15 completed, 8 unknown, 7 recruiting, 5 terminated. 40 Phase 1, 17 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 40 | Completed 15, Unknown 8, Recruiting 7, Terminated 5, Withdrawn 4, Active not recruiting 1 |
| Phase 2 | 17 | Completed 4, Recruiting 4, Terminated 4, Unknown 4, Withdrawn 1 |
Follow Ventilator-Induced Lung Injury: new trials by email Literature Review of Ventilator-Induced Lung Injury trials Research Report on Ventilator-Induced Lung Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| High-energy Human Milk Diets in the First Two Weeks After Birth to Reduce BPD in Extremely Preterm Infants High-energy group, Standard-energy group - Extreme Prematurity, Enteral Nutrition | Phase 1 / Phase 2 | Recruiting | University of Alabama at Birmingham | 150 | 2026-09-21 | 2026-09-24 |
| 129Xe MRI in Pediatric Population With BPD MagniXene, hyperpolarized 129Xe MRI - Bronchopulmonary Dysplasia | Phase 1 | Withdrawn | Xemed LLC | 2026-08-01 | 2026-02-05 | |
| Pharmacokinetics and Placental Transfer of Caffeine Caffeine citrate - Preterm Labor With Preterm Delivery, Premature Birth | Phase 1 | Recruiting | Indiana University | 30 | 2026-06-01 | 2026-06-04 |
| PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia montelukast 4 mg granule, Placebo - Bronchopulmonary Dysplasia (BPD), Premature Births | Phase 1 / Phase 2 | Recruiting | Duke University | 28 | 2026-02-23 | 2026-07-14 |
| Inhaled Ciclesonide Study in Preterm Infants Alvesco Inhalant Product - Bronchopulmonary Dysplasia | Phase 1 | Recruiting | Venkatesh Sampath | 30 | 2025-09-16 | 2026-09-09 |
| Inhaled Treatment for Bronchopulmonary Dysplasia GSNO - Bronchopulmonary Dysplasia | Phase 1 | Withdrawn | University Hospitals Cleveland Medical Center | 2025-08-01 | 2025-08-22 | |
| Safety and Efficacy of Umbilical Cord-derived Mesenchymal Stem Cell(MSC) Transplantation in the Treatment of Bronchopulmonary Dysplasia(BPD) in Premature Infants MSC - BPD - Bronchopulmonary Dysplasia | Phase 1 / Phase 2 | Recruiting | The Children's Hospital of Zhejiang University School of Medicine | 10 | 2024-08-09 | 2025-01-23 |
| Different Levels of BiPAP BiPAP setting - Bronchopulmonary Dysplasia | Phase 1 / Phase 2 | Unknown | King's College Hospital NHS Trust | 21 | 2024-05-23 | 2024-06-11 |
| Recombinant Surfactant Protein D (rfhSP-D) to Prevent Neonatal Chronic Lung Disease Recombinant fragment of human surfactant protein D (rfhSP-D) - Chronic Lung Disease of Prematurity, Respiratory Distress Syndrome in Premature Infant | Phase 1 | Completed | University College, London | 18 | 2024-04-06 | 2026-04-07 |
| Safety and Efficacy of MSC-EVs in the Prevention of BPD in Extremely Preterm Infants Endotracheopulmonary Instillation, Suspension - Bronchopulmonary Dysplasia | Phase 1 / Phase 2 | Recruiting | EXO Biologics S.A. | 265 | 2023-12-28 | 2024-09-19 |
| Cellular Therapy for Extreme Preterm Infants at Risk of Developing Bronchopulmonary Dysplasia Allogeneic Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells - Bronchopulmonary Dysplasia | Phase 1 | Active not recruiting | Ottawa Hospital Research Institute | 9 | 2022-10-17 | 2025-07-16 |
| Inhaled Tobramycin in BPD Tobramycin solution for inhalation 78mg dose, Tobramycin solution for inhalation 150mg dose, Tobramycin solution for inhalation 216mg dose - Bronchopulmonary Dysplasia | Phase 1 | Completed | Erik Allen Jensen | 27 | 2022-03-22 | 2025-01-31 |
| Anakinra for Preterm Infants Pilot Anakinra - Prematurity; Extreme, Inflammation | Phase 1 / Phase 2 | Unknown | Monash Medical Centre | 25 | 2022-02-15 | 2024-09-19 |
| A Clinical Safety Study of AT-100 (rhSP-D) in Preterm Neonates at High Risk for Bronchopulmonary Dysplasia (BPD) AT-100, Air-sham - Bronchopulmonary Dysplasia | Phase 1 | Completed | Airway Therapeutics, Inc. | 37 | 2021-09-01 | 2024-07-03 |
| Intratracheal Umbilical Cord-derived Mesenchymal Stem Cell for the Treatment of Bronchopulmonary Dysplasia (BPD) Human Umbilical Cord-derived Mesenchymal stem cell, placebo - Bronchopulmonary Dysplasia | Phase 1 / Phase 2 | Withdrawn | Children's Hospital of Fudan University | 2019-12-01 | 2023-12-29 | |
| Budesonide With Intratracheal Surfactants in Extremely Preterm Infants Budesonide in bovine lipid extract surfactant (BLES) - Bronchopulmonary Dysplasia, Respiratory Distress Syndrome in Premature Infant | Phase 1 / Phase 2 | Unknown | University of Manitoba | 30 | 2019-10-15 | 2019-07-17 |
| A Safety Study of IV Stem Cell-derived Extracellular Vesicles (UNEX-42) in Preterm Neonates at High Risk for BPD UNEX-42, Phosphate-buffered saline - Bronchopulmonary Dysplasia | Phase 1 | Terminated | United Therapeutics | 3 | 2019-10-09 | 2021-10-12 |
| Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia inhaled nitric oxide, Placebo - Pulmonary Hypertension, Bronchopulmonary Dysplasia | Phase 1 / Phase 2 | Terminated | AdventHealth | 32 | 2019-07-15 | 2025-01-15 |
| Mesenchymal Stem Cell Therapy for Bronchopulmonary Dysplasia in Preterm Babies Mesenchymal Stem Cell (MSC) therapy - Bronchopulmonary Dysplasia | Phase 1 | Completed | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | 10 | 2019-04-02 | 2025-03-17 |
| Umbilical Cord Mesenchymal Stem Cells Transplantation in the Treatment of Bronchopulmonary Dysplasia stem cell transplantation - Bronchopulmonary Dysplasia | Phase 1 | Completed | Vinmec Research Institute of Stem Cell and Gene Technology | 10 | 2019-03-01 | 2024-06-04 |
Showing 20 of 40. Sign in to see all of them.
Bronchopulmonary Dysplasia (40) · Premature Birth (15) · Hypertension, Pulmonary (3) · Enterocolitis, Necrotizing (2) · Infant, Premature, Diseases (2) · Lung Diseases (2) · Pneumonia (2) · Respiratory Distress Syndrome (2) · Respiratory Distress Syndrome, Newborn (2) · Anemia, Neonatal (1) · Apnea (1) · Central Nervous System Diseases (1) · Critical Illness (1) · Hematologic Diseases (1) · Infant, Newborn, Diseases (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (40) · Lung Injury (40) · Respiratory Tract Diseases (40) · Infant, Newborn, Diseases (39) · Infant, Premature, Diseases (38) · Lung Diseases (38) · Female Urogenital Diseases and Pregnancy Complications (15) · Obstetric Labor Complications (15) · Pregnancy Complications (15) · Urogenital Diseases (15) · Obstetric Labor, Premature (14) · Pathological Conditions, Signs and Symptoms (6) · Respiration Disorders (6) · Infections (5)
Budesonide (2) · montelukast (2) · Azithromycin (1) · Inhalation (1) · Interleukin 1 Receptor Antagonist Protein (1) · Positive-Pressure Respiration (1) · Saline Solution (1) · Stem Cell Transplantation (1) · Suspensions (1) · Therapeutics (1) · Umbilical Cord Clamping (1) · Uteroglobin (1) · Vitamin A (1) · caffeine citrate (1) · calfactant (1)
Children's Hospital of Chongqing Medical University (3) · Children's Hospital of Philadelphia (2) · NICHD Neonatal Research Network (2) · University of Alabama at Birmingham (2) · AdventHealth (1) · Airway Therapeutics, Inc. (1) · Children's Hospital Medical Center, Cincinnati (1) · Children's Hospital of Fudan University (1) · China Medical University Hospital (1) · Clarassance, Inc. (1) · Cynthia McEvoy (1) · Duke University (1) · EXO Biologics S.A. (1) · Erik Allen Jensen (1) · Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal (1)
United States (23) · China (5) · Canada (2) · Spain (2) · Taiwan (2) · United Kingdom (2) · Australia (1) · Belgium (1) · Italy (1) · New Zealand (1) · Poland (1) · South Korea (1) · Vietnam (1)
Zhou Fu (3) · Charles R. Bauer, MD (2) · Edward F. Donovan, MD (2) · Anna Thomas, MD (1) · Ariel A. Salas, MD, MSPH (1) · Avroy A. Fanaroff, MD (1) · Bai-Horng Su, MD, PhD (1) · Barbara J. Stoll, MD (1) · Beatrice De Vos, M.D., Ph.D. (1) · Boguslaw Machalinski, MD, PhD, BSc (1) · Charles V Smith, PhD (1) · Chen Chao, PhD,MD (1) · Claudia Nold, Prof (1)
PMID 24508444, PMID 10379020, PMID 15342835, PMID 15713907, PMID 15774846, PMID 23364976, PMID 26547399, PMID 26643677, PMID 29021519, PMID 30992220, PMID 32006953, PMID 34004189, PMID 36389766, PMID 37223507, PMID 37549675, PMID 37640809, PMID 39153779, PMID 39643111, PMID 41018057, PMID 9179535
M01RR008084 (2), U10HD021364 (2), U10HD021397 (2), U10HD027853 (2), U10HD034216 (2), M01RR000070 (1), M01RR000080 (1), M01RR000750 (1), M01RR000997 (1), M01RR006022 (1), M01RR016587 (1), R01HD113201 (1), R01NR010015 (1), R21HD116421 (1), R34HL183268 (1)