107 completed, 33 unknown, 23 recruiting, 15 terminated. 75 Not applicable, 17 Phase 2, 10 Phase 3, 8 Phase 1, 7 Phase 4.
Follow this condition Literature Review of Coma trials Research Report on Coma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sodium Lactate in Severe TBI Sodium Lactate, placebo - Traumatic Brain Injury | Phase 2 | Not yet recruiting | University of California, Los Angeles | 264 | 2028-01-10 | 2026-01-16 |
| Miniature In-line Respirator Hope inVent - Brain Death, Respiration, Artificial | Not applicable | Not yet recruiting | National Institutes of Health Clinical Center (CC) | 5 | 2026-10-26 | 2026-10-21 |
| Efficacy of High-Flow Humidified Oxygen (HFHO) in Apneic Oxygenation for Apnea Testing: A Comparison With Continuous Positive Airway Pressure (CPAP) Apnea test under HHFO followed by an apnea test under CPAP., Apnea test under CPAP followed by an apnea test under HHFO. - Death, Brain | Not applicable | Not yet recruiting | Centre Hospitalier Régional d'Orléans | 28 | 2026-09-15 | 2026-07-10 |
| Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP) Consciousness Disorders, Persistent Vegetative State | Not yet recruiting | Nicosia General Hospital | 40 | 2026-09-15 | 2026-07-30 | |
| Kinetics and Prognostic Value of NeuroFilament Light in Post-cardiac Arrest: A Prospective Multicenter Study Value of neurofilament light chain (NFL) at different time points - Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 270 | 2026-09-01 | 2026-08-12 | |
| Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence Terminal Illness, End-of-Life Care | Not yet recruiting | Noah Tech, Corp. | 20 | 2026-09-01 | 2026-03-17 | |
| NEURO - Prognostication Using Late Somatosensory Evoked - Potentials EEGs - Comatose, Prognosis | Not applicable | Not yet recruiting | University Hospital, Bordeaux | 50 | 2026-06-30 | 2026-04-02 |
| Vagus Nerve Stimulation in Patients in Comatose State Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS) - Traumatic Brain Injury, Severe Traumatic Brain Injury | Not applicable | Recruiting | Sima Mofakham | 10 | 2026-06-26 | 2026-07-22 |
| Promoting Recovery After Brain Injury Using Focused Ultrasound Low-intensity focused ultrasound - Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury | Not applicable | Recruiting | Massachusetts General Hospital | 36 | 2026-05-26 | 2026-06-15 |
| fNIRS for Disorders of Consciousness Functional Near-Infrared Spectroscopy Monitoring - Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness | Recruiting | University of California, Los Angeles | 55 | 2026-05-01 | 2026-06-08 | |
| The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury Coma Family Program 1, Coma Family Program 2 - Caregiver Distress, Emotional Distress | Not applicable | Not yet recruiting | Massachusetts General Hospital | 150 | 2026-05-01 | 2026-02-20 |
| SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury SeeMe Multimodal Auditory Command Protocol - Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury | Not applicable | Recruiting | Stony Brook University | 80 | 2026-03-30 | 2026-05-05 |
| Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac Arrest advanced whole-brain sMRI/fMRI/contrast-enhanced MRI scan - Coma, Cardiac Arrest | Not applicable | Recruiting | University Hospital, Toulouse | 263 | 2026-03-16 | 2026-06-29 |
| Palpatory and Ultrasonographic Assessment of Tissue Compressibility: Validation and Learning Effects in Phantom Models Ultrasonographic Compression Measurment and Palpation of Standardized Phantom Models - Exanimation, Diagnostic Ultrasound | Active not recruiting | Insel Gruppe AG, University Hospital Bern | 40 | 2026-01-31 | 2026-04-17 | |
| CT-Angiography Versus Angiogram as Ancillary Tests in the Determination of Death by Neurologic Criteria Infarction, Brain | Recruiting | Region Stockholm | 50 | 2026-01-01 | 2026-03-17 | |
| Assessment of Structural Brain Changes Related to Anoxic Coma Using High-field and Very Low Field Mobile MRI High-field and very-low-field MRI acquisitions - Anoxic Coma, Cardiac Arrest (CA) | Not applicable | Not yet recruiting | University Hospital, Toulouse | 60 | 2025-09-15 | 2025-09-17 |
| Vagal Nerve Stimulation to Treat Disorders of Consciousness stimulated group, Sham (No Treatment) - Disorder of Consciousness | Not applicable | Not yet recruiting | Fondazione IRCCS San Gerardo dei Tintori | 106 | 2025-09-01 | 2025-07-22 |
| Family-Centered Affective Stimulation for Patients With Traumatic Brain Injury: Its Effects on Coma Recovery Family-Centered Affective Stimulation (FCAS) - Patients With Traumatic Brain Injury, Coma, Traumatic | Not applicable | Completed | Cairo University | 120 | 2025-05-02 | 2026-06-04 |
| The Safety and Efficacy of Median Nerve Electrical Stimulation for Improving Neurological Function Prognosis in Patients With Cardiac Arrest MNS, Sham stimulation - Median Nerve, Coma | Not applicable | Not yet recruiting | Tang Ziren | 400 | 2025-05-01 | 2025-04-11 |
| Ultrasound Stimulation for Patients in a Disorder of Consciousness The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain. - Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury | Not applicable | Recruiting | University of California, Los Angeles | 60 | 2025-04-26 | 2026-05-22 |
Showing 20 of 205. Sign in to see all of them.
Brain Death (71) · Brain Injuries, Traumatic (31) · Consciousness Disorders (26) · Heart Arrest (25) · Brain Injuries (22) · Persistent Vegetative State (22) · Stroke (12) · Hypoxia-Ischemia, Brain (9) · Hypoxia, Brain (8) · Critical Illness (7) · Hypothermia (7) · Respiratory Insufficiency (7) · Coma, Post-Head Injury (6) · Shock (6)
Neurobehavioral Manifestations (205) · Neurologic Manifestations (204) · Nervous System Diseases (203) · Pathological Conditions, Signs and Symptoms (203) · Unconsciousness (202) · Consciousness Disorders (179) · Signs and Symptoms (139) · Central Nervous System Diseases (134) · Brain Diseases (132) · Pathologic Processes (101) · Death (70) · Cardiovascular Diseases (56) · Wounds and Injuries (45) · Craniocerebral Trauma (43)
Sodium Chloride (5) · Hypothermia, Induced (4) · Thyroxine (4) · Amantadine (3) · Ultrasonography, Doppler, Transcranial (3) · Blood Specimen Collection (2) · Cytidine Triphosphate (2) · Drug Delivery Systems (2) · Flumazenil (2) · Magnetic Resonance Imaging (2) · Minocycline (2) · Naloxone (2) · Standard of Care (2) · 5,10-dihydro-5-methylphenazine (1) · 8-((E)-4-fluoro-but-2-enyl)-3beta-p-tolyl-8-aza-bicyclo(3.2.1)octane-2beta-carboxylic acid methyl ester (1)
Assistance Publique - Hôpitaux de Paris (10) · Massachusetts General Hospital (6) · Hospices Civils de Lyon (4) · University Hospital, Basel, Switzerland (4) · Life Recovery Systems (3) · University Hospital, Bordeaux (3) · University Hospital, Toulouse (3) · University of California, Los Angeles (3) · Azienda Ospedaliera San Gerardo di Monza (2) · Brno University Hospital (2) · Central Hospital, Nancy, France (2) · Centre Hospitalier Régional d'Orléans (2) · Chinese Academy of Medical Sciences (2) · Helsinki University Central Hospital (2) · Hospital de Clinicas de Porto Alegre (2)
United States (45) · France (44) · China (14) · Canada (11) · Turkey (Türkiye) (11) · Brazil (8) · Italy (8) · Switzerland (8) · Netherlands (5) · Denmark (4) · Germany (4) · Belgium (3) · Egypt (3) · Sweden (3) · Argentina (2)
Ognjen Gajic, MD (2) · Rajat Dhar, MD (2) · Alain Cariou, MD, PhD (1) · Alberto Addis, MD (1) · Alex Topjian, MD (1) · Alison Fox-Robichaud, MD (1) · Amy Wagner, M.D. (1) · Andrea O Rossetti, MD (1) · Andreas Bender, MD (1) · Andrew J Mannes, M.D. (1) · Angela Morreale, MD (1) · Anna-Maija Antman, MD (1) · Anne Julie Frenette, M.Sc (1) · Anqi Wang (1)
PMID 19954851, PMID 21156950, PMID 21876461, PMID 22224835, PMID 27567470, PMID 28901969, PMID 37178149, PMID 10390410, PMID 10634801, PMID 10798503, PMID 10869046, PMID 11498461, PMID 12243491, PMID 12425407, PMID 12478412, PMID 12625169, PMID 12625171, PMID 12637700, PMID 12709114, PMID 1447002, PMID 14526234, PMID 15016135, PMID 15913465, PMID 16178024, PMID 16186047, PMID 16306057, PMID 16350986, PMID 16424709, PMID 16552208, PMID 16568810, PMID 16733422, PMID 16799075, PMID 16953990, PMID 17275466, PMID 17387118, PMID 17579950, PMID 17643226, PMID 17671503, PMID 18636057, PMID 18856250, PMID 19145262, PMID 19150228, PMID 19232208, PMID 19406767, PMID 19556415, PMID 19565357, PMID 19566636, PMID 19597668, PMID 19857731, PMID 20220416
2017 (2), R61MH138612 (2), 1UG3HL159134-01 (1), 2014 (1), 2019 (1), 2023 (1), DP2HD101400 (1), K23AG066929 (1), K23NS136745 (1), K23NS140495 (1), R01NS102176 (1), R01NS128342 (1), U01AI126610 (1), U01NS073476 (1), U24HL159132 (1)