47 completed, 15 unknown, 11 recruiting, 5 not yet recruiting. 40 Not applicable, 10 Phase 2, 5 Phase 1, 3 Phase 3, 2 Phase 4.
Follow Persistent Vegetative State: new trials by email Literature Review of Persistent Vegetative State trials Research Report on Persistent Vegetative State
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness AI-Assisted Personalized Hyperbaric Oxygen Therapy, Conventional Hyperbaric Oxygen Therapy - Disorders of Consciousness, Vegetative State | Not applicable | Not yet recruiting | Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd. | 200 | 2026-12-01 | 2026-10-02 |
| Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP) Consciousness Disorders, Persistent Vegetative State | Not yet recruiting | Nicosia General Hospital | 40 | 2026-09-15 | 2026-07-30 | |
| Temporal Interference Stimulation for Disorders of Consciousness Temporal Interference - Disorder of Consciousness, Minimally Conscious State | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Liege | 4 | 2026-09-01 | 2026-10-19 |
| Promoting Recovery After Brain Injury Using Focused Ultrasound Low-intensity focused ultrasound - Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury | Not applicable | Recruiting | Massachusetts General Hospital | 36 | 2026-05-26 | 2026-06-15 |
| fNIRS for Disorders of Consciousness Functional Near-Infrared Spectroscopy Monitoring - Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness | Recruiting | University of California, Los Angeles | 55 | 2026-05-01 | 2026-06-08 | |
| Auditory Processing in DOC Patients Coma Recovery Scale-Revised (CRS-R), Electroencephalography (EEG) - Disorder of Consciousness, Unresponsive Wakefulness Syndrome | Not yet recruiting | BDH-Klinik Hessisch Oldendorf | 42 | 2026-04-15 | 2026-03-06 | |
| Effectiveness of tTIs for Improving Consciousness in Patients With DoC Theta-burst Patterned Temporal Interference Stimulation (tTIs), Sham Temporal Interference Stimulation - Disorders of Consciousness, Vegetative State | Not applicable | Recruiting | Zhujiang Hospital | 136 | 2026-03-08 | 2026-04-20 |
| Assessment of Consciousness With CRS-R and SECONDs Simplified Evaluation of CONsciousness Disorders (SECONDs), Coma Recovery Scale-Revised (CRS-R) - Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State | Recruiting | BDH-Klinik Hessisch Oldendorf | 110 | 2026-02-01 | 2026-03-11 | |
| Neurorehabilitation in Patients With Disorders of Consciousness: Multidimensional Ambispective Study on the Impact of Single and Combined Approaches Multidisciplinary neurorehabilitation - Disorder of Consciousness | Recruiting | IRCCS Centro Neurolesi Bonino Pulejo | 140 | 2026-01-16 | 2026-05-27 | |
| Neurological and Physiological Effects of Animal-assisted Therapy for Patients in a Minimally Conscious State Animal Assisted Occupational Therapy - Minimally Conscious State | Not applicable | Recruiting | University of Basel | 26 | 2025-07-08 | 2025-12-18 |
| Ultrasound Stimulation for Patients in a Disorder of Consciousness The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain. - Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury | Not applicable | Recruiting | University of California, Los Angeles | 60 | 2025-04-26 | 2026-05-22 |
| Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness tTIS - Disorders of Consciousness, Severe Brain Injury | Not applicable | Recruiting | Xijing Hospital | 10 | 2025-04-07 | 2025-04-09 |
| Characterization of the Sleep-Wake Cycle in Traumatic Brain Injury Patients with a Disorder of Consciousness Actimetry, Subjective assessments, questionnaire - Trauma, Nervous System, Brain Trauma | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 40 | 2025-02-01 | 2025-01-09 |
| Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU Repeated behavioral assessments, functional electroencephalography and brain imagery, TMS-EEG - Consciousness Disorders | Not applicable | Recruiting | Massachusetts General Hospital | 120 | 2024-11-08 | 2025-05-15 |
| mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness mindBEAGLE daily device use - Disorders of Consciousness | Not applicable | Enrolling by invitation | Amy Wagner | 40 | 2024-10-01 | 2026-06-04 |
| Antiseizure Medication in Seizure Networks at Early Acute Brain Injury Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product - Brain Injuries, Acute, Brain Injuries, Traumatic | Phase 4 | Terminated | University of North Carolina, Chapel Hill | 5 | 2023-11-20 | 2025-11-14 |
| Survival and Predictive Factors of Clinical Outcome in Patients With Acquired Brain Injury Acquired Brain Injury | Completed | Charles University, Czech Republic | 211 | 2023-08-28 | 2024-02-07 | |
| Window On the Brain Ultrasound technique for diagnosis; Focused Ultrasound Stimulation for intervention - Disorders of Consciousness | Not applicable | Completed | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 100 | 2023-05-20 | 2026-07-01 |
| Prognostication of Recovery in Early Disorders of Consciousness Study Functional MRI (fMRI) - Disorder of Consciousness, Comatose | Not applicable | Enrolling by invitation | University of Pennsylvania | 150 | 2023-03-08 | 2026-07-30 |
| Brain Network Characteristics in Patients With Disorders of Consciousness PET-fMRI-EEG - Disorders of Consciousness | Unknown | Xijing Hospital | 40 | 2022-09-01 | 2022-09-28 |
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Consciousness Disorders (62) · Coma (22) · Brain Injuries, Traumatic (21) · Brain Injuries (20) · Stroke (8) · Hypoxia, Brain (5) · Cognitive Dysfunction (3) · Hypoxia-Ischemia, Brain (3) · Disease (2) · Hypoxia (2) · Locked-In Syndrome (2) · Trauma, Nervous System (2) · Akinetic Mutism (1) · Brain Diseases (1)
Brain Damage, Chronic (87) · Neurobehavioral Manifestations (87) · Neurologic Manifestations (87) · Pathological Conditions, Signs and Symptoms (87) · Signs and Symptoms (87) · Brain Diseases (86) · Central Nervous System Diseases (86) · Nervous System Diseases (86) · Unconsciousness (86) · Mental Disorders (63) · Neurocognitive Disorders (63) · Craniocerebral Trauma (33) · Wounds and Injuries (32) · Trauma, Nervous System (31) · Consciousness Disorders (25)
Transcranial Direct Current Stimulation (13) · Apomorphine (3) · Sodium Chloride (3) · Transcranial Magnetic Stimulation (3) · Amantadine (2) · Animal Assisted Therapy (2) · Magnetic Resonance Imaging (2) · Rehabilitation (2) · Surveys and Questionnaires (2) · Congresses as Topic (1) · Dexmedetomidine (1) · Diagnosis (1) · Diagnostic Imaging (1) · Eye-Tracking Technology (1) · Flumazenil (1)
Hangzhou Normal University (11) · University of Liege (10) · Hospices Civils de Lyon (5) · Xijing Hospital (4) · BDH-Klinik Hessisch Oldendorf (2) · Hadassah Medical Organization (2) · Hospitales Nisa (2) · Jing Wang (2) · Massachusetts General Hospital (2) · University of Basel (2) · University of California, Los Angeles (2) · Amy Wagner (1) · AssisTech Sp. z o.o. (1) · Assistance Publique - Hôpitaux de Paris (1) · Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd. (1)
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2019 (1), K23NS136745 (1), K23NS140495 (1), R01NS138257 (1)