16 completed, 5 unknown, 2 active not recruiting. 10 Phase 2, 9 Phase 1, 3 Not applicable, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 7, Active not recruiting 2, Unknown 1 |
| Phase 1 | 9 | Completed 7, Unknown 2 |
| Not applicable | 3 | Completed 2, Unknown 1 |
| Phase 3 | 3 | Completed 3 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation Safety and Explore Efficacy Long-term Follow-up Study on Subjects Receiving SMUP-IA-01 or Active Control SMUP-IA-01(low-dose), SMUP-IA-01(mid-dose), High Hyal Plus - Knee Osteoarthritis | Phase 2 | Active not recruiting | Medipost Co Ltd. | 84 | 2023-03-20 | 2025-02-07 |
| Clinical Trial to Evaluate Efficacy and Safety of SMUP-IA-01 in Patients With Knee Osteoarthritis SMUP-IA-01(low dose), SMUP-IA-01(mid dose), Active Control Group Sodium chloride - Knee Osteoarthritis | Phase 2 | Completed | Medipost Co Ltd. | 94 | 2022-02-24 | 2025-02-05 |
| Exploratory Efficacy Study of NEUROSTEM® in Subjects Who Control Group of NEUROSTEM® human umbilical cord blood derived mesenchymal stem cells - Alzheimer's Disease | Not applicable | Unknown | Samsung Medical Center | 9 | 2021-07-12 | 2021-07-14 |
| Follow-up Safety and Efficacy Evaluation on Subjects Who Completed Phase I Clinical Trial SMUP-IA-01(low-dose), SMUP-IA-01(mid-dose), SMUP-IA-01(high-dose) - Knee Osteoarthritis | Phase 1 | Unknown | Medipost Co Ltd. | 12 | 2020-04-14 | 2023-03-15 |
| Efficacy and Safety of Allogenic Stem Cell Product(CARTISTEM®) for Osteochondral Lesion of Talus CARTISTEM®, Microfracture - Chondral or Osteochondral Lesion of Talus | Phase 3 | Completed | Hyundai Bioland Co., Ltd. | 102 | 2020-03-03 | 2022-11-29 |
| Evaluate Safety and Explore Efficacy of SMUP-IA-01 in Patients With Knee Osteoarthritis SMUP-IA-01(low-dose), SMUP-IA-01(mid-dose), SMUP-IA-01(high-dose) - Knee Osteoarthritis | Phase 1 | Completed | Medipost Co Ltd. | 12 | 2019-10-07 | 2021-02-24 |
| Follow-up Study of Safety and Efficacy in Subjects Who Completed PNEUMOSTEM® Phase II (MP-CR-012) Clinical Trial PNEUMOSTEM®, normal saline - Bronchopulmonary Dysplasia, BPD | Phase 2 | Active not recruiting | Medipost Co Ltd. | 60 | 2019-07-05 | 2025-02-07 |
| Hair Growth Efficacy and Safety of NGF-574H in Adult With Androgenic Alopecia conditioned media of umbilical cord blood-derived stem cells, Placebo - Androgenic Alopecia | Not applicable | Completed | Medipost Co Ltd. | 84 | 2018-10-02 | 2019-08-12 |
| PNEUMOSTEM for the Prevention and Treatment of Severe BPD in Premature Infants PNEUMOSTEM, Placebo - Severe Bronchopulmonary Dysplasia | Phase 2 | Completed | Medipost Co Ltd. | 60 | 2018-08-13 | 2025-01-24 |
| Follow-up Study of Safety and Efficacy in Subjects Who Completed NEUROSTEM® Phase-I/IIa Clinical Trial. human umbilical cord blood derived mesenchymal stem cells, Normal saline 2mL - Alzheimer's Disease | Phase 1 / Phase 2 | Completed | Medipost Co Ltd. | 36 | 2017-05-19 | 2023-03-15 |
| Safety and Efficacy of PNEUMOSTEM® in Premature Infants at High Risk for Bronchopulmonary Dysplasia (BPD) - a US Study Human Umbilical Cord Blood Derived-Mesenchymal Stem Cells - Bronchopulmonary Dysplasia | Phase 1 / Phase 2 | Completed | Medipost, Inc. | 12 | 2015-03-01 | 2018-08-16 |
| Long-term Safety and Efficacy Follow-up Study of PNEUMOSTEM® in Patients Who Completed PNEUMOSTEM® Phase-I Study PNEUMOSTEM - Bronchopulmonary Dysplasia, Respiratory Tract Infections | Completed | Medipost Co Ltd. | 8 | 2014-04-01 | 2018-09-04 | |
| Safety and Exploratory Efficacy Study of NEUROSTEM® Versus Placebo in Patients With Alzheimer's Disease human umbilical cord blood derived mesenchymal stem cells, Normal saline 2mL - Alzheimer's Disease | Phase 1 / Phase 2 | Completed | Medipost Co Ltd. | 46 | 2014-03-01 | 2020-08-28 |
| Follow-up Safety and Efficacy Evaluation on Subjects Who Completed PNEUMOSTEM® Phase-II Clinical Trial Pneumostem®, normal saline - Bronchopulmonary Dysplasia | Not applicable | Completed | Medipost Co Ltd. | 62 | 2014-01-01 | 2020-08-07 |
| Efficacy and Safety Evaluation of Pneumostem® Versus a Control Group for Treatment of BPD in Premature Infants Pneumostem®, Normal Saline - Bronchopulmonary Dysplasia | Phase 2 | Completed | Medipost Co Ltd. | 69 | 2013-04-01 | 2019-09-06 |
| Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect CARTISTEM, Microfracture - Degenerative Osteoarthritis, Defect of Articular Cartilage | Phase 3 | Completed | Medipost Co Ltd. | 103 | 2012-06-01 | 2017-04-20 |
| The Long-Term Safety and Efficacy Follow-Up Study of Subjects Who Completed the Phase I Clinical Trial of Neurostem®-AD NEUROSTEM®-AD - Alzheimer Disease, Dementia | Unknown | Duk Lyul Na | 14 | 2012-03-01 | 2012-10-01 | |
| Umbilical Cord Blood-derived Mesenchymal Stem Cells for the Treatment of Steroid-refractory Acute or Chronic Graft-versus-host-disease Human umbilical cord blood-derived mesenchymal stem cells - Graft-Versus-Host Disease, GVHD | Phase 1 / Phase 2 | Unknown | Samsung Medical Center | 30 | 2012-01-01 | 2012-03-16 |
| Follow-Up Study of Safety and Efficacy of Pneumostem® in Premature Infants With Bronchopulmonary Dysplasia Pneumostem® - Bronchopulmonary Dysplasia | Unknown | Samsung Medical Center | 9 | 2011-09-01 | 2019-04-09 | |
| The Safety and The Efficacy Evaluation of NEUROSTEM®-AD in Patients With Alzheimer's Disease Human Umbilical Cord Blood Derived-Mesenchymal Stem Cells - Dementia of the Alzheimer's Type | Phase 1 | Completed | Medipost Co Ltd. | 9 | 2011-02-01 | 2012-04-23 |
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Bronchopulmonary Dysplasia (8) · Premature Birth (7) · Alzheimer Disease (5) · Osteoarthritis, Knee (4) · Osteoarthritis (2) · Alopecia (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Dementia (1) · Graft vs Host Disease (1) · Hyperplasia (1) · Infant, Newborn, Diseases (1) · Infant, Premature, Diseases (1) · Joint Diseases (1) · Lung Diseases (1)
Saline Solution (5) · Arthroplasty, Subchondral (2) · Sodium Chloride (1)
South Korea (22) · United States (1)
Won-Soon Park, MD, PhD (3) · Ai-Rhan Kim, MD, PhD (2) · Hong-chul Lim, MD, PhD (2) · Myungchul Lee, MD, PhD (2) · Wonsoon Park, MD, PhD (2) · Ai-Rhan Kim (1) · Airhan Kim (1) · Beom-gu Lee, MD, PhD (1) · Chongbum Chang, MD, PhD (1) · Chonghyuk Choi, MD, PhD (1) · Choong-hyuk Choi, MD, PhD (1) · Chul-won Ha, MD, PhD (1) · Duk L. Na, M.D. (1) · Duk L. Na, MD, PhD (1)
PMID 41220869, PMID 29854930, PMID 33490296, PMID 33876883, PMID 34521461, PMID 24508444, PMID 28341525, PMID 30992220, PMID 37468918, PMID 37604693, PMID 41814444