154 completed. 154 Phase 2, 20 Phase 1, 17 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 154 | Completed 154 |
| Phase 1 | 20 | Completed 20 |
| Phase 3 | 17 | Completed 17 |
Follow Tobacco Use Disorder: new trials by email Literature Review of Tobacco Use Disorder trials Research Report on Tobacco Use Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study Assessing Efficacy and Safety of NFL-101 on Reduction of Reinforcing Properties of Cigarettes (PRECESTO) NFL-101, Placebo - Smoking Cessation, Nicotine Dependence | Phase 2 | Completed | NFL Biosciences SAS | 34 | 2023-02-21 | 2023-10-19 |
| Effects of Semaglutide on Nicotine Intake Semaglutide, Sham/placebo - Tobacco Use Disorder, Nicotine Addiction | Phase 2 | Completed | University of North Carolina, Chapel Hill | 24 | 2022-10-07 | 2025-08-22 |
| Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties Coaching calls, Nicotine replacement therapy, Financial Incentives - Cigarette Smoking, Nicotine Dependence | Phase 2 | Completed | University of Oklahoma | 165 | 2022-03-09 | 2024-12-30 |
| CO Monitoring for Tobacco Cessation in Quitlines Quitline Treatment as Usual (TAU), Remote Carbon Monoxide (CO) Monitoring, Incentivized Remote CO Monitoring - Tobacco Dependence | Phase 1 / Phase 2 | Completed | Consumer Wellness Solutions | 229 | 2021-12-31 | 2024-10-28 |
| UW Withdraw From Tobacco Study Combination nicotine replacement therapy (Nicotine patch + nicotine mini-lozenge) - Tobacco Dependence | Phase 2 | Completed | University of Wisconsin, Madison | 232 | 2021-07-13 | 2025-05-08 |
| Quit Smoking Study for People Who Use E-Cigarettes Nicotine replacement therapy patch, Nicotine replacement therapy lozenge, Quit electronic cigarettes - Nicotine Addiction, E-Cig Use | Phase 2 | Completed | University of Vermont | 396 | 2021-06-27 | 2025-05-22 |
| The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence E-cigarettes - Nicotine Dependence | Phase 1 / Phase 2 | Completed | Duke University | 20 | 2021-05-21 | 2024-02-21 |
| Study Assessing Efficacy and Safety of NFL-101 as a Tobacco Cessation Therapy NFL-101 dose 1, NFL-101 dose 2, Placebo - Smoking Cessation, Nicotine Dependence | Phase 2 | Completed | NFL Biosciences SAS | 318 | 2021-04-12 | 2025-06-19 |
| Do Flavors Increase the Addiction Potential of Nicotine? Nicotine, JUUL e-cigarette - Nicotine Dependence | Phase 2 | Completed | University of Vermont | 19 | 2021-03-01 | 2022-03-22 |
| E-cigarette Nicotine Study Nicotine, Juul e-cigarette, Reduction - Nicotine Dependence, Electronic Cigarette Use | Phase 2 | Completed | University of Vermont | 77 | 2021-01-20 | 2022-08-26 |
| Omega-3 Fatty Acids for Smoking Cessation in Pregnancy Fish Oil (Containing Omega-3 Acids), Olive Oil - Preterm Labor, Tobacco Use Disorder | Phase 2 | Completed | Vanderbilt University Medical Center | 237 | 2020-11-10 | 2026-06-04 |
| Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes - Tobacco Use Disorder | Phase 2 | Completed | Brown University | 326 | 2020-10-18 | 2025-04-01 |
| Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder Cigarettes with varying nicotine content, E-Cigarettes - Tobacco Use Disorder | Phase 2 | Completed | University of Vermont | 326 | 2020-10-18 | 2025-03-30 |
| Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use Juul Electronic cigarette, Very Low Nicotine Cigarettes, Active Nicotine Patch - Nicotine Dependence | Phase 2 | Completed | University of Wisconsin, Madison | 209 | 2020-09-09 | 2023-05-25 |
| Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes - Nicotine Dependence, Cigarettes, Uncomplicated | Phase 1 / Phase 2 | Completed | Brown University | 57 | 2019-10-10 | 2023-12-19 |
| Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women Very low nicotine content cigarettes - Tobacco Use Disorder | Phase 1 / Phase 2 | Completed | University of Vermont | 30 | 2019-08-21 | 2026-05-18 |
| The Effects of Sedatives on Tobacco Use Disorder midazolam intravenous infusion, placebo intravenous infusion, ketamine intravenous infusion - Tobacco Use Disorder | Phase 1 / Phase 2 | Completed | Wake Forest University Health Sciences | 10 | 2019-06-01 | 2022-10-06 |
| Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds - Nicotine Addiction, Cigarette Smoking | Phase 2 | Completed | Rose Research Center, LLC | 150 | 2019-05-01 | 2022-01-14 |
| Comparing NicoBloc to Nicotine Lozenges NicoBloc, Nicotine Lozenge - Smoking Cessation, Nicotine Dependence | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 45 | 2019-03-21 | 2025-04-08 |
| Enhancing Self Regulation Among Smokers sirolimus, Placebo - Smoking Cessation, Smoking, Cigarette | Phase 2 | Completed | Medical University of South Carolina | 22 | 2018-10-01 | 2021-03-09 |
Showing 20 of 154. Sign in to see all of them.
Smoking Cessation (37) · Smoking (31) · Cigarette Smoking (13) · Tobacco Use Cessation (9) · Alcoholism (8) · Carcinoma, Non-Small-Cell Lung (6) · Lung Neoplasms (6) · Schizophrenia (6) · Tobacco Use (6) · Vaping (6) · Body Weight (4) · Small Cell Lung Carcinoma (4) · Harm Reduction (3) · Recurrence (3)
Chemically-Induced Disorders (154) · Mental Disorders (154) · Substance-Related Disorders (153) · Behavior (83) · Health Behavior (45) · Smoking (19) · Tobacco Use (14) · Tobacco Smoking (13) · Lung Diseases (9) · Pathological Conditions, Signs and Symptoms (9) · Respiratory Tract Diseases (9) · Neoplasms (8) · Neoplasms by Site (8) · Respiratory Tract Neoplasms (8) · Thoracic Neoplasms (8)
Tobacco Use Cessation Devices (25) · Varenicline (20) · Bupropion (15) · Nicotine (15) · Behavior Therapy (8) · Sugars (8) · Nicotine Replacement Therapy (7) · Nicotine Chewing Gum (6) · Electronic Nicotine Delivery Systems (5) · Naltrexone (5) · Acetylcysteine (4) · Tobacco Products (4) · Aspirin (3) · Counseling (3) · Ethanol (3)
National Institute on Drug Abuse (NIDA) (25) · University of Pennsylvania (12) · Yale University (11) · Brown University (10) · Mayo Clinic (10) · University of Vermont (8) · Medical University of South Carolina (7) · University of Minnesota (7) · Duke University (6) · National Cancer Institute (NCI) (6) · Wake Forest University Health Sciences (3) · Centre for Addiction and Mental Health (2) · Johns Hopkins University (2) · Massachusetts General Hospital (2) · NFL Biosciences SAS (2)
United States (140) · Canada (4) · France (3) · Australia (1) · Germany (1) · India (1) · Italy (1) · South Africa (1) · Sweden (1)
Dorothy Hatsukami, Ph.D. (9) · Dorothy Hatsukami, PhD (5) · Jed E Rose, Ph.D. (4) · Jennifer Tidey, Ph.D. (4) · Jennifer W. Tidey (3) · Rebecca Ashare, Ph.D. (3) · Caryn Lerman, Ph.D. (2) · Jed E. Rose, Ph.D. (2) · John R Hughes, MD (2) · Jon O Ebbert, MD (2) · Robert A Schnoll, PhD (2) · Stephen T. Higgins, Ph.D. (2) · Suchitra Krishnan-Sarin, Ph.D. (2) · Yves Donazzolo, MD (2) · Adam Bisaga, MD (1)
PMID 37230961, PMID 37142273, PMID 42560883, PMID 32628945, PMID 33079196, PMID 34242666, PMID 34255068, PMID 36208817, PMID 38236223, PMID 25192771, PMID 39240566, PMID 16960700, PMID 17587504, PMID 18096137, PMID 18381502, PMID 18837602, PMID 19339135, PMID 20056957, PMID 20078491, PMID 20542391, PMID 20590478, PMID 20707784, PMID 20934835, PMID 20947286, PMID 21221531, PMID 21276244, PMID 21475970, PMID 21652735, PMID 21762878, PMID 21846661, PMID 22007015, PMID 22097928, PMID 22160487, PMID 22197799, PMID 22218402, PMID 22352784, PMID 22452559, PMID 22993168, PMID 23261228, PMID 23429725, PMID 23454876, PMID 23460656, PMID 23536105, PMID 23586456, PMID 23603206, PMID 23873976, PMID 24345329, PMID 25005652, PMID 25118794, PMID 25419583
P50DA027840 (5), P50AA015632 (4), P50DA036114 (3), U54DA036114 (3), N01CN00031 (2), P30CA023074 (2), P50DA013333 (2), U01DA019378 (2), 1RC1DA028279-01 (1), K01DA019446 (1), K01MD015295 (1), K23DA019950 (1), K23DA035295 (1), N01CN00034 (1), N01CN35000 (1)