12 completed, 9 unknown, 3 terminated, 2 recruiting. 8 Phase 2, 7 Phase 1, 6 Phase 3, 5 Phase 4, 1 Not applicable.
Follow Surface-Active Agents: new trials by email Literature Review of Surface-Active Agents trials Research Report on Surface-Active Agents
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa Surfactant - Respiratory Distress Syndrome in Premature Infant, RDS of Prematurity | Phase 4 | Recruiting | Indiana University | 1512 | 2025-01-01 | 2026-03-27 |
| Implementing LISA Surfactant in Nigeria Surfactant - Respiratory Distress Syndrome, Neonatal Death | Phase 4 | Completed | Indiana University | 349 | 2023-06-25 | 2025-08-24 |
| Daily Chlorexidine Bath for Health Care Associated Infection Prevention 2% chlorhexidine digluconate solution with surface-active agents, Usual Baths - Health Care Associated Infection, Ventilator Associated Pneumonia | Phase 3 | Completed | Hospital do Coracao | 15730 | 2022-08-03 | 2024-06-13 |
| LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve EG-70 (phase 1), EG-70 (phase 2) Master Protocol, Surfactant Bladder Pre-Rinse and EG-70 (Substudy) - Superficial Bladder Cancer, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ | Phase 1 / Phase 2 | Recruiting | enGene, Inc. | 350 | 2021-04-22 | 2026-08-07 |
| The Budesonide in Babies (BiB) Trial budesonide (Pulmicort nebulizing suspension)., surfactant (poractant alfa;Curosurf) - Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome | Phase 3 | Active not recruiting | NICHD Neonatal Research Network | 642 | 2021-04-01 | 2026-04-15 |
| The Safety and Preliminary Tolerability of Lyophilized Lucinactant in Adults With Coronavirus Disease 2019 (COVID-19) Lucinactant - COVID-19, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) | Phase 2 | Completed | Windtree Therapeutics | 20 | 2021-01-05 | 2023-06-23 |
| London's Exogenous Surfactant Study for COVID19 Bovine Lipid Extract Surfactant - ARDS, Human, COVID-19 | Phase 1 / Phase 2 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 20 | 2020-11-23 | 2021-11-11 |
| Surfactant-BL in Adult Acute Respiratory Distress Syndrome Due to COVID-19 Surfactant - ARDS Due to COVID-19 | Unknown | Biosurf LLC. | 120 | 2020-07-03 | 2021-07-21 | |
| Surfactant for Neonatal Respiratory Distress Syndrome at High Altitude Areas:a Prospective Cohort Study surfactant - Surfactant | Unknown | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 200 | 2020-03-01 | 2021-02-17 | |
| Cold Heart Study: A Randomized Pilot Trial of Surfactant Therapy Curosurf, Sham - Congenital Heart Disease, Hypoplastic Left Heart Syndrome | Phase 1 | Terminated | University of Michigan | 2 | 2020-02-25 | 2023-09-13 |
| Safety and Tolerability of Topically Applied Bovine Lung Surfactant on Intact Skin Surfactants, Saline Solution - Skin and Connective Tissue Diseases | Phase 1 | Completed | Prof. Dr. Dr. Ursula Mirastschijski | 24 | 2016-12-08 | 2017-09-07 |
| Does The Surfactant Administration by Aerosolization Effective? surfactant, nasal continuous positive airway pressure, non-invasive intermittent positive-pressure ventilation - Respiratory Distress Syndrome, Surfactant Administration by Aerosolization | Not applicable | Unknown | nihat demir | 75 | 2016-01-01 | 2016-07-11 |
| Pulmonary Surfactant(PS) Therapy at High Altitude Area surfactant - NRDS, Surfactant | Completed | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 400 | 2015-01-01 | 2018-02-27 | |
| Aerosolized Surfactant in Neonatal RDS Surfactant - Respiratory Distress Syndrome, Newborn | Phase 1 / Phase 2 | Completed | Sood, Beena G., MD, MS | 159 | 2014-12-01 | 2021-08-25 |
| Antimicrobial Photodynamic Therapy Applied in Orthodontic. Orthodontic Patients. Curcumin, LED, Surfactant - Dentist-Patient Relations | Phase 1 | Completed | University of Sao Paulo | 24 | 2014-01-01 | 2015-01-13 |
| Lung Lavage With Dilute Poractant Alfa for Meconium Aspiration Syndrome Lung lavage with surfactant, Bolus surfactant - Meconium Aspiration Syndrome | Phase 4 | Completed | Zekai Tahir Burak Women's Health Research and Education Hospital | 30 | 2013-09-01 | 2016-08-03 |
| First In Human Study on Synthetic Surfactant CHF 5633 in Respiratory Distress Syndrome synthetic surfactant (CHF5633) - Respiratory Distress Syndrome in Premature Infants | Phase 1 | Completed | Chiesi Farmaceutici S.p.A. | 40 | 2012-10-01 | 2020-07-31 |
| Minimally Invasive Surfactant Therapy Followed by CPAP (MISTCPAP) in Preterm Infants With RDS Surfactant - Respiratory Distress Syndrome | Phase 2 | Unknown | China Medical University Hospital | 60 | 2012-02-01 | 2012-11-08 |
| Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory Distress Syndrome surfactant, surfactant+vitamin A - RDS, Infant, Newborn | Phase 3 | Unknown | Third Military Medical University | 100 | 2012-01-01 | 2011-07-26 |
| Efficacy of Surfactant and Perinatal Risk Factors in NRDS With Different Gestational Ages Surfactant, Pulmonary，Curosurf, Perinatal risk factors of NRDS - Infant, Newborn, NRDS | Unknown | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 1500 | 2011-01-01 | 2017-12-29 |
Showing 20 of 27. Sign in to see all of them.
Respiratory Distress Syndrome (9) · Premature Birth (5) · Bronchopulmonary Dysplasia (4) · COVID-19 (3) · Meconium Aspiration Syndrome (2) · Respiratory Distress Syndrome In Premature Infants (2) · Respiratory Distress Syndrome, Newborn (2) · Acute Lung Injury (1) · Carcinoma in Situ (1) · Cross Infection (1) · Heart Defects, Congenital (1) · Hypoplastic Left Heart Syndrome (1) · Infant, Newborn, Diseases (1) · Non-Muscle Invasive Bladder Neoplasms (1) · Perinatal Death (1)
Windtree Therapeutics (4) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (3) · Indiana University (2) · NICHD Neonatal Research Network (2) · Biosurf LLC. (1) · Chiesi Farmaceutici S.p.A. (1) · China Medical University Hospital (1) · China Medical University, China (1) · Hospital do Coracao (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Pontificia Universidad Catolica de Chile (1) · Prof. Dr. Dr. Ursula Mirastschijski (1) · Rabin Medical Center (1) · Sood, Beena G., MD, MS (1) · Third Military Medical University (1)
United States (9) · China (4) · Brazil (2) · Canada (2) · Chile (2) · Germany (2) · Nigeria (2) · Taiwan (2) · United Kingdom (2) · Argentina (1) · Australia (1) · Central African Republic (1) · France (1) · Ghana (1) · Israel (1)
Osayame A Ekhaguere, MBBS, MPH (2) · Abbot R. Laptook, MD (1) · Abhik Das, PhD (1) · Adrienne Randolph, MD (1) · Alexandre B Cavalcanti, M.D (1) · Alvaro Gonzalez, MD (1) · Bai-Horng Su, MD, PhD (1) · Barbara J. Stoll, MD (1) · Beena G. Sood, MD, MS (1) · Brenda B. Poindexter, MD MS (1) · Bruno M Tomazini, M.D (1) · Carlos Guardia, MD (1) · Christian Speer, MD (1) · Christine Tosone, Ms, RAC (1) · Edgardo Szyld, MD, MS (1)
PMID 10830460, PMID 1750756, PMID 19117865, PMID 20472937, PMID 20472939, PMID 20587676, PMID 22371462, PMID 22738947, PMID 22791092, PMID 23268664, PMID 24703280, PMID 24725582, PMID 24876196, PMID 25425651, PMID 25554820, PMID 26351971, PMID 27344218, PMID 28279433, PMID 28465315, PMID 28600154, PMID 30292492, PMID 305471, PMID 30690595, PMID 30692613, PMID 33338661, PMID 34337553, PMID 35474746, PMID 35715492, PMID 37640232, PMID 40571094, PMID 41026481, PMID 41732706, PMID 42536986, PMID 436851, PMID 8131364
2015 (1), M01RR000633 (1), M01RR000750 (1), M01RR008084 (1), U10HD021364 (1), U10HD021373 (1), U10HD021385 (1), U10HD021397 (1), U10HD027851 (1), U10HD027853 (1), U10HD027856 (1), U10HD027871 (1), U10HD027880 (1), U10HD027904 (1), U10HD034216 (1)