196 completed, 41 unknown, 39 recruiting, 10 not yet recruiting. 215 Not applicable, 14 Phase 4, 11 Phase 1, 10 Phase 2, 6 Phase 3.
Follow Sleep Deprivation: new trials by email Literature Review of Sleep Deprivation trials Research Report on Sleep Deprivation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evolution of Sleep in Intensive Care Unit Patients Sleep monitoring using Sleepscan®, Actigraphy - ICU, Sleep Deprivation | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Saint Etienne | 40 | 2026-12-01 | 2026-10-09 |
| Sleep Harmonization Via Bundled Team-Based Interventions in the ICU Nighttime noise & light reduction, Clustering patient-care interactions, Non-pharmacologic sleep aids - Sleep Deprivation, Critical Illness | Not applicable | Not yet recruiting | University of California, San Diego | 62500 | 2026-10-01 | 2026-09-25 |
| Acupuncture for Sleep Fragmentation in Older Adults: A Single-Arm Pilot Study Acupuncture - Sleep Fragmentation, Poor Sleep Quality | Not applicable | Not yet recruiting | Chang Gung Memorial Hospital | 20 | 2026-10-01 | 2026-09-25 |
| The Neurocognitive Effects of Total and Partial Sleep Deprivation in Younger Adults. Total sleep deprivation, Partial sleep deprivation, Normal sleep - Sleep Deprivation | Not applicable | Not yet recruiting | Örebro University, Sweden | 24 | 2026-09-01 | 2026-09-16 |
| Study of Single Doses of HBS-104 in Acutely Sleep-deprived Healthy Participants HBS-104, Placebo - Sleep Deprivation | Phase 1 | Recruiting | Harmony Biosciences Management, Inc. | 12 | 2026-08-28 | 2026-09-30 |
| Neurobehavioral Changes Following Spaceflight Stressors Alcohol Administration, Sleep Deprivation, Control - Stressor, Individual, Alcohol Impairment | Not applicable | Recruiting | University of Pennsylvania | 56 | 2026-08-04 | 2026-08-06 |
| Sleep and Circadian Rhythm Intervention in ICU Sound and Light Optimization, Night-time Patient Care Activities, Enhanced Daytime Mobility - ICU Hospitalization, Circadian Rhythm | Not applicable | Recruiting | Shanghai Zhongshan Hospital | 70 | 2026-08-01 | 2026-10-13 |
| The Acute Effects of Onnit Alpha Brain on Cognition and Mood States Alpha Brain proprietary cognitive dietary supplement, Alpha Brain 2.0 proprietary cognitive dietary supplement, Controlled Placebo - Cognitive, Mood and Cognitive Performance | Not applicable | Completed | Applied Science & Performance Institute | 32 | 2026-05-01 | 2026-07-08 |
| TESTING AN MTM THEORY-BASED INTERVENTION ON REDUCING DROWSY DRIVING BEHAVIOR, "STAY AWAKE, STAY ALIVE ©," AMONG COLLEGE STUDENTS MTM Theory based intervention, Standard AAA Knowledge based - Drowsiness, Sleep Deprivation | Not applicable | Enrolling by invitation | University of Nevada, Las Vegas | 72 | 2026-04-07 | 2026-05-26 |
| Evaluation of Sex Differences in Glucose Metabolism in Response to Sleep Curtailment Sleep restriction - Sleep Deprivation, Sex Differences | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 32 | 2026-04-01 | 2025-12-10 |
| Reliability of Standardized IQ Testing Under Modafinil, Racetam-Class Compounds, Sleep Restriction and Daily Activity Modafinil, Oxiracetam, Pramiracetam - Healthy, Cognition | Phase 1 | Completed | Abdulraheem Mohamed Gouda | 70 | 2026-03-09 | 2026-10-01 |
| Mind After Midnight Sleep Pressure Manipulation - Suicidal Ideation, Circadian Rhythm Disorders | Not applicable | Recruiting | University of Arizona | 90 | 2026-03-06 | 2026-10-01 |
| Sleep Promotion and Pediatric Hypertension Intervention - Insufficient Sleep, Hypertension | Not applicable | Recruiting | Children's Hospital of Philadelphia | 10 | 2026-02-16 | 2026-08-28 |
| Nighttime Synchrony of Your Nutrition and Circadian Health Central Clock Misalignment, Peripheral Misalignment - Sleep, Metabolism Changes | Not applicable | Recruiting | University of Utah | 120 | 2025-12-19 | 2026-01-22 |
| Circadian Rhythms and Time Perception in Healthy Adults During Constant Wakefulness Constant Routine Wakefulness - Sleep Deprivation, Circadian Rhythm | Not applicable | Recruiting | University of Aarhus | 30 | 2025-12-05 | 2025-12-22 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| Restorative Effects of Sleep on Everyday Health and Wellbeing: A Treatment Study Cognitive Behavioral Therapy for Insomnia - Chronic Insomnia | Not applicable | Recruiting | University of Notre Dame | 115 | 2025-09-29 | 2026-04-23 |
| Effects of Non-Invasive Superficial Craniocervical Lymphatic Drainage (NSCLD) on Memory and Cognitive Function in Adults With Sleep Deprivation: A Proof-of-Concept Study Non-Invasive Superficial Craniocervical Lymphatic Drainage (NSCLD), sham-intervention treatment - Sleep Deprivation | Not applicable | Recruiting | Tao Liu | 30 | 2025-09-15 | 2026-01-13 |
| Shift Hours' Impact on Fatigue and Tracking of Eye Dynamics Electroencephalogram, Actigraphy, Eye Tracking - Sleep Deprivation, Sleepiness | Not applicable | Not yet recruiting | IMADIS Technologies et Services | 40 | 2025-09-15 | 2025-09-25 |
| The Effect of a Psychosocial Adjustment Program on Healthy Lifestyle Behaviors and Sleep Deprivation in Ninth-Grade Boarding Female Students Implementation of the Psychosocial Adaptation Program - Healthy Lifestyle, Sleep Deprivation | Not applicable | Completed | Akdeniz University | 52 | 2025-09-12 | 2026-03-04 |
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Sleep Initiation and Maintenance Disorders (41) · Sleep Wake Disorders (21) · Depression (16) · Fatigue (13) · Obesity (13) · Parasomnias (12) · Sleep Hygiene (11) · Chronobiology Disorders (10) · Critical Illness (10) · Delirium (10) · Sleep Disorders, Circadian Rhythm (10) · Anxiety Disorders (9) · Sleep Apnea Syndromes (8) · Sleepiness (7)
Neurologic Manifestations (309) · Pathological Conditions, Signs and Symptoms (309) · Mental Disorders (308) · Nervous System Diseases (308) · Signs and Symptoms (308) · Dyssomnias (306) · Sleep Wake Disorders (288) · Behavior (57) · Sleep Disorders, Intrinsic (53) · Behavioral Symptoms (29) · Nutritional and Metabolic Diseases (29) · Pathologic Processes (25) · Neurocognitive Disorders (21) · Metabolic Diseases (19) · Glucose Metabolism Disorders (17)
Modafinil (6) · Sleep (6) · Exercise (5) · Surveys and Questionnaires (5) · Blood Specimen Collection (4) · Caffeine (4) · Cognitive Behavioral Therapy (4) · Beds (3) · Dexmedetomidine (3) · Melatonin (3) · Phototherapy (3) · Zolpidem (3) · Actigraphy (2) · Anesthesia, General (2) · Donepezil (2)
Brigham and Women's Hospital (8) · Beth Israel Deaconess Medical Center (5) · Children's Hospital of Philadelphia (5) · Institut de Recherche Biomedicale des Armees (5) · University of Arizona (5) · University of Chicago (5) · University of Pittsburgh (5) · University of Utah (5) · Uppsala University (5) · Cairo University (4) · China Medical University, China (4) · United States Army Research Institute of Environmental Medicine (4) · Federal University of São Paulo (3) · Hospices Civils de Lyon (3) · Johns Hopkins University (3)
United States (145) · France (31) · Turkey (Türkiye) (12) · China (11) · Canada (8) · Denmark (7) · Sweden (7) · Israel (6) · Brazil (5) · Egypt (5) · Spain (5) · United Kingdom (5) · Germany (4) · Hong Kong (4) · Switzerland (4)
Christian Benedict, PhD (3) · Ariel Williamson, PhD (2) · Aviva Abosch, MD, PhD (2) · Brian K Gehlbach, MD (2) · Charles A Czeisler, PhD, MD (2) · Elizabeth B Klerman, MD PhD (2) · Jeff S Volek, PhD (2) · Jessica C Levenson (2) · Jonathan Mitchell, PhD (2) · Joseph Tonna, MD, FAAEM (2) · Plamen D Penev, MD, PhD (2) · Robyn Stremler, RN, PhD (2) · Thorsten Kahnt, PhD (2) · Abolfazl Sadeghinejad, MD (1)
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R01HL089637 (2), R34MH132724 (2), 1UH3NS113769 (1), 2005 (1), 2017 (1), I01RX003140 (1), K23AG033763 (1), K23HD094905 (1), K23HL088020 (1), P01AG009975 (1), P20GM113125 (1), P30AG063786 (1), R01AG023977 (1), R01AG028769 (1), R01AG053838 (1)