27 recruiting, 23 unknown, 19 completed, 13 active not recruiting. 29 Not applicable, 15 Phase 2, 6 Phase 4, 2 Phase 1, 2 Phase 3.
Follow REM Sleep Behavior Disorder: new trials by email Literature Review of REM Sleep Behavior Disorder trials Research Report on REM Sleep Behavior Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Artificial Intelligence-based Parkinson's Disease Risk Assessment (AI-PRA) Study Smartwatch and phone app - Parkinson Disease (PD), REM Sleep Behavior Disorder (iRBD) | Not yet recruiting | Queen Mary University of London | 60 | 2026-10-01 | 2026-10-02 | |
| An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD) Adalimumab, Placebo - REM Sleep Behavior Disorder | Phase 2 | Recruiting | Yale University | 108 | 2026-08-17 | 2026-10-08 |
| INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns., Sham (No Treatment) - Nightmare, Insomnia | Not applicable | Not yet recruiting | Uniformed Services University of the Health Sciences | 180 | 2026-06-01 | 2026-04-28 |
| Understanding Alpha-Synuclein Spread in Parkinson's Disease Through Blood Biomarkers and Neuroimaging brain imaging, blood draw, Skin biopsy - Parkinson's Disease (PD), GBA1 Parkinson Disease | Not applicable | Not yet recruiting | University of Pavia | 160 | 2026-05-11 | 2026-05-01 |
| PET-MRI of Reward System in Parkinson's Disease With RBD PET-MRI (Positron Emission Tomography - Magnetic Resonance Imaging). - Parkinson's Disease (PD) | Not applicable | Recruiting | University Hospital, Clermont-Ferrand | 44 | 2026-05-07 | 2026-07-08 |
| L-THEANINE AND MEDITERRANEAN DIET ON RBD, GI FUNCTION, AND INFLAMMATION IN PARKINSON'S DISEASE Dietary Supplement, Control group (placebo) - Parkinson Disease (PD) | Not applicable | Recruiting | Medipol University | 52 | 2026-05-02 | 2026-07-06 |
| Pain Assessment in Patients With Idiopathic Rapid Eye Movement (REM) Sleep Behaviour Disorder Thermo test pain, Pain questionnaires, No motors symptoms evaluations - REM Sleep Behavior Disorder (iRBD), Narcolepsy Type 1 | Not applicable | Recruiting | University Hospital, Toulouse | 24 | 2026-02-24 | 2026-05-01 |
| Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders UHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain with ¹⁸F-SynVesT-1 - Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 300 | 2026-02-13 | 2026-04-03 |
| A Comprehensive, Multimodal Characterization of Prodromal PD in Subjects With RBD REM Sleep Behavior Disorder, Synucleinopathies | Recruiting | Danish Research Centre for Magnetic Resonance | 100 | 2026-02-01 | 2026-08-27 | |
| Role of Slow Waves in the Progression of Neurodegeneration in Isolated REM Sleep Behavior Disorder Tosoo Axora - Parkinson Disease, REM Sleep Behavior Disorder (iRBD) | Not applicable | Recruiting | University of Zurich | 80 | 2026-01-15 | 2026-02-17 |
| Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease Ginger - REM Sleep Behavior Disorder, Parkinson s Disease | Not applicable | Recruiting | Cambridge University Hospitals NHS Foundation Trust | 72 | 2025-12-17 | 2026-10-21 |
| Development and Online Evaluation of an Online Course for Parasomnias Parasomnia Education, Sleep Hygiene Control - Sleep Terror, Sleepwalking | Not applicable | Recruiting | University of Manitoba | 20 | 2025-11-14 | 2026-01-23 |
| The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions Probiotic Supplementation with L. reuteri - PARKINSON DISEASE (Disorder), Parkinson | Not applicable | Recruiting | University of Cambridge | 215 | 2025-11-01 | 2026-08-25 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| Unmet Needs Among Patients With Isolated REM Sleep Behavior Disorder (iRBD) and Their Significant Others REM Sleep Behavior Disorder, Isolated REM Sleep Behavior Disorder | Recruiting | Universita di Verona | 150 | 2025-05-06 | 2026-03-27 | |
| Study of Sleep Disorders in Prodromal and Definite Parkinsons Disease Polysomnography - Parkinson Disease, REM Sleep Behavior Disorder (iRBD) | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 457 | 2025-03-18 | 2026-03-06 |
| The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake Disorders Transcranial Magnetic Stimulation - Insomnia Chronic, Narcolepsy | Not applicable | Recruiting | Second Affiliated Hospital of Soochow University | 20 | 2025-02-01 | 2025-02-14 |
| Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's Disease REM Behavior Disorder, Parkinson Disease | Active not recruiting | CND Life Sciences | 100 | 2024-12-17 | 2026-10-20 | |
| [18F] - FD17 PET Imaging of α-synuclein: A Clinical Study in α-synucleinopathy Patients PET - α-synucleinopathy, Parkinson's Disease (PD) | Completed | Ruijin Hospital | 55 | 2024-12-14 | 2026-03-05 | |
| IMPACT 360 for Parkinson's Disease Exercise, Meditation, Diet - Parkinson's Disease (PD), REM Sleep Behavior Disorder | Phase 2 | Active not recruiting | University of British Columbia | 60 | 2024-10-28 | 2026-06-25 |
Showing 20 of 101. Sign in to see all of them.
Parkinson Disease (54) · Lewy Body Disease (14) · Nerve Degeneration (9) · Synucleinopathies (9) · Multiple System Atrophy (8) · Parkinsonian Disorders (7) · Dementia (5) · Cognitive Dysfunction (4) · Narcolepsy (4) · Neurodegenerative Diseases (4) · Parkinson Disease, Secondary (4) · Sleep Initiation and Maintenance Disorders (4) · Sleep Wake Disorders (4) · Alzheimer Disease (3)
Mental Disorders (100) · Nervous System Diseases (100) · Parasomnias (99) · REM Sleep Parasomnias (99) · Sleep Wake Disorders (97) · Central Nervous System Diseases (65) · Brain Diseases (64) · Basal Ganglia Diseases (61) · Movement Disorders (61) · Neurodegenerative Diseases (58) · Parkinsonian Disorders (54) · Synucleinopathies (51) · Pathological Conditions, Signs and Symptoms (27) · Neurocognitive Disorders (18) · Pathologic Processes (15)
Clonazepam (3) · Melatonin (3) · Blood Specimen Collection (2) · Carvedilol (2) · Magnetic Resonance Imaging (2) · Polysomnography (2) · idebenone (2) · ioflupane (2) · nelotanserin (2) · ramelteon (2) · (methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine (1) · 3-Iodobenzylguanidine (1) · Adalimumab (1) · Biological Factors (1) · Cognitive Behavioral Therapy (1)
Chinese University of Hong Kong (11) · University Hospital, Clermont-Ferrand (6) · Seoul National University Hospital (5) · Cedars-Sinai Medical Center (3) · Mayo Clinic (3) · Ruijin Hospital (3) · Axovant Sciences Ltd. (2) · CND Life Sciences (2) · IRCCS San Raffaele (2) · NYU Langone Health (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · University Hospital, Toulouse (2) · University of Minnesota (2) · Washington University School of Medicine (2) · Yale University (2)
United States (35) · France (15) · Hong Kong (11) · United Kingdom (9) · Canada (7) · China (7) · South Korea (7) · Italy (6) · Germany (3) · Spain (3) · Denmark (2) · Switzerland (2) · Argentina (1) · Australia (1) · Austria (1)
Jihui Zhang, PhD (4) · Yun Kwok Wing, MBChB (4) · Yun Kwok Wing, Professor (4) · Bradley Boeve, MD (3) · Baorong Zhang, MD (2) · Horacio C Kaufmann, MD (2) · Ilise Lombardo, MD (2) · Michele Tagliati, MD, FAAN (2) · Shirley Xin Li, PhD (2) · Todd Levine (2) · Vincent Chung Tong Mok, MBChB (2) · Aleksandar Videnovic, M.D. (1) · Alexander Shtilbans, MD (1) · Andreas Luft, Prof. Dr. med. (1) · Artur F Schuh-Schumacher, Dr. (1)
PMID 10214756, PMID 10406987, PMID 10527042, PMID 10853813, PMID 10979878, PMID 11076832, PMID 11400186, PMID 11724917, PMID 12498954, PMID 12904089, PMID 15175402, PMID 15345186, PMID 15645531, PMID 15779234, PMID 16025231, PMID 16442563, PMID 16715205, PMID 16837857, PMID 17190953, PMID 18079166, PMID 18349024, PMID 19018276, PMID 20146689, PMID 20188504, PMID 20846908, PMID 20887968, PMID 20976736, PMID 21045744, PMID 21421334, PMID 21538520, PMID 21571570, PMID 21700495, PMID 21802993, PMID 22321865, PMID 22483040, PMID 22508280, PMID 23024438, PMID 23160999, PMID 23266935, PMID 23329524, PMID 23347909, PMID 23562390, PMID 23647842, PMID 23970363, PMID 24332912, PMID 24637128, PMID 25483722, PMID 25589269, PMID 25666029, PMID 25681454
2023 (1), R01AG095016 (1), R01NS095562 (1), R34AG056639 (1), U19AG071754 (1)