45 completed, 9 terminated, 5 recruiting, 3 active not recruiting. 25 Phase 3, 12 Phase 2, 10 Not applicable, 5 Phase 1.
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Continued Pressure for Alveolar Protection (CPAP Trial) CPAP, Nasal Cannula - Bronchopulmonary Dysplasia (BPD) | Not applicable | Recruiting | NICHD Neonatal Research Network | 860 | 2026-11-05 | 2026-07-14 |
| Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial Milrinone infusion, Placebo infusion - Post-ligation Cardiac Syndrome | Phase 3 | Recruiting | NICHD Neonatal Research Network | 316 | 2025-06-13 | 2026-07-01 |
| Neonatal Platelet Transfusion Threshold Trial Higher Platelet Transfusion Threshold, Lower Platelet Transfusion Threshold - Thrombocytopenia, Neonatal | Not applicable | Recruiting | NICHD Neonatal Research Network | 2433 | 2025-06-13 | 2026-03-25 |
| The Budesonide in Babies (BiB) Trial budesonide (Pulmicort nebulizing suspension)., surfactant (poractant alfa;Curosurf) - Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome | Phase 3 | Active not recruiting | NICHD Neonatal Research Network | 642 | 2021-04-01 | 2026-04-15 |
| Cycled Phototherapy Phototherapy lights - Hyper Bilirubinemia, Premature Infant | Not applicable | Active not recruiting | NICHD Neonatal Research Network | 1700 | 2020-07-16 | 2026-06-17 |
| Moderately Preterm Infants With Caffeine at Home for Apnea (MoCHA) Trial Caffeine Citrate, Placebo - Apnea of Prematurity | Phase 3 | Terminated | NICHD Neonatal Research Network | 827 | 2019-02-27 | 2024-07-31 |
| Management of the PDA Trial Active Treatment, Expectant Management - Infant, Premature, Patent Ductus Arteriosus | Phase 3 | Active not recruiting | NICHD Neonatal Research Network | 482 | 2019-02-22 | 2026-05-12 |
| Milrinone in Congenital Diaphragmatic Hernia Milrinone, Placebo (5% Dextrose) - Congenital Diaphragmatic Hernia, Persistent Pulmonary Hypertension of the Newborn | Phase 2 | Completed | NICHD Neonatal Research Network | 66 | 2017-10-24 | 2025-11-06 |
| Darbepoetin Trial to Improve Red Cell Mass and Neuroprotection in Preterm Infants Darbepoetin, Placebo - Neurocognitive, Neuroprotective | Phase 3 | Completed | NICHD Neonatal Research Network | 650 | 2017-09-20 | 2026-07-01 |
| Preemie Hypothermia for Neonatal Encephalopathy Hypothermia, Normothermic Control - Infant, Newborn, Hypoxia, Brain | Not applicable | Completed | NICHD Neonatal Research Network | 168 | 2015-05-01 | 2024-11-04 |
| Early-Onset Sepsis an NICHD/CDC Surveillance Study Infant, Newborn, Diseases, Early Onset Neonatal Sepsis | Completed | NICHD Neonatal Research Network | 570 | 2015-04-01 | 2019-03-11 | |
| Incubator Weaning of Moderately Preterm Infants Weaning from an incubator at a lower weight (1600 grams), Weaning from an incubator at a higher weight (1800 grams) - Infant, Newborn, Infant, Moderate Preterm | Not applicable | Completed | NICHD Neonatal Research Network | 366 | 2015-02-01 | 2019-03-22 |
| Hydrocortisone for Term Hypotension Hydrocortisone, Placebo - Infant, Newborn, Diseases, Cardiovascular Insufficiency | Phase 3 | Completed | NICHD Neonatal Research Network | 12 | 2014-06-19 | 2021-07-06 |
| Inositol to Reduce Retinopathy of Prematurity myo-Inositol 5% Injection, Placebo - Retinopathy of Prematurity (ROP) | Phase 3 | Terminated | NICHD Neonatal Research Network | 638 | 2014-04-17 | 2019-03-22 |
| Transfusion of Prematures Trial Liberal Cell Transfusion, Restricted red cell transfusion - Infant, Newborn, Diseases, Infant, Extremely Low Birth Weight | Not applicable | Completed | NICHD Neonatal Research Network | 1824 | 2012-12-01 | 2025-11-14 |
| Donor Milk vs. Formula in Extremely Low Birth Weight (ELBW) Infants Donor Milk, Preterm Formula - Infant, Newborn, Infant, Small for Gestational Age | Phase 3 | Completed | NICHD Neonatal Research Network | 483 | 2012-08-01 | 2026-07-16 |
| Generic Database of Moderate Preterm Infants Infant, Newborn, Infant, Moderate Preterm | Completed | NICHD Neonatal Research Network | 7057 | 2012-03-01 | 2019-03-22 | |
| Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF) Aerosolized Normal Saline, Inhaled PGE1 - Prematurity, Respiratory Insufficiency | Phase 2 | Terminated | NICHD Neonatal Research Network | 7 | 2011-11-01 | 2019-04-24 |
| Hydrocortisone for BPD Hydrocortisone, Placebo - Infant, Newborn, Infant, Small for Gestational Age | Phase 3 | Completed | NICHD Neonatal Research Network | 800 | 2011-08-11 | 2025-02-27 |
| Vitamin E for Extremely Preterm Infants Vitamin E, Placebo - Infant, Newborn, Infant, Small for Gestational Age | Phase 1 | Completed | NICHD Neonatal Research Network | 93 | 2010-10-01 | 2015-11-11 |
Showing 20 of 63. Sign in to see all of them.
Premature Birth (41) · Bronchopulmonary Dysplasia (14) · Infant, Newborn, Diseases (8) · Respiratory Distress Syndrome (8) · Respiratory Insufficiency (8) · Hypertension, Pulmonary (5) · Persistent Fetal Circulation Syndrome (5) · Respiratory Distress Syndrome, Newborn (5) · Retinopathy of Prematurity (5) · Sepsis (5) · Hypothermia (4) · Hypoxia-Ischemia, Brain (4) · Enterocolitis, Necrotizing (3) · Hypoxia, Brain (3) · Intracranial Hemorrhages (3)
Hydrocortisone (3) · Glucose (2) · Saline Solution (2) · Sodium Chloride (2) · Surface-Active Agents (2) · beractant (2) · Alprostadil (1) · Budesonide (1) · Cannula (1) · Continuous Positive Airway Pressure (1) · Darbepoetin alfa (1) · Dexamethasone (1) · Dopamine (1) · Drainage (1) · Erythropoietin (1)
United States (63) · Canada (1)
Seetha Shankaran, MD (47) · Barbara J. Stoll, MD (33) · Richard A. Ehrenkranz, MD (31) · Abhik Das, PhD (30) · Waldemar A. Carlo, MD (27) · Edward F. Donovan, MD (22) · Abbot R. Laptook, MD (20) · David K. Stevenson, MD (18) · Krisa P. Van Meurs, MD (18) · Sheldon B. Korones, MD (18) · Avroy A. Fanaroff, MD (17) · Charles R. Bauer, MD (17) · James A. Lemons, MD (17) · Ronald N. Goldberg, MD (17) · William Oh, MD (17)
PMID 35835616, PMID 10802492, PMID 10835060, PMID 11430325, PMID 12114906, PMID 14510324, PMID 14520225, PMID 14523165, PMID 15060228, PMID 15286223, PMID 15507925, PMID 15520109, PMID 15547163, PMID 15713907, PMID 15741371, PMID 15741374, PMID 15930228, PMID 15956871, PMID 15973322, PMID 15995042, PMID 16000352, PMID 16107873, PMID 16143580, PMID 16221780, PMID 16322158, PMID 16396864, PMID 16549503, PMID 16585322, PMID 16615955, PMID 16647401, PMID 16769377, PMID 16818526, PMID 16982497, PMID 17079582, PMID 17307536, PMID 17403821, PMID 17586184, PMID 17606555, PMID 17908750, PMID 17961693, PMID 17984212, PMID 18166553, PMID 18245420, PMID 18390958, PMID 18420500, PMID 18534246, PMID 18678807, PMID 18762491, PMID 18762517, PMID 18829776
U10HD021385 (47), U10HD027880 (44), U10HD027904 (42), U10HD021364 (41), U10HD027851 (41), U10HD027853 (41), U10HD021373 (39), U10HD027856 (39), U10HD034216 (36), U10HD027871 (34), U10HD040689 (29), M01RR008084 (28), U10HD021397 (26), U10HD040492 (26), M01RR000070 (24)