25 completed, 12 unknown, 7 terminated, 5 withdrawn. 29 Not applicable, 13 Phase 2, 9 Phase 3, 2 Phase 1, 1 Phase 4.
Follow this drug Literature Review of Hypothermia, Induced trials Research Report on Hypothermia, Induced
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Targeted Hypothermia Versus Targeted Normothermia After Convulsive Refractory Status Epilepticus Targeted Hypothermia - Convulsive Refractory Status Epilepticus, Status Epilepticus | Phase 3 | Not yet recruiting | Versailles Hospital | 466 | 2026-03-01 | 2026-02-10 |
| Targeted Temperature Management in Acute Ischemic Stroke Targeted Temperature Management with CB240_Aurora, Standard of care Temperature treatment - Ischemic Stroke | Not applicable | Recruiting | Azienda Usl di Bologna | 22 | 2025-09-11 | 2025-09-17 |
| Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy in Vietnam Therapeutic Hypothermia - Hypoxic-ischemic Encephalopathy (HIE) | Not applicable | Recruiting | National Children's Hospital, Vietnam | 120 | 2025-06-10 | 2026-04-29 |
| Proteomic Analysis of Serum Samples After Cardiac Arrest: a TTM-trial Substudy Proteomic analysis, targeted temperature management - Cardiac Arrest (CA), Proteomics | Active not recruiting | Region Skane | 682 | 2025-05-22 | 2026-04-28 | |
| The Long-term Consequences of Neonatal Encephalopathy in the Hypothermia Era Therapeutic hypothermia - Neonatal Encephalopathy, Therapeutic Hypothermia | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 198 | 2023-11-01 | 2023-10-23 | |
| Safety and Efficacy of Therapeutic Hypothermia in Acute Ischemic Stroke Therapeutic hypothermia - Stroke, Ischemic | Not applicable | Unknown | RenJi Hospital | 252 | 2023-05-01 | 2023-03-22 |
| Effects of Induced Moderate Hypothermia on ARDS Patients Under Venovenous ExtraCorporeal Membrane Oxygenation Moderate Hypothermia, Normothermia - ARDS, Human, Extracorporeal Membrane Oxygenation Complication | Not applicable | Unknown | Central Hospital, Nancy, France | 30 | 2022-09-01 | 2022-04-01 |
| Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP) Therapeutic Hypothermia - Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced | Not applicable | Recruiting | University of Michigan | 900 | 2022-08-05 | 2026-10-14 |
| Adjunct Targeted Temperature Management in Acute Severe Carbon Monoxide Poisoning Targeted therapeutic hypothermia, Targeted therapeutic normothermia - Carbon Monoxide Poisoning, Neurologic Sequelae | Not applicable | Completed | Wonju Severance Christian Hospital | 37 | 2021-10-25 | 2026-04-28 |
| Trial of Therapeutic Hypothermia in Patients With ARDS Hypothermia, Neuromuscular Blocking Agents, Standard of care - Respiratory Distress Syndrome, Adult | Phase 2 | Active not recruiting | University of Maryland, Baltimore | 340 | 2021-06-29 | 2026-09-09 |
| CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort) Cardiac MRI, Hyperbaric oxygen therapy - Carbon Monoxide Poisoning, Myocardial Injury | Recruiting | Wonju Severance Christian Hospital | 1500 | 2020-07-29 | 2024-07-23 | |
| Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients Therapeutic Hypothermia - Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced | Not applicable | Completed | University of Michigan | 1158 | 2020-05-18 | 2026-07-15 |
| TIME Study: Therapeutic Hypothermia for Infants With Mild Encephalopathy Therapeutic Hypothermia, Normothermia - Hypoxic-Ischemic Encephalopathy Mild, Neonatal Encephalopathy | Not applicable | Unknown | Stanford University | 68 | 2020-05-01 | 2020-03-18 |
| Optimising the Duration of Cooling in Mild Encephalopathy Therapeutic hypothermia - Neonatal Encephalopathy, Hypothermia Neonatal | Not applicable | Unknown | Thayyil, Sudhin | 140 | 2019-10-10 | 2023-08-04 |
| Hypothermia After Cardiac Arrest - Effects on Myocardial Function and Inflammatory Response. Targeted temperature management, Standard care, early treatment of fever - Out of Hospital Cardiac Arrest, Inflammatory Response | Not applicable | Completed | Oslo University Hospital | 26 | 2018-11-08 | 2021-09-20 |
| Mild Hypothermia and Acute Kidney Injury in Liver Transplantation Esophageal cooling/warming device, Mild hypothermia, Normothermia - Cirrhosis, End Stage Liver Disease | Not applicable | Terminated | University of California, San Francisco | 175 | 2018-07-07 | 2025-05-16 |
| TaIwan Network of Targeted Temperature ManagEment for CARDiac Arrest Registry (TIMECARD) targeted temperature management - Cardiac Arrest, Targeted Temperature Management | Unknown | National Taiwan University Hospital | 800 | 2018-06-01 | 2020-06-23 | |
| Pilot RCT of Therapeutic Hypothermia Plus Neuromuscular Blockade in COVID-19 Patients With ARDS Hypothermia, Neuromuscular Blocking Agents, Standard of Care - Respiratory Distress Syndrome, Adult, Sars-CoV2 | Phase 2 | Withdrawn | University of Maryland, Baltimore | 2018-05-01 | 2021-04-30 | |
| Therapeutic Hypothermia in "Expanded Criteria" Brain-dead Donors and Kidney-graft Function Procedure control: normothermia, Procedure active - Organ Donor, Brain Death | Not applicable | Completed | Nantes University Hospital | 532 | 2017-11-08 | 2026-09-14 |
| Improvement of Perioperative Care of Elderly Patients Systematic inclusion of family members, Preoperative information, Physical and breathing exercises - Perioperative Care | Not applicable | Completed | Universitätsklinikum Hamburg-Eppendorf | 310 | 2017-11-01 | 2021-05-18 |
Showing 20 of 57. Sign in to see all of them.
Hypothermia (20) · Heart Arrest (16) · Hypoxia-Ischemia, Brain (9) · Out-of-Hospital Cardiac Arrest (7) · Ischemic Stroke (6) · Brain Diseases (3) · Brain Injuries, Traumatic (3) · Coma (3) · Respiratory Distress Syndrome (3) · Acute Kidney Injury (2) · Carbon Monoxide Poisoning (2) · Cerebral Hemorrhage (2) · Post-Cardiac Arrest Syndrome (2) · Seizures (2) · Shock, Cardiogenic (2)
University of Aarhus (4) · University of Michigan (4) · Assistance Publique - Hôpitaux de Paris (2) · Central Hospital, Nancy, France (2) · Thayyil, Sudhin (2) · University of California, San Francisco (2) · University of Maryland, Baltimore (2) · WellStar Health System (2) · Wonju Severance Christian Hospital (2) · Australia and New Zealand Intensive Care Society (1) · Azienda Usl di Bologna (1) · Bayside Health (1) · C. R. Bard (1) · Centre Hospitalier Departemental Vendee (1) · Centre Hospitalier Universitaire, Amiens (1)
United States (21) · Canada (8) · France (8) · United Kingdom (6) · Australia (5) · Denmark (5) · Germany (4) · South Korea (4) · Italy (3) · New Zealand (3) · Norway (3) · India (2) · Austria (1) · Belgium (1) · China (1)
Frank Moler, MD (2) · Jeffrey D Hasday, MD (2) · Rishi Gupta, MD (2) · Seetha Shankaran, MD (2) · Sudhin Thayyil, PhD (2) · Yong Sung Cha, MD (2) · Abbot R. Laptook, MD (1) · Abhik Das, PhD (1) · Ahmed F Hegazy, MD, FRCPC (1) · Alex Topjian, MD (1) · Ana Igric, MD, FRCSC (1) · Andrea Zini (1) · Anni Norgaard Jeppesen, MD (1) · Balraj Guhan, MD (1)
PMID 19451846, PMID 19455024, PMID 20935561, PMID 23295834, PMID 23842585, PMID 25268768, PMID 29884735, PMID 30922934, PMID 12165594, PMID 16221780, PMID 17079582, PMID 18534246, PMID 18720323, PMID 18762517, PMID 18829776, PMID 19020525, PMID 19252411, PMID 19854555, PMID 19948631, PMID 20921569, PMID 21169065, PMID 22646631, PMID 22839656, PMID 22950861, PMID 23584469, PMID 23664370, PMID 24019415, PMID 24105303, PMID 24524452, PMID 25447805, PMID 25466837, PMID 25882712, PMID 25913022, PMID 25923575, PMID 26387012, PMID 26940987, PMID 27142588, PMID 27325409, PMID 27737774, PMID 27776752, PMID 27894327, PMID 28002714, PMID 28118559, PMID 28602694, PMID 28742911, PMID 29305927, PMID 29325753, PMID 29370008, PMID 29637198, PMID 30026282
1UG3HL159134-01 (1), M01RR000030 (1), M01RR000039 (1), M01RR000044 (1), M01RR000070 (1), M01RR000080 (1), M01RR000633 (1), M01RR000750 (1), M01RR006022 (1), M01RR007122 (1), M01RR008084 (1), M01RR016587 (1), U01HL094339 (1), U01HL094345 (1), U01NS073476 (1)