2476 completed, 767 unknown, 663 recruiting, 259 terminated. 2071 Not applicable, 660 Phase 2, 450 Phase 1, 309 Phase 3, 182 Phase 4.
Follow Synucleinopathies: new trials by email Literature Review of Synucleinopathies trials Research Report on Synucleinopathies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Terazosin And Metabolic Energetics in Parkinson's Disease Terazosin 5 MG, Placebo - Parkinson's Disease (PD) | Phase 2 | Suspended | Ergun Y. Uc | 120 | 2028-07-01 | 2026-10-09 |
| Double-Blind Clinical Trial of Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease active subthalamic nucleus deep brain stimulation plus optimal drug therapy, inactive subthalamic nucleus deep brain stimulation plus optimal drug therapy - Parkinson Disease | Not applicable | Not yet recruiting | Mallory Hacker | 40 | 2028-01-01 | 2026-02-20 |
| Study to Evaluate the Safety, Tolerability, Efficacy, and PK of FHL-301 in Parkinson's Disease Patients. Gemfibrozil, Placebo - Parkinson Disease | Phase 2 | Withdrawn | Forest Hills Lab | 2027-11-01 | 2026-08-19 | |
| Terazosin for Dementia With Lewy Bodies Terazosin Hydrochloride, Placebo - Dementia With Lewy Bodies | Phase 1 / Phase 2 | Not yet recruiting | Qiang Zhang | 40 | 2027-10-01 | 2026-03-12 |
| A Study to Evaluate the Safety, Tolerability and Efficacy of MT101-5 in Subjects With Early Parkinson's Disease MT101-5 - Parkinson's Disease | Phase 2 | Not yet recruiting | Mthera Pharma Co., Ltd. | 120 | 2027-09-01 | 2026-10-16 |
| Function-based Accelerated Stimulation Therapy (FAST-therapy) for Freezing of Gait (FOG) After Parkinson's Disease (PD) rTMS - Parkinson Disease | Not applicable | Not yet recruiting | University of Michigan | 20 | 2027-09-01 | 2026-10-20 |
| Gastrointestinal Dopamine Decarboxylase and Levodopa Pharmacokinetics Levodopa (L-dopa) - Parkinson's Disease | Phase 4 | Not yet recruiting | Beth Israel Deaconess Medical Center | 40 | 2027-07-01 | 2026-08-28 |
| Fecal MicrobiotaTransplant for the Treatment of Parkinson's Disease Fecal Microbiota Transplant - Parkinson Disease | Phase 1 | Not yet recruiting | ProgenaBiome | 10 | 2027-07-01 | 2026-10-09 |
| Engage-PD: a Physical Activity Coaching Program Via Telehealth for People With Parkinson's Disease. A Single-cohort Study in Spain. Physical Activity Coaching - PARKINSON DISEASE (Disorder) | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 30 | 2027-06-01 | 2026-10-05 |
| Sustained Release Oral Formulation For Treatment Of Parkinsons Disease Formulation A, Formulation B, Formulation C - Healthy Volunteers | Phase 1 / Phase 2 | Not yet recruiting | University of Minnesota | 32 | 2027-04-01 | 2026-10-01 |
| A Study of AB-1005 Gene Therapy in Japanese Adults With Moderate Parkinson's Disease (J-REGENERATE-PD) AB-1005 - Parkinson Disease | Phase 2 | Not yet recruiting | Bayer | 8 | 2027-01-25 | 2026-07-29 |
| Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy Bodies Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB) | Not yet recruiting | BioSensics | 60 | 2027-01-15 | 2026-10-13 | |
| Exploring the Efficacy of the Effortful Swallow Maneuver for Improving Swallowing in People With PD Effortful swallow - Dysphagia, Parkinson Disease (PD) | Not applicable | Not yet recruiting | University of Alberta | 74 | 2027-01-01 | 2026-08-19 |
| A Trial of ONO-2808 in Participants With the Parkinsonian Subtype of Multiple System Atrophy (MSA-P) ONO-2808, Placebo - Multiple System Atrophy, Parkinson Variant | Phase 3 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 486 | 2027-01-01 | 2026-09-17 |
| Probing Gut-Brain Communication in Parkinson's Disease taVNS, Sham taVNS - Parkinson Disease (PD) | Not applicable | Not yet recruiting | Spaulding Rehabilitation Hospital | 45 | 2027-01-01 | 2026-10-08 |
| Disease-modifying Efficacy of Sitagliptin Therapy in Early-stage Parkinson's Disease Sitagliptin, Sitagliptin placebo - Parkinson Disease | Phase 2 | Not yet recruiting | Yonsei University | 160 | 2026-12-15 | 2026-09-10 |
| Utilization of Aerobic Exercise to Maintain Neurologic Health Aerobic Exercise - Parkinson's Disease | Not applicable | Not yet recruiting | The Cleveland Clinic | 100 | 2026-12-15 | 2026-10-20 |
| Bayesian Optimization of DBS for Gait Deep Brain Stimulation - Parkinson Disease (PD) | Early Phase 1 | Recruiting | University of Minnesota | 15 | 2026-12-01 | 2026-09-28 |
| Low Intensity Focused Ultrasound for Parkinson's Disease LIFU Neuromodulation - Parkinson Disease | Not applicable | Not yet recruiting | Ali Rezai | 15 | 2026-12-01 | 2026-02-17 |
| ZR001 Chemogenetics Gene Therapy Study in Patients With Parkinson's Disease ZR001 - Parkinson's Disease (PD), Parkinsonian Disorders | Phase 1 | Not yet recruiting | Qianfoshan Hospital | 8 | 2026-12-01 | 2026-07-22 |
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Parkinson Disease (4473) · Lewy Body Disease (236) · Alzheimer Disease (209) · Multiple System Atrophy (204) · Parkinsonian Disorders (167) · Movement Disorders (164) · Cognitive Dysfunction (163) · Motor Activity (162) · Dementia (143) · Neurodegenerative Diseases (129) · Dyskinesias (107) · Depression (97) · Multiple Sclerosis (97) · Essential Tremor (96) · Stroke (87)
Basal Ganglia Diseases (4712) · Central Nervous System Diseases (4699) · Brain Diseases (4696) · Nervous System Diseases (4674) · Neurodegenerative Diseases (4620) · Movement Disorders (4580) · Parkinsonian Disorders (4476) · Pathological Conditions, Signs and Symptoms (883) · Signs and Symptoms (740) · Mental Disorders (703) · Neurologic Manifestations (604) · Neurocognitive Disorders (488) · Behavior (321) · Tauopathies (260)
Levodopa (89) · Deep Brain Stimulation (82) · Exercise (78) · carbidopa, levodopa drug combination (74) · Transcranial Direct Current Stimulation (51) · rasagiline (46) · Transcranial Magnetic Stimulation (45) · Pramipexole (44) · rotigotine (43) · opicapone (42) · Carbidopa (35) · Physical Therapy Modalities (34) · Control Groups (29) · Apomorphine (26) · entacapone (23)
National Institute of Neurological Disorders and Stroke (NINDS) (63) · Bial - Portela C S.A. (56) · Boehringer Ingelheim (42) · University of Florida (42) · VA Office of Research and Development (42) · University Hospital, Toulouse (39) · Oregon Health and Science University (36) · Radboud University Medical Center (35) · University of Minnesota (34) · University of Colorado, Denver (33) · Washington University School of Medicine (32) · AbbVie (30) · National Taiwan University Hospital (27) · University Hospital, Grenoble (27) · Assistance Publique - Hôpitaux de Paris (25)
United States (1731) · France (463) · Italy (360) · China (293) · Germany (268) · United Kingdom (263) · Canada (258) · Spain (227) · Turkey (Türkiye) (170) · Israel (124) · Netherlands (121) · Taiwan (117) · Brazil (100) · Japan (89) · Austria (88)
Giuseppe Frazzitta, MD (16) · Italo Biaggioni, MD (13) · Danna Jennings, MD (11) · Alice Nieuwboer, PhD (8) · Bastiaan R Bloem, MD, PhD (7)
PMID 36602886, PMID 38588457, PMID 40680102, PMID 31356217, PMID 25623333, PMID 30741694, PMID 31127735, PMID 10816186, PMID 19126811, PMID 27538531, PMID 28494751, PMID 34816053, PMID 41626017, PMID 11253156, PMID 12112073, PMID 12360555, PMID 12498954, PMID 1454205, PMID 15097290, PMID 16267188, PMID 16401616, PMID 16436781, PMID 17941858, PMID 19025984, PMID 19058133, PMID 20457959, PMID 20519680, PMID 20574039, PMID 20582993, PMID 20841416, PMID 20937936, PMID 20946640, PMID 21484867, PMID 21542016, PMID 22209649, PMID 22750016, PMID 22850494, PMID 23263599, PMID 23667214, PMID 23860343, PMID 24078735, PMID 24251381, PMID 24332532, PMID 24412048, PMID 24711047, PMID 25185211, PMID 26347184, PMID 26523919, PMID 26833853, PMID 26882318
2019 (15), 2023 (14), 2016 (13), 2025 (13), 2009 (11), 2018 (11), 2008 (10), 2014 (10), 2017 (10), 2004 (7), 2015 (7), 2005 (3), R01HL144568 (3), U01NS043128 (3), I01RX003397 (2)