564 completed, 67 terminated, 64 unknown, 38 recruiting. 186 Phase 3, 135 Not applicable, 133 Phase 4, 121 Phase 2, 72 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CKM For Safe Use of SGLT2i in Type 1 Diabetes Sotagliflozin Low Dose, Sotagliflozin High Dose, Dual Continuous Glucose and Ketone Monitor - Type 1 Diabetes (T1D) | Phase 3 | Not yet recruiting | University of California, San Diego | 52 | 2027-04-01 | 2026-11-04 |
| Achieving Optimal Medical Therapy Through Percutaneous Treatment of Secondary Mitral Regurgitation to Improve Outcome in Patients With HFrEF M-TEER, Standardized GDMT Up-Titration - Mitral Regurgitation Functional, Heart Failure With Reduced Ejection Fraction (HFrEF) | Not applicable | Recruiting | University Medical Center Mainz | 520 | 2026-10-15 | 2026-11-02 |
| Kids Injury Detection Study Using the i-STAT i-STAT TBI Cartridge with the i-STAT Alinity System - Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury | Not applicable | Not yet recruiting | Children's Healthcare of Atlanta | 700 | 2026-10-01 | 2026-09-23 |
| Ablation With Transcatheter Edge-to-edge Repair for Atrial Functional Mitral Regurgitation and Atrial Fibrillation Transcatheter edge to edge repair, Catheter ablation - Atrial Functional Mitral Regurgitation, Atrial Fibrillation (AF) | Not applicable | Not yet recruiting | Mao Chen | 384 | 2026-09-01 | 2026-08-04 |
| ORbital Atherectomy for Lesion Preparation in Patients With Chronic Limb-threatening ischEmia Stealth 360™ Peripheral Orbital Atherectomy System from Abbott - Chronic Limb Threatening Ischemia, Chronic Limb-Threatening Ischemia | Recruiting | Cardiovascular and Interventional Radiological Society of Europe | 250 | 2026-08-31 | 2026-09-23 | |
| REsorbable SCaffolds With everolimUs-Elution for the Treatment of Infrapopliteal Artery Disease in Patients With Chronic Limb-threatening Ischemia Esprit BTK™ Everolimus Eluting Resorbable Scaffold from Abbott - Chronic Limb Threatening Ischemia, Chronic Limb-Threatening Ischemia | Recruiting | Cardiovascular and Interventional Radiological Society of Europe | 400 | 2026-08-31 | 2026-09-23 | |
| PULSed Field Ablation for Atrial Fibrillation Using a Balloon for Early Intervention - Study Ablation of atrial fibrillation (AF) - Atrial Fibrillation | Not applicable | Recruiting | Asklepios proresearch | 264 | 2026-08-19 | 2026-10-06 |
| Single Chamber Atrial Leadless Pacing for Isolated Sinus Node Dysfunction Implantable Loop Recorder - Atrial Fibrillation | Recruiting | Northwell Health | 50 | 2026-05-18 | 2026-06-10 | |
| Randomized Controlled Trial- Ablation Strategy for Paroxysmal Atrial Fibrillation - Trigger and Substrate Guided Wide Area Radiofrequency Ablation Compared to Pulsed Field Ablation Pulmonary Vein Isolation PVI-ONLY, CONTROL ARM, PVI-PLUS ARM, INTERVENTIONAL ARM - Atrial Fibrillation, Catheter Ablation | Not applicable | Recruiting | Ottawa Heart Institute Research Corporation | 556 | 2026-03-23 | 2026-09-03 |
| Continuous Glucose Monitoring (CGM) in an Underserved Population Continuous Glucose Monitoring (CGM) - Diabetes, Diabetes Mellitus | Not applicable | Recruiting | Tulane University | 50 | 2026-03-19 | 2026-05-05 |
| Nutrition+: Effect of a High-Protein Diabetes Formula on Body Composition in Type 2 Diabetes Patients Treated With Incretin Mimetics protein supplement - Type 2 Diabetes | Not applicable | Recruiting | Joslin Diabetes Center | 60 | 2026-01-01 | 2026-05-29 |
| Efficacy and Feasibility of BurstDR SCS in Painful Diabetic Neuropathy BurstDR Spinal Cord Stimulation - Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy | Not applicable | Enrolling by invitation | TriCity Research Center | 20 | 2025-12-15 | 2026-05-08 |
| Automated Insulin Delivery Versus Usual Insulin Treatment Modality Before and During Pregnancy in Women With Type 1 Diabetes Automated closed-loop insulin delivery - Diabete Type 1, Pregnancy Complications | Not applicable | Recruiting | Copenhagen University Hospital, Rigshospitalet | 305 | 2025-12-01 | 2026-08-12 |
| Optical Coherence Tomography in Acute Vessel Evaluation Angiographic Guided PCI, OCT Guided PCI - Ischemic Heart Disease, Ischemic Coronary Artery Disease | Not applicable | Enrolling by invitation | Aarhus University Hospital Skejby | 3000 | 2025-11-23 | 2026-11-12 |
| International Multicenter Study of the Navitor/Navitor Vision Transcatheter Aortic Valve Platform Severe Native Aortic Stenosis | Recruiting | IRCCS Policlinico S. Donato | 1000 | 2025-10-11 | 2026-07-24 | |
| OCT-Guided Stent Optimization for Short-Duration Dual Antiplatelet Therapy in Stable Angina Short DAPT, Standard DAPT, Extended DAPT - Stable Angina, Coronary Artery Disease | Not applicable | Recruiting | Korea University Guro Hospital | 130 | 2025-09-30 | 2025-12-17 |
| The Integrated Female Sexually Transmitted Infection Testing for HIV Epidemic Control Through PrEP (IN-STEP) Study Self-Reported Risk Screening for PrEP and Diagnostic STI testing, Self-reported risk screening for PrEP and syndromic management for STIs - Gonorrhea Female, Chlamydia Females | Not applicable | Recruiting | Johns Hopkins University | 5560 | 2025-09-08 | 2026-09-18 |
| Orbital Atherectomy vs Intravascular Lithotripsy for the Treatment of Calcified Coronary Nodules (ORBIT-SHOCK). Orbital atherectomy, Intravascular lithotripsy, Optical Coherence Tomography (OCT) - Coronary Arterial Disease (CAD), Coronary Calcification | Not applicable | Recruiting | Spanish Society of Cardiology | 50 | 2025-06-12 | 2026-04-30 |
| Biomarker Role in Assessing Imaging Needs for Mild Cranial Trauma Biomarker Testing using the Alinity Whole-blood TBI biomarker i-STAT - Brain Injuries, Head Injury | Not applicable | Active not recruiting | Emory University | 351 | 2025-05-31 | 2026-08-07 |
| Assessment of Coronary Microvascular Dysfunction After STEMI Using Continuous Saline Thermodilution Continuous Saline Thermodilution - ST Elevation Myocardial Infarction, Coronary Microvascular Dysfunction | Recruiting | The Cleveland Clinic | 35 | 2025-05-29 | 2026-10-01 |
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HIV Infections (71) · Arthritis, Rheumatoid (48) · Coronary Artery Disease (33) · Acquired Immunodeficiency Syndrome (27) · Crohn Disease (27) · Renal Insufficiency, Chronic (27) · Atrial Fibrillation (22) · Heart Failure (21) · Psoriasis (19) · Hyperparathyroidism, Secondary (17) · Dyslipidemias (16) · Hepatitis C (16) · Diabetes Mellitus, Type 2 (15) · Cardiovascular Diseases (14) · Obesity (14)
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Beverly Paperiello (10) · Rita Jain, MD (6) · Laura Redden, MD, PhD (5) · Mihail Obrocea, MD (5) · Suntje Sander-Struckmeier, PhD (5) · Daniel Cohen, MD (4) · Helen Eliopoulos, MD (4) · Laura Williams, M.D. (4) · Raeefuddin Ahmed, MD (4) · Roopal Thakkar, MD (4) · Seung-Jung Park, MD, PhD (4)
PMID 27338778, PMID 29380251, PMID 18783301, PMID 20136164, PMID 20573750, PMID 26547918, PMID 30054164, PMID 16183552, PMID 17666313, PMID 18305915, PMID 18557952, PMID 19201775, PMID 19325497, PMID 19703304, PMID 19723613, PMID 20024643, PMID 20553600, PMID 21600054, PMID 21752491, PMID 22263674, PMID 22325170, PMID 22344964, PMID 22704916, PMID 23188490, PMID 24067881, PMID 24460746, PMID 29018564, PMID 29767684, PMID 30865281, PMID 31642213, PMID 31707982, PMID 34134520, PMID 34447995, PMID 34546360, PMID 37634149, PMID 37634188, PMID 41211931, PMID 11239844, PMID 12147537, PMID 14657064, PMID 15320564, PMID 15364899, PMID 15381674, PMID 15553310, PMID 15619281, PMID 15911902, PMID 16075824, PMID 16278523, PMID 16339220, PMID 16458134
2008 (9), 2009 (6), 2005 (4), 2014 (1), 2018 (1), K23HL177311 (1), P30AI050410 (1), R01AA014562 (1), R01AG037679 (1), R01AI064074 (1), R01AI177132 (1), R01DK045343 (1), R01HL063895 (1), R01MH050165 (1), U01AG050499 (1)