5 completed, 2 terminated, 1 recruiting, 1 withdrawn. 9 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 5, Terminated 2, Recruiting 1, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
Follow Pure Autonomic Failure: new trials by email Literature Review of Pure Autonomic Failure trials Research Report on Pure Autonomic Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| [18F]F-DOPA Imaging in Patients With Autonomic Failure [18F]FDOPA, Carbidopa 200mg oral dose, Entacapone 400mg oral dose - Autonomic Failure, Pure Autonomic Failure | Phase 1 | Recruiting | Daniel Claassen | 40 | 2020-02-04 | 2026-03-16 |
| Automated Abdominal Binder for Orthostatic Hypotension automated abdominal binder, Sham binder, Placebo - Orthostatic Hypotension, Autonomic Failure | Phase 1 / Phase 2 | Completed | Vanderbilt University Medical Center | 28 | 2018-03-01 | 2026-05-05 |
| Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure Droxidopa, Midodrine, Placebo - Autonomic Failure, Pure Autonomic Failure | Phase 1 | Terminated | Vanderbilt University Medical Center | 34 | 2016-09-01 | 2026-10-23 |
| Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure Abdominal compression, Sham abdominal compression, Placebo pill - Orthostatic Hypotension, Pure Autonomic Failure | Phase 1 | Completed | Vanderbilt University Medical Center | 21 | 2015-04-01 | 2026-05-05 |
| Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure Losartan, Captopril, Placebo - Hypertension, Pure Autonomic Failure | Phase 1 | Terminated | Vanderbilt University | 12 | 2011-03-01 | 2018-08-24 |
| The Role of Endothelin in the Supine Hypertension of Autonomic Failure BQ123, Bq123, Saline - Hypertension, Pure Autonomic Failure | Phase 1 | Withdrawn | Vanderbilt University | 2010-05-01 | 2021-10-05 | |
| The Autonomic Nervous System and Obesity Trimethaphan, Pseudoephedrine - OBESITY, HYPERTENSION | Phase 1 | Completed | Vanderbilt University | 128 | 2003-04-01 | 2018-03-01 |
| Treatment of Orthostatic Hypotension in Autonomic Failure Atomoxetine, Acarbose, Pyridostigmine Bromide - Autonomic Failure, Orthostatic Hypotension | Phase 1 | Completed | Vanderbilt University | 389 | 2002-03-01 | 2017-01-18 |
| Treatment of Supine Hypertension in Autonomic Failure Clonidine, Nitroglycerin transdermal, Dipyridamole/ Aspirin (Aggrenox) - Hypertension | Phase 1 | Completed | Vanderbilt University | 152 | 2001-01-01 | 2017-10-13 |
Multiple System Atrophy (7) · Hypertension (4) · Hypotension, Orthostatic (4) · Parkinson Disease (2) · Shy-Drager Syndrome (2) · Lewy Body Disease (1) · Obesity (1)
Autonomic Nervous System Diseases (9) · Nervous System Diseases (9) · Primary Dysautonomias (9) · Basal Ganglia Diseases (8) · Brain Diseases (8) · Cardiovascular Diseases (8) · Central Nervous System Diseases (8) · Movement Disorders (8) · Vascular Diseases (8) · Neurodegenerative Diseases (7) · Synucleinopathies (7) · Hypotension (6) · Orthostatic Intolerance (4) · Parkinsonian Disorders (2) · Body Weight (1)
Midodrine (4) · Carbidopa (3) · Captopril (2) · Losartan (2) · Pseudoephedrine (2) · Acarbose (1) · Acetazolamide (1) · Arginine (1) · Aspirin (1) · Aspirin, Dipyridamole Drug Combination (1) · Atomoxetine Hydrochloride (1) · Bosentan (1) · Celecoxib (1) · Clonidine (1) · Deamino Arginine Vasopressin (1)
Vanderbilt University (5) · Vanderbilt University Medical Center (3) · Daniel Claassen (1)
United States (9)
Italo Biaggioni, MD (7) · Luis E Okamoto, MD (2) · Italo Biaggioni, M.D. (1)
PMID 11927799, PMID 12119802, PMID 15738343, PMID 10662747, PMID 10851208, PMID 11904109, PMID 12832331, PMID 12923400, PMID 15066944, PMID 15710782, PMID 16391172, PMID 16533484, PMID 17116758, PMID 17515447, PMID 17515448, PMID 18426998, PMID 19047577, PMID 19738158, PMID 20837887, PMID 22311903, PMID 22469621, PMID 22801444, PMID 23266540, PMID 27271310, PMID 39727053, PMID 9369256, PMID 9727818, PMID 9890307
R01HL144568 (2)