6 completed, 6 unknown, 3 terminated, 2 withdrawn. 19 Phase 2, 4 Phase 1, 3 Phase 3.
Follow Thoracic Injuries: new trials by email Literature Review of Thoracic Injuries trials Research Report on Thoracic Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures Dexmedetomidine with Bupivacaine in ESPB, Dexamethasone with Bupivacaine in ESPB - Rib Fractures, Acute Pain | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-09-18 |
| Ultrasound Guided Emergency Physician Performed Erector Spinae Nerve Block for Rib Fracture Analgesia ESP block with bupivacaine, Saline control/sham injection - Rib Fractures | Phase 1 / Phase 2 | Withdrawn | Yale University | 2025-05-01 | 2025-07-01 | |
| Comparison of Continuous Intravenous Lidocaine Infusion Versus ESP Block for Rib Fracture Analgesia Lidocaine IV Infusion, 2% Lidocaine via ESPB - Rib Fractures | Phase 2 | Withdrawn | Stanford University | 2025-05-01 | 2026-05-05 | |
| Kinesiotaping Method for Rib Fractures Kinesiotaping, Painkillers - Rib Fractures, Pain, Chest | Phase 2 / Phase 3 | Completed | Kastamonu University | 34 | 2024-01-24 | 2024-10-09 |
| Stem Cell Treatment for Lung Injury Caused by Major Infectious Diseases mesenchymal stem cells, saline - Lung Injury | Phase 1 / Phase 2 | Unknown | Cell Energy Life Sciences Group Co. LTD | 80 | 2023-05-10 | 2024-05-16 |
| RAPA-501-Allo Therapy of COVID-19-ARDS RAPA-501-Allo off-the-shelf Therapy of COVID-19, Placebo - Severe COVID-19 Disease | Phase 1 / Phase 2 | Terminated | Rapa Therapeutics LLC | 1 | 2020-12-30 | 2021-11-11 |
| Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19 Ramelteon 8mg - Covid19, Lung Injury | Phase 2 | Unknown | Associação Fundo de Incentivo à Pesquisa | 100 | 2020-09-01 | 2020-07-24 |
| Study of Oral Ibrutinib Capsules to Assess Respiratory Failure in Adult Participants With Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Pulmonary Injury Ibrutinib, Placebo - CoronaVirus Induced Disease-2019 (COVID-19) | Phase 2 | Completed | AbbVie | 46 | 2020-06-06 | 2022-06-01 |
| A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE) Gimsilumab, Placebo - COVID-19 | Phase 2 | Completed | Kinevant Sciences GmbH | 227 | 2020-04-15 | 2021-12-14 |
| Prophylactic Inhaled Steroids to Reduce Radiation Pneumonitis Frequency and Severity in Lung Cancer Patients Inhaled budesonide - Radiation Pneumonitis | Phase 2 | Recruiting | Instituto Nacional de Cancerologia de Mexico | 72 | 2018-09-01 | 2026-04-08 |
| Intercostal Liposomal Bupivacaine for the Management of Blunt Chest Wall Trauma Liposomal bupivacaine, 0.9% sodium chloride - Blunt Chest Wall Trauma, Rib Fracture | Phase 2 | Completed | University of Cincinnati | 100 | 2018-03-09 | 2022-04-04 |
| Thoracic Epidural Analgesia in Flail Chest Morphine Sulfate, Triamcinolone Acetonide - Flail Chest | Phase 2 / Phase 3 | Unknown | Assiut University | 40 | 2018-02-01 | 2018-01-29 |
| Pectoralis and Serratus Nerves Block in Thoracic Surgery Bupivacaine Hydrochloride, Ultrasound, Thoracotomy - Anesthesia, Surgery | Phase 2 | Unknown | Soroka University Medical Center | 168 | 2017-02-01 | 2017-01-18 |
| Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Paraquat Poisoning Induced Lung Injury UCMSC group, Control group(Normal saline) - Paraquat Poisoning, Lung Injury | Phase 1 / Phase 2 | Unknown | Affiliated Hospital to Academy of Military Medical Sciences | 40 | 2015-05-01 | 2015-05-15 |
| Study of GSK2862277 in Subjects Undergoing Oesophagectomy Surgery GSK2862277, Placebo - Lung Injury, Acute and Respiratory Distress Syndrome, Adult | Phase 2 | Terminated | GlaxoSmithKline | 35 | 2015-04-28 | 2020-10-27 |
| Trial of Steroids in Pediatric Acute Lung Injury/ARDS methylprednisolone, Normal Saline (0.9%) - Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury (ALI) | Phase 2 | Unknown | University of Tennessee | 100 | 2010-10-01 | 2014-05-28 |
| Level of Continuous Positive Airway Pressure (CPAP) in Preterm Infants After Extubation (L-CPAP Study) Nasal CPAP, level 7 to 9 cmH2O, Nasal CPAP, level 4 to 6 cmH2O - Respiratory Insufficiency of Prematurity | Phase 2 | Terminated | Hamilton Health Sciences Corporation | 23 | 2007-07-01 | 2009-02-10 |
| Trial of Operative Fixation of Fractured Ribs in Patients With Flail Chest operative fixation of fractured ribs - Flail Chest, Ventilation | Phase 2 | Completed | The Alfred | 48 | 2007-01-01 | 2012-12-11 |
| Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant Etanercept - Lung Injury, Acute, Respiratory Distress Syndrome, Adult | Phase 2 | Completed | University of Michigan Rogel Cancer Center | 34 | 2003-10-01 | 2015-12-03 |
Lung Injury (11) · Respiratory Distress Syndrome (6) · Rib Fractures (5) · COVID-19 (4) · Acute Lung Injury (3) · Coronavirus Infections (2) · Cytokine Release Syndrome (2) · Flail Chest (2) · Lung Diseases (2) · Pneumonia (2) · Respiratory Insufficiency (2) · Acute Pain (1) · Bites and Stings (1) · Bronchiolitis Obliterans (1) · Carcinoma, Non-Small-Cell Lung (1)
Wounds and Injuries (19) · Respiratory Tract Diseases (12) · Lung Diseases (9) · Respiration Disorders (8) · Pathological Conditions, Signs and Symptoms (7) · Fractures, Bone (5) · Infections (5) · Pathologic Processes (5) · Respiratory Tract Infections (5) · Coronaviridae Infections (4) · Nidovirales Infections (4) · Pneumonia, Viral (4) · RNA Virus Infections (4) · Virus Diseases (4)
Bupivacaine (3) · Morphine (2) · Saline Solution (2) · Sodium Chloride (2) · Acetaminophen (1) · Analgesics, Opioid (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Athletic Tape (1) · Dexamethasone (1) · Dexmedetomidine (1) · Etanercept (1) · GSK2862277 (1) · Lidocaine (1) · Methylprednisolone (1) · Thoracotomy (1)
Assiut University (2) · AbbVie (1) · Affiliated Hospital to Academy of Military Medical Sciences (1) · Associação Fundo de Incentivo à Pesquisa (1) · Cell Energy Life Sciences Group Co. LTD (1) · GlaxoSmithKline (1) · Hamilton Health Sciences Corporation (1) · Instituto Nacional de Cancerologia de Mexico (1) · Kastamonu University (1) · Kinevant Sciences GmbH (1) · Rapa Therapeutics LLC (1) · Soroka University Medical Center (1) · Stanford University (1) · The Alfred (1) · University of Cincinnati (1)
United States (7) · China (2) · Australia (1) · Mexico (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Bing Liu, M.D. (1) · Chunyan Wang, M.D. (1) · Cristiana Baloescu, MD (1) · Dalva Poyares, PhD (1) · Daniel Fowler, M.D. (1) · Emad Z Saed (1) · Giulherme M SantAnna, MD (1) · Gregory A Yanik, MD (1) · Haochun Wang, M.D. (1) · Michael D Goodman, MD (1) · Oscar Arrieta, MD MSc (1) · Silvana Marasco, FRACS (1)
PMID 17050868, PMID 19962042, PMID 20583979, PMID 22155140, PMID 23909719, PMID 24459776, PMID 25276362, PMID 25634565, PMID 25808113, PMID 26545141, PMID 26830686, PMID 27066464, PMID 28477633, PMID 28596060, PMID 28865520, PMID 34789700, PMID 35290169, PMID 35493119, PMID 39691747
2014 (1)