60 completed, 6 terminated, 5 unknown, 4 recruiting. 77 Phase 3, 25 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 77 | Completed 60, Terminated 6, Unknown 5, Recruiting 4, Active not recruiting 2 |
| Phase 2 | 25 | Completed 17, Unknown 4, Terminated 3, Recruiting 1 |
Follow Tobacco Use Disorder: new trials by email Literature Review of Tobacco Use Disorder trials Research Report on Tobacco Use Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches - Smoking Cessation | Phase 2 / Phase 3 | Recruiting | Mayo Clinic | 150 | 2026-06-04 | 2026-09-25 |
| Semaglutide for Smoking Cessation in Patients With Diabetes Semaglutide, Nicotine replacement - Diabetes Mellitus, Type 2, Nicotine Addiction | Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 100 | 2026-02-13 | 2026-09-08 |
| Cannabis-Tobacco Co-Use Treatment Study Varenicline, Counseling, Psychosocial modules - Tobacco Use Disorder, Tobacco Use Cessation | Phase 3 | Recruiting | Medical University of South Carolina | 200 | 2025-05-06 | 2026-04-03 |
| Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity. Aerobic Exercise, Counseling, Nicotine patch - Nicotine Dependence | Phase 3 | Recruiting | Jasper A. Smits | 360 | 2023-12-27 | 2026-05-15 |
| Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment EMB-01 - Smoking Cessation, Tobacco Use Disorder | Phase 2 / Phase 3 | Unknown | Rose Research Center, LLC | 25 | 2021-05-19 | 2021-05-28 |
| Optimizing Tobacco Use Treatment for PLWHA Varenicline, Nicotine patch, Standard treatment - HIV/AIDS, Nicotine Dependence | Phase 3 | Active not recruiting | Abramson Cancer Center at Penn Medicine | 340 | 2020-02-17 | 2026-09-04 |
| Early Withdrawal Exposure and Negative Affect Withdrawal (NAW) Regulation Training for Smoking Cessation cognitive-behavioral withdrawal regulation strategies, relaxation strategies, early withdrawal exposure - Tobacco Dependence | Phase 3 | Active not recruiting | University of Alabama at Birmingham | 400 | 2019-08-01 | 2026-10-30 |
| Comparing NicoBloc to Nicotine Lozenges NicoBloc, Nicotine Lozenge - Smoking Cessation, Nicotine Dependence | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 45 | 2019-03-21 | 2025-04-08 |
| Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes - Tobacco Smoking, Nicotine Dependence | Phase 3 | Completed | University of Minnesota | 799 | 2018-06-01 | 2024-08-20 |
| Optimizing Tobacco Dependence Treatment in the Emergency Department Brief Negotiated Interview (BNI), Nicotine replacement therapy (NRT), CT Smokers Quitline (QL) - Tobacco Use Disorder | Phase 3 | Completed | Yale University | 1056 | 2017-02-13 | 2020-12-04 |
| Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day Very low nicotine content (VLNC) cigarettes and nicotine replacement therapy (NRT), Reduce cigarettes per day (CPD) with nicotine replacement therapy (NRT) - Tobacco Use Disorder | Phase 2 / Phase 3 | Completed | University of Vermont | 74 | 2017-02-08 | 2022-10-04 |
| Examination of Sleep, Smoking Cessation, and Cardiovascular Health Sleep Advancement Counseling, General Health Information - Nicotine Dependence | Phase 3 | Completed | University of Delaware | 30 | 2016-11-01 | 2019-08-30 |
| Efficacy and Neural Correlates of Personalized Treatment With Transdermal Nicotine Replacement Nicotine patch, Nicotine mouthspray - Tobacco Use Disorder, Nicotine Dependence | Phase 2 / Phase 3 | Terminated | Centre for Addiction and Mental Health | 18 | 2015-07-01 | 2018-07-19 |
| Study to Determine the Efficacy and Safety of a Novel Nicotine Replacement Therapy Nicotine Spray, Placebo - Tobacco Dependence | Phase 3 | Completed | McNeil Consumer Healthcare Division of McNEIL-PPC, Inc. | 1198 | 2015-01-31 | 2019-01-08 |
| Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers Standard Smoking Cessation, Extended Nicotine Replacement Therapy, Nicotine replacement therapy - Smoking, Pulmonary Disease, Chronic Obstructive | Phase 3 | Completed | University of Kansas Medical Center | 398 | 2014-05-01 | 2017-10-06 |
| Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers Nicotine replacement therapy - Transdermal nicotine patch, Nicotine replacement therapy - Nicotine gum, Nicotine replacement therapy - Nicotine lozenge - Nicotine Dependence, Tobacco Use | Phase 3 | Unknown | Mark Vander Weg | 411 | 2013-07-01 | 2017-07-11 |
| Providing Free Nicotine Patches to Quitline Smokers Telephone counseling, Voucher, Nicotine patches - Smoking Cessation | Phase 3 | Completed | University of California, San Diego | 3706 | 2013-04-01 | 2020-02-19 |
| Extended Varenicline Treatment for Smoking Among Cancer Patients Varenicline, Placebo, Smoking Cessation Counseling - Nicotine Dependence | Phase 3 | Completed | University of Pennsylvania | 207 | 2013-01-01 | 2019-07-30 |
| Studying the Effects of Administration of Polyunsaturated Fatty Acids (PUFAS) of Omega-3 Series in Nicotine Dependence Omega 3, Placebo - Tobacco Dependence, Nicotine Dependence | Phase 3 | Completed | Federal University of São Paulo | 58 | 2013-01-01 | 2020-10-14 |
| Varenicline for Nicotine Dependence Among Those With HIV/AIDS Varenicline, Placebo, Smoking Cessation Counseling - Nicotine Dependence | Phase 3 | Completed | University of Pennsylvania | 179 | 2012-10-01 | 2019-09-18 |
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Smoking Cessation (33) · Smoking (22) · Tobacco Use Cessation (11) · Tobacco Use (6) · Cigarette Smoking (5) · Alcoholism (3) · Depression (3) · Acquired Immunodeficiency Syndrome (2) · Behavior, Addictive (2) · Cardiovascular Diseases (2) · HIV Infections (2) · Alcohol Drinking (1) · Asthma (1) · Body Weight (1)
Chemically-Induced Disorders (77) · Mental Disorders (77) · Substance-Related Disorders (77) · Behavior (55) · Health Behavior (39) · Smoking (6) · Tobacco Use (6) · Immune System Diseases (5) · Tobacco Smoking (5) · Blood-Borne Infections (4) · Communicable Diseases (4) · Genital Diseases (4) · Immunologic Deficiency Syndromes (4) · Infections (4) · Lentivirus Infections (4)
Tobacco Use Cessation Devices (24) · Varenicline (23) · Bupropion (11) · Nicotine (11) · Nicotine Replacement Therapy (5) · Counseling (4) · Nicotine Chewing Gum (4) · Sugars (4) · Fluoxetine (2) · Naltrexone (2) · Topiramate (2) · Behavior Therapy (1) · Crisis Intervention (1) · Decision Support Techniques (1) · Docosahexaenoic Acids (1)
Mayo Clinic (11) · National Institute on Drug Abuse (NIDA) (7) · University of California, San Francisco (6) · Duke University (3) · Queen Mary University of London (3) · University of California, San Diego (3) · University of Minnesota (3) · University of Pennsylvania (3) · Butler Hospital (2) · M.D. Anderson Cancer Center (2) · McNeil Consumer Healthcare Division of McNEIL-PPC, Inc. (2) · Medical University of South Carolina (2) · UConn Health (2) · US Department of Veterans Affairs (2) · University Hospital, Gentofte, Copenhagen (2)
United States (66) · Canada (3) · United Kingdom (3) · Denmark (2) · Australia (1) · Brazil (1) · France (1)
Jon O Ebbert, MD (3) · Shu-Hong Zhu, Ph.D. (3) · Eric T. Moolchan, M.D. (2) · Gary Humfleet, Ph.D. (2) · Jed E Rose, Ph.D. (2) · Jon O. Ebbert, M.D. (2) · Marc E Mooney, Ph.D. (2) · Paul Cinciripini, PhD (2) · Robert A Schnoll, PhD (2) · Al-Rehan A A Dhanji, MB BS BSc MRCP (1) · Al-Rehan A A Dhanji, MB BS BSc MRCS (1) · Al-Rehan Abdul Aziz Dhanji, MB.BS., BSc.,MRCS. (1) · Amit Sood, M.D. (1) · Andrew Myers, MD (1) · Bankole A Johnson, MD (1)
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P50DA009253 (3), K01DA019446 (2), P50DA027840 (2), R01DA002538 (2), 2005 (1), 2008 (1), K24AA013736 (1), M01RR006192 (1), R01AA019720 (1), R01CA118035 (1), R01CA121165 (1), R01CA133068 (1), R01CA201873 (1), R01CA243914 (1), R01CA273221 (1)