98 completed, 55 unknown, 22 recruiting, 17 terminated. 68 Not applicable, 28 Phase 2, 17 Phase 3, 16 Phase 1, 6 Phase 4.
Follow Enterocolitis, Necrotizing: new trials by email Literature Review of Enterocolitis, Necrotizing trials Research Report on Enterocolitis, Necrotizing
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neonatal Laparotomy - A Trial Investigating the Impact of Location of Surgery IN theatre, ON unit - Necrotising Enterocolitis Neonatal | Not applicable | Not yet recruiting | Guy's and St Thomas' NHS Foundation Trust | 15 | 2026-10-01 | 2026-08-10 |
| Gut Permeability and Microbiome in Preterm Infants measurement of intestinal permeability - Prematurity Complications | Phase 1 | Recruiting | University of Maryland, Baltimore | 150 | 2026-09-30 | 2026-10-05 |
| Fecal Calprotectin in Breastfed vs Formula-Fed Preterm Infants and NEC Necrotizing Enterocolitis, Premature | Not yet recruiting | Assiut University | 112 | 2026-09-03 | 2026-09-10 | |
| Effect of Rectal Administration of Breast Milk on Gut Microbiota in Preterm Infants Rectal irrigation with maternal breast milk, Rectal irrigation with salin - Premature, Gut Microbiota Diversity and Composition | Not applicable | Not yet recruiting | Zekai Tahir Burak Women's Health Research and Education Hospital | 60 | 2026-06-15 | 2026-04-30 |
| Pattern And Outcome Of Neonatal Gastrointestinal Emergencies In Assiut University Children Hospital Necrotizing Enterocolitis, Intestinal Atresia | Not yet recruiting | Assiut University | 120 | 2026-05-01 | 2026-04-13 | |
| Multidimensional Dynamic Early Warning System for Neonatal Necrotizing Enterocolitis: A Multicenter Clinical Study No Intervention: Observational Cohort - NEC - Necrotizing Enterocolitis | Not yet recruiting | Guangzhou Women and Children's Medical Center | 1050 | 2026-04-15 | 2026-04-22 | |
| Assessing the Efficacy of Probiotics in Prevention of NEC in Preterm Babies Probiotic, 10% dextrose - NEC, NEC - Necrotizing Enterocolitis | Not applicable | Active not recruiting | Hayatabad Medical Complex | 196 | 2026-04-01 | 2026-08-18 |
| Investigation of Allergen Sensitization in Newborn Babies Diagnosed With Necrotizing Enterocolitis. skin prick test - Necrotizing Enterocolitis, Allergy | Not applicable | Not yet recruiting | Saglik Bilimleri Universitesi | 130 | 2026-04-01 | 2026-05-01 |
| Administration of Extracellular Vesicles From Donor Human Milk in Preterm Infants Donor human milk extracellular vesicles (DHM-EVs) - Very Preterm Infants (<32 Weeks of Gestation) | Recruiting | Instituto de Investigacion Sanitaria La Fe | 20 | 2026-02-05 | 2026-02-11 | |
| Effects of Enteral Feeding Regimens on NEC, Mortality, and Neurodevelopment in Very Preterm Infants Pasteurized Donor Milk for Insufficient Breastfeeding, Preterm Formula for Insufficient Breastfeeding, Routine fortification - Very Preterm Infant, Necrotizing Enterocolitis (NEC) | Not applicable | Recruiting | The Children's Hospital of Zhejiang University School of Medicine | 2324 | 2026-01-23 | 2026-10-26 |
| Characterization of Extracellular Vesicles From the Cord Blood of Extremely Preterm New Borns and Their Correlation With Severe Morbidity and Mortality Venous Cord blood sample, Arterial cord blood sample - Intraventricular Hemorrhage, Pulmonary Hemorrhage | Recruiting | University Hospital, Montpellier | 30 | 2026-01-13 | 2026-02-23 | |
| Long-term Nutritional Impact of Necrotizing Enterocolitis in Premature Newborns. Observation of related perinatal and postnatal factors - Necrotising Enterocolitis Neonatal, Nutrition Disorder, Child | Enrolling by invitation | Central Hospital, Nancy, France | 200 | 2025-12-10 | 2026-03-24 | |
| Mechanisms Affecting the Gut of Preterm Infants Receiving Blood Transfusion With Different Enteral Feed Interventions NEC - Necrotizing Enterocolitis, NEC | Recruiting | Imperial College Healthcare NHS Trust | 270 | 2025-11-03 | 2026-04-01 | |
| Calprotectin and Gut Disease Study Congenital Heart Disease | Not yet recruiting | Great Ormond Street Hospital for Children NHS Foundation Trust | 300 | 2025-11-01 | 2025-08-08 | |
| Delayed Versus Immediate Cord Clamping in Preterm Birth Delayed Umbilical Cord Clamping, Immediate Umbilical Cord Clamping - Preterm Birth Complication, Neonatal Morbidity and Mortality | Not applicable | Recruiting | Faculty of Medicine of Tunis | 200 | 2025-10-02 | 2026-07-13 |
| The Correlation Between Red Cell Transfusion and Complications of Prematurity Wechsler Intelligence Test, performed by educated psychologists - Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD) | Recruiting | Clinical Hospital Center Rijeka | 128 | 2025-09-01 | 2026-10-22 | |
| Health-Related Quality-of-Life and Household Financial and Wellbeing Impacts of Prematurity and Necrotising Enterocolitis (NEC). Prematurity; Extreme, Prematurity; Decision Support | Recruiting | Imperial College London | 90 | 2025-08-08 | 2026-03-30 | |
| Application of Transcriptome Sequencing Combined With Family-Based Whole Genome Sequencing in Improving Precise Diagnosis of Critically Ill Newborns in Northeast China Whole genome sequencing analysis - Necrotizing Enterocolitis | Not yet recruiting | The First Hospital of Jilin University | 1000 | 2025-06-01 | 2025-05-25 | |
| Multi-strain Probiotics to Prevent Necrotizing Enterocolitis in Very Preterm Infants Multi-strain probiotics - Necrotizing Enterocolitis (NEC) | Phase 3 | Not yet recruiting | University of Calgary | 2170 | 2025-06-01 | 2025-02-05 |
| Predictive Diagnosis of Ulcero-Necrotizing EnteroColitis in Premature Babies Using an Artificial Intelligence Approach Based on Early Analysis of the Fecal Microbiota Ability of early digestive microbiota analysis (using artificial intelligence) to predict the occurrence of NEC diagnosed according to the Bell classification. - Necrotizing Enterocolitis (NEC), Healthy Control | Not applicable | Recruiting | University Hospital, Clermont-Ferrand | 1000 | 2025-04-01 | 2026-04-06 |
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Premature Birth (77) · Neonatal Sepsis (18) · Sepsis (18) · Bronchopulmonary Dysplasia (13) · Intestinal Perforation (10) · Anemia (7) · Intestinal Atresia (7) · Ductus Arteriosus, Patent (6) · Retinopathy of Prematurity (6) · Death (5) · Enterocolitis (5) · Gastroschisis (5) · Heart Defects, Congenital (5) · Hyperphagia (5)
Digestive System Diseases (222) · Gastroenteritis (222) · Gastrointestinal Diseases (220) · Intestinal Diseases (219) · Enterocolitis (217) · Female Urogenital Diseases and Pregnancy Complications (79) · Urogenital Diseases (79) · Obstetric Labor Complications (78) · Pregnancy Complications (78) · Obstetric Labor, Premature (77) · Pathological Conditions, Signs and Symptoms (68) · Pathologic Processes (56) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (55) · Infections (43) · Inflammation (36)
Probiotics (9) · Milk, Human (4) · Spectroscopy, Near-Infrared (4) · Laparotomy (3) · Ampicillin (2) · Arginine (2) · Docosahexaenoic Acids (2) · Drainage (2) · Fish Oils (2) · Gentamicins (2) · Glucose (2) · Indomethacin (2) · Melatonin (2) · Metronidazole (2) · Observation (2)
Ain Shams University (6) · University of Utah (6) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (5) · Per Torp Sangild (5) · Children's Mercy Hospital Kansas City (4) · Coordinación de Investigación en Salud, Mexico (4) · Imperial College London (4) · The Hospital for Sick Children (4) · Zekai Tahir Burak Women's Health Research and Education Hospital (4) · Assiut University (3) · Copenhagen University Hospital, Rigshospitalet (3) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (3) · NICHD Neonatal Research Network (3) · Princess Anna Mazowiecka Hospital, Warsaw, Poland (3) · Shaare Zedek Medical Center (3)
United States (61) · China (20) · United Kingdom (14) · France (13) · Turkey (Türkiye) (13) · Canada (12) · Egypt (8) · Denmark (7) · Israel (7) · Poland (6) · Sweden (6) · Italy (5) · Mexico (5) · Indonesia (4) · Spain (3)
Josef Neu, MD (4) · Cathy Hammerman, MD (3) · Mariana Baserga, MD (3) · Seetha Shankaran, MD (3) · Waldemar A. Carlo, MD (3) · Abbot R. Laptook, MD (2) · Avroy A. Fanaroff, MD (2) · Barbara J. Stoll, MD (2) · Charles R. Bauer, MD (2) · Christian C Yost, MD (2) · David K. Stevenson, MD (2) · Jennifer Garcia, MD (2) · Judy L Aschner, MD (2) · Luigi T Corvaglia, Prof (2) · Qing Yang, MD, PhD (2)
PMID 33058137, PMID 37493095, PMID 20980771, PMID 23453547, PMID 26561627, PMID 32336643, PMID 32433511, PMID 32855507, PMID 33006765, PMID 34815288, PMID 35313308, PMID 36535423, PMID 37794545, PMID 38564081, PMID 39905329, PMID 11061778, PMID 11430325, PMID 11875138, PMID 12084585, PMID 12622582, PMID 13403593, PMID 14497096, PMID 15858098, PMID 15912048, PMID 16078076, PMID 16521683, PMID 16549503, PMID 16647401, PMID 16723614, PMID 16769377, PMID 16950321, PMID 16984980, PMID 17188612, PMID 17307535, PMID 17336180, PMID 17374854, PMID 17636753, PMID 17943776, PMID 18245398, PMID 18562745, PMID 18784730, PMID 18829790, PMID 19019028, PMID 19020529, PMID 19117897, PMID 19403484, PMID 19524719, PMID 19944837, PMID 20051059, PMID 20403939
U10HD021364 (3), U10HD021373 (3), U10HD021385 (3), U10HD027851 (3), U10HD027880 (3), U10HD027904 (3), U10HD034216 (3), M01RR000070 (2), M01RR008084 (2), R01HD093826 (2), U10HD021397 (2), U10HD027853 (2), U10HD027856 (2), U10HD027871 (2), U10HD036790 (2)