71 completed, 12 unknown, 11 terminated, 10 withdrawn. 39 Not applicable, 25 Phase 4, 24 Phase 2, 16 Phase 3, 8 Phase 1.
Follow Nitrous Oxide: new trials by email Literature Review of Nitrous Oxide trials Research Report on Nitrous Oxide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Evaluation of Intranasal Atomized Midazalom Combined With Nitrous Oxide Versus Nitrous Oxide Monotherapy Midazolam (Intranasal), Nitrous oxide/oxygen inhalation sedation alone, Intranasal normal saline placebo - Dental Anxiety in Children, Child Behaviour | Not applicable | Recruiting | Shaheed Zulfiqar Ali Bhutto Medical University | 68 | 2026-10-15 | 2026-11-03 |
| Efficacy of EMONO as an add-on Therapy to Conventional Antidepressants for the Treatment of Depressive Symptoms in Nursing-home Residents With Neurocognitive Disorders: a Randomized Controlled Trial- EMONO, Medical air - Depression, Neurocognitive Disorders | Phase 2 | Not yet recruiting | University Hospital, Tours | 96 | 2026-09-01 | 2026-06-17 |
| Concentrations of Nitrous Oxide in Blood, Exhaled Air and Urine After Various Types of Exposure. Nitrous Oxide 99 %, Nitrous Oxide + Oxygen Gas - Intoxication by Drug | Not applicable | Recruiting | University of Aarhus | 40 | 2026-06-01 | 2026-07-08 |
| Intracervical Balloon Placement With Nitrous Oxide Administration Nitrous oxide, Oxygen - Labor Pain, Induced; Birth | Phase 3 | Withdrawn | Jefferson Drapkin | 2026-03-01 | 2026-09-17 | |
| N2O for Acute Suicidality and Depression in the ED Nitrous oxide gas for inhalation, Placebo - Suicidal Ideation, Major Depressive Disorder | Phase 2 | Withdrawn | University of Chicago | 2026-02-27 | 2026-03-04 | |
| A Randomized, Placebo-controlled Trial of Nitrous Oxide During In-office Bladder Botox Injections Pro-Nox Nitrous Oxide/Oxygen Delivery System, Standard Care for Bladder Botox Injection, Sham Mask - Overactive Bladder, Neurogenic Bladder | Phase 4 | Not yet recruiting | TriHealth Inc. | 96 | 2026-02-01 | 2026-02-04 |
| Sustained Mood Improvement With Laughing Gas Exposure Inhalation of Nitrous oxide (Laughing gas) + intravenous saline, inhalation of %100 oxygen + intravenous midazolam - Major Depressive Disorder, Treatment Resistant Depression | Phase 3 | Not yet recruiting | Women's College Hospital | 120 | 2026-02-01 | 2025-12-10 |
| A Trial of Self-Adjusted Nitrous Versus Placebo During Office Vasectomy Nitrous Oxide, Oxygen - Vasectomy | Early Phase 1 | Recruiting | Alexandra J. Berger Eberhardt, MD | 50 | 2025-10-20 | 2025-11-24 |
| Nitrous Oxide Neuroimaging Nitrous oxide, Peripheral Nerve Stimulation - Anesthesia, Pain | Early Phase 1 | Completed | Keith M Vogt | 34 | 2025-01-13 | 2026-08-19 |
| Nitrous Oxyde During Labour Nitrous oxide for labour analgesia - Nitrous Oxide, Labour Analgesia | Completed | Erasme University Hospital | 70 | 2024-11-05 | 2025-05-21 | |
| Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide Nitrous oxide, Medical air - Suicidal Ideation, Emergency Psychiatric | Phase 2 | Unknown | University Hospital, Tours | 30 | 2024-06-01 | 2024-06-07 |
| Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery Ketamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg - Cleft Lip Palate, Orofacial Cleft | Not applicable | Recruiting | Iva Smiljanić | 90 | 2024-05-16 | 2026-04-29 |
| Anxiolysis for Laceration Repair in Children Dexmedetomidine, Midazolam Nasal Spray, Nitrous oxide - Laceration of Skin, Distress, Emotional | Phase 3 | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 300 | 2023-12-19 | 2025-04-30 |
| Virtual Reality vs Nitrous Oxide in Pediatric Dentistry Virtual Reality Headset, Nitrous Oxide - Pediatric Dentistry | Not applicable | Completed | Geisinger Clinic | 62 | 2023-09-19 | 2025-09-26 |
| Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy Nitrous oxide - Procedural Pain, Pain Catastrophizing | Phase 4 | Recruiting | Beth Israel Deaconess Medical Center | 35 | 2023-05-24 | 2026-02-06 |
| A Pilot Study to Assess Effects of Self-Administered Nitrous Oxide (SANO) on Urodynamic Study (UDS) Parameters Self-Administered Nitrous Oxide, Oxygen - Lower Urinary Tract Symptoms | Phase 4 | Completed | Beth Israel Deaconess Medical Center | 19 | 2023-01-10 | 2026-03-12 |
| Use of Nitrous Oxide for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Dilatation and Evacuation Nitrous oxide (N2O/O2), Oxygen (O2) - Pain Alleviation, Dilatation and Evacuation | Early Phase 1 | Unknown | Sheba Medical Center | 60 | 2022-12-01 | 2022-10-13 |
| Virtual Reality Hypnosis Versus Inhaled Nitrous Oxide in Anterior Shoulder Dislocation Reduction: an Open Multicenter Randomized Controlled Trial Virtual reality hypnosis, Nitrous oxide - Shoulder Dislocation | Not applicable | Unknown | CHU de Reims | 126 | 2022-10-09 | 2023-02-23 |
| Effect of Nitrous Oxide on Aggression. Nitrous oxide, Room Air - Intermittent Explosive Disorder | Phase 2 | Recruiting | Ohio State University | 50 | 2022-09-06 | 2025-03-27 |
| Virtual Reality Games in Pediatric Surgery Virtual reality gaming, Nitrous oxide - Analgesia, Surgical Procedure, Unspecified | Not applicable | Unknown | Insel Gruppe AG, University Hospital Bern | 100 | 2022-08-24 | 2024-04-11 |
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Pain (17) · Agnosia (9) · Depressive Disorder, Major (9) · Opioid-Related Disorders (9) · Substance-Related Disorders (9) · Depression (8) · Anxiety Disorders (7) · Depressive Disorder, Treatment-Resistant (6) · Abscess (4) · Breech Presentation (3) · Labor Pain (3) · Neurocognitive Disorders (3) · Suicidal Ideation (3) · Acute Pain (2) · Bipolar Disorder (2)
University of Chicago (12) · Washington University School of Medicine (7) · The Cleveland Clinic (5) · Bayside Health (3) · Beth Israel Deaconess Medical Center (3) · University of New Mexico (3) · Air Liquide Santé International (2) · Albert Einstein Healthcare Network (2) · Assistance Publique - Hôpitaux de Paris (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Stanford University (2) · University Hospital, Geneva (2) · University Hospital, Toulouse (2) · University Hospital, Tours (2) · Albert Einstein College of Medicine (1)
United States (58) · France (11) · Australia (5) · Canada (5) · Israel (4) · Austria (3) · China (3) · Germany (3) · Switzerland (3) · Turkey (Türkiye) (3) · Belgium (2) · Croatia (2) · India (2) · Brazil (1) · Czechia (1)
James Zacny, Ph.D. (9) · Peter Nagele, MD, MSc (4) · Alparslan Turan, M.D. (3) · Heidi Rayala, MD, PhD (3) · Ben Palanca, MD (2) · Charles R Conway, MD (2) · Paul Myles, MD (2) · Peter Nagele, MD (2) · Rameet Singh, MD, MPH (2) · Alexandra J Berger Eberheardt, MD (1) · Amitabh Dutta, MD, PGDHR (1) · Andrea Hoogerland, MD (1) · Arlyne Thung, MD (1)
PMID 37585253, PMID 17667565, PMID 18580170, PMID 18682411, PMID 18813051, PMID 19192300, PMID 19249419, PMID 19339913, PMID 21835837, PMID 21889262, PMID 22136779, PMID 23406077, PMID 24486835, PMID 25142708, PMID 25488309, PMID 27481016, PMID 27956679, PMID 27994412, PMID 28100522, PMID 29533264, PMID 30303904, PMID 31377, PMID 31630398, PMID 32609959, PMID 32637725, PMID 33044394, PMID 34735395, PMID 35050957, PMID 36579458, PMID 36701604, PMID 37491196, PMID 37990597, PMID 39185528, PMID 39732915, PMID 39833849, PMID 40113655, PMID 40465577, PMID 40775649, PMID 42049811, PMID 42092800, PMID 42314868, PMID 42376225
R01DA008391 (9), 2023 (1), I01CX001789 (1), R01DK032640 (1), R34MH087390 (1), R35GM146822 (1)