7 completed, 3 terminated, 2 unknown, 1 not yet recruiting. 5 Phase 2, 5 Phase 3, 4 Not applicable, 3 Phase 1, 1 Phase 4.
Follow calfactant: new trials by email Literature Review of calfactant trials Research Report on calfactant
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Little Lungs Study Calfactant, Budesonide - Invasive Mechanical Ventilation, Severe Respiratory Distress Syndrome | Phase 1 / Phase 2 | Not yet recruiting | University of Wisconsin, Madison | 24 | 2026-10-01 | 2026-09-29 |
| Calfactant vs Poractant Alfa Using a Less Invasive Technique in Preterm Infants With Respiratory Distress Syndrome Poractant alfa, Calfactant - Respiratory Distress Syndrome in Premature Infants, Respiratory Distress Syndrome (RDS) | Phase 4 | Recruiting | Uludag University | 234 | 2026-01-20 | 2026-04-28 |
| Infasurf®(Calfactant) Aerosol for Infants With Bronchiolitis-AERO-04 Aerosolized Infasurf - Bronchiolitis | Phase 1 | Terminated | ONY | 13 | 2019-01-12 | 2020-10-23 |
| Comparison of Aerosol Delivery of Infasurf to Usual Care in Spontaneously Breathing RDS Patients Aerosolized Calfactant, Solarys - Respiratory Distress Syndrome | Phase 3 | Completed | ONY | 477 | 2017-03-29 | 2024-05-29 |
| Steroids and Surfactant in Extremely Low Gestation Age Infants Dose Escalation Trial Budesonide in Calfactant - Bronchopulmonary Dysplasia (BPD) | Phase 1 / Phase 2 | Terminated | Cynthia McEvoy | 25 | 2016-09-01 | 2025-04-04 |
| Comparison of Curosurf and Infasurf in the Treatment of Preterm Infants With Respiratory Distress Syndrome Poractant alfa, calfactant - Respiratory Distress Syndrome | Not applicable | Completed | University of Missouri-Columbia | 30 | 2013-07-01 | 2017-06-06 |
| Pilot Study of Topical Steroid for Prevention of Chronic Lung Disease in Extremely Premature Infants. Infasurf, Pulmicort, Sham - Bronchopulmonary Dysplasia | Phase 2 | Unknown | East Carolina University | 45 | 2010-07-01 | 2010-12-29 |
| CALIPSO: Calfactant for Acute Lung Injury in Pediatric Stem Cell Transplant and Oncology Patients Calfactant, Air placebo - Acute Lung Injury | Phase 2 / Phase 3 | Completed | Milton S. Hershey Medical Center | 43 | 2010-06-01 | 2018-03-16 |
| Calfactant for Direct Acute Respiratory Distress Syndrome Calfactant, Room Air (placebo) - Respiratory Distress Syndrome, Adult | Phase 3 | Terminated | Pneuma Pharmaceuticals Incorporated | 332 | 2008-05-01 | 2012-07-24 |
| Self-dispersing Liquids as Aerosol Drug Carriers calfactant, isotonic saline - Cystic Fibrosis | Not applicable | Completed | University of Pittsburgh | 8 | 2008-03-01 | 2017-08-24 |
| Trial of Late Surfactant to Prevent BPD: A Pilot Study in Ventilated Preterm Neonates Receiving Inhaled Nitric Oxide Infasurf (ONY Inc.), Sham - Respiratory Distress Syndrome of Prematurity (Surfactant Dysfunction), Bronchopulmonary Dysplasia | Phase 3 | Completed | Roberta Ballard | 85 | 2008-01-01 | 2021-05-11 |
| The Use of Surfactant in Lung Transplantation: A Randomized Control Pilot Study Surfactant (calfactant) - Lung Transplantation, Primary Graft Dysfunction | Phase 2 / Phase 3 | Unknown | Rabin Medical Center | 42 | 2005-01-01 | 2007-07-25 |
| Pilot Trial of Surfactant Booster Prophylaxis For Ventilated Preterm Neonates Infasurf - Respiratory Distress Syndrome, Bronchopulmonary Dysplasia | Not applicable | Completed | Children's Hospital of Philadelphia | 89 | 2004-09-01 | 2007-11-22 |
| Pilot Trial of Surfactant Therapy For Preterm Neonates 5-21 Days Old With Respiratory Decompensation Infasurf (drug) - Respiratory Distress Syndrome | Not applicable | Completed | Children's Hospital of Philadelphia | 11 | 2003-06-01 | 2007-11-22 |
Respiratory Distress Syndrome (8) · Premature Birth (6) · Bronchopulmonary Dysplasia (4) · Lung Diseases (2) · Acute Lung Injury (1) · Bronchiolitis (1) · Cystic Fibrosis (1) · Drowning (1) · Inflammation (1) · Neoplasms (1) · Pneumonia (1) · Primary Graft Dysfunction (1) · Respiratory Aspiration (1) · Respiratory Distress Syndrome In Premature Infants (1) · Surfactant Dysfunction (1)
Children's Hospital of Philadelphia (2) · ONY (2) · Cynthia McEvoy (1) · East Carolina University (1) · Milton S. Hershey Medical Center (1) · Pneuma Pharmaceuticals Incorporated (1) · Rabin Medical Center (1) · Roberta Ballard (1) · Uludag University (1) · University of Missouri-Columbia (1) · University of Pittsburgh (1) · University of Wisconsin, Madison (1)
United States (10) · Canada (2) · Israel (2) · Australia (1) · New Zealand (1) · South Korea (1) · Turkey (Türkiye) (1)
Roberta A Ballard, MD (3) · James Cummings, MD (2) · Michael Posencheg, MD (2) · Cynthia McEvoy, MD, MCR (1) · Dinushan Kaluarachchi, MBBS (1) · Douglas Willson, MD (1) · Jonathon Truwit, MD (1) · Karl Kaminski, RRT-NPS (1) · MordechaI R Kramer, Prof (1) · Naomi Lauriello, MD (1) · Neal J Thomas, MD, MSc (1) · Robert F Tamburro, MD, MSc (1) · Scott MacGilvray, MD (1) · Tim Corcoran, Ph.D. (1) · Waleed M Maamoun, MD (1)