24 completed, 10 unknown, 8 terminated, 2 not yet recruiting. 48 Phase 3, 11 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 48 | Completed 24, Unknown 10, Terminated 8, Not yet recruiting 2, Recruiting 2, Active not recruiting 1, Withdrawn 1 |
| Phase 2 | 11 | Completed 5, Recruiting 2, Terminated 2, Unknown 2 |
Follow Ventilator-Induced Lung Injury: new trials by email Literature Review of Ventilator-Induced Lung Injury trials Research Report on Ventilator-Induced Lung Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dexamethasone Regimens for BPD Prevention in Preterm Infants Dexamethasone. Dart, Dexametasone. Medium - Infant, Premature, Bronchopulmonary Dysplasia (BPD) | Phase 3 | Not yet recruiting | The Children's Hospital of Zhejiang University School of Medicine | 970 | 2026-02-01 | 2025-11-24 |
| Efficacy and Safety of Zelpultide Alfa in Preterm Neonates at High Risk of Developing Bronchopulmonary Dysplasia (BPD) Air-sham, Zelpultide alfa - Bronchopulmonary Dysplasia | Phase 2 / Phase 3 | Recruiting | Airway Therapeutics, Inc. | 366 | 2025-02-03 | 2026-10-09 |
| Enhancing Lung Health in Kids With Structural Lung Damage and Malformations: Azithromycin (AZI) for Airway Infection Prevention Azithromycin 40 MG/ML, Placebo - Tracheomalacia, Bronchopulmonary Dysplasia (BPD) | Phase 3 | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 150 | 2024-09-01 | 2024-05-14 |
| Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory Distress Caffeine citrate, Placebo - Prematurity, Respiratory Disease | Phase 2 / Phase 3 | Recruiting | Ministry of Health, Saudi Arabia | 134 | 2023-10-12 | 2025-06-27 |
| Individualized Positive End-expiratory Pressure Guided by End-expiratory Lung Volume in the Acute Respiratory Distress Syndrome Invasive Mechanical ventilation, Neuromuscular Blocking Agents, Prone positioning - Respiratory Distress Syndrome, Adult | Phase 3 | Terminated | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 18 | 2022-11-01 | 2025-09-30 |
| Effect of Caffeine Versus Probiotic on Preterm Neonates With Bronchopulmonary Dysplasia Caffeine, Probiotic Formula - Bronchopulmonary Dysplasia | Phase 3 | Unknown | Tanta University | 90 | 2022-06-30 | 2023-01-12 |
| Intratracheal Budesonide With Surfactant to Prevent Bronchopulmmonary Dysplasia. Poractant Alfa Intratracheal Suspension [Curosurf], Budesonide 0.5 MG/ML - Bronchopulmonary Dysplasia, Respiratory Distress Syndrome in Premature Infant | Phase 3 | Unknown | Hospital Clinic of Barcelona | 50 | 2021-10-01 | 2021-09-13 |
| Effect of Autologous Cord Blood Mononuclear Cells for Treatment of Bronchopulmonary Dysplasia in Extremely Preterm Neonates autologous cord blood mononuclear cells - BPD | Phase 3 | Unknown | Guangdong Women and Children Hospital | 76 | 2021-10-01 | 2021-10-08 |
| The Budesonide in Babies (BiB) Trial budesonide (Pulmicort nebulizing suspension)., surfactant (poractant alfa;Curosurf) - Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome | Phase 3 | Active not recruiting | NICHD Neonatal Research Network | 642 | 2021-04-01 | 2026-04-15 |
| Treatment of Classic Mid-trimester PPROM by Means of Continuous Amnioinfusion Continuous amnioinfusion with Amnion Flush Solution through the intraamniotic catheter - Bronchopulmonary Dysplasia, Necrotizing Enterocolitis | Phase 3 | Unknown | Martin-Luther-Universität Halle-Wittenberg | 68 | 2021-01-01 | 2021-01-12 |
| Effect of Autologous Cord Blood Mononuclear Cells for Prevention of Bronchopulmonary Dysplasia or Death in Extremely Preterm Neonates autologous cord blood mononuclear cells, normal saline - BPD | Phase 3 | Unknown | Guangdong Women and Children Hospital | 140 | 2020-06-20 | 2023-11-01 |
| Effects of Fat-soluble Vitamins Supplementation on Common Complications and Neural Development in Very Low Birth Weight Infants High dose of fat-Soluble Vitamin, Conventional dose of fat-Soluble Vitamin - Vitamin A Deficiency, Vitamin D Deficiency | Phase 3 | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 120 | 2019-01-29 | 2019-03-15 |
| Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome Mid frequency ventilation, Standard frequency ventilation - Ventilator-Induced Lung Injury, Respiratory Distress Syndrome | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 60 | 2017-08-02 | 2024-10-15 |
| A Study to Assess the Safety and Effectiveness of Palivizumab Administered to Children at High Risk of Severe Respiratory Syncytial Virus (RSV) Infection in the Russian Federation and the Republic of Belarus Palivizumab - Respiratory Syncytial Virus (RSV) | Phase 3 | Completed | AbbVie | 50 | 2016-11-09 | 2018-03-13 |
| pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure VV-ECCO2R to enable lower tidal volume mechanical ventilation - Acute Respiratory Failure With Hypoxia | Phase 3 | Unknown | Belfast Health and Social Care Trust | 1120 | 2016-05-12 | 2022-03-02 |
| Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia DHA-rich algal oil, Placebo - Bronchopulmonary Dysplasia, Child Development | Phase 3 | Terminated | CHU de Quebec-Universite Laval | 461 | 2015-06-23 | 2026-08-13 |
| TINN2: Treat Infection in NeoNates 2 Azithromycin, Placebo - Bronchopulmonary Dysplasia | Phase 3 | Withdrawn | Institut National de la Santé Et de la Recherche Médicale, France | 2015-01-01 | 2016-02-25 | |
| Study of Inhaled Nitric Oxide (iNO) and Respiratory Outcomes in Late Preterm Infants inhaled nitric oxide, Placebo Comparator - nitrogen gas - Bronchopulmonary Dysplasia | Phase 2 / Phase 3 | Terminated | Tufts Medical Center | 3 | 2013-03-01 | 2017-07-19 |
| Determining the Effect of Spironolactone on Electrolyte Supplementation in Preterm Infants With Chronic Lung Disease Spironolactone, Placebo - Chronic Lung Disease, Bronchopulmonary Dysplasia | Phase 2 / Phase 3 | Unknown | West Virginia University Healthcare | 40 | 2012-10-01 | 2016-11-30 |
| Vitamin D Supplementation for Extremely Preterm Infants Cholecalciferol, Placebo - Vitamin D Deficiency, Preterm Infants | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 100 | 2012-06-01 | 2017-02-10 |
Showing 20 of 48. Sign in to see all of them.
Bronchopulmonary Dysplasia (45) · Premature Birth (21) · Respiratory Distress Syndrome (10) · Lung Diseases (5) · Leukomalacia, Periventricular (3) · Respiratory Insufficiency (3) · Retinopathy of Prematurity (3) · Sepsis (3) · Anemia (2) · Enterocolitis, Necrotizing (2) · Hyaline Membrane Disease (2) · Infant, Newborn, Diseases (2) · Lung Injury (2) · Surfactant Dysfunction (2)
Respiratory Tract Diseases (47) · Lung Injury (46) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (45) · Infant, Premature, Diseases (45) · Infant, Newborn, Diseases (43) · Lung Diseases (43) · Female Urogenital Diseases and Pregnancy Complications (21) · Obstetric Labor Complications (21) · Obstetric Labor, Premature (21) · Pregnancy Complications (21) · Urogenital Diseases (21) · Respiration Disorders (13) · Pathological Conditions, Signs and Symptoms (7) · Cardiovascular Diseases (6)
Budesonide (3) · Endothelium-Dependent Relaxing Factors (3) · Sodium Chloride (3) · Azithromycin (2) · Continuous Positive Airway Pressure (2) · Dexamethasone (2) · Hydrocortisone (2) · Palivizumab (2) · Surface-Active Agents (2) · poractant alfa (2) · salicylhydroxamic acid (2) · Air (1) · Airway Extubation (1) · Beclomethasone (1) · Caffeine (1)
NICHD Neonatal Research Network (6) · Guangdong Women and Children Hospital (2) · McMaster University (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Roberta Ballard (2) · University of Alabama at Birmingham (2) · AbbVie (1) · Abbott (1) · Airway Therapeutics, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Belfast Health and Social Care Trust (1) · CHU de Quebec-Universite Laval (1) · Canadian Critical Care Trials Group (1) · Copenhagen University Hospital, Rigshospitalet (1) · Erhan Calisici (1)
United States (21) · Canada (6) · China (5) · Belgium (4) · France (4) · Germany (4) · Italy (4) · Netherlands (3) · United Kingdom (3) · Israel (2) · Saudi Arabia (2) · Sweden (2) · Turkey (Türkiye) (2) · Argentina (1) · Australia (1)
Seetha Shankaran, MD (5) · Barbara J. Stoll, MD (4) · Avroy A. Fanaroff, MD (3) · Charles R. Bauer, MD (3) · David K. Stevenson, MD (3) · Edward F. Donovan, MD (3) · Jon E. Tyson, MD MPH (3) · Richard A. Ehrenkranz, MD (3) · Sheldon B. Korones, MD (3) · Aaron Chiu, MD (2) · Abhik Das, PhD (2) · Bradley Yoder, MD (2) · Haresh Kirpalani, MD, MSc (2) · James A. Lemons, MD (2) · Lu-Ann Papile, MD (2)
PMID 10400143, PMID 10545589, PMID 11150359, PMID 12219057, PMID 15767942, PMID 16651303, PMID 16870913, PMID 16870914, PMID 16939737, PMID 18245420, PMID 19117884, PMID 19841125, PMID 19841128, PMID 20138299, PMID 20472937, PMID 20472939, PMID 20587676, PMID 20591191, PMID 22059409, PMID 22371462, PMID 22738947, PMID 22943074, PMID 23268664, PMID 23339639, PMID 23944299, PMID 24289974, PMID 24388320, PMID 24725582, PMID 24876196, PMID 25425651, PMID 25554820, PMID 26162889, PMID 26192398, PMID 26465983, PMID 26500107, PMID 26916176, PMID 27079965, PMID 27344218, PMID 27583380, PMID 27650090, PMID 28100402, PMID 28279433, PMID 28384828, PMID 28600154, PMID 28710882, PMID 28973344, PMID 29275926, PMID 29320647, PMID 29348196, PMID 29627188
U10HD021373 (5), U10HD021385 (5), U10HD027851 (5), U10HD027853 (5), U10HD027880 (5), U10HD021364 (4), U10HD021397 (4), U10HD027856 (4), U10HD027871 (4), U10HD027904 (4), M01RR000750 (3), M01RR008084 (3), U10HD021415 (3), U10HD027881 (3), U10HD034216 (3)