222 completed, 90 unknown, 63 recruiting, 34 terminated. 174 Not applicable, 68 Phase 2, 48 Phase 3, 40 Phase 1, 19 Phase 4.
Follow Ventilator-Induced Lung Injury: new trials by email Literature Review of Ventilator-Induced Lung Injury trials Research Report on Ventilator-Induced Lung Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Strap To Reduce Apnea in Preterm Infants: A Randomized Crossover Trial Chinstrap - Apnea of Prematurity, Intermittent Hypoxemia | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 20 | 2027-01-15 | 2026-10-27 |
| Heterologous Cord Blood-Derived Red Blood Cell for Transfusion in Extremely Preterm Infants Cord Blood Red Blood Cells, Standard Adult Donor Red Blood Cells - Extremely Premature Infant, Anemia Neonatal | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 176 | 2027-01-01 | 2026-03-31 |
| Continued Pressure for Alveolar Protection (CPAP Trial) CPAP, Nasal Cannula - Bronchopulmonary Dysplasia (BPD) | Not applicable | Recruiting | NICHD Neonatal Research Network | 860 | 2026-11-05 | 2026-07-14 |
| Development and Prospective Validation of the AutoEIT Foundation Model for ARDS AutoEIT Model Training, AutoEIT Blinded Validation - ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure | Not yet recruiting | Ruijin Hospital | 1200 | 2026-11-01 | 2026-10-27 | |
| A Study of the Determinants of Neurological Outcomes in Patients With Acute Respiratory Distress Syndrome Blood test scores calculations - Acute Respiratory Distress Syndrome (ARDS), s100b | Not applicable | Not yet recruiting | University Hospital, Angers | 150 | 2026-10-17 | 2026-07-27 |
| National Surveillance and Prevention of Neonatal VAP Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD) | Not yet recruiting | University of Alberta | 1500 | 2026-10-01 | 2026-06-25 | |
| Preliminary Study on Microplastics Deposition in Ventilator Circuit and the Risk of Bronchopulmonary Dysplasia in Premature Infants Bronchopulmonary Dysplasia | Not yet recruiting | Huiyi Li | 100 | 2026-10-01 | 2026-09-30 | |
| Early Prediction of Bronchopulmonary Dysplasia in Preterm Infants Using Clinical Data Artificial Intelligence-Based Risk Prediction - Bronchopulmonary Dysplasia | Not yet recruiting | Konya City Hospital | 108 | 2026-10-01 | 2026-07-09 | |
| Parent Perceptions of OptiPAP Junior Nasal CPAP interface: OptiPAP Junior, Nasal CPAP interface: FlexiTrunk - Bronchopulmonary Dysplasia (BPD), Preterm Birth Complication | Not applicable | Not yet recruiting | Sharp HealthCare | 60 | 2026-10-01 | 2026-09-23 |
| Ventilator Pressure and Optimization of Compliance and Hemodynamics Increase in the PEEP followed by decrease in the PEEP, Decrease in the PEEP followed by increase in the PEEP - Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia | Not applicable | Recruiting | University of Alabama at Birmingham | 24 | 2026-10-01 | 2026-10-26 |
| Pulmonary Hypertension and Oxygen Saturation Targeting in Preterm Infants higher oxygen saturation target using Nellcor pulse oximetry sensors, lower oxygen saturation target using Nellcor pulse oximetry sensors - Bronchopulmonary Dysplasia, Pulmonary Hypertension | Not applicable | Recruiting | University of Alabama at Birmingham | 39 | 2026-09-22 | 2026-10-06 |
| High-energy Human Milk Diets in the First Two Weeks After Birth to Reduce BPD in Extremely Preterm Infants High-energy group, Standard-energy group - Extreme Prematurity, Enteral Nutrition | Phase 1 / Phase 2 | Recruiting | University of Alabama at Birmingham | 150 | 2026-09-21 | 2026-09-24 |
| Predictors of Prolonged Mechanical Ventilation in Preterm Infants Premature Birth, Respiration Failure | Not yet recruiting | Assiut University | 100 | 2026-09-10 | 2026-09-16 | |
| Mechanical Power and Mortality in Mechanically Ventilated Adults Mechanical Ventilation Complication, Ventilator Induced Lung Injury | Not yet recruiting | Zagazig University | 116 | 2026-09-10 | 2026-09-23 | |
| Trial of Total Lung Protective Ventilation in Adult VV-ECMO Patients With Severe ARDS Mechanical Power Targeted Ventilation - ARDS (Acute Respiratory Distress Syndrome), VV ECMO | Not applicable | Not yet recruiting | University of Virginia | 24 | 2026-09-01 | 2026-09-01 |
| Early Predictors of Bronchopulmonary Dysplasia in Extremely Preterm Infants Bronchopulmonary Dysplasia | Not yet recruiting | Medical University of Vienna | 140 | 2026-09-01 | 2026-08-18 | |
| Personalized Ventilator Settings for Patients on ECMO Personalized Positive End-Expiratory Pressure (PEEP) - Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation | Not applicable | Enrolling by invitation | University of California, San Diego | 62 | 2026-09-01 | 2026-09-02 |
| 129Xe MRI in Pediatric Population With BPD MagniXene, hyperpolarized 129Xe MRI - Bronchopulmonary Dysplasia | Phase 1 | Withdrawn | Xemed LLC | 2026-08-01 | 2026-02-05 | |
| Impact of Higher Zinc Supplementation on Neonatal Weight Velocity 1 mg/day Zinc Supplementation, 3 mg/day Zinc Supplementation - Extreme Prematurity,Extremely Low Birthweight, BPD - Bronchopulmonary Dysplasia | Phase 4 | Recruiting | Augusta University | 30 | 2026-08-01 | 2026-10-26 |
| Mechanical Power During Different Ventilation Modes in Laparoscopic Surgery Volume-Controlled Ventilation (VCV), Pressure-Regulated Volume Control (PRVC) - Laparoscopic Cholecystectomy, Mechanical Ventilation | Not applicable | Recruiting | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | 80 | 2026-07-01 | 2026-07-08 |
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Bronchopulmonary Dysplasia (360) · Premature Birth (154) · Respiratory Distress Syndrome (69) · Lung Diseases (24) · Respiratory Insufficiency (21) · Retinopathy of Prematurity (19) · Acute Lung Injury (13) · Enterocolitis, Necrotizing (13) · Hypertension, Pulmonary (13) · Respiratory Aspiration (13) · Respiratory Distress Syndrome, Newborn (13) · Infant, Newborn, Diseases (11) · Infant, Premature, Diseases (11) · Lung Injury (11)
Respiratory Tract Diseases (466) · Lung Injury (462) · Lung Diseases (449) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (361) · Infant, Newborn, Diseases (349) · Infant, Premature, Diseases (349) · Female Urogenital Diseases and Pregnancy Complications (159) · Urogenital Diseases (159) · Pregnancy Complications (157) · Obstetric Labor Complications (154) · Obstetric Labor, Premature (153) · Respiration Disorders (112) · Pathological Conditions, Signs and Symptoms (95) · Pathologic Processes (69)
Budesonide (11) · Saline Solution (11) · Continuous Positive Airway Pressure (8) · Azithromycin (7) · Sodium Chloride (7) · Hydrocortisone (5) · poractant alfa (5) · Dexamethasone (4) · Ibuprofen (4) · Positive-Pressure Respiration (4) · Surface-Active Agents (4) · caffeine citrate (4) · calfactant (4) · Air (3) · Albuterol (3)
NICHD Neonatal Research Network (14) · Children's Hospital of Philadelphia (10) · University of Alabama at Birmingham (9) · Assistance Publique - Hôpitaux de Paris (6) · Centre Hospitalier Intercommunal Creteil (6) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (6) · Medipost Co Ltd. (6) · Copenhagen University Hospital, Rigshospitalet (5) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (5) · Indiana University (5) · National Heart, Lung, and Blood Institute (NHLBI) (5) · Boston Children's Hospital (4) · Centre hospitalier de l'Université de Montréal (CHUM) (4) · Children's Hospital of Chongqing Medical University (4) · Duke University (4)
United States (165) · Canada (45) · China (44) · France (30) · Italy (28) · Turkey (Türkiye) (25) · United Kingdom (15) · Germany (13) · Spain (13) · Netherlands (12) · Australia (9) · South Korea (9) · Belgium (8) · Sweden (7) · Switzerland (7)
Barbara J. Stoll, MD (9) · Seetha Shankaran, MD (9) · Richard A. Ehrenkranz, MD (8) · Waldemar A. Carlo, MD (7) · Abhik Das, PhD (6) · Charles R. Bauer, MD (6) · Edward F. Donovan, MD (6) · Abbot R. Laptook, MD (5) · David K. Stevenson, MD (5) · Jon E. Tyson, MD MPH (5) · Ronald N. Goldberg, MD (5) · Avroy A. Fanaroff, MD (4) · Bradley Yoder, MD (4) · Brenda B. Poindexter, MD MS (4) · Dale L. Phelps, MD (4)
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U10HD027853 (11), U10HD021364 (10), U10HD021373 (10), U10HD021385 (10), U10HD027851 (10), U10HD027880 (10), U10HD027856 (9), U10HD027871 (9), U10HD027904 (9), U10HD034216 (9), M01RR008084 (8), U10HD021397 (8), M01RR000750 (6), M01RR000070 (5), M01RR000997 (5)