 | 2024-08-01 | 2026-02-04 |
| Sleep-Wake Patterns on Illness Trajectories and Treatment Response in MDD Transdiagnostic Intervention for Sleep and Circadian Dysfunction - Depression, Sleep Disorders, Circadian Rhythm | Not applicable | Unknown | Chinese University of Hong Kong | 70 | 2024-06-01 | 2024-05-30 |
| Longitudinal Ecological Study on Sleep-Wake Patterns in MDD Using Actigraphy No intervention involved - Depression, Sleep Disorders, Circadian Rhythm | Unknown | Chinese University of Hong Kong | 140 | 2024-06-01 | 2024-05-22 |
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Sleep Initiation and Maintenance Disorders (26) · Sleep Wake Disorders (21) · Chronobiology Disorders (18) · Disorders of Excessive Somnolence (11) · Parasomnias (11) · Sleep Deprivation (10) · Depression (9) · Fatigue (9) · Jet Lag Syndrome (7) · Sleep Apnea, Obstructive (7) · Blindness (5) · Cognitive Dysfunction (5) · Narcolepsy (5) · Restless Legs Syndrome (5)
Mental Disorders (136) · Dyssomnias (134) · Nervous System Diseases (134) · Occupational Diseases (132) · Chronobiology Disorders (120) · Sleep Wake Disorders (117) · Pathological Conditions, Signs and Symptoms (55) · Signs and Symptoms (51) · Neurologic Manifestations (36) · Sleep Disorders, Intrinsic (31) · Behavior (21) · Behavioral Symptoms (15) · Pathologic Processes (11) · Respiratory Tract Diseases (11) · Respiration Disorders (10)
Melatonin (16) · tasimelteon (8) · Phototherapy (4) · Modafinil (3) · Sleep (3) · Therapeutics (3) · lemborexant (3) · ramelteon (3) · Cognitive Behavioral Therapy (2) · Electroencephalography (2) · Mass Screening (2) · Transcranial Direct Current Stimulation (2) · Anesthesia, Conduction (1) · Anesthesia, General (1) · Chronotherapy (1)
Brigham and Women's Hospital (13) · Vanda Pharmaceuticals (9) · University of Bergen (4) · University of California, San Francisco (4) · Chinese University of Hong Kong (3) · Stanford University (3) · Takeda (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Cephalon (2) · Finnish Institute of Occupational Health (2) · Henry Ford Health System (2) · Northwestern University (2) · Shanghai Zhongshan Hospital (2) · SuperPatch Limited LLC (2) · University of Chicago (2)
United States (73) · Norway (7) · Germany (5) · Turkey (Türkiye) (5) · Denmark (4) · Austria (3) · China (3) · Finland (3) · France (3) · Hong Kong (3) · Russia (3) · Taiwan (3) · Canada (2) · Greece (2) · Netherlands (2)
Jeanne F Duffy, MBA, PhD (3) · Andrew D Krystal, MD, MS (2) · Charles A Czeisler, Ph.D., M.D. (2) · Christine M Swanson, MD, MCR (2) · Emmanuel Mignot, MD, PhD (2) · Jeanne F Duffy, PhD (2) · Agneta Markstroem, Ass. Prof. (1) · Alan Lankford, PhD (1) · Alexandra Ruan, MD (1) · Allison G Harvey, PhD (1) · Ane Wilhelmsen-Langeland, PhD (1) · Anette Harris, PhD (1) · Antoni Caimari Palou, PhD (1)
PMID 26466871, PMID 11556941, PMID 1798888, PMID 18041487, PMID 18853704, PMID 19054552, PMID 19544753, PMID 19880686, PMID 20483660, PMID 21527892, PMID 21532953, PMID 22294820, PMID 22910327, PMID 23036285, PMID 24132057, PMID 24144243, PMID 24694994, PMID 24951039, PMID 25678831, PMID 26446111, PMID 27964860, PMID 28460563, PMID 28851459, PMID 30423177, PMID 31410909, PMID 31824318, PMID 31853633, PMID 31956421, PMID 32484552, PMID 33853394, PMID 34344312, PMID 35313849, PMID 35428642, PMID 36000763, PMID 36006948, PMID 37068889, PMID 37470678, PMID 37590443, PMID 38033548, PMID 38445651, PMID 38485134, PMID 38521925, PMID 38581363, PMID 39441802, PMID 40250869, PMID 40462685, PMID 40952742, PMID 41057672, PMID 41663167, PMID 41697175
R01HL151332 (2), 2015 (1), K23HL088020 (1), K23HL138229 (1), M01RR000051 (1), P50DA046346 (1), R01AG006072 (1), R01AG044416 (1), R01DK105072 (1), R01HL069988 (1), R01HL081761 (1), R01HL094654 (1), R01HL159647 (1), R01HL163659 (1), R01HL164462 (1)