89 completed, 26 unknown, 12 recruiting, 10 not yet recruiting. 41 Phase 4, 39 Not applicable, 26 Phase 2, 25 Phase 3, 19 Phase 1.
Follow Thyroxine: new trials by email Literature Review of Thyroxine trials Research Report on Thyroxine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Discontinuation of Low-Dose Levothyroxine in Older Adults With Subclinical Hypothyroidism Levothyroxine Pill, Placebo - Hypothyroidism | Phase 4 | Not yet recruiting | Spyridoula Maraka | 138 | 2027-10-01 | 2026-08-26 |
| COACH - Comparing Two Different Methods to Suppress Thyrotropin in Patients With Advanced Thyroid Cancer Levothyroxine Oral Tablet [Synthroid] - Advanced Differentiated Thyroid Gland Carcinoma | Phase 2 | Not yet recruiting | AHS Cancer Control Alberta | 70 | 2026-12-01 | 2026-02-06 |
| T4/T3 Therapy in Hypothyroidism Liothyronine (L-T3), Levothyroxine Sodium (LT4) Tablets, Liothyronine (LT3) placebo - Hypothyroidism Primary | Phase 2 | Not yet recruiting | University of Pennsylvania | 60 | 2026-11-01 | 2026-08-20 |
| Thyroid Hormone Replacement After Radio Iodine: Value and Efficacy Euthyrox (levothyroxine), Cytomel (liothyronine) - Differentiated Thyroid Cancer, Thyroid Cancer | Not yet recruiting | University Medical Center Groningen | 40 | 2026-09-01 | 2026-02-10 | |
| Thyroxine Supplementation in Small for Gestational Age (SGA) Infants With Birth Weight <1500g and TSH 6-20 mIU/ml Levothyroxine Sodium (LT4) Tablets - Thyroid Function, Preterm | Not applicable | Not yet recruiting | Shandong Provincial Hospital | 106 | 2026-06-20 | 2026-06-04 |
| Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletes Testosterone Enanthate, Testosterone Cypionate, Testosterone Propionate - Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes | Not applicable | Enrolling by invitation | Enhanced Emirates Limited | 60 | 2026-03-12 | 2026-05-06 |
| Desiccated Thyroid Extract Combined With Levothyroxine for TSH Suppression Therapy in DTC desiccated thyroid extract (DTE)+levothyroxine (L-T4) - Intermediate-to-High Risk Differentiated Thyroid Cancer | Phase 3 | Not yet recruiting | West China Hospital | 646 | 2025-11-30 | 2025-11-20 |
| Levothyroxine as Adjuvant to a Hypocaloric Diet for the Treatment of Obesity. Levothyroxine, Placebo - Obesity | Phase 3 | Recruiting | Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud | 286 | 2025-11-05 | 2026-01-12 |
| Levothyroxine Dosing in Neonatal Congenital Hypothyroidism Levothyroxine - Congenital Hypothyroidism | Phase 4 | Completed | Menoufia University | 101 | 2025-11-02 | 2026-08-10 |
| Comparison of Two Timings of Levothyroxine Intake in Hypothyroid Patients: A Cross-over Randomized Control Trial Levothyroxine Pill - Hypothyroidism Primary | Phase 4 | Active not recruiting | Elyes Kamoun | 102 | 2025-07-24 | 2026-10-28 |
| A Clinical Trial of Adjunctive Thyroxine for Avolition in Schizophrenia Antipsychotics plus Levothyroxine Sodium, Antipsychotics plus Placebo - Schizophrenia, Avolition | Early Phase 1 | Not yet recruiting | Peking University | 90 | 2025-07-01 | 2025-06-10 |
| Necessity of TSH Suppression Therapy in Active Surveillance for Thyroid Cancer Patients. Levothyroxin - Thyroid Cancer, Papillary Thyroid Carcinoma | Not applicable | Not yet recruiting | National Cancer Center, Korea | 578 | 2025-06-02 | 2025-05-14 |
| LIGHT Trial: Levothyroxine for Gestational Hypothyroidism in Recurrent Pregnancy Loss Levothyroxin, Placebo - Abortion, Habitual | Phase 3 | Not yet recruiting | Women's Hospital School Of Medicine Zhejiang University | 200 | 2025-06-01 | 2025-06-04 |
| Levothyroxine Treatment on Cardiac Function in Children With Subclinical Hypothyroidism L-thyroxine - Levothyroxine, Cardiac Function | Not applicable | Recruiting | Tanta University | 40 | 2025-05-24 | 2026-02-06 |
| Novel Approaches to the Treatment of Hypothyroidism Levothyroxine, Levothyroxine/Liothyronine once daily, Levothyroxine/Liothyronine twice daily - Hypothyroidism | Phase 2 / Phase 3 | Recruiting | UConn Health | 90 | 2024-12-10 | 2026-03-19 |
| Role of Levothyroxine Supplementation in Delayed Recovery Following Cardiac Surgery L-thyroxine, Placebo Oral Tablet - Cardiac Surgery Intensive Care Treatment, Delayed Recovery From Anaesthesia | Phase 3 | Completed | Ain Shams University | 70 | 2024-11-30 | 2025-08-17 |
| Effect of HCQ Combined With LT4 on LBR in Euthyroid Women With URPL and TPO-Ab hydroxychloroquine and levothyroxine, Levothyroxine - Recurrent Pregnancy Loss, Euthyroid With Thyroid Antibodies | Not applicable | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 796 | 2024-11-15 | 2026-09-30 |
| Levothyroxine Intervention in Pregnant Women with TSH （2.5 MIU/L-upper Limit of Reference Range） and Negative Thyroid Peroxidase Antibody Levothyroxine Sodium (LT4) Tablets, Placebo - Thyroid Abnormalities, Pregnant Woman | Phase 4 | Not yet recruiting | Yang ZHANG | 400 | 2024-10-25 | 2024-10-23 |
| A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028) Levothyroxine, Enlicitide Decanoate - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 28 | 2024-07-08 | 2024-10-03 |
| A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants Armour Thyroid, Levothyroxine - Hypothyroidism | Phase 2 / Phase 3 | Active not recruiting | AbbVie | 2701 | 2024-04-26 | 2026-10-13 |
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Hypothyroidism (59) · Thyroid Diseases (19) · Thyroid Neoplasms (9) · Congenital Hypothyroidism (6) · Atherosclerosis (4) · Brain Death (4) · Heart Failure (4) · Insulin Resistance (4) · Diabetes Mellitus (3) · Dyslipidemias (3) · Endocrine System Diseases (3) · Euthyroid Sick Syndromes (3) · Goiter (3) · Graves Disease (3) · Hypopituitarism (3)
Insel Gruppe AG, University Hospital Bern (6) · Ain Shams University (4) · Mylan Pharmaceuticals Inc (4) · Shandong Provincial Hospital (3) · University of Pennsylvania (3) · Azienda USL Modena (2) · Chinese Academy of Medical Sciences, Fuwai Hospital (2) · Heidelberg University (2) · Herlev Hospital (2) · IBSA Institut Biochimique SA (2) · Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany (2) · Newcastle-upon-Tyne Hospitals NHS Trust (2) · Poznan University of Physical Education (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · University of Aarhus (2)
United States (50) · China (17) · Germany (9) · Egypt (8) · Italy (6) · Switzerland (6) · Denmark (5) · Netherlands (4) · Canada (3) · France (3) · Mexico (3) · United Kingdom (3) · Brazil (2) · India (2) · Poland (2)
Nicolas Rodondi, MD MAS (5) · James D Carlson, Pharm. D. (3) · Jacobijn Gussekloo, MD (2) · Ahmed M Sayed, Prof. (1) · Alan K Copa, Pharm. D. (1) · Alex Tessnow, MD (1) · Alice P Chen, M.D. (1) · Andrea Kelly, MD, MSCE (1) · Andrea M Isidori, MD, PhD (1) · Angeliki M Stamatouli, MD (1) · Anne Julie Frenette, M.Sc (1)
PMID 31702015, PMID 35381390, PMID 36721961, PMID 11172193, PMID 11580992, PMID 14749496, PMID 15247962, PMID 16205094, PMID 16275864, PMID 16984248, PMID 17433800, PMID 17711927, PMID 17932107, PMID 17964598, PMID 18407156, PMID 19581264, PMID 19682539, PMID 20427509, PMID 20447070, PMID 20463094, PMID 21190974, PMID 21411559, PMID 21424182, PMID 21568669, PMID 21586104, PMID 21765997, PMID 21865366, PMID 22134702, PMID 23124142, PMID 23264396, PMID 23448784, PMID 23585666, PMID 23773982, PMID 23884915, PMID 24157158, PMID 24345793, PMID 24423358, PMID 24951271, PMID 24969506, PMID 25036648, PMID 26700485, PMID 27338133, PMID 27766119, PMID 28158982, PMID 28249134, PMID 28402245, PMID 28460140, PMID 28473851, PMID 28548569, PMID 28853052
2015 (2), 2005 (1), 2014 (1), 2017 (1), I01CX002436 (1), K24AG042765 (1), R01AG081698 (1), R01DK137207 (1), R01HD071981 (1), R03DK114642 (1), R21DK122310 (1), R21NS095723 (1), U10HD021410 (1), U10HD027860 (1), U10HD027869 (1)