57 completed, 25 recruiting, 9 not yet recruiting, 7 active not recruiting. 75 Not applicable, 8 Phase 2, 5 Phase 3, 4 Phase 1, 2 Phase 4.
Follow this condition Literature Review of Harm Reduction trials Research Report on Harm Reduction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adapting a Telehealth Intervention for Suicide Prevention Among Patients With Alcohol Use Disorder in Tanzania IDEAS-AUD - Alcohol Use Disorder, Suicide Prevention | Not applicable | Not yet recruiting | Duke University | 30 | 2027-08-01 | 2026-03-17 |
| Clinical Decision Support for Safety of Opioid Transitions Opioid Transitions Clinical Decision Support (CDS) - Medication Abuse, Harm Reduction | Not yet recruiting | University of Colorado, Denver | 200000 | 2026-12-01 | 2026-09-21 | |
| Prevention and Rapid Outreach for Treatment, Engagement, and Care Transition From the Emergency Department PROTECT-ED Care Coordination - Opioid Overdose Prevention, HIV Prevention and Care | Not applicable | Not yet recruiting | Johns Hopkins University | 120 | 2026-11-01 | 2026-10-09 |
| Evaluation of Clinical Decision Support in Opioid Tapering Observational study without a prospective intervention - Medication Abuse, Harm Reduction | Not yet recruiting | University of Colorado, Denver | 200000 | 2026-11-01 | 2026-09-30 | |
| Pilot Study of an Adapted Partner Navigation Intervention Booster Session for Sustained Healthcare Engagement Among People Who Inject Drugs Partner navigation intervention booster session - HEPATITIS C (HCV), Opioid Use Disorder | Not applicable | Not yet recruiting | University of California, San Francisco | 50 | 2026-09-01 | 2026-06-08 |
| Harm Reduction Intervention for Anabolic-androgenic Steroids Users: a Randomized Controlled Trial harm reduction intervention in non-clinical anabolic-androgenic steroids users - Drug Abuse, Harm Reduction | Not applicable | Not yet recruiting | University of Sao Paulo | 32 | 2026-08-01 | 2026-07-16 |
| Combining Social Network Strategies and Routine Substance Use Screening Substance use disorder screening, Social network intervention - HIV, Substance Use Disorder (SUD) | Not applicable | Not yet recruiting | University of California, San Diego | 500 | 2026-07-31 | 2026-05-05 |
| Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder Medications for Opioid Use Disorder Pathway Clinical Decision Support (CDS) - Medication Abuse, Harm Reduction | Recruiting | University of Colorado, Denver | 200000 | 2026-07-07 | 2026-09-21 | |
| Smoking Harm Reduction Using E-cigarettes and Cytisine E-cigarette e-liquid, Cytisine - Tobacco Smoking, Harm Reduction | Not applicable | Not yet recruiting | Centre for Addiction and Mental Health | 6000 | 2026-05-01 | 2026-03-19 |
| Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use Oral Nicotine Pouch, Smoking Cue Reactivity Task - Nicotine Dependence | Not applicable | Recruiting | University of Southern California | 45 | 2026-04-30 | 2026-07-13 |
| Innovating Technology Solutions for Residents in Support Housing Communities w SUD Through Community-Engaged Research Technology-based Intervention - Housing Problems, Household Substance Abuse | Not applicable | Completed | Oregon Research Behavioral Intervention Strategies, Inc. | 15 | 2026-04-29 | 2026-07-13 |
| Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit HRP Sampling period, NPL Sampling period - Cigarette Smoking, Tobacco Use | Not applicable | Recruiting | Abramson Cancer Center at Penn Medicine | 472 | 2026-01-12 | 2026-06-11 |
| Testing the Effects of Cann'App, a Digital Intervention for Cannabis Harm Reduction Personalized Feedback on Cannabis Protective Behavioral Strategies, Cannabis Use, Cannabis Expenditures, and Cannabis-Related Consequences (PF), Imagining the Future Using Counterfactual Thinking and Episodic Future Thinking (IMAGIN), Behavioral Economics-Informed Exercises to Increase Motivation to Engage in Substance-Free Activities (SFAS) - Cannabis Use, Harm Reduction | Not applicable | Enrolling by invitation | Jacques Gaume | 565 | 2026-01-05 | 2026-01-12 |
| Evaluation of an Educational Intervention on Abscesses in People Who Self-inject Drugs Educational hand hygiene intervention - People Who Inject Drugs | Not applicable | Withdrawn | Institut National de la Santé Et de la Recherche Médicale, France | 2025-12-01 | 2026-05-12 | |
| Wellness, Alcohol, Vitals, and Emotions Mindfulness based relapse prevention - Alcohol Use | Not applicable | Recruiting | University of New Mexico | 120 | 2025-10-01 | 2026-07-15 |
| An Augmented Reality Videogame for Alcohol Use Prevention and Harm Reduction in Teens Experimental: Augmented Reality ("No Time Wasted") - Alcohol Prevention, Harm Reduction | Not applicable | Enrolling by invitation | Yale University | 20 | 2025-09-12 | 2025-11-18 |
| Shelter HArm Reduction Evaluation Overdose, Harm Reduction | Recruiting | NYU Langone Health | 80 | 2025-07-23 | 2026-08-25 | |
| Integrating Sexual Pleasure Into Harm Reduction Services for Men Who Have Sex With Men and Transgender Persons Who Engage in Chemsex or Substance Use in Thailand Pleasuremeter-guided qualitative interview, Pleasuremeter-based sexual pleasure discussion integrated with harm reduction services - HIV Prevention, Substance Use | Not applicable | Recruiting | Institute of HIV Research and Innovation Foundation, Thailand | 300 | 2025-05-01 | 2026-04-08 |
| THRIVE: Culturally AdapTed Harm Reduction Intervention harm reduction intervention - Opioid Use, Stimulant Use | Not applicable | Completed | Brittany Miller-Roenigk | 63 | 2025-04-02 | 2026-06-30 |
| Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy Electronic Cigarettes (EC), Nicotine replacement therapy (NRT) - Smoking Cessation, Obesity and Obesity-related Medical Conditions | Not applicable | Recruiting | Brown University | 60 | 2025-04-01 | 2026-05-18 |
Showing 20 of 114. Sign in to see all of them.
Substance-Related Disorders (25) · Opioid-Related Disorders (16) · Smoking Cessation (16) · Vaping (11) · Opiate Overdose (10) · Smoking (10) · Alcohol Drinking (9) · Cigarette Smoking (9) · Alcoholism (8) · Tobacco Use (8) · Tobacco Use Disorder (8) · Sexually Transmitted Diseases (6) · Behavior, Addictive (5) · Drug Overdose (5)
Behavior (113) · Mental Disorders (63) · Chemically-Induced Disorders (59) · Substance-Related Disorders (35) · Narcotic-Related Disorders (23) · Health Behavior (18) · Communicable Diseases (15) · Infections (15) · Pathological Conditions, Signs and Symptoms (15) · Drug Misuse (14) · Prescription Drug Misuse (14) · Urogenital Diseases (13) · Genital Diseases (12) · Pathologic Processes (12) · Blood-Borne Infections (10)
Nicotine (7) · Electronic Nicotine Delivery Systems (6) · Tobacco Use Cessation Devices (6) · Nicotine Chewing Gum (5) · Therapeutics (4) · Tobacco, Smokeless (4) · Chewing Gum (3) · Nicotine Replacement Therapy (3) · Transdermal Patch (3) · Varenicline (2) · Autogenic Training (1) · Crisis Intervention (1) · Cycloserine (1) · Diet (1) · Dosage Forms (1)
Rose Research Center, LLC (6) · Brown University (5) · University of Colorado, Denver (5) · Institute of HIV Research and Innovation Foundation, Thailand (4) · University of Washington (4) · Yale University (4) · Contract Research Organization el AB (3) · Montefiore Medical Center (3) · NYU Langone Health (3) · University of Nebraska (3) · University of New Mexico (3) · University of Pittsburgh (3) · Abramson Cancer Center at Penn Medicine (2) · BC Centre on Substance Use (2) · Institut National de la Santé Et de la Recherche Médicale, France (2)
United States (76) · Canada (6) · Sweden (5) · France (4) · Thailand (4) · Denmark (3) · Switzerland (3) · Taiwan (3) · Armenia (1) · Belgium (1) · Brazil (1) · Georgia (1) · Italy (1) · Tanzania (1)
Erik Lunell, MD, PhD (3) · Jason Hoppe, DO (3) · Stephen I Rennard, MD (3) · Brandon DL Marshall, PhD (2) · Gary Smith, MD, DRPH (2) · Nichole Michaels, PhD (2) · Nittaya Phanuphak, MD,PhD. (2) · Robert F Leeman, Ph.D. (2) · Susan E Collins, PhD (2) · Akarin Hiransuthikul, MD,MSc (1) · Ashley Lincoln, MSW (1) · Ayana Jordan, MD, PhD (1)
PMID 20078491, PMID 24962502, PMID 25192771, PMID 25404724, PMID 25535265, PMID 28572079, PMID 29986845, PMID 30621699, PMID 31306331, PMID 31352486, PMID 31495379, PMID 31504882, PMID 31601199, PMID 31956726, PMID 34702229, PMID 34729851, PMID 34766785, PMID 34803760, PMID 35012570, PMID 36050677, PMID 36113946, PMID 36526146, PMID 36721903, PMID 37014673, PMID 37482128, PMID 37962917, PMID 38419058, PMID 38506503, PMID 38569425, PMID 39146062, PMID 39232778, PMID 39420312, PMID 40017794, PMID 40550628, PMID 40675636, PMID 41193189, PMID 41213113, PMID 41723493, PMID 42065984, PMID 42271368
R61DA057610 (4), P20GM130414 (3), 2018 (1), 2025 (1), F31DA049457 (1), K01AA019694 (1), K01AA030053 (1), K23AA031729 (1), K24DA061103 (1), R01AA022309 (1), R01AA026593 (1), R01AA030017 (1), R01AA031159 (1), R01CA135884 (1), R01CA192940 (1)