21 completed, 6 terminated, 6 unknown, 2 enrolling by invitation. 12 Not applicable, 8 Phase 2, 8 Phase 3, 4 Phase 1, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cell-Based Therapy for White Matter Repair in Periventricular Leukomalacia Investigational Combination Product - Periventricular Leukomalacia, White Matter Disease | Early Phase 1 | Withdrawn | MGAM LLC | 2027-01-01 | 2025-07-22 | |
| Neonatal White Matter Injury Trial (WRAP) Clemastine fumarate - White Matter Injury, Brain Injury, Fetus and Neonate | Phase 1 | Recruiting | Bridget LaMonica Ostrem, M.D., Ph.D. | 24 | 2026-07-26 | 2026-07-28 |
| Intelligent Physiological Monitoring to Predict Preterm Brain Injury EEG, NIRS - Cerebral Palsy (CP), Intraventricular Hemorrhage Neonatal | Enrolling by invitation | University College Cork | 413 | 2026-04-13 | 2026-10-19 | |
| Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates Prospective Clinical and Neurodevelopmental Data Collection - Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE | Recruiting | Brigham and Women's Hospital | 60 | 2025-07-07 | 2025-12-10 | |
| A Multicenter, International, Prospective and Retrospective, Follow-up Registry to Monitor the Efficacy and Safety of the Occlutech Paravalvular Leak Device (PLD) in Patients With Mitral or Aortic Paravalvular Leaks Transcatheter paravalvular leak closure device - Paravalvular Leak | Enrolling by invitation | Occlutech International AB | 200 | 2025-02-05 | 2026-07-31 | |
| PUFAs in Preterm Infants Necrotizing Enterocolitis, Intraventricular Hemorrhage | Unknown | The First Hospital of Jilin University | 600 | 2023-09-21 | 2023-09-21 | |
| Spinal Stimulation and Mobility Devices Mobility Device, Spinal Stimulation - Cerebral Palsy, Stroke | Not applicable | Completed | University of Washington | 10 | 2022-08-04 | 2026-09-18 |
| A Study to Investigate the Safety and Efficacy of UC-MSCs in Pediatric Patients With Cerebral Palsy UDI-001 - Cerebral Palsy, Periventricular Leukomalacia | Phase 1 / Phase 2 | Completed | Rohto Pharmaceutical Co., Ltd. | 6 | 2021-06-02 | 2025-04-06 |
| Sonographic QUantification of Venous Circulation In the Preterm Brain Doppler Ultrasound of venous cerebral circulation - Prematurity; Extreme, Cerebral Circulatory Failure | Not applicable | Completed | Universitair Ziekenhuis Brussel | 47 | 2021-01-01 | 2024-05-17 |
| Evaluation of Long-term Neurodevelopment in Neonatal Encephalopathy by Infant Treadmill Baby treadmill, Physical rehabilitation training - Hypoxic-Ischemic Encephalopathy, Periventricular Leukomalacia | Not applicable | Withdrawn | Children's Hospital of Fudan University | 2020-12-01 | 2023-12-29 | |
| Evaluation of Long-Term Gait Development in Infants With Neonatal Encephalopathy Using Infant Treadmill Baby treadmill, Conventional physical rehabilitation training - Hypoxic-Ischemic Encephalopathy, Periventricular Leukomalacia | Not applicable | Terminated | Children's Hospital of Fudan University | 20 | 2020-12-01 | 2023-12-29 |
| Randomized Controlled Trial of Early Intensive Leg Exercise to Improve Walking in Children With Diplegia Intensive exercise - Spastic Diplegia, Periventricular Leukomalacia | Not applicable | Active not recruiting | University of Alberta | 60 | 2019-01-28 | 2026-05-06 |
| Single-session tDCS in Cerebral Palsy Active tDCS, Sham tDCS - Cerebral Palsy, Perinatal Stroke | Not applicable | Completed | University of Minnesota | 20 | 2018-05-01 | 2021-04-13 |
| MISA to NRDS：a Multicenter Study in China Minimal Invasive surfactant administration - Bronchopulmonary Dysplasia, Patent Ductus Arteriosus | Not applicable | Completed | Peking University Third Hospital | 237 | 2017-07-01 | 2019-09-06 |
| The Role of Cerebral NIRS in Preventing Brain Injury of Very Low Birth Weight Preterm Infants NIRS, SafeboosC - Neonatal Cerebral Leukomalacia, Intracranial Nontraumatic Haemorrhage of Fetus and Newborn | Not applicable | Completed | Dr Cipto Mangunkusumo General Hospital | 129 | 2017-05-01 | 2025-11-12 |
| Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Erythropoietin, Normal saline - Premature Infants, Intracranial Hemorrhages | Phase 3 | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 400 | 2017-04-10 | 2017-10-02 |
| Antibiotic "Dysbiosis" in Preterm Infants Antibiotic, Gastric fluid, Breast milk - Enterocolitis, Necrotizing, Bacteremia | Phase 2 | Completed | University of Florida | 98 | 2017-01-16 | 2024-06-05 |
| Prediction of Brain Injury in Premature Infants Brain Monitoring Platform - Intraventricular Hemorrhage, Periventricular Leukomalacia | Completed | Baylor College of Medicine | 70 | 2016-08-11 | 2026-07-01 | |
| Safety and Efficacy Study of the Draeger Babylog VN500 Device in HFOV Mode in VLBW Neonates Babylog VN500 in HFOV Mode - Respiratory Distress Syndrome In Premature Infants | Not applicable | Unknown | Draeger Medical Systems, Inc. | 225 | 2015-07-01 | 2019-09-19 |
| Management of Hypotension In the Preterm Infant Dopamine hydrochloride, Dextrose 5% - Hypotension, Low Blood Pressure | Phase 3 | Terminated | University College Cork | 58 | 2015-02-01 | 2019-10-02 |
Showing 20 of 40. Sign in to see all of them.
Premature Birth (16) · Cerebral Palsy (11) · Brain Injuries (8) · Bronchopulmonary Dysplasia (7) · Intracranial Hemorrhages (7) · Hypoxia-Ischemia, Brain (6) · Ductus Arteriosus, Patent (3) · Enterocolitis, Necrotizing (3) · Retinopathy of Prematurity (3) · Anemia (2) · Cerebral Infarction (2) · Hypoglycemia (2) · Hypotension (2) · Kernicterus (2)
Brain Diseases (40) · Cardiovascular Diseases (40) · Central Nervous System Diseases (40) · Cerebrovascular Disorders (40) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (40) · Encephalomalacia (40) · Infant, Newborn, Diseases (40) · Infant, Premature, Diseases (40) · Nervous System Diseases (40) · Vascular Diseases (40) · Pathological Conditions, Signs and Symptoms (17) · Female Urogenital Diseases and Pregnancy Complications (16) · Obstetric Labor Complications (16) · Obstetric Labor, Premature (16) · Pregnancy Complications (16)
Sodium Chloride (3) · Erythropoietin (2) · Magnesium Sulfate (2) · Saline Solution (2) · Ampicillin (1) · Anti-Bacterial Agents (1) · Cefotaxime (1) · Clemastine (1) · Dopamine (1) · Electroencephalography (1) · Erythrocyte Transfusion (1) · Gentamicins (1) · Indomethacin (1) · Magnesium (1) · Milk, Human (1)
Baylor College of Medicine (2) · Children's Hospital of Fudan University (2) · NICHD Neonatal Research Network (2) · University College Cork (2) · Atlantic Health System (1) · Bridget LaMonica Ostrem, M.D., Ph.D. (1) · Brigham and Women's Hospital (1) · Children's Hospital of Philadelphia (1) · China Medical University Hospital (1) · Dr Cipto Mangunkusumo General Hospital (1) · Draeger Medical Systems, Inc. (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · Hong Huang (1) · IRCCS Fondazione Stella Maris (1)
United States (19) · Canada (4) · China (4) · Belgium (2) · France (2) · Ireland (2) · Australia (1) · Brazil (1) · Czechia (1) · Germany (1) · Greece (1) · Hungary (1) · Indonesia (1) · Israel (1) · Italy (1)
Avroy A. Fanaroff, MD (2) · Barbara J. Stoll, MD (2) · David K. Stevenson, MD (2) · Edward F. Donovan, MD (2) · James A. Lemons, MD (2) · Lu-Ann Papile, MD (2) · Raymond Bain, PhD (2) · Richard A. Ehrenkranz, MD (2) · Seetha Shankaran, MD (2) · Sheldon B. Korones, MD (2) · William Oh, MD (2) · Ann R. Stark, MD (1) · Bai-Horng Su, MD, PhD (1) · Bridget Ostrem, MD, PhD (1) · Chad Andersen, MD (1)
PMID 25157725, PMID 25534356, PMID 27187300, PMID 10625862, PMID 12114906, PMID 15930233, PMID 16939737, PMID 18676556, PMID 18753646, PMID 19117884, PMID 19622997, PMID 20027029, PMID 20591191, PMID 21199970, PMID 22059409, PMID 22776958, PMID 24012586, PMID 24136687, PMID 24837863, PMID 24969309, PMID 25123212, PMID 25644966, PMID 25782975, PMID 25863661, PMID 26254839, PMID 26828941, PMID 27130143, PMID 27244862, PMID 31143877, PMID 33479274, PMID 33627329, PMID 36477478, PMID 37308133, PMID 38805228, PMID 39373498, PMID 9250849
M01RR000070 (2), M01RR000750 (2), M01RR000997 (2), M01RR006022 (2), M01RR008084 (2), U10HD021364 (2), U10HD021385 (2), U10HD021415 (2), U10HD027851 (2), U10HD027853 (2), U10HD027856 (2), U10HD027871 (2), U10HD027880 (2), U10HD027881 (2), U10HD027904 (2)