Pure Autonomic Failure: Clinical Trials

2 terminated, 1 completed. 3 Early Phase 1.

By phase and status

Phase	Trials	Status
Early Phase 1	3	Terminated 2, Completed 1

Follow Pure Autonomic Failure: new trials by email Literature Review of Pure Autonomic Failure trials Research Report on Pure Autonomic Failure

Trials (filtered) newest first · largest first

All 3 trials

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients Midodrine, Placebo pill, Abdominal compression - Neurogenic Orthostatic Hypotension, Autonomic Failure	Early Phase 1	Completed	Vanderbilt University Medical Center	31	2020-11-09	2026-08-07
Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure Angiotensin-(1-7), Saline - Autonomic Nervous System Disorders, Pure Autonomic Failure	Early Phase 1	Terminated	Vanderbilt University Medical Center	7	2016-02-01	2021-01-12
Water and Sudafed in Autonomic Failure Pseudoephedrine + 480 ml water, Pseudoephedrine + 50 ml water, Placebo + 480 ml water (optional) - Shy-Drager Syndrome, Multiple System Atrophy	Early Phase 1	Terminated	Vanderbilt University	35	2014-10-01	2021-05-05

Narrower conditions

Multiple System Atrophy (2)  ·  Shy-Drager Syndrome (2)  ·  Autonomic Nervous System Diseases (1)  ·  Hypertension (1)  ·  Parkinson Disease (1)

Broader conditions

Basal Ganglia Diseases (3)  ·  Brain Diseases (3)  ·  Central Nervous System Diseases (3)  ·  Movement Disorders (3)  ·  Nervous System Diseases (3)  ·  Primary Dysautonomias (3)  ·  Autonomic Nervous System Diseases (2)  ·  Cardiovascular Diseases (2)  ·  Hypotension (2)  ·  Neurodegenerative Diseases (2)  ·  Synucleinopathies (2)  ·  Vascular Diseases (2)  ·  Multiple System Atrophy (1)  ·  Parkinsonian Disorders (1)

Interventions

Acetates (1)  ·  Drinking Water (1)  ·  Midodrine (1)  ·  Pseudoephedrine (1)  ·  Saline Solution (1)  ·  Sodium Chloride (1)  ·  Sugars (1)  ·  Water (1)  ·  angiotensin I (1-7) (1)

Sponsors

Vanderbilt University Medical Center (2)  ·  Vanderbilt University (1)

Countries

United States (3)

Top investigators

Emily M Garland, PhD, MSCI (1)  ·  Italo Biaggioni, MD (1)  ·  Luis Okamoto, MD (1)

NIH funding

P01HL056693 (1), R01HL144568 (1), UL1TR000445 (1)