18 completed, 8 unknown, 7 recruiting, 2 enrolling by invitation. 22 Not applicable, 7 Phase 2, 5 Phase 1, 3 Phase 4, 1 Phase 3.
Follow Carbon Dioxide: new trials by email Literature Review of Carbon Dioxide trials Research Report on Carbon Dioxide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion Carbon Dioxide, Mechano-acoustic device - Exercise-Induced Vocal Cord Dysfunction, Paradoxical Vocal Fold Motion | Phase 2 | Recruiting | Indiana University | 130 | 2026-08-12 | 2026-08-14 |
| Liquid Nitrogen Cryotherapy Versus CO₂ Laser for Palmoplantar Warts Liquid Nitrogen Cryotherapy, Carbon Dioxide (CO₂) Laser Therapy - Palmoplantar Warts | Not applicable | Recruiting | Bkahtawar Amin Medical and Dental College Multan | 88 | 2026-06-04 | 2026-10-19 |
| siRNA Microneedle Patches for Ear Keloid Post-Surgical Scars Small interfering RNA (siRNA) Microneedle Patches, Carbon Dioxide (CO2) Laser Surgery, Intralesional Triamcinolone 40 mg/mL - Keloid of Ear Lobe | Phase 2 | Not yet recruiting | Ong Kim Yao | 158 | 2026-06-01 | 2026-07-06 |
| Transcriptomic Profile Changes in Benign Tracheal Stenosis: Wedge Resection vs. Radial Incision Bronchoscopy, carbon dioxide (CO2) laser wedge resection, Radial incision with dilation - Tracheal Stenosis | Not applicable | Recruiting | University of Maryland, Baltimore | 40 | 2026-05-01 | 2026-08-20 |
| Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography Carbon Dioxide - Sickle Cell Disease, Cerebral Stroke | Not applicable | Recruiting | Washington University School of Medicine | 120 | 2025-10-01 | 2026-08-20 |
| A Contrast Medium Sparing Strategy Using Automated CO2 Injection During PVI for Prevention of Major Adverse Kidney Events (MAKE) CO2, Iodinated Contrast Media (ICM) - Peripheral Vascular Diseases, Kidney Diseases | Phase 3 | Recruiting | University of Leipzig | 1960 | 2025-04-14 | 2026-03-23 |
| Short Title: Standard vs. Lower Pressure Pneumoperitoneum Carbon dioxide, Bupivacaine, Oxycodone - Laparoscopic Surgery | Not applicable | Recruiting | Cedars-Sinai Medical Center | 294 | 2024-05-03 | 2024-05-10 |
| In Vivo Pulse Oximeter Validation Study Mixtures of nitrogen, air, and carbon dioxide - Hypoxia | Not applicable | Completed | Gabi SmartCare | 12 | 2023-02-28 | 2024-12-12 |
| Application of Carbon Dioxide for Identifying the Intersegmental Plane in Thoracoscopic Segmentectomy 100% oxygen, Carbon dioxide - Lung Cancer, Pulmonary Nodule, Solitary | Not applicable | Completed | Tongji Hospital | 52 | 2022-02-11 | 2024-02-15 |
| Low Versus Standard Pressure Pneumoperitoneum carbon dioxide - Gynecologic Surgery | Not applicable | Unknown | Erzincan Military Hospital | 230 | 2021-07-01 | 2021-07-01 |
| Metabolic and Hemodynamic Reserve in Pediatric SCA Carbon Dioxide - Child, Only, Brain Diseases | Not applicable | Active not recruiting | Washington University School of Medicine | 120 | 2021-06-30 | 2026-08-19 |
| The Correlation Between Intraoperative End Tidal Carbon Dioxide, Perfusion Index and Pulse Variability Index on Postoperative Nausea Vomiting and Pain Carbon dioxide (CO2) gas insufflation - Postoperative Nausea and Vomiting, Postoperative Pain, Acute | Enrolling by invitation | Naime Yalçın | 90 | 2021-03-15 | 2025-03-07 | |
| a Randomized Clinical Trial Evaluating the Effectiveness of Carbon Dioxide Use in Cardiac Surgery carbon dioxide insufflation, No carbon dioxide insufflation - Carbon Dioxide | Not applicable | Unknown | Meshalkin Research Institute of Pathology of Circulation | 120 | 2020-06-19 | 2020-09-14 |
| The Effect of Respiratory Challenge on the BOLD Signal Carbon Dioxide - Hypoxia, Brain, Hyperoxia | Not applicable | Enrolling by invitation | Washington University School of Medicine | 48 | 2020-01-29 | 2026-01-16 |
| Is End Tidal CO2 Level Elevation During Upper Endoscopy With CO2 Gas Insufflation Physiologically Significant Air, Carbon Dioxide - Endoscopy | Not applicable | Completed | University of Nebraska | 200 | 2019-11-18 | 2023-10-10 |
| Cerebral Oxygen Metabolism in Children Carbon Dioxide - Sickle Cell Disease, Cerebral Stroke | Not applicable | Recruiting | Washington University School of Medicine | 350 | 2019-10-17 | 2025-09-11 |
| Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military Sildenafil Citrate 50Mg Tab, functional Near-infrared Spectroscopy (fNIRS), Carbon Dioxide (CO2) 5% - Traumatic Brain Injury | Phase 2 | Terminated | Uniformed Services University of the Health Sciences | 1 | 2019-08-09 | 2024-02-28 |
| Comparison of Carbon Dioxide and Saline Flush to Saline Flush in TEVAR and TAVI Procedures to Reduce Cerebral Ischemia Carbon Dioxide and Saline Flush, Standard Saline Flush - Thoracic Aortic Aneurysm, Aortic Stenosis Symptomatic | Phase 1 | Unknown | University Health Network, Toronto | 20 | 2019-07-20 | 2020-09-23 |
| Comparisons of SWI, WWI and CI in Potentially Difficult Colonoscopy. whole colon water immersion and sigmoid water immersion - Colonoscopy | Not applicable | Completed | Shenzhen People's Hospital | 240 | 2018-04-03 | 2019-01-02 |
| Safety and Efficacy of CO2 for Endoscopy Carbon dioxide (CO2) gas insufflation, Air insufflation - Endoscopy, Insufflation | Phase 4 | Completed | Warren Bishop | 180 | 2017-11-27 | 2022-01-19 |
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Anemia, Sickle Cell (3) · Pain (3) · Stroke (3) · Heart Failure (2) · Pain, Postoperative (2) · Abdominal Pain (1) · Aortic Aneurysm, Thoracic (1) · Asthma (1) · Brain Diseases (1) · Brain Injuries, Traumatic (1) · Cicatrix (1) · Colorectal Neoplasms (1) · Delirium (1) · Diabetes Mellitus, Type 1 (1) · Hidradenitis Suppurativa (1)
Washington University School of Medicine (4) · Imperial College London (3) · Hospital Clinic of Barcelona (2) · University of Leipzig (2) · Bkahtawar Amin Medical and Dental College Multan (1) · Cedars-Sinai Medical Center (1) · Duke University (1) · Erzincan Military Hospital (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Forschungsinstitut für Balneologie und Kurortwissenschaft Bad Elster (1) · Gabi SmartCare (1) · GlaxoSmithKline (1) · Henry Ford Health System (1) · Indiana University (1) · Kaiser Clinic and Hospital (1)
United States (15) · United Kingdom (4) · Germany (3) · China (2) · Norway (2) · Turkey (Türkiye) (2) · Austria (1) · Belgium (1) · Brazil (1) · Canada (1) · Italy (1) · Pakistan (1) · Poland (1) · Russia (1) · Singapore (1)
Darrel P Francis, MD (2) · Alexander V. Bogachev-Prokophiev, MD, PhD (1) · Chinenye R Dike, MD (1) · David MacLeod, MB BS (1) · Francisco Carmona, MD PhD (1) · Gary E McVeigh, MD PhD FRCP (1) · Isabel Blanco, MD, PhD (1) · JAsper Verguts, MD, PhD (1) · Kimbra Kenney, MD (1) · Kjetil K Garborg, MD (1) · Kong Teng Tan, MD, FRCPC (1) · Kristin P Guilliams, MD (1) · Latifa Yamlahi, MSc (1) · Luiz G Quadros, MD (1)
PMID 12411660, PMID 17143244, PMID 17188664, PMID 18072057, PMID 18234750, PMID 18418368, PMID 20137879, PMID 20571524, PMID 21468088, PMID 25412093, PMID 26314998, PMID 26363332, PMID 27178892, PMID 27464582, PMID 29065769, PMID 32304555, PMID 36821847
R01DC023381 (1), R01NS121065 (1)