141 completed, 37 unknown, 27 recruiting, 10 terminated. 124 Not applicable, 16 Phase 3, 12 Phase 2, 12 Phase 4, 7 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit Sleep chronobundle, Control - Sleep, Circadian Dysregulation | Early Phase 1 | Not yet recruiting | University of Alberta | 50 | 2026-11-30 | 2026-10-21 |
| Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption Standard Periodontal Treatment - Gingivitis, Circadian Rhythm Disruption | Not yet recruiting | Inonu University | 116 | 2026-11-01 | 2026-10-27 | |
| Recovery and Early Sleep Tracking Using the SuperPatch REM Patch SuperPatch REM Patch, Sham REM Patch - Shift Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder | Not applicable | Enrolling by invitation | SuperPatch Limited LLC | 20 | 2026-05-15 | 2026-08-25 |
| Improvement of Sleep Disorders in Patients With Alzheimer's Disease After Sunlight Exposure Therapy. sunlight therapy - Alzheimer's Disease (AD), Sleep Disorders, Circadian Rhythm | Not applicable | Active not recruiting | National Taiwan University Hospital | 60 | 2026-05-13 | 2026-07-17 |
| Body Clocks - Coordination of Peripheral and Central Oscillators Circadian Dysregulation | Recruiting | Stanford University | 20 | 2026-04-15 | 2026-08-12 | |
| Feasibility of Light Therapy in the Pediatric Intensive Care Unit (ICU) Light Therapy - Circadian Dysregulation, Light Exposure | Not applicable | Recruiting | Laura Beth Kalvas | 30 | 2026-03-26 | 2026-05-22 |
| Mind After Midnight Sleep Pressure Manipulation - Suicidal Ideation, Circadian Rhythm Disorders | Not applicable | Recruiting | University of Arizona | 90 | 2026-03-06 | 2026-10-01 |
| Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers Verum (A), Placebo (B) - Obesity & Overweight, Circadian Rhythm Disorders | Not applicable | Recruiting | FH Joanneum Gesellschaft mbH | 200 | 2026-01-20 | 2026-02-27 |
| Nighttime Synchrony of Your Nutrition and Circadian Health Central Clock Misalignment, Peripheral Misalignment - Sleep, Metabolism Changes | Not applicable | Recruiting | University of Utah | 120 | 2025-12-19 | 2026-01-22 |
| Evaluation of the Effect of Seasonality on Biological Age in Adults Aging, Aging, Biological | Active not recruiting | Société des Produits Nestlé (SPN) | 60 | 2025-11-24 | 2026-09-23 | |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| Circadian Health Regulation and Optimization for Rejuvenation Outcomes Circadian Rhythm Optimization - Aging, Healthy, Blood Sugar; High | Not applicable | Active not recruiting | Salk Institute for Biological Studies | 16 | 2025-10-22 | 2025-12-31 |
| A Study on the Effectiveness of a Dietary Supplement FitoAvia for Jet Lag Fitoavia, Placebo, Questionnaire and Physical Exam - Jet Lag Disorder, Jet Lag | Not applicable | Completed | MiraxBioPharma | 120 | 2025-10-01 | 2026-07-10 |
| Pupillometry in Delayed Sleep Wake Phase Disorder Light and Citalopram - Delayed Sleep-Wake Phase Disorder | Not applicable | Recruiting | Northwestern University | 220 | 2025-09-01 | 2026-06-08 |
| A Prospective Study: the Impact of Sleep Disturbances on Immunotherapy in Patients With Lung Cancer PSQI, PQSI - Lung Cancer (NSCLC), Sleep Disorders, Circadian Rhythm | Not yet recruiting | Shanghai Zhongshan Hospital | 350 | 2025-06-01 | 2025-05-01 | |
| Chronotherapeutic Optimization of Teriparatide Administration in Postmenopausal Osteoporosis Morning administration group of teriparatide, Evening administration group of teriparatide - Circadian Rhythm Disorders, Osteoporosis | Not applicable | Not yet recruiting | Peking University Third Hospital | 28 | 2025-05-01 | 2025-04-30 |
| The Effects of Naturalistic Light on Post Stroke Complications Related Brain Areas in Stroke Patients During Admission for Rehabilitation. Naturalistic Light Intervention - Post Stroke Depression, Post Stroke Fatigue | Not applicable | Recruiting | Copenhagen University Hospital, Rigshospitalet | 45 | 2025-04-10 | 2025-04-15 |
| Effects of VR-based Respiratory Training on Motor Reaction Time and Correctness, Stress Levels, Attention, Motor Skills, Postural Stability and Sleep Quality in Shift Healthcare Workers Experimental group (B) - breathing training using VR, Experimental group (C) - breathing training using relaxation music - Healthcare Workers, Stress Level | Not applicable | Not yet recruiting | Poznan University of Physical Education | 60 | 2025-04-07 | 2025-04-13 |
| Tailored Treatment of Insomnia in Social and Health Care Sector Shift Workers in Occupational Health Care Cognitive behavioral therapy for insomnia, Sleep hygiene counselling - Insomnia Chronic, Shift Work Sleep Disorder | Not applicable | Active not recruiting | Finnish Institute of Occupational Health | 84 | 2025-02-17 | 2026-04-13 |
| Psychobiological Interventions in Pregnancy Step count goal, Actigraph watch - Pregnancy Complications, Mental Health Issue | Not applicable | Enrolling by invitation | Stanford University | 88 | 2025-01-13 | 2026-05-15 |
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Sleep Disorders, Circadian Rhythm (132) · Sleep Wake Disorders (39) · Sleep Initiation and Maintenance Disorders (33) · Sleep Deprivation (18) · Parasomnias (17) · Smith-Magenis Syndrome (17) · Depression (15) · Fatigue (13) · Disorders of Excessive Somnolence (11) · Obesity (9) · Critical Illness (8) · Alzheimer Disease (7) · Jet Lag Syndrome (7) · Sleep Apnea, Obstructive (7)
Nervous System Diseases (233) · Mental Disorders (182) · Dyssomnias (150) · Sleep Wake Disorders (133) · Occupational Diseases (132) · Pathological Conditions, Signs and Symptoms (105) · Signs and Symptoms (98) · Neurologic Manifestations (67) · Behavior (41) · Sleep Disorders, Intrinsic (40) · Nutritional and Metabolic Diseases (25) · Behavioral Symptoms (23) · Pathologic Processes (23) · Central Nervous System Diseases (21)
Melatonin (21) · Sleep (10) · tasimelteon (9) · Phototherapy (5) · ramelteon (5) · Ultraviolet Therapy (4) · Cognitive Behavioral Therapy (3) · Electroencephalography (3) · Modafinil (3) · Therapeutics (3) · lemborexant (3) · Blood Specimen Collection (2) · Chronotherapy (2) · Mass Screening (2) · Transcranial Direct Current Stimulation (2)
Brigham and Women's Hospital (15) · Vanda Pharmaceuticals (11) · University of California, Berkeley (9) · Northwestern University (5) · Stanford University (5) · Chinese University of Hong Kong (4) · Massachusetts General Hospital (4) · University of Bergen (4) · University of California, San Francisco (4) · University of Pittsburgh (4) · Hospices Civils de Lyon (3) · Neurim Pharmaceuticals Ltd. (3) · Oregon Health and Science University (3) · Shanghai Zhongshan Hospital (3) · Takeda (3)
United States (125) · France (11) · Denmark (9) · Spain (9) · China (8) · Netherlands (8) · Turkey (Türkiye) (8) · Norway (7) · Germany (6) · Austria (5) · Canada (5) · Greece (5) · Israel (5) · Taiwan (5) · Finland (4)
Allison Harvey, PhD (7) · Jeanne F Duffy, MBA, PhD (3) · Andrew D Krystal, MD, MS (2) · Charles A Czeisler, Ph.D., M.D. (2) · Christine M Swanson, MD, MCR (2) · Emmanuel Mignot, MD, PhD (2) · Jeanne F Duffy, PhD (2) · Junchao Zhu (2) · Kaloyan S Tanev, MD (2) · Kenneth Wright, PhD (2) · Laurel Sarfan, PhD (2) · Melissa Knauert, MD, PhD (2) · William A Gahl, M.D. (2)
PMID 1798888, PMID 26466871, PMID 40799745, PMID 10704520, PMID 11163282, PMID 11556941, PMID 11604479, PMID 12749557, PMID 14680142, PMID 16251950, PMID 16376591, PMID 17369106, PMID 17520797, PMID 17936039, PMID 18041487, PMID 18052566, PMID 18583104, PMID 18673165, PMID 18853704, PMID 19054552, PMID 19084897, PMID 19215573, PMID 19454302, PMID 19497681, PMID 19544753, PMID 19880686, PMID 20483660, PMID 20580916, PMID 20842007, PMID 21527892, PMID 21532953, PMID 22294820, PMID 22337154, PMID 22553268, PMID 22910327, PMID 23036285, PMID 23494200, PMID 23515802, PMID 23871587, PMID 24132057, PMID 24144243, PMID 24694994, PMID 24938584, PMID 24951039, PMID 25466406, PMID 25678831, PMID 25852963, PMID 26114228, PMID 26148316, PMID 26411693
R01HL151332 (2), R01MH120147 (2), 2015 (1), 2017 (1), K23HD113845 (1), K23HL088020 (1), K23HL138229 (1), K23MH120503 (1), KL2TR002370 (1), M01RR000051 (1), P30AG024978 (1), P50DA046346 (1), R01AG006072 (1), R01AG044416 (1), R01CA207446 (1)