12 completed, 2 not yet recruiting, 2 recruiting, 2 terminated. 10 Not applicable, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 5, Not yet recruiting 2, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Terminated 1 |
Follow Airway Extubation: new trials by email Literature Review of Airway Extubation trials Research Report on Airway Extubation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Randomized Evaluation of Operating Room Extubation After Cardiac Surgery OR extubation, ICU extubation - Cardiac Surgery | Not applicable | Not yet recruiting | Massachusetts General Hospital | 120 | 2026-10-01 | 2026-09-28 |
| Comparison of Acute Airway/Respiratory Complications and Intervention Requirements in Extubations Performed During On-Hours Versus Off-Hours Extubation, Survey/Questionnaire Administration - Extubation Failures, Extubation | Recruiting | Kocaeli City Hospital | 2640 | 2026-08-03 | 2026-09-29 | |
| Comparative Study About The Effect Of Dexmedetomidine Vs Lignocaine On Hemodynamic Stability During Tracheal Extubation, Especially In Resource Limited Populations Tracheal Extubation - Hemodynamic Responses During Tracheal Extubation, Peri-extubation Hypertension | Not applicable | Not yet recruiting | Mayo Hospital Lahore | 60 | 2026-07-01 | 2026-06-16 |
| Site of Tracheal Extubation and Operating Room Efficiency During Robot-assisted Surgery Extubation in post-anesthesia care unit (PACU), Extubation in operating room (OR) - Robotic Surgical Procedures, Airway Extubation | Not applicable | Completed | Peking University First Hospital | 218 | 2026-01-24 | 2026-10-21 |
| Platform of Randomized Adaptive Clinical Trials in Critical Illness Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL) - Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication | Not applicable | Recruiting | University Health Network, Toronto | 6250 | 2023-04-30 | 2026-10-06 |
| EXtubation With SUctioning or With Positive End-Expiratory Pressure in Intensive Care Unit Extubation with PEEP, Endotracheal Aspiration - Extubation in Intensive Care Unit | Not applicable | Completed | Centre Hospitalier de Bourg en Bresse | 425 | 2023-03-22 | 2025-12-05 |
| Investigation of the Effects of Pressure Support Ventilation and Positive Airway Pressure Modes During Extubation extubation - Anesthesia | Completed | Eskisehir Osmangazi University | 199 | 2023-03-15 | 2024-04-10 | |
| Individualized Positive End-expiratory Pressure Guided by End-expiratory Lung Volume in the Acute Respiratory Distress Syndrome Invasive Mechanical ventilation, Neuromuscular Blocking Agents, Prone positioning - Respiratory Distress Syndrome, Adult | Phase 3 | Terminated | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 18 | 2022-11-01 | 2025-09-30 |
| Endotracheal Extubation With Suctioning Versus Positive Pressure in Children After General Anaesthesia. Endotracheal extubation with suctioning, Endotracheal extubation with positive pressure - Endotracheal Extubation | Not applicable | Completed | Pakistan Navy Station Shifa Hospital | 40 | 2022-04-01 | 2022-08-05 |
| Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon Esophageal balloon, Intervention Spontaneous Breathing Trial (SBT) and Extubation, Control Spontaneous Breathing Trial and Extubation - Obesity, Morbid, Ventilator-Induced Lung Injury | Not applicable | Terminated | University of North Carolina, Chapel Hill | 6 | 2021-03-31 | 2024-06-05 |
| Impact of Extubation Location After Surgery on Perioperative Times Extubation in operative room, Extubation in post anesthesia care unit - Anesthesia, Intubation | Completed | University Hospital, Clermont-Ferrand | 756 | 2020-09-01 | 2024-02-08 | |
| Comparison of Deep Versus Awake Tracheal Extubation in Adults Extubation - Airway Complication of Anesthesia, Respiratory Complications of Care | Not applicable | Completed | United States Navy | 220 | 2020-08-28 | 2023-05-06 |
| Early Extubation and Postoperative Complications After Liver Transplantation extubation in the operating room, extubation in the ICU - Liver Transplantation | Completed | West China Hospital | 438 | 2020-01-15 | 2021-06-10 | |
| EFFECT OF PRE EXTUBATION MANUAL HYPERINFLATION TECHNIQUE VS REGULAR EXTUBATION AFTER STERNOTOMY Extubation, Manual Hyperinflation - Sternotomy | Not applicable | Completed | Foundation University Islamabad | 54 | 2017-09-01 | 2020-11-12 |
| The NEUROlogically-impaired Extubation Timing Trial Extubation, Usual Care - Acute Brain Injury | Not applicable | Unknown | Sunnybrook Health Sciences Centre | 27 | 2017-02-01 | 2020-02-05 |
| Early Versus Late Extubation in Myasthenia Gravis Patients extubation - Myasthenia Gravis Associated With Thymoma | Completed | First Affiliated Hospital, Sun Yat-Sen University | 96 | 2015-01-01 | 2018-03-16 | |
| Mechanical Ventilation in Brain-injured Patients Pass recommendations on ventilation factors and extubation - Brain-injury, Stroke | Completed | Nantes University Hospital | 560 | 2013-07-01 | 2015-02-23 | |
| Clinical Evaluation of Swallowing Disorders as a Predictor of Extubation Failure extubation - Central Nervous System Diseases, Acute Respiratory Failure | Completed | Assistance Publique - Hôpitaux de Paris | 160 | 2008-10-01 | 2017-01-04 | |
| A Prospective Trial of Elective Extubation in Brain Injured Patients. extubation, continued intubation - Brain Injury | Phase 1 | Completed | Mayo Clinic | 16 | 2004-08-01 | 2015-04-28 |
Brain Injuries (3) · Respiratory Insufficiency (3) · Brain Injuries, Traumatic (2) · Postoperative Complications (2) · Subarachnoid Hemorrhage (2) · Ventilator-Induced Lung Injury (2) · Brain Neoplasms (1) · Central Nervous System Diseases (1) · Deglutition Disorders (1) · Heart Arrest (1) · Heart Failure (1) · Ischemic Stroke (1) · Meningitis (1) · Obesity, Morbid (1) · Respiratory Distress Syndrome (1)
Assistance Publique - Hôpitaux de Paris (1) · Centre Hospitalier de Bourg en Bresse (1) · Eskisehir Osmangazi University (1) · First Affiliated Hospital, Sun Yat-Sen University (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Foundation University Islamabad (1) · Kocaeli City Hospital (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Mayo Hospital Lahore (1) · Nantes University Hospital (1) · Pakistan Navy Station Shifa Hospital (1) · Peking University First Hospital (1) · Sunnybrook Health Sciences Centre (1) · United States Navy (1)
United States (5) · France (4) · Pakistan (3) · Canada (2) · China (2) · Italy (2) · Turkey (Türkiye) (2) · Australia (1) · Colombia (1) · Hong Kong (1) · New Zealand (1) · Saudi Arabia (1) · Singapore (1) · Spain (1)
Anastasia Newman, PhD (1) · Andrea Castellvi Font, MD, PhD (1) · Audrey De Jong, MD, PhD (1) · Bijan Teja, MD (1) · Bram Rochwerg, MD, MSc (1) · Damon Scales, MD, PhD (1) · Dmitry Rozenberg, MD, PhD (1) · Domenico Luca Grieco, MD (1) · Dong-Xin Wang, MD, PhD (1) · Eddy Fan, MD, PhD (1) · Edward M. Manno, M.D. (1) · Ewan Goligher, MD, PhD (1) · Irene Telias, MD, PhD (1)
PMID 10806150, PMID 19000302, PMID 28315940, PMID 31744867, PMID 33121440, PMID 33784416, PMID 34794387, PMID 35057852, PMID 39696646, PMID 39947817, PMID 40745279