4 completed, 3 recruiting. 3 Not applicable, 2 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Completed 2, Recruiting 1 |
| Phase 3 | 2 | Completed 2 |
| Early Phase 1 | 1 | Recruiting 1 |
Follow Surfactant Dysfunction: new trials by email Literature Review of Surfactant Dysfunction trials Research Report on Surfactant Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hydroxychloroquine in Children's Interstitial Lung Diseases With Genetic Causes Hydroxychloroquine - Interstitial Lung Disease, Surfactant Dysfunction | Early Phase 1 | Recruiting | Children's Hospital of Fudan University | 60 | 2024-09-01 | 2026-03-16 |
| Infants With Severe Acute Respiratory Distress Syndrome: The Prone Trial Prone positioning - Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Surfactant Dysfunction | Not applicable | Recruiting | Medical University of Vienna | 14 | 2022-07-30 | 2026-08-06 |
| Early Bolus Surfactant Replacement Therapy Versus Standard Care in Term Neonates With Meconium Aspiration Syndrome Bovine surfactant - Meconium Aspiration Syndrome, Surfactant Dysfunction | Not applicable | Completed | Lady Hardinge Medical College | 60 | 2022-03-12 | 2024-07-09 |
| Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(NARDS) one dose of surfactant replacement, two and more doses of surfactant replacement - Respiratory Distress Syndrome, Preterm Birth | Recruiting | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 400 | 2021-01-01 | 2025-07-01 | |
| Hydroxychloroquin (HCQ) in chILD of Genetic Defect Hydroxychloroquin - Surfactant Dysfunction | Not applicable | Completed | Children's Hospital of Fudan University | 25 | 2017-07-01 | 2026-03-19 |
| Trial of Late Surfactant for Prevention of Bronchopulmonary Dysplasia Infasurf surfactant (ONY, Inc.), Sham (No Treatment) - Bronchopulmonary Dysplasia | Phase 3 | Completed | Roberta Ballard | 511 | 2010-01-01 | 2021-05-13 |
| Trial of Late Surfactant to Prevent BPD: A Pilot Study in Ventilated Preterm Neonates Receiving Inhaled Nitric Oxide Infasurf (ONY Inc.), Sham - Respiratory Distress Syndrome of Prematurity (Surfactant Dysfunction), Bronchopulmonary Dysplasia | Phase 3 | Completed | Roberta Ballard | 85 | 2008-01-01 | 2021-05-11 |
Premature Birth (3) · Respiratory Distress Syndrome (3) · Bronchopulmonary Dysplasia (2) · Lung Diseases, Interstitial (2) · Acute Lung Injury (1) · Meconium Aspiration Syndrome (1)
Lung Diseases (7) · Respiratory Tract Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (4) · Lung Injury (4) · Pregnancy Complications (4) · Respiration Disorders (4) · Urogenital Diseases (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Infant, Newborn, Diseases (3) · Obstetric Labor Complications (3) · Obstetric Labor, Premature (3) · Infant, Premature, Diseases (2) · Ventilator-Induced Lung Injury (2) · Fetal Diseases (1)
Hydroxychloroquine (2) · salicylhydroxamic acid (2) · Air (1) · Prone Position (1) · Therapeutics (1) · calfactant (1)
Children's Hospital of Fudan University (2) · Roberta Ballard (2) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (1) · Lady Hardinge Medical College (1) · Medical University of Vienna (1)
China (3) · United States (2) · Austria (1) · India (1)
Roberta A Ballard, MD (2) · Sushma Nangia, MD, DM (Neo) (1) · Tobias Werther (1)
PMID 17885266, PMID 23905526, PMID 25491573, PMID 25657025, PMID 26135832, PMID 26500107, PMID 27362365, PMID 27583380, PMID 28100402, PMID 28148924, PMID 28732825, PMID 29627188
U01HL094338 (1)