10 completed, 7 not yet recruiting, 3 recruiting, 2 terminated. 10 Not applicable, 3 Phase 3, 2 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 5, Not yet recruiting 4, Recruiting 1 |
| Phase 3 | 3 | Completed 2, Terminated 1 |
| Phase 2 | 2 | Terminated 1, Withdrawn 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Hyaline Membrane Disease: new trials by email Literature Review of Hyaline Membrane Disease trials Research Report on Hyaline Membrane Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The NEU - CAP Trial Local standard care of monitoring non-invasive ventilation, CO₂-guided Non-Invasive Ventilation - Infant, Premature, Diseases, Birth, Preterm | Not applicable | Not yet recruiting | Leiden University Medical Center | 1860 | 2027-01-01 | 2026-08-10 |
| Effect of Automated Oxygen Control on Early-childhood Lung Mechanics Forced oscillometry technique - Prematurity, Respiratory Distress Neonatal | Not yet recruiting | King's College Hospital NHS Trust | 60 | 2026-10-12 | 2026-10-14 | |
| ADINA vs. High Flow Nasal Cannula Comparison Study Adaptive Dynamic Inspiratory Nasal Apparatus, High flow Nasal Canula - Respiratory Distress Neonatal | Not applicable | Not yet recruiting | Loma Linda University | 40 | 2026-07-01 | 2026-01-30 |
| Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal) | Recruiting | Vastra Gotaland Region | 300 | 2026-05-25 | 2026-08-20 | |
| Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant | Recruiting | Mayo Clinic | 500 | 2026-03-11 | 2026-03-18 | |
| Combined Oscillation-Volume guarantEe Study HFOV, HFOV+VG - Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Bronchopulmonary Dysplasia (BPD) | Not applicable | Not yet recruiting | Xingwang Zhu | 348 | 2026-02-01 | 2026-01-30 |
| Early Surfactant Administration at FiO₂ >0.25 Under NIPPV for RDS in Very Preterm Infants Threshold FiO₂ - Respiratory Distress Syndrome (&Amp; [Hyaline Membrane Disease]) | Not applicable | Not yet recruiting | Jiulongpo No.1 People's Hospital | 384 | 2026-01-01 | 2025-08-03 |
| Delayed Versus Immediate Cord Clamping in Preterm Birth Delayed Umbilical Cord Clamping, Immediate Umbilical Cord Clamping - Preterm Birth Complication, Neonatal Morbidity and Mortality | Not applicable | Recruiting | Faculty of Medicine of Tunis | 200 | 2025-10-02 | 2026-07-13 |
| Comparison of the Silverman-Andersen Score and the Downes Score Respiratory Distress Neonatal, Noninvasive Ventilation | Not yet recruiting | Muğla Sıtkı Koçman University | 220 | 2025-09-15 | 2025-09-19 | |
| Heterogeneity Index in Neonatologist-performed Lung Ultrasound in Neonates Receiving Respiratory Support - a Pilot Study Intensive Care Units, Neonatal, Infant, Newborn | Not yet recruiting | Medical University of Graz | 40 | 2025-08-15 | 2025-08-12 | |
| Impact of Antenatal Corticosteroid Therapy on Postnatal Surfactant Use in Preterm Infants Impact of antenatal corticosteroid therapy on surfactants use postnatal - Hyaline Membrane Disease (HMD) | Completed | Hôpital NOVO | 145 | 2022-06-20 | 2024-09-19 | |
| Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns chest physiotherapy - Preterm Birth, Premature | Not applicable | Completed | Sanko University | 60 | 2022-04-01 | 2025-09-12 |
| Short Term Effects of Synchronized vs. Non-synchronized NIPPV in Preterm Infants. NIPPV, SNIPPV - Newborn Respiratory Distress, Preterm Infant | Not applicable | Completed | University of Turin, Italy | 30 | 2020-11-16 | 2026-09-15 |
| Evaluation of the Neonatal Autonomic Stress During Intubations Under Propofol in a Population of Premature Infants Under 33 w'GA electrocardiogram - Hyaline Membrane Disease, Preterm Infant | Completed | Centre Hospitalier Universitaire de Saint Etienne | 21 | 2019-02-25 | 2024-03-04 | |
| Biomarker for Hyaline Fibromatosis Syndrome (BioHFS) Hyalinosis, Hyaline Membrane Disease | Withdrawn | CENTOGENE GmbH Rostock | 2018-08-20 | 2023-02-13 | ||
| The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Beta carotene, Vitamin D3, Zinc - Hyaline Membrane Disease, Necrotizing Enterocolitis of Newborn | Phase 4 | Unknown | Universitas Indonesia | 120 | 2017-01-01 | 2018-08-13 |
| Efficacy of a New Technique -"IN-REC-SUR-E"- in Preterm Neonates With RDS Poractant alfa, 200 mg/kg, Ventilator for High-frequency Oscillatory Ventilation (HFOV), Nasal Continuous Positive Airway Pressure (nCPAP) - Respiratory Distress Syndrome, Hyaline Membrane Disease | Not applicable | Completed | Catholic University of the Sacred Heart | 206 | 2015-11-01 | 2019-02-15 |
| Anti-MERS-CoV Convalescent Plasma Therapy Convalescent plasma - Respiratory Distress Syndrome (& [Hyaline Membrane Disease]) | Phase 2 | Withdrawn | King Abdullah International Medical Research Center | 2014-05-01 | 2018-11-21 | |
| MISurf Versus InSurE. A Comparison of Minimally Invasive Surfactant Application Techniques in Preterm Infants Minimally invasive endotracheal surfactant application - Hyaline Membrane Disease | Phase 2 | Terminated | Hamilton Health Sciences Corporation | 4 | 2012-07-01 | 2017-08-22 |
| Betamethasone and Severity of Hyaline Membrane Disease Pregnant Women Receive Celesten | Completed | Assistance Publique - Hôpitaux de Paris | 127 | 2012-01-12 | 2026-03-04 |
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Premature Birth (11) · Respiratory Distress Syndrome (10) · Bronchopulmonary Dysplasia (4) · Dyspnea (2) · Pulmonary Atelectasis (2) · Anemia (1) · Enterocolitis, Necrotizing (1) · Fetofetal Transfusion (1) · Hyaline Fibromatosis Syndrome (1) · Infant, Premature, Diseases (1) · Lung Diseases (1) · Meconium Aspiration Syndrome (1) · Perinatal Death (1) · Pneumothorax (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (25) · Infant, Newborn, Diseases (25) · Respiration Disorders (25) · Respiratory Tract Diseases (25) · Infant, Premature, Diseases (24) · Lung Diseases (24) · Respiratory Distress Syndrome, Newborn (24) · Respiratory Distress Syndrome (15) · Female Urogenital Diseases and Pregnancy Complications (13) · Pregnancy Complications (13) · Urogenital Diseases (13) · Obstetric Labor Complications (11) · Obstetric Labor, Premature (11) · Lung Injury (5) · Pathological Conditions, Signs and Symptoms (5)
Beclomethasone (1) · Betamethasone (1) · Cannula (1) · Cholecalciferol (1) · Continuous Positive Airway Pressure (1) · Dexamethasone (1) · Umbilical Cord Clamping (1) · Ventilators, Mechanical (1) · Zinc (1) · beta Carotene (1) · betamethasone acetate phosphate (1) · picolinic acid (1) · poractant alfa (1)
Assistance Publique - Hôpitaux de Paris (1) · CENTOGENE GmbH Rostock (1) · Catholic University of the Sacred Heart (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Centre Hospitalier Universitaire, Amiens (1) · Faculty of Medicine of Tunis (1) · Hamilton Health Sciences Corporation (1) · Hôpital NOVO (1) · Instituto Materno Infantil Prof. Fernando Figueira (1) · Jiulongpo No.1 People's Hospital (1) · King Abdullah International Medical Research Center (1) · King's College Hospital NHS Trust (1) · Leiden University Medical Center (1) · Loma Linda University (1) · Mansoura University (1)
France (4) · United States (3) · Austria (2) · Canada (2) · Italy (2) · Sweden (2) · Turkey (Türkiye) (2) · United Kingdom (2) · Belgium (1) · Brazil (1) · China (1) · Egypt (1) · Germany (1) · India (1) · Indonesia (1)
Aaron Chiu, MD (1) · Alessandra Coscia, Prof. (1) · Anders Elfvin, Professor (1) · Bradley Yoder, MD (1) · Brigitte Lemyre, MD (1) · David Millar, MD (1) · Elena Maggiora, MD (1) · Francesco Cresi, PhD (1) · Giovanni Vento, MD (1) · Haresh Kirpalani, MD, MSc (1) · Hesham Abdel Hady, MD (1) · Melania Amorim, MD, PhD (1) · Mitchell R Goldstein, MD (1)
PMID 10835057, PMID 11401896, PMID 11420416, PMID 12781540, PMID 1388792, PMID 16009843, PMID 16182673, PMID 16763218, PMID 17943779, PMID 18272893, PMID 18841536, PMID 20180736, PMID 20439601, PMID 20472939, PMID 20956431, PMID 21276671, PMID 21487057, PMID 22025591, PMID 22150698, PMID 23359457, PMID 23595061, PMID 23736015, PMID 23944299, PMID 24094879, PMID 24838096, PMID 24947477, PMID 24951077, PMID 25624390, PMID 26162889, PMID 26618098, PMID 26777151, PMID 27538798, PMID 29275926, PMID 305471, PMID 30924897, PMID 31236018, PMID 31935746, PMID 32394434, PMID 32687801, PMID 33889679, PMID 34127040, PMID 37138252, PMID 37466143, PMID 40365096, PMID 41213831, PMID 41218846, PMID 413500, PMID 41458086
2018 (1), U01HL049803 (1)